Subacute thyroiditis and HIV infection: Case report and literature review

This case report is on Subacute thyroiditis (SAT) with thyrotoxicosis in a 22year-old housewife . She had been married for 2years to a long-distance driver. She presented with a fever and neurological features which were followed by features of SAT such as pain and difficulty in swallowing, swelling of the anterior aspect of the neck, palpitations, shaking of the body, tenderness over the neck, coarse tremors of the hands and worsening of fever. She appeared depressed and was restless. The fever with the neurological features (lower motor neurone lesion of the facial nerve) suggested a form of viraemia, which could have been from any virus. HIV infection was confirmed in this patient but there was no weight loss, no diarrhoea nor lymphadenopathy. This suggests a probable viraemia of seroconversion of HIV infection. There were also no features of other infections or other diseases. This case report may suggest an aetiological association between HIV and subacute thyroiditis. However, HIV has not been reported before as an aetiology of subacute thyroiditis.Jos Journal of Medicine, Volume 7 No.

Reduced thyrotropin in euthyroid goitrous patients suggesting subclinical hyperthyroidism

No Abstract. Nigerian Journal of Medicine Vol. 16 (2) 2007: pp.133-13

Yersinia enterocolitica, a Neglected Cause of Human Enteric Infections in Côte d’Ivoire

International audienceBackground: Enteropathogenic Yersinia circulate in the pig reservoir and are the third bacterial cause of human gastrointestinal infections in Europe. In West Africa, reports of human yersiniosis are rare. This study was conducted to determine whether pathogenic Yersinia are circulating in pig farms and are responsible for human infections in the Abidjan District. Methodology/Principal findings: From June 2012 to December 2013, pig feces were collected monthly in 41 swine farms of the Abidjan district. Of the 781 samples collected, 19 Yersinia strains were isolated in 3 farms: 7 non-pathogenic Yersinia intermedia and 12 pathogenic Yersinia enterocolitica bioserotype 4/O:3. Farm animals other than pigs and wild animals were not found infected. Furthermore, 2 Y. enterocolitica 4/O:3 strains were isolated from 426 fecal samples of patients with digestive disorders. All 14 Y. enterocolitica strains shared the same PFGE and MLVA profile, indicating their close genetic relationship. However, while 6 of them displayed the usual phage type VIII, the other 8 had the highly infrequent phage type XI. Whole genome sequencing and SNP analysis of individual colonies revealed that phage type XI strains had unusually high rates of mutations. These strains displayed a hypermutator phenotype that was attributable to a large deletion in the mutS gene involved in DNA mismatch repair. Conclusions/Significance: This study demonstrates that pathogenic Y. enterocolitica circulate in the pig reservoir in Côte d'Ivoire and cause human infections with a prevalence comparable to that of many developed countries. The paucity of reports of yersiniosis in West Africa is most likely attributable to a lack of active detection rather than to an absence of the microorganism. The identification of hypermutator strains in pigs and humans is of concern as these strains can rapidly acquire selective advantages that may increase their fitness, pathogenicity or resistance to commonly used treatments