L\u2019allattamento tra cura e cultura: dall\u2019Africa all\u2019ipertrofia tecnologica

Breastfeeding is a practice so far unobtrusively studied by cultural and medical anthropology, an act placed between nature and culture, between private and social women spheres and which, like birth and pregnancy. It expresses hierarchies in roles and gender relations among biopolitical dynamics which denote the organization of society itself. As a cultural practice, breastfeeding differs itself on the basis of the so-cial and ethnic belonging of the mother and the child, leading to ritual differences such as the law of the \u201ckinship of milk\u201d in muslim societies or the apothecary taboo of Sub-Saharan Africa. The paper reflects on how much this is occurring in Western society where breastfeeding is less and less widespread and how much the lobbies in-fluence technological and biomedical hypertrophy

Anthropological reflections on breastfeeding between care and culture

Breastfeeding is a practice so far unobtrusively studied by cultural and medical anthropology, an act placed between nature and culture, between private and social women spheres and which, like birth and pregnancy. It expresses hierarchies in roles and gender relations among biopolitical dynamics which denote the organization of society itself. As a cultural practice, breastfeeding differs itself on the basis of the social and ethnic belonging of the mother and the child, leading to ritual differences such as the law of the \u201ckinship of milk\u201d in muslim societies or the apothecary taboo of Sub-Saharan Africa. The paper reflects on how much this is occurring in Western society where breastfeeding is less and less widespread and how much the lobbies influence technological and biomedical hypertrophy

A Probabilistic Approach for the Optimal Sizing of Storage Devices to Increase the Penetration of Plug-in Electric Vehicles in Direct Current Networks

The growing diffusion of electric vehicles connected to distribution networks for charging purposes is an ongoing problem that utilities must deal with. Direct current networks and storage devices have emerged as a feasible means of satisfying the expected increases in the numbers of vehicles while preserving the effective operation of the network. In this paper, an innovative probabilistic methodology is proposed for the optimal sizing of electrical storage devices with the aim of maximizing the penetration of plug-in electric vehicles while preserving efficient and effective operation of the network. The proposed methodology is based on an analytical solution of the problem concerning the power losses minimization in distribution networks equipped with storage devices. The closed-form expression that was obtained is included in a Monte Carlo simulation procedure aimed at handling the uncertainties in loads and renewable generation units. The results of several numerical applications are reported and discussed to demonstrate the validity of the proposed solution. Also, different penetration levels of generation units were analyzed in order to focus on the importance of renewable generation

A New Theoretical Approach of Studying Resonances in Single Finline Transitions

In this article an innovative method of studying and removing the resonances, inherently exhibit by some waveguide to microstrip transitions, is presented. By modeling an equivalent circuit, this new approach allows to obtain the constructive parameters of a finline to microstrip transition, only using the values of the resistance and capacitance components of the equivalent circuit. This procedure will allow small microwave design Companies to realize these transitions only implementing circuit analysis software, and not having to afford electromagnetic analysis software, which are very expensive and time-consuming. A full 3D electromagnetic analysis confirms that the simulation results are in excellent agreement with the results obtained by the new equations discussed in this work

Surface and bulk modifications of amphibole asbestos in mimicked gamble's solution at acidic PH

This study aimed at investigating the surface modifications occurring on amphibole asbestos (crocidolite and tremolite) during leaching in a mimicked Gamble’s solution at pH of 4.5 and T = 37 °C, from 1 h up to 720 h. Results showed that the fibre dissolution starts with the release of cations prevalently allocated at the various M- and (eventually) A-sites of the amphibole structure (incongruent dissolution). The amount of released silicon, normalized to fibre surface area, highlighted a leaching faster for the crocidolite sample, about twenty times higher than that of tremolite. Besides, the fast alteration of crocidolite promotes the occurrence of Fe centres in proximity of the fibre surface, or possibly even exposed, particularly in the form of Fe(II), of which the bulk is enriched with respect to the oxidized surface. Conversely, for tremolite fibres the very slow fibre dissolution prevents the underlying cations of the bulk to be exposed on the mineral surface, and the iron oxidation, faster than the leaching process, significantly depletes the surface Fe(II) centres initially present. Results of this work may contribute to unravel possible correlations between surface properties of amphibole asbestos and its long-term toxicity

Surface and Bulk Modifications of Fibrous Erionite in Mimicked Gamble's Solution at Acidic pH

This study aimed at investigating both the surface and bulk modifications occurring on fibrous erionite during leaching in a mimicked Gamble's solution (MGS) at pH of 4.5 and T = 37 degrees C, up to one month of incubation. Samples were characterized by a multi-analytical approach: field-emission scanning electron microscopy (FE-SEM) was employed to investigate the morphological changes of both pristine and reacted fibres, inductively coupled plasma optical emission spectrometry (ICP-OES) was used to measure the concentration of the released cations; X-ray photoelectron spectroscopy (XPS) was exploited for highlighting possible modifications of surface chemistry; X-ray powder diffraction (XRPD) and high-resolution transmission electron microscopy (HR-TEM) were applied aiming to get information on the structural state of the fibres following the incubation. ICP results integrated with those obtained by both bulk- and surface-chemical characterization highlighted that erionite binds Na especially in the first 24 h of sample incubation in the MGS, following ion exchange with the extra framework cations, in particular Ca. Moreover, our new results show that the Na binding process caused structural modifications with the migration of Na toward the Ca2 site and redistribution of the cations within the erionite cage. TEM investigation pointed out that the interaction between erionite and MGS results in the formation of a new surface amorphous layer with an irregular lobate pattern on an earlier surface weathered layer. However, the silicate framework is not weakened by incubation in the MGS at acidic pH. In addition, on the basis of the Si release normalized to the mineral surface area, fibrous erionite resulted significantly more biodurable than amphibole asbestos. Notably, considering the primary role played by biodurability in inducing pathogenicity, this result certainly supports in vivo observations showing that erionite is much more tumorigenic than asbestos. Moreover, the ions released by erionite when immersed in MGS may trigger biological effects, such as those on lipid packing and membrane permeability. On this basis, we expect a regulatory definition that would provide protection from this carcinogenic fibre

Local and systemic vascular hemodynamic response to passive static stretching in young healthy humans

The aim of the present study was to determine the acute effects of passive static stretching (PSS) on femoral blood flow (FBF) in a stretched and non-stretched limb. Our hypothesis was that PSS would increase FBF in the stretched limb mainly through local vasodilator mechanisms. PSS effects may be expected also in the non-stretched limb possibly through an imbalance between the systemic hemodynamic control and the local vasodilator response. To this purpose, eight young healthy individuals (age: 22\ub13 yrs) underwent PSS (5 cycles of 45 s stretch/15 s rest) of the knee extensors of the dominant limb. Femoral artery blood velocity and diameter were taken from both limbs by ultrasound. FBF was then calculated. PSS increased FBF by 3c78% in the stretched limb (from 495\ub1110 to 882\ub1121 ml/min; P<0.05). FBF returned to baseline within the end of the 45 s stretch. Conversely, FBF decreased transitory by 3c71% (from 334\ub1155 to 138\ub117 ml/min; P<0.05) in the non-stretched limb during PSS maneuver. In conclusion, PSS increased FBF in the stretched limb, and induced a FBF decrease in the contralateral limb. These findings may suggest the predominance of a local vasodilator mechanism in the stretched limb during PSS maneuver, probably induced by nitric oxide release. On the contrary, a possible systemic vasoconstriction, likely mediated by an elevation of sympathetic nerve activity, may prevail in the contralateral limb

Dissolution Reaction and Surface Modification of UICC Amosite in Mimicked Gamble’s Solution: A Step towards Filling the Gap between Asbestos Toxicity and Its Crystal Chemical Features

This study focuses on the dissolution process and surface characterization of amosite fibres following interaction with a mimicked Gamble's solution at a pH of 4.5 and T = 37 degrees C, up to 720 h. To achieve this, a multi-analytical approach was adopted, and the results were compared to those previously obtained on a sample of asbestos tremolite and UICC crocidolite, which were investigated under the same experimental conditions. Combining surface chemical data obtained by XPS with cation release quantified by ICP-OES, an incongruent behaviour of the fibre dissolution was highlighted for amosite fibres, similarly to asbestos tremolite and UICC crocidolite. In particular, a preferential release of Mg and Ca from the amphibole structure was observed, in agreement with their Madelung site energies. Notably, no Fe release from amosite fibres was detected in our experimental conditions (pH of 4.5 and atmospheric pO2), despite the occurrence of Fe(II) at the M(4) site of the amphibole structure, where cations are expected to be rapidly leached out during mineral dissolution. Moreover, the oxidation of both the Fe centres initially present on the fibre surface and those promoted from the bulk, because of the erosion of the outmost layers, was observed. Since biodurability (i.e., the resistance to dissolution) is one of the most important toxicity parameters, the knowledge of the surface alteration of asbestos possibly occurring in vivo may help to understand the mechanisms at the basis of its long-term toxicity

From field analysis to nanostructural investigation: A multidisciplinary approach to describe natural occurrence of asbestos in view of hazard assessment

The environmental impact of natural occurrences of asbestos (NOA) and asbestos-like minerals is a growing concern for environmental protection agencies. The lack of shared sampling and analytical procedures hinders effectively addressing this issue. To investigate the hazard posed by NOA, a multidisciplinary approach that encompasses geology, mineralogy, chemistry, and toxicology is proposed and demonstrated here, on a natural occurrence of antigorite from a site in Varenna Valley, Italy. Antigorite is, together with chrysotile asbestos, one of the serpentine polymorphs and its toxicological profile is still under debate. We described field and petrographic analyses required to sample a vein and to evaluate the NOA-hazard. A combination of standardized mechanical stress and automated morphometrical analyses on milled samples allowed to quantify the asbestoslike morphology. The low congruent solubility in acidic simulated body fluid, together with the toxicity-relevant surface reactivity due to iron speciation, signalled a bio-activity similar or even greater to that of chrysotile. Structural information on the genetic mechanism of antigorite asbestos-like fibres in nature were provided. Overall, the NOA site was reported to contain veins of asbestos-like antigorite and should be regarded as source of potentially toxic fibres during hazard assessment procedure

Rate and determinants of treatment response to different antiretroviral combination strategies in subjects presenting at HIV-1 diagnosis with advanced disease

<p>Abstract</p> <p>Background</p> <p>The optimal therapeutic strategies for patients presenting with advanced disease at HIV-1 diagnosis are as yet incompletely defined.</p> <p>Methods</p> <p>All patients presenting at two outpatient clinics in 2000-2009 with an AIDS-defining clinical condition or a CD4+ T cell count < 200/μL at HIV-1 diagnosis were analyzed for the presence of combined immunovirological response, defined by the concomitant presence of an absolute number of CD4+ T cells > 200 cells/μL and a plasma HIV-1 RNA copy number < 50/mL after 12 months of HAART.</p> <p>Results</p> <p>Among 102 evaluable patients, first-line regimens were protease inhibitors [PI]-based in 78 cases (77%) and efavirenz-based in 24 cases (23%). The overall response rate was 65% (95% CI: 55-74), with no differences by gender, age, nationality, route of transmission, hepatitis virus coinfections, presence of AIDS-defining clinical events, baseline HIV-1 viral load, or type of regimen (response rates with PI-based and efavirenz-based therapy: 63% and 71%, respectively, p = 0.474). Response rate was significantly better with higher baseline CD4+ T cell counts (78% with CD4+ ≥ 100/μL, compared to 50% with CD4+ < 100/μL; odds ratio: 3.5; 95% CI: 1.49-8.23, p = 0.003). Median time on first-line antiretroviral therapy was 24 months (interquartile range: 12-48). Switch to a second line treatment occurred in 57% of patients, mainly for simplification (57%), and was significantly more common with PI-based regimens [adjusted hazard ratios (AHR) with respect to efavirenz-based regimens: 3.88 for unboosted PIs (95% CI: 1.40-10.7, p = 0.009) and 4.21 for ritonavir-boosted PI (95%CI 1.7-10.4, p = 0.002)] and in older subjects (≥ 50 years) (AHR: 1.83; 95% CI: 1.02-3.31, p = 0.044). Overall mortality was low (3% after a median follow up of 48 months).</p> <p>Conclusions</p> <p>Our data indicate that a favorable immunovirological response is possible in the majority of naive patients presenting at HIV-1 diagnosis with AIDS or low CD4+ T cell counts, and confirm that starting HAART with a more compromised immune system may be associated with a delayed and sometimes partial immune recovery. Simpler regimens may be preferable in this particular population.</p