Possible changes in the Holocene wind pattern recorded on southeastern Brazilian coast

The Pacific oceanographic phenomenon "EL Niño" is responsible, during some months, for very significant atmospheric circulation disturbances in the coasts of southern Equador and Northern Peru. Consequently, derangements of some natural mechanisms, directly or indirectly related to wind patterns, are produced along northeastern, southeastern or southern coasts of Brazil. During Holocene, "El Niño" - like disturbances with longer duration (some tens or even hundreds of years), have been recorded in some places of this country

Cartografia e diplomacia: usos geopolíticos da informação toponímica (1750-1850)

O artigo explora dimensões geopolíticas da toponímia, registradas em documentos cartográficos, desde as reformas empreendidas pelo consulado pombalino em meados do século XVIII, até às primeiras décadas do século XIX, em meio ao processo de afirmação do Estado imperial pós-colonial.This paper explores the geopolitical dimensions of toponymy as registered in cartographic documents dating from the reforms pushed through by the consulate of Marquis of Pombal in the mid 18th century to the early decades of the 19th century, as the post-colonial imperial State established itself

An appraisal of the Serra da Cangalha impact structure using the Euler deconvolution method

The applicability of the Euler deconvolution method in imaging impact crater structure vis- vis delineation of source depth of the circular magnetic anomaly and/or basement depth beneath the crater is addressed in this paper. The efficacy of the method has been evaluated using the aeromagnetic data obtained over the Serra da Cangalha impact crater, northeastern Brazil. The analyses of the data have provided characteristic Euler deconvolution signatures and structural indices associated with impact craters. Also, through the interpretation of the computed Euler solutions, our understanding of the structural features present around the impact structure has been enhanced. The Euler solutions obtained indicate shallow magnetic sources that are interpreted as possibly post-impact faults and a circular structure. The depth of these magnetic sources varies between 0.8 and 2.5 km, while the Precambrian basement depth was found at ~1.5 km. This is in good agreement with the estimates of the Precambrian basement depth of about 1.1 km, calculated using aeromagnetic data. The reliability of the depth solutions obtained through the implementation of the Euler method was confirmed through the use of the existing information available in the area and the result of previous studies. We find that the Euler depth solutions obtained in this study are consistent with the results obtained using other methods.The Meteoritics & Planetary Science archives are made available by the Meteoritical Society and the University of Arizona Libraries. Contact [email protected] for further information.Migrated from OJS platform February 202

Portaria 044/CCB/2009

Coordenadora Módulo I - Fonoaudiologia - Eliane Goldfeder

RAR-independent RXR signaling induces t(15;17) leukemia cell maturation.

Although retinoic acid receptor alpha (RARalpha) agonists induce the maturation of t(15;17) acute promyelocytic leukemia (APL) cells, drug treatment also selects leukemic blasts expressing PML-RARalpha fusion proteins with mutated ligand-binding domains that no longer respond to all-trans retinoic acid (ATRA). Here we report a novel RARalpha-independent signaling pathway that induces maturation of both ATRA-sensitive and ATRA-resistant APL NB4 cells, and does not invoke the ligand-induced alteration of PML-RARalpha signaling, stability or compartmentalization. This response involves a cross-talk between RXR agonists and protein kinase A signaling. Our results indicate the existence of a separate RXR-dependent maturation pathway that can be activated in the absence of known ligands for RXR heterodimerization partners