Epigenetic modulators as therapeutic targets in prostate cancer

Prostate cancer is one of the most common non-cutaneous malignancies among men worldwide. Epigenetic aberrations, including changes in DNA methylation patterns and/or histone modifications, are key drivers of prostate carcinogenesis. These epigenetic defects might be due to deregulated function and/or expression of the epigenetic machinery, affecting the expression of several important genes. Remarkably, epigenetic modifications are reversible and numerous compounds that target the epigenetic enzymes and regulatory proteins were reported to be effective in cancer growth control. In fact, some of these drugs are already being tested in clinical trials. This review discusses the most important epigenetic alterations in prostate cancer, highlighting the role of epigenetic modulating compounds in pre-clinical and clinical trials as potential therapeutic agents for prostate cancer management.info:eu-repo/semantics/publishedVersio

Competência ortográfica e metafonológica: influências e correlações na leitura e escrita de escolares da 4ª série Orthographic and metaphonological competences: influences and correlations with reading and writing abilities of 4th grade students

OBJETIVO: Estudar o desempenho de escolares da 4ª série em tarefas de leitura e escrita e de consciência fonológica. MÉTODOS: Trinta e dois escolares de 4ª série (50,0% meninas), entre nove e 11 anos, foram avaliados segundo os procedimentos: anamnese, avaliação da leitura, escrita (54 itens linguísticos) e consciência fonológica. Foram divididos em: GPI: escreveram e, após, leram em voz alta; GPII: leram em voz alta e, após, escreveram; GCI: apenas escreveram; GCII: apenas leram. RESULTADOS: Na escrita, GPII apresentou as maiores médias de acerto, sendo que GPI, GPII e GCI apresentaram melhor desempenho para as palavras frequentes, seguido das pseudopalavras e das de baixa frequência. Na leitura, os desempenhos dos GPI, GPII e GCII foram semelhantes, sendo que GPI e GPII apresentaram mais acertos para as pseudopalavras, seguido das de alta frequência. A correlação entre consciência fonológica e escrita mostrou-se moderada e entre consciência fonológica e leitura e entre escrita e leitura foi bem fraca. CONCLUSÕES: A consciência fonológica mostrou moderada correlação com a escrita e baixa com a leitura; a característica psicolinguística baixa familiaridade determinou as maiores médias de erro, tanto na leitura quanto na escrita.<br>PURPOSE: To study the performance of 4th grade students on reading, writing and phonological awareness tasks. METHODS: Thirty-two 4th grade children (50% of each gender), with ages between nine and 11 years, were evaluated according to the following procedure: anamnesis, reading and writing task (54 linguistic tokens), and phonological awareness task. The students were divided into two research groups and two comparison groups: GPI: carried out the writing task first, and then the reading task; GPII: completed the reading, followed by the writing task; GCI: completed only the writing items; GCII: completed only the reading items. RESULTS: In the writing task, GPII showed the highest rates of correct answers, and GPI, GPII and GCI had better performances in writing high frequency words, followed by pseudowords and low frequency words. The reading evaluation showed that the performances of GPI, GPII and GCII were similar, and GPI and GPII had more correct answers for pseudowords, followed by high frequency words. The correlation between phonological awareness and writing was moderate, while correlations between phonological awareness and reading, and writing and reading were very weak. CONCLUSION: Phonological awareness was moderately correlated to the performance on the writing task, and weakly correlated to the performance on the reading task. The psycholinguistic feature low familiarity determined the highest error averages, both in reading and writing tasks

PARP inhibitors as first-line maintenance therapy in ovarian cancer: recommendations from an expert panel from Brazil

To report consensus recommendations on the current role of poly(ADP-ribose) polymerase (PARP) inhibitors in the front-line management of patients with epithelial ovarian cancer (EOC) in the healthcare setting of Brazil. The expert panel convened in March 2021 and comprised 20 medical oncologists focus on gynecological oncology. The panel answered anonymously and based on scientific evidence a total of 67 questions. The panel reached consensus (at least 75% of votes for the same recommendation) or majority vote (50% to 74.9%) for the majority of questions that addressed: (1) who and when to test for BRCA mutations or homologous recombination deficiency (2) what test should be used; (3) when should maintenance PARP inhibitor therapy be indicated; (4) which PARP inhibitor should be used; (5) when should bevacizumab be combined; and (6) toxicity management. The current recommendations may help Brazilian practitioners to improve the use of PARP inhibitors in front-line management of EOC