44 research outputs found

    The Effects of Observed Friendship Formation on Group Level Peer Experiences: A Study of Behaviorally Inhibited Preschooler

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    Early social withdrawal places children at a greater risk for later internalizing disorders and peer difficulties. However, positive friendships can serve as a buffer against this trajectory. Currently, very little is known about if friendships develop between preschool aged withdrawn children, and how this affects their group level peer processes. The purpose of the current study was to examine whether socially withdrawn children who made a friend demonstrated gains in social skills in their preschool classrooms over an 8-week period during which they had participated in an intervention designed to increase social interaction and decrease social reticence. Overall, the children who made a friend over the intervention period had less observed reticent behavior and more prosocial behavior in their preschool classrooms both before and after the intervention period. These children entered the intervention with more advanced social skills and were able to utilize them to develop a meaningful friendship

    Genetic diversity and risk factors for the transmission of antimicrobial resistance across human, animals and environmental compartments in East Africa: a review.

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    BACKGROUND The emergence and spread of antimicrobial resistance (AMR) present a challenge to disease control in East Africa. Resistance to beta-lactams, which are by far the most used antibiotics worldwide and include the penicillins, cephalosporins, monobactams and carbapenems, is reducing options for effective control of both Gram-positive and Gram-negative bacteria. The World Health Organization, Food and Agricultural Organization and the World Organization for Animal Health have all advocated surveillance of AMR using an integrated One Health approach. Regional consortia also have strengthened collaboration to address the AMR problem through surveillance, training and research in a holistic and multisectoral approach. This review paper contains collective information on risk factors for transmission, clinical relevance and diversity of resistance genes relating to extended-spectrum beta-lactamase-producing (ESBL) and carbapenemase-producing Enterobacteriaceae, and Methicillin-resistant Staphylococcus aureus (MRSA) across the human, animal and environmental compartments in East Africa. MAIN BODY The review of the AMR literature (years 2001 to 2019) was performed using search engines such as PubMed, Scopus, Science Direct, Google and Web of Science. The search terms included 'antimicrobial resistance and human-animal-environment', 'antimicrobial resistance, risk factors, genetic diversity, and human-animal-environment' combined with respective countries of East Africa. In general, the risk factors identified were associated with the transmission of AMR. The marked genetic diversity due to multiple sequence types among drug-resistant bacteria and their replicon plasmid types sourced from the animal, human and environment were reported. The main ESBL, MRSA and carbapenem related genes/plasmids were the CTX-Ms (45.7%), SCCmec type III (27.3%) and IMP types (23.8%), respectively. CONCLUSION The high diversity of the AMR genes suggests there may be multiple sources of resistance bacteria, or the possible exchange of strains or a flow of genes amongst different strains due to transfer by mobile genetic elements. Therefore, there should be harmonized One Health guidelines for the use of antibiotics, as well as regulations governing their importation and sale. Moreover, the trend of ESBLs, MRSA and carbapenem resistant (CAR) carriage rates is dynamic and are on rise over time period, posing a public health concern in East Africa. Collaborative surveillance of AMR in partnership with regional and external institutions using an integrated One Health approach is required for expert knowledge and technology transfer to facilitate information sharing for informed decision-making

    Vol13#4_The Elusive Adult

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    Remembering to remember : does event-based prospective memory decline with Age?

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    M.S.Christopher Hertzo

    HCS Golden Fleece road map, Tasmania [cartographic material].

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    Map showing classes of roads, highways, railways, mileages, index to main towns and tourist information.; Panel title.; On verso: City of Launceston -- Map of State Highways -- City of Hobart -- Table of distances.; Also available in an electronic version via the internet at: http://nla.gov.au/nla.map-vn511004
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