Soundless Screams: Graffiti and Drawings in the Prisons of the Holy Office in Palermo

The discovery of graffiti in the early years of the twentieth century by the folklorist Giuseppe Pitre left by prisoners of the tribunal of the Spanish Inquisition in Palermo has been followed by more extensive investigations in recent years. These images and words have added a concrete and particular dimension to Sicily's position at the crossroads of the Mediterranean. As well as images of saints and naval battles are to be found inscriptions not only in Italian, Sicilian and Latin but also in English and Hebrew. This article cross references this visual and textual evidence with the relevant archives of the tribunal in order to provide a powerful microhistory of suffering and resilience in this most inhospitable of environments. The result adds a new dimension to our understanding of the prison's organization, judicial proceedings and the impact of the inquisition on the lives and consciences of those people from all over Europe, North Africa and the Middle East, who found themselves unwilling denizens of what must have been perhaps the most international community of prisoners in the early modern Christian world

La schiavit\uf9 mediterranea tra medioevo e et\ue0 moderna. Una proposta bibliografica

Un ausilio bibliografico composto da un centinaio di titoli di libri, articoli, saggi per avviare allo studio del fenomeno studenti e giovani ricercatori di storia. Indice: Introduzione, Un Mediterraneo frammentato e interconnesso; Fonti; Schiavit\uf9 pan-mediterranea; Prigionieri, schiavi, galeotti; Corsari e pirati; Le Reggenze barbaresche; Lingua franca; Il declino della corsa (la strada degli accordi diplomatici); Schiavi di musulmani e di ebrei; Santi e confraternite neri; Lunghe diacronie, ampi contesti; Osservazione ravvicinata sulla penisola iberica; Il riscatto: il commercio dei captivi; Lettere dalla schiavit\uf9 e r\ue9cits d'esclavage; Abiure e conversioni: i rinnegati

Human herpesvirus 6: An emerging pathogen.

Infections with human herpesvirus 6 (HHV-6), a beta-herpesvirus of which two variant groups (A and B) are recognized, is very common, approaching 100% in seroprevalence. Primary infection with HHV-6B causes roseola infantum or exanthem subitum, a common childhood disease that resolves spontaneously. After primary infection, the virus replicates in the salivary glands and is shed in saliva, the recognized route of transmission for variant B strains; it remains latent in lymphocytes and monocytes and persists at low levels in cells and tissues. Not usually associated with disease in the immunocompetent, HHV-6 infection is a major cause of opportunistic viral infections in the immunosuppressed, typically AIDS patients and transplant recipients, in whom HHV-6 infection/reactivation may culminate in rejection of transplanted organs and death. Other opportunistic viruses, human cytomegalovirus and HHV-7, also infect or reactivate in persons at risk. Another disease whose pathogenesis may be correlated with HHV-6 is multiple sclerosis. Data in favor of and against the correlation are discussed

Probing the role of nuclear-envelope invaginations in the nuclear-entry route of lipofected DNA by multi-channel 3D confocal microscopy

Nuclear breakdown was found to be the dominant route for DNA entry into the nucleus in actively dividing cells. The possibility that alternative routes contribute to DNA entry into the nucleus, however, cannot be ruled out. Here we address the process of lipofection by monitoring the localization of fluorescently-labelled DNA plasmids at the single-cell level by confocal imaging in living interphase cells. As test formulation we choose the cationic 3β-[N-(N,N-dimethylaminoethane)-carbamoyl] cholesterol (DC-Chol) and the zwitterionic helper lipid dioleoylphosphatidylethanolamine (DOPE) with plasmidic DNA pre-condensed by means of protamine. By exploiting the spectral shift of the fluorescent dye FM4-64 (N-(3-triethylammoniumpropyl)-4-(p-diethylaminophenylhexatrienyl)-pyridinium 2Br) we monitor the position of the nuclear envelope (NE), while concomitantly imaging the whole nucleus (by Hoechst) and the DNA (by Cy3 fluorophore) in a multi-channel 3D confocal imaging experiment. Reported results show that DNA clusters are typically associated with the NE membrane in the form of tubular invaginations spanning the nuclear environment, but not completely trapped within the NE invaginations, i.e. the DNA may use these NE regions as entry-points towards the nucleus. These observations pave the way to investigating the molecular details of the postulated processes for a better exploitation of gene-delivery vectors, particularly for applications in non-dividing cells

The 1998 outburst of the X-ray transient XTE J2012+381 as observed with BeppoSAX

We report on the results of a series of X-ray observations of the transient black hole candidate XTE J2012+381 during the 1998 outburst performed with the BeppoSAX satellite. The observed broad-band energy spectrum can be described with the superposition of an absorbed disk black body, an iron line plus a high energy component, modelled with either a power law or a Comptonisation tail. The source showed pronounced spectral variability between our five observations. While the soft component in the spectrum remained almost unchanged throughout our campaign, we detected a hard spectral tail which extended to 200 keV in the first two observations, but became barely detectable up to 50 keV in the following two. A further re-hardening is observed in the final observation. The transition from a hard to a soft and then back to a hard state occurred around an unabsorbed 0.1-200 keV luminosity of 10^38 erg/s (at 10 kpc). This indicates that state transitions in XTE 2012+281 are probably not driven only by mass accretion rate, but additional physical parameters must play a role in the evolution of the outburst.Comment: Paper accepted for publication on A&A (macro included, 9 pages, 5 figures

Evidence for a Molecular Cloud Origin for Gamma-Ray Bursts: Implications for the Nature of Star Formation in the Universe

It appears that the majority of rapidly-, well-localized gamma-ray bursts with undetected, or dark, optical afterglows, or `dark bursts' for short, occur in clouds of size R > 10L_{49}^{1/2} pc and mass M > 3x10^5L_{49} M_{sun}, where L is the isotropic-equivalent peak luminosity of the optical flash. We show that clouds of this size and mass cannot be modeled as a gas that is bound by pressure equilibrium with a warm or hot phase of the interstellar medium (i.e., a diffuse cloud): Such a cloud would be unstable to gravitational collapse, resulting in the collapse and fragmentation of the cloud until a burst of star formation re-establishes pressure equilibrium within the fragments, and the fragments are bound by self-gravity (i.e., a molecular cloud). Consequently, dark bursts probably occur in molecular clouds, in which case dark bursts are probably a byproduct of this burst of star formation if the molecular cloud formed recently, and/or the result of lingering or latter generation star formation if the molecular cloud formed some time ago. We then show that if bursts occur in Galactic-like molecular clouds, the column densities of which might be universal, the number of dark bursts can be comparable to the number of bursts with detected optical afterglows: This is what is observed, which suggests that the bursts with detected optical afterglows might also occur in molecular clouds. We confirm this by modeling and constraining the distribution of column densities, measured from absorption of the X-ray afterglow, of the bursts with detected optical afterglows: We find that this distribution is consistent with the expectation for bursts that occur in molecular clouds, and is not consistent with the expectation for bursts that occur in diffuse clouds. More...Comment: Accepted to The Astrophysical Journal, 22 pages, 6 figures, LaTe