Patient-centered pharmacovigilance: A review

Purpose: To determine through a literature review, the current status of patients’ involvement in adverse drug reactions (ADRs) reporting.Methods: Eighteen (18) studies which were published within the period from 2010 to 2016 were reviewed. The studies were extracted from seven databases, viz, Google Scholars, Medline, Academic Search Complete “EBSCO”, Health and Medical Complete ProQuest, Science Direct- Elsevier, SCOPUS and Wiley Online Library.Results: The review revealed that although the reports by patients were of good quality, the patients’ awareness of, and attitude towards, ADR reporting were generally poor.Conclusion: The results of this review suggest the need for patients’ enlightenment on ADRs reporting. Information on how to improve ADRs reporting is provided.Keywords: Adverse drug reaction, Patients’ reporting; Systematic review, Patient-centeredpharmacovigilanc

Ther Adv Drug Saf

Background: Our aim in this study was to evaluate the effect of a combined educational intervention and year-long monthly text message reinforcements via the Short Messaging System (SMS) on the knowledge, attitude and practice (KAP) of healthcare professionals (HCPs) towards pharmacovigilance. Methods: Six randomly selected teaching hospitals in the South-South zone of Nigeria were randomized in 1:1 ratio into intervention and control groups. The educational intervention consisted of delivering a seminar followed by sending monthly texts message reinforcements via SMS over 12 months. Then a semi-structured questionnaire regarding the KAP of pharmacovigilance was completed by HCPs working in the hospitals after the intervention. Data was analysed descriptively and inferentially. Results: A total of 931 HCPs participated in the post intervention study (596 in the intervention and 335 in the control). The M:F ratio was 1:1.5. According to the KAP questionnaire, a significant difference was observed between the intervention and control groups, regarding knowledge of the types of adverse drug reactions (ADRs). ADR resulting from pharmacological action of the drug (85.6% versus 77%, p = 0.001), the fact that ADRs can persist for a long time; (60.1% versus 53.4%, p = 0.024) and a higher awareness of the ADR reporting form (48.7% versus 18.8%, p < 0.001). Most respondents in the intervention group (68.5% versus 60.6%, p = 0.001) believed they should report ADRs even if they were unsure an ADR has occurred, a greater proportion of HCPs from the intervention group had significantly observed an ADR (82% versus 73.4%, p = 0.001). Furthermore, of the 188 who had ever reported an ADR, 41% from the intervention group used the national ADR reporting form compared with 19.8% from the controls (p < 0.001). Conclusion: This educational intervention and the use of SMS as a reinforcement tool appeared to have positively impacted on the knowledge and practice of pharmacovigilance in South-South Nigeria with a less-than-impressive change in attitude. Continuous medical education may be required to effect long-lasting changes

Impact des inhibiteurs de l'acétylcholinestérase dans la maladie d'Alzheimer et les maladies apparentées

BORDEAUX2-BU Santé (330632101) / SudocSudocFranceF

Consommation médicamenteuse du sujet âgé de 75 ans et plus (une étude en Médecine Générale)

BORDEAUX2-BU Santé (330632101) / SudocPARIS-BIUM (751062103) / SudocSudocFranceF

Prévalence de la consommation de psychotropes chez les enfants et les adolescents de la cohorte GAZEL jeune, et facteurs associés, en France, en 1991

BORDEAUX2-BU Santé (330632101) / SudocSudocFranceF

Consommation des Antibiotiques dans les Etablissements de Santé (description, Critères d'Ajustement et Relation avec la Politique de Bon Usage des Antibiotiques)

La maitrise de la résistance bactérienne et l utilisation prudente des antibiotiques à l hôpital constituent des enjeux majeurs pour les autorités de santé dans tous les pays européens. Toutefois, les connaissances en matière de consommation des antibiotiques et de politique de bon usage des antibiotiques dans les établissements sont limitées. Dans ce contexte, le travail de cette thèse permet de donner une meilleure vision de la consommation des antibiotiques dans les pays européens à partir des données de surveillance disponibles. Il apporte également des cibles d amélioration de la prescription des antibiotiques et identifie plusieurs indicateurs de qualité pour mener à bien une politique de bon usage des antibiotiques. De plus, ce travail utilise le modèle des hôpitaux français pour identifier des critères d ajustement de la consommation des antibiotiques facilement disponibles qui sont essentiels à mettre en œuvre pour établir des comparaisons entre les différents hôpitaux. Il s intéresse également à la relation entre la politique de bon usage des antibiotiques dans les hôpitaux et une moindre consommation des antibiotiques. En conclusion, les données de surveillance de la consommation des antibiotiques ont donc permis de répondre à plusieurs hypothèses de recherche et de dégager de nouveaux axes de réflexions.The control of bacterial resistance and the prudent use of antibiotics in hospitals are major challenges for health authorities in all European countries. However, little is known regarding antibiotic consumption and antibiotic policies in hospitals. In this context, this thesis provides insight into the antibiotic consumption using available survey databases. It also identifies targets for quality improvement and several quality indicators which are essencial to carry out a prudent use antibiotic policy. Moreover, the model of French hospitals was used to explore easily available adjustment criteria for the antibiotic consumption which are crucial to implement comparisons between different types of hospitals. This work brings light onto the relationship between the antibiotic policy and a low level of antibiotic use in French hospitals. In conclusion, survey databases have enabled us to answer several research assumptions and to generate new horizons of reflection.BORDEAUX2-Bib. électronique (335229905) / SudocSudocFranceF

Introduction

Caubet Annie, Fourrier Sabine, Yon Marguerite. Introduction. In: Kition-Bamboula VI. Le sanctuaire sous la colline. Lyon : Maison de l'Orient et de la Méditerranée Jean Pouilloux, 2015. pp. 13-32. (Travaux de la Maison de l'Orient et de la Méditerranée. Série recherches archéologiques, 67

Kition-Bamboula VI. Le sanctuaire sous la colline

International audienceL'ouvrage présente les résultats de la fouille française dans le sanctuaire de Kition-Bamboula (1976-1989)