7 research outputs found
Role of the IRS-1 and/or -2 in the pathogenesis of insulin resistance in Dahl salt-sensitive (S) rats
Get PDFInsulin resistance is a common finding in hypertensive humans and animal models. The Dahl salt-sensitive (S) rat is an ideal model of genetically predetermined insulin resistance and salt-sensitive hypertension. Along the insulin signaling pathway, the insulin receptor substrates 1 and 2 (IRS-1 and -2) are important mediators of insulin signaling. IRS-1 and/or IRS-2 genetic variant(s) and/or enhanced serine phosphorylation correlate with insulin resistance. The present commentary was designed to highlight the significance of IRS-1 and/or -2 in the pathogenesis of insulin resistance. An emphasis will be given to the putative role of IRS-1 and/or -2 genetic variant(s) and serine phosphorylation in precipitating insulin resistance
Cyclic Stretch up-regulates Proliferation and Heat Shock Protein 90 Expression in Human Melanocytes
No full textMolecular Cytogenetics: : PCR-based diagnosis of human trisomies using computer-assisted laser densitometry
No full textSodium hydrosulfide alleviates pulmonary artery collagen remodeling in rats with high pulmonary blood flow
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