Solvent effect on protonation of tpps in water-DMF mixtures

The protonation of 5,10,15,20-tetrakis(4-sulfonatophenyl)porphyrin was investigated in aqueous solutions of N,N-dimethyformamide at 25 °C and 0.1 mol.dm-3 sodium perchlorate. The solvent effect on value of protonation constant was examined by using the linear solvation energy relationship concept. The value of logK1,logK2 and logKt was correlated with the macroscopic (dielectric constant) and microscopic Kamlet-Taft parameters (a, b and p*) of binary mixtures. The solvent effects were analyzed in the terms of Kamlet, Abboud and Taft model (KAT). Multiple linear regression were used to find the contribution of the microscopic parameters containing a (hydrogen-bond acidity), p* (dipolarity/polarizability) and b (hydrogen-bond basicity). It was found that a and b were the most predominant descriptors. Also, relationship with reciprocal of dielectric constant was obtained based on Born’s model, showing the significance of specific solute-solvent interactions. Therefore the hydrogen bonding interactions between solute and solvent components are mainly responsible for the change in protonation constants of 5,10,15,20-tetrakis(4-sulfonatophenyl)porphyrin in water- N,N-dimethyformamid binary mixtures. KEY WORDS: Protonation, TPPS, Solvent effects, Aqueous mixture, DMF Bull. Chem. Soc. Ethiop. 2016, 30(3), 457-464DOI: http://dx.doi.org/10.4314/bcse.v30i3.1

Left ventricular thrombus in a patient with antiphospholipid antibody syndrome and hyperhomocysteinemia

This report describes the case of a 39-year-old man, admitted for the occasional finding of left ventricular, irregular and pedicled mass. Because of the elevated risk of thromboembolism, cardiac surgery was performed with complete removal of the mass. Histologic examination showed it to be composed entirely of thrombotic material. Additional laboratory data revealed the simultaneous presence of two thrombophilic disorders: antiphospholipid syndrome and hyperhomocysteinemia. Screening laboratory evaluation for hypercoagulable states is recommended in similar cases

In Vitro Antifungal Susceptibility Profile of Miltefosine against a Collection of Azole and Echinocandins Resistant Fusarium Strains

Fusarium species are filamentous fungi that cause a variety of infections in humans. Because they are commonly resistant to many antifungal drugs currently available in clinical settings, research into alternative targets in fungal cells and therapeutic approaches is required. The antifungal activity of miltefosine and four comparators, amphotericin B, voriconazole, itraconazole, and caspofungin, were tested in vitro against a collection of susceptible and resistant clinical (n = 68) and environmental (n = 42) Fusarium isolates. Amphotericin B (0.8 μg/mL) had the lowest geometric mean (GM) MICs/MECs values followed by miltefosine (1.44 μg/mL), voriconazole (2.15 μg/mL), caspofungin (7.23 μg/mL), and itraconazole (14.19 μg/mL). Miltefosine was the most effective agent against Fusarium isolates after amphotericin B indicating that miltefosine has the potential to be studied as a novel treatment for Fusarium infections