Upper- and mid-mantle interaction between the Samoan plume and the Tonga-Kermadec slabs

Mantle plumes are thought to play a key role in transferring heat from the core\u2013mantle boundary to the lithosphere, where it can significantly influence plate tectonics. On impinging on the lithosphere at spreading ridges or in intra-plate settings, mantle plumes may generate hotspots, large igneous provinces and hence considerable dynamic topography. However, the active role of mantle plumes on subducting slabs remains poorly understood. Here we show that the stagnation at 660 km and fastest trench retreat of the Tonga slab in Southwestern Pacific are consistent with an interaction with the Samoan plume and the Hikurangi plateau. Our findings are based on comparisons between 3D anisotropic tomography images and 3D petrological-thermo-mechanical models, which self-consistently explain several unique features of the Fiji\u2013Tonga region. We identify four possible slip systems of bridgmanite in the lower mantle that reconcile the observed seismic anisotropy beneath the Tonga slab (VSH4VSV) with thermo-mechanical calculations

Metformin and the gastrointestinal tract

Metformin is an effective agent with a good safety profile that is widely used as a first-line treatment for type 2 diabetes, yet its mechanisms of action and variability in terms of efficacy and side effects remain poorly understood. Although the liver is recognised as a major site of metformin pharmacodynamics, recent evidence also implicates the gut as an important site of action. Metformin has a number of actions within the gut. It increases intestinal glucose uptake and lactate production, increases GLP-1 concentrations and the bile acid pool within the intestine, and alters the microbiome. A novel delayed-release preparation of metformin has recently been shown to improve glycaemic control to a similar extent to immediate-release metformin, but with less systemic exposure. We believe that metformin response and tolerance is intrinsically linked with the gut. This review examines the passage of metformin through the gut, and how this can affect the efficacy of metformin treatment in the individual, and contribute to the side effects associated with metformin intolerance

The intraplate character of supercontinent tectonics

For several decades geoscientists have recognised intraplate tectonic activity far from plate margins, both from modern and ancient examples. This apparent disconnect with the drivers of plate tectonics does not necessarily imply unconnected processes, but rather an uncertainty in understanding exactly how these systems operate. Are the driving forces derived locally or do they propagate from plate-margins? How do these forces interact with a complex tectonic inheritance to generate the observed tectonism? Furthermore, what novel approaches have been applied to understand these processes? Here we review the general literature and the contents of this special issue to develop some partial answers to these questions. Key observations include the critical importance of local lithospheric heterogeneities as a control on the mode of orogenesis, and also the role of locally derived forces from mantle upwelling or from depositing thick piles of magmatic or sedimentary rocks.

Subduction dynamics and the origin of Andean orogeny and the Bolivian orocline

The building of the Andes results from the subduction of the oceanic Nazca plate underneath the South American continent1. However, how and why the Andes and their curvature, the Bolivian orocline, formed in the Cenozoic era (65.5 million years (Myr) ago to present), despite subduction continuing since the Mesozoic era(251.0–65.5 Myr ago), is still unknown. Three-dimensional numerical subduction models demonstrate that variations in slab thickness, arising from the Nazca plate’s age at the trench, produce a cordilleran morphology consistent with that observed. The age-dependent sinking of the slab in the mantle drives traction towards the trench at the base of the upper plate, causing it to thicken. Thus, subducting older Nazca plate below the Central Andes can explain the locally thickened crust and higher elevations. Here we demonstrate that resultant thickening of the South American plate modifies both shear force gradients and migration rates along the trench to produce a concave margin that matches the Bolivian orocline. Additionally, the varying forcing along the margin allows stress belts to form in the upper-plate interior, explaining the widening of the Central Andes and the different tectonic styles found on their margins, the Eastern and Western Cordilleras. The rise of the Central Andes and orocline formation are directly related to the local increase of Nazca plate age and an age distribution along the margin similar to that found today; the onset of these conditions only occurred in the Eocene epoch. This may explain the enigmatic delay of the Andean orogeny, that is, the formation of the modern Andes.Peer Reviewe