Adaptação cultural e validação da versão portuguesa do questionário Medical Outcomes Study Social Support Survey (MOS-SSS)

O objectivo deste trabalho é calcular as propriedades psicométricas da versão portuguesa do questionário Medical Outcomes Study Social Support Survey (MOS-SSS). Este questionário foi traduzido e adaptado à cultura portuguesa. A amostra é constituída por 101 doentes com doença crónica, utentes de um centro de saúde rural de Portugal. A idade média é 63,4 anos; 56,4% são mulheres. 29% são analfabetos e 2% possuem estudos superiores. 78% sofrem de hipertensão arterial e 56,4% sofrem de diabetes mellitus tipo 2. A consistência interna foi avaliada com o alpha de Cronbach. Depois, foi realizada uma análise factorial exploratória e confirmatória com o objectivo de confirmar a validade e fiabilidade da escala e as suas características multidimensionais. A confiabilidade teste-reteste realizada às duas semanas foi estimada usando a análise kappa ponderado para as variáveis ordinais e o coeficiente de correlação intraclasse para as variáveis quantitativas. A alpha de Cronbach para as subescalas varia entre 0,873 e 0,967 no teste e 0,862 e 0,972 no reteste. A análise factorial exploratória revelou a existência de quatro factores (apoio emocional, material, afectivo e interacção social positiva) que explicam o 72,71% da variância. A análise factorial confirmatória permite concluir a existência destes quatro factores que permitem a aplicação da escala com os itens do questionário original. Os índices de ajustamento são satisfatórios e verificam a estrutura inicial, apresentando valores de χ2/df =2,01; GFI =0,998; CFI=0,999; AGFI =0,998; TLI =0,999; NFI =0,998; SRMR =0,332; RMSEA =0,76. A confiabilidade teste-reteste às duas semanas da versão portuguesa do MOS-SSS foi estimada pelo coeficiente de correlação intraclasse que variou entre 0,941 e 0,966 para as quatro dimensões do questionário e para o índice de apoio total. Os índices kappa ponderados variaram entre 0,67 e 0,87 para todos os itens. A versão portuguesa do MOS-SSS demonstrou boas características psicométricas e parece ser útil para avaliar as características multidimensionais do apoio social em população portuguesa.The aim of this study was the assesment of psychometric properties of the Portuguese version of the instrument «Medical Outcomes Study – Social Support Survey (MOSSSS) ». This questionnaire has been translated and adapted in a Portuguese sample of 101 patients with chronic illness of a rural health centre in Portugal. The average age of patients was 63.4 years, 56.4% female. 29% were illiterate and 2% had completed high school. 78% had arterial hypertension and the 56.4% had diabetes mellitus type 2. The internal consistency was evaluated using Cronbach’s alpha. Exploratory and Confirmatory factor analysis were performed in order to confirm reliability and validity of the scale and its multidimensional characteristics. The 2-week test-retest reliability was estimated using weighted kappa for the ordinals variables and intraclass coefficient correlation for the quantitative variables. Cronbach’s alphas for the subscales ranged from 0.873 to 0.967 at test, and 0.862 to 0.972 at retest. Exploratory factor analysis revealed the existence of four factors (emotional, tangible, positive interaction and affection support) that explain the 72.71% of the variance. Confirmatory factor analysis supported the existence of four factors that allowed the application of the scale with original items. The goodness-of-fit measures corroborate the initial structure, with χ2/ df=2.01, GFI=0.998, CFI=0.999, AGFI=0.998, TLI=0.999, NFI=0.998, SRMR=0.332, RMSEA=0.76. The 2-weeks test-retest reliability of the Portuguese MOS-SSS as measured by the intraclass correlation coefficient was ranged from 0.941 to 0.966 for the four dimensions and the overall support index. The weighted kappa was ranged from 0.67 to 0.87 for all the items. The MOS-SSS Portuguese version demonstrates good psychometric properties and seems to be useful to measure multidimensional aspects of social support in the Portuguese population.Sociedade Espanhola de Medicina Familiar e Comunitária (SEMFYC

Vaccines against toxoplasma gondii : challenges and opportunities

Development of vaccines against Toxoplasma gondii infection in humans is of high priority, given the high burden of disease in some areas of the world like South America, and the lack of effective drugs with few adverse effects. Rodent models have been used in research on vaccines against T. gondii over the past decades. However, regardless of the vaccine construct, the vaccines have not been able to induce protective immunity when the organism is challenged with T. gondii, either directly or via a vector. Only a few live, attenuated T. gondii strains used for immunization have been able to confer protective immunity, which is measured by a lack of tissue cysts after challenge. Furthermore, challenge with low virulence strains, especially strains with genotype II, will probably be insufficient to provide protection against the more virulent T. gondii strains, such as those with genotypes I or II, or those genotypes from South America not belonging to genotype I, II or III. Future studies should use animal models besides rodents, and challenges should be performed with at least one genotype II T. gondii and one of the more virulent genotypes. Endpoints like maternal-foetal transmission and prevention of eye disease are important in addition to the traditional endpoint of survival or reduction in numbers of brain cysts after challenge

A abordaxe da cronicidade: a encrucillada da Atención Primaria

The progressive aging of the Galician population results in increasing costs of healthcare and appears as an emerging social challenge to address the care and needs of older patients. Currently, the fragmentation of the healthcare system and the scarce coordination between healthcare and sociosanitary systems should lead to development of tools and ways to optimize the resources towards integrated chronicity healthcare models. Over the last years, diverse chronicity care models to improve healthcare efficiency, have been defined. This article describes a comprehensive healthcare model focused on networking and cross-working between the different stakeholders involved in chronicity healthcare, as well as the opportunities to implement improvement strategies in chronic diseases management.O progresivo envellecemento da poboación galega supón un crecemento nos custos do sistema sanitario e un desafío para a sociedade no seu conxunto para abordar os coidados e necesidades destes pacientes. Na actualidade a fragmentación do sistema sanitario en niveis e a práctica ausencia dunha coordinación entre estes e os servizos sociais fai necesario o desenvolvemento de instrumentos e canles que optimicen os recursos e melloren de forma progresiva a atención integral das persoas en situación de cronicidade. Durante os últimos anos definíronse diversos modelos de atención á cronicidade nun intento de mellorar a eficiencia da xestión dos sistemas sanitarios. Neste artigo descríbese un modelo de atención integral centrado no traballo en rede e transversal entre os diferentes actores de sistema sanitario implicados na atención á cronicidade, así como as oportunidades de mellora do modelo de atención á cronicidade

Toxoplasma gondii Antigenuria in Patients with Acquired Immune Deficiency Syndrome

A longitudinal study was performed with sera and urine of patients with acquired immune deficiency syndrome (AIDS), taken before, during and after clinically Toxoplasma infection. The tested patients were followed for an average of two years. The titres of the specific IgG and IgM antibodies were measured by an indirect fluorescent antibody test (IFAT), and the appearance of circulating antigens of T. gondii was determined in 36 urine samples of 13 patients with neurotoxoplasmosis by means of the coagglutination test. The presence of T. gondii antigens in the urine of AIDS patients by this test was correlated with the immunoblot technique, with clinical symptoms and also with pathological findings. Our results indicate that the detection of T. gondii antigens in the urine of AIDS patients can be regarded as a rapid and efficient method for the diagnosis of acute toxoplasmosi

Usefulness of the detection of Toxoplasma gondii antigens in AIDS patients Utilidad de la detección de antígenos de Toxoplasma gondii en pacientes con SIDA

Toxoplasmic encephalitis (TE) is a mayor cause of central nervous system infection in patients with acquired immunodeficiency syndrome (AIDS). Toxoplasma antibodies were detected in 56 of 79 patients with AIDS (71%), in the present study. Fourteen out of 57 seropositive patients developed TF (25%) and had Toxoplasma gondii antigen detected in their urine. For this, most of them received an effective therapy, with the subsequent disappearance of the symptoms and discontinuity of excretion of the T. gondii antigens. Our results suggest that the monitoring of T. gondii antigen in the urine of AIDS patients may be useful to decide on the proper time for therapy, as well as to avoid the beginning of neurologic signs in these patients.<br>La Encefalitis Toxoplásmica (ET) es la más importante complicación infecciosa del Sistema Nervioso Central en pacientes de SIDA. Anticuerpos anti-Toxoplasma gondii fueron detectados en 57 de 79 pacientes de SIDA (71%). De estos seropositivos, desarrollaron la enfermedad (ET) 14 (25%), en los que coincidentemente se detectó la presencia de antígeno del parásito en orina y por tanto fueron objeto de una terapia efectiva, con la subsecuente desaparición de los sintomas y de los antígenos excretados. Por los resultados del presente trabajo, consideramos lo útil de monitorear en estos pacientes la presencia de antígenos de T. gondii con el objetivo de aplicar oportunamente métodos quimoprofilácticos que eviten el surgimiento de manifestaciones neurológicas en estos pacientes