Arbitral decision-making: an issue of consistency and a response to bias

The issues of consistency and bias in arbitral decision-making cannot be underestimated. They have given rise to criticisms regarding the legitimacy and transparency of arbitration as a dispute resolution process for resolving disputes involving public and private interests. Elucidating the arbitral decision-making process can be the much needed reply to such criticisms proving the effectiveness of arbitration as an alternative to domestic courts

ABUSE OF RIGHTS IN INTERNATIONAL ARBITRATION

PhDWhile international arbitration offers the prominent scheme for resolution of transnational disputes, the arbitration community must constantly examine areas of concern. Any system of justice, including the arbitration system, is not meant for abuse. Thus, it would be paradoxical to support a mischief that the arbitration system seeks to obviate. This could cast doubts as to the system’s efficiency and induce distrust in a system formed to accommodate parties’ interests and uphold their common intentions. In recent years, international arbitration has been plagued by different forms of procedural abuse. Abusive practices developed by parties may undermine the fair resolution of disputes and frustrate the administration of arbitral justice. There are pre-existing tools and legal rules at the disposal of arbitrators that can be utilised to prevent abuse and administer arbitral justice. However, these tools are inherently rigid in their application. The thesis introduces the principle of abuse of rights in international arbitration and argues for its application as a general principle of law to prevent the transmogrification of international arbitration into a process profoundly tainted with abuse. The virtue and efficacy of a single theory with a wide scope of application and an overarching premise, is that it can be used to address different abusive behaviours, and equally enjoys the flexibility of general principles of law

Transformation of Cybersecurity Posture in IT Telecommunication : A Case Study of a Telecom Operator

Organisations are facing sophisticated and advanced persistent threats (APT) that are targeting sensitive information assets. Any form of cyber-presence can be typically attacked by adversaries, and the motives of such attacks are context dependent. Besides, users and organisations are prone to software vulnerabilities, misconfigura-tions, outdated systems and several other systemic deficiencies which can be leveraged to compromise enterprise assets and gain an initial foothold within an organisation network. The aim of the pa-per is to develop a flexible and generally comprehensive organisa-tional strategy to defend against the massive increase in cyberat-tacks, in order to protect the strategic business objectives of an or-ganisation and keep an alignment between business objectives and security. Moreover, this paper reflects on the work undertaken by multiple teams within the chosen case study organisation to enhance the cybersecurity

Knowledge sharing in the supply chain networks: A perspective of supply chain complexity drivers

Background: Knowledge transfer has been an important aspect in supply chain systems, however, there are many factors that affect the impact of transfer effectiveness. In previous studies, less attention has been given to the process of knowledge transfer and therefore, this paper highlights the significance of the process of knowledge transfer in supply chain processes. Enhanced supply chain networks have better performance when knowledge sharing is present, and it is important to identify and eliminate any supply chain complex-ity to improve the supply chain processes. Methods: A systematic review on the literature has been conducted to critically identify and evaluate the factors of supply chain complexity which impacts knowledge transfer. Findings: The findings highlight the key benefits of effective knowledge transfer in supply chain systems by identifying risks associated with supply chain networks. Conclusion: The balanced power of facilitating knowledge transfer in supply chain processes helps in supply chain partnerships and reduces the supply chain complexity. This paper has both theoretical and practical contributions as it adds to the literature by identifying the factors of supply chain complexity drivers which are impacting the knowledge transfer

Phenotypic and Molecular Detection of Antiseptic Resistance Genes among Clinical Staphylococcus aureus Isolates During COVID-19 Pandemic

The coronavirus disease (COVID-19) pandemic has expanded the use of chlorhexidine digluconate, a biocide frequently used in hospitals, to inhibit the spread of infection. Genes responsible for resistance against the quaternary ammonium compound qac in Staphylococcus aureus isolates have been shown to confer tolerance to a number of biocidal chemicals, including chlorhexidine. The aim of this study was to determine the occurrence of antiseptic resistance genes (qacA/B and qacC) in clinical isolates of methicillin-susceptible (MSSA) and methicillin-resistant Staphylococcus aureus (MRSA). The study also aimed to investigate the association between the presence of the mecA, qacA/B, and qacC genes in MRSA isolates and the susceptibility of the isolates to chlorhexidine to evaluate its future use in the Theodor Bilharz Research Institute (TBRI) hospital, following the Centers for Disease Control and Prevention recommendations for patients with MRSA. S. aureus isolates (n = 100) were collected from inpatients and outpatients at TBRI. A minimal inhibitory concentration of chlorhexidine was also detected. Polymerase chain reaction was used to detect the mecA, qacA/B, and qacC genes. The results revealed that 84% of S. aureus isolates were MRSA. MRSA (61.9%) and MSSA (68.8%) isolates were susceptible to chlorhexidine. The qacA/B gene was more dominant, being detected in 34%, while qacC was detected in only 5% of S. aureus isolates. All S. aureus isolates with reduced susceptibility to chlorhexidine harbored either the qacA/B or qacC genes. The clinical use of chlorhexidine may continue to increase, emphasizing the significance of continuous caution underlining the emergence of new clones with reduced susceptibility and avoiding antiseptic misuse

Military and Development in Bangladesh

SUMMARY This article traces the origins of the Bangladesh army back to the British East India Company's army and follows its development through the colonial period, looking at the consequences of the exclusion of Bengalis after 1857. It shows why the Bengali sections of the Pakistan army were brought to the point of revolt in the national liberation struggle of 1971, and examines the factors which inhibited the development of a people's army and people's war. The erosion of public support for the Mujib government and the 1971 takeover are discussed. It is concluded that though there were important grievances internal to the military, the economic situation was the most significant element in these events. Resume Militarisme et développement au Bangladesh Cet article attribue les origines de l'armée du Bangladesh à l'armée de la British East India Company et suit son développement au cours de la période coloniale, examinant les conséquences de l'exclusion des Bengalis, après 1857. Il démontre pourquoi les factions bengalis de l'armée pakistanaise furent au point de se révolter lors de la lutte de libération nationale de 1971, et examine les facteurs qui entravèrent le développement d'une armée populaire et d'une guerre populaire. L'érosion du soutien public pour le gouvernement Mujib et la prise de pouvoir de 1971, sont examinées. L'article conclut que, malgré l'existence de griefs considérables au sein même de l'armée, c'est à la situation économique qu'il convient d'attribuer le rôle prépondérant, dans ces événements. Resumen El militarismo y el desarrollo en Bangladesh En este artículo se investigan los orígenes del ejército de Bangladesh remontándose hasta el ejército de la Compañía británica de la India Oriental y sigue su evolución a través del período colonial, poniendo de relieve las consecuencias de la exclusión de los bengalíes después de 1857. Se indica por qué las secciones bengalíes del ejército de Pakistán casi llegaron al borde de la revuelta en la lucha de liberación nacional de 1971 y se examinan los factores que impidieron la creación de un ejército del pueblo y una guerra del pueblo. Se analizan la erosión del apoyo popular para el gobierno de Mujib y el golpe de estado de 1971. Se llega a la conclusión de que aunque existían importantes agravios internos hacia los militares, la situación económica fue el elemento más significativo de dichos acontecimientos

Proinflammatory isoforms of IL-32 as novel and robust biomarkers for control failure in HIV-infected slow progressors.

International audienceHIV-infected slow progressors (SP) represent a heterogeneous group of subjects who spontaneously control HIV infection without treatment for several years while showing moderate signs of disease progression. Under conditions that remain poorly understood, a subgroup of these subjects experience failure of spontaneous immunological and virological control. Here we determined the frequency of SP subjects who showed loss of HIV control within our Canadian Cohort of HIV(+) Slow Progressors and identified the proinflammatory cytokine IL-32 as a robust biomarker for control failure. Plasmatic levels of the proinflammatory isoforms of IL-32 (mainly β and γ) at earlier clinic visits positively correlated with the decline of CD4 T-cell counts, increased viral load, lower CD4/CD8 ratio and levels of inflammatory markers (sCD14 and IL-6) at later clinic visits. We present here a proof-of-concept for the use of IL-32 as a predictive biomarker for disease progression in SP subjects and identify IL-32 as a potential therapeutic target

Diosgenin alleviates D-galactose-induced oxidative stress in rats’ brain and liver targeting aging and apoptotic marker genes

The theory of aging is primarily concerned with oxidative stress caused by an imbalance in reactive oxygen species generation and cellular antioxidants. To alleviate the oxidative stress, we investigated the protective effect of diosgenin (DSG) for D-galactose (D-gal) using 20 and 40 mg of DSG/kg/day/orally for 42 days. The findings showed that D-gal caused brain and liver oxidative injuries by upregulating aging and oxidative markers. To counteract the oxidative stress caused by D-gal, DSG upregulated glutathione peroxidase-1, superoxide dismutase-1, and glutathione S-transferase-α. DSG also diminished the expression of p53, p21, Bcl-2-associated X protein, caspase-3, and mammalian target of rapamycin in brain and liver, as well as the build-up of β-galactosidase. DSG, in a dose-dependent manner, decreased the oxidative aging effects of D-gal in brain and liver tissues through targeting of aging and apoptotic marker genes. Finally, it should be noted that consuming DSG supplements is a suggesting natural preventative agent that may counteract aging and preserve health through improvement of body antioxidant status and control aging associated inflammation and cellular apoptosis

Dietary clenbuterol modifies the expression of genes involved in the regulation of lipid metabolism and growth in the liver, skeletal muscle, and adipose tissue of Nile tilapia (Oreochromis niloticus)

The current study aimed to evaluate whether clenbuterol, a β2-adrenergic agonist, supplementation in Nile tilapia (Oreochromis niloticus) diets can influence growth and blood parameters. Besides, assessment of adipogenic genes as fatty acid synthase (FAS) and lipoprotein lipase (LPL) which is a key enzyme in the regulation of the flux of fatty acids in liver, muscle, and adipose tissue as well as muscle growth-regulating genes as myostatin (MYO) in muscle and insulin-like growth factor-1 (IGF-1) in liver. The fish were allocated into three equal groups; control group that fed basal diet only and the other two groups fed a basal diet containing clenbuterol at two doses 5 ppm and 10 ppm/kg diet for 30 consecutive days. Results revealed that clenbuterol supplementation significantly increased body weight, decreased liver, spleen and abdominal fat weights, and decreased total circulatory cholesterol and triacylglycerol levels. Moreover, clenbuterol inhibits lipogenesis by downregulation of FAS gene expression by dose and time-dependent manner in the liver while enhanced lipolysis in both the liver and in the adipose tissue. Moreover, lipolysis was reduced in muscle by dose 10 ppm on day 30. Furthermore, clenbuterol presented higher gene expression of MYO and IGF-1 in muscle and liver respectively by dose 5 ppm at day 15 on the other hand, these findings were reversed by day 30 compared with control. In conclusion, clenbuterol efficacy was apparent in a dose and time response pattern to boost growth and reduce fat deposition rates, indicating for the first time that clenbuterol has a profitable growth impact on Nile tilapia

Convalescent plasma in patients admitted to hospital with COVID-19 (RECOVERY): a randomised controlled, open-label, platform trial

SummaryBackground Azithromycin has been proposed as a treatment for COVID-19 on the basis of its immunomodulatoryactions. We aimed to evaluate the safety and efficacy of azithromycin in patients admitted to hospital with COVID-19.Methods In this randomised, controlled, open-label, adaptive platform trial (Randomised Evaluation of COVID-19Therapy [RECOVERY]), several possible treatments were compared with usual care in patients admitted to hospitalwith COVID-19 in the UK. The trial is underway at 176 hospitals in the UK. Eligible and consenting patients wererandomly allocated to either usual standard of care alone or usual standard of care plus azithromycin 500 mg once perday by mouth or intravenously for 10 days or until discharge (or allocation to one of the other RECOVERY treatmentgroups). Patients were assigned via web-based simple (unstratified) randomisation with allocation concealment andwere twice as likely to be randomly assigned to usual care than to any of the active treatment groups. Participants andlocal study staff were not masked to the allocated treatment, but all others involved in the trial were masked to theoutcome data during the trial. The primary outcome was 28-day all-cause mortality, assessed in the intention-to-treatpopulation. The trial is registered with ISRCTN, 50189673, and ClinicalTrials.gov, NCT04381936.Findings Between April 7 and Nov 27, 2020, of 16 442 patients enrolled in the RECOVERY trial, 9433 (57%) wereeligible and 7763 were included in the assessment of azithromycin. The mean age of these study participants was65·3 years (SD 15·7) and approximately a third were women (2944 [38%] of 7763). 2582 patients were randomlyallocated to receive azithromycin and 5181 patients were randomly allocated to usual care alone. Overall,561 (22%) patients allocated to azithromycin and 1162 (22%) patients allocated to usual care died within 28 days(rate ratio 0·97, 95% CI 0·87–1·07; p=0·50). No significant difference was seen in duration of hospital stay (median10 days [IQR 5 to >28] vs 11 days [5 to >28]) or the proportion of patients discharged from hospital alive within 28 days(rate ratio 1·04, 95% CI 0·98–1·10; p=0·19). Among those not on invasive mechanical ventilation at baseline, nosignificant difference was seen in the proportion meeting the composite endpoint of invasive mechanical ventilationor death (risk ratio 0·95, 95% CI 0·87–1·03; p=0·24).Interpretation In patients admitted to hospital with COVID-19, azithromycin did not improve survival or otherprespecified clinical outcomes. Azithromycin use in patients admitted to hospital with COVID-19 should be restrictedto patients in whom there is a clear antimicrobial indication