Propriedades farmacológicas da Aloe vera (L.) Burm. f.

A Aloe vera (L.) Burm.f. tem sido utilizada há milhares de anos na medicina tradicional para o tratamento de diversos males. O intuito desse trabalho foi o levantamento bibliográfico de artigos que evidenciassem a atividade farmacológica da Aloe vera. A revisão contemplou livros e periódicos nacionais e internacionais indexados nas bases de dados MEDLINE, LILACS e SciElo, nos idiomas português, inglês e espanhol, utilizando as palavras-chave citadas. Após o levantamento bibliográfico, constatou-se que várias atividades biológicas são atribuídas a Aloe vera. Evidências sugerem eficácia no tratamento da psoríase, herpes genital, queimaduras e hiperglicemia. Além disto, também foram demonstradas atividades antineoplásica, antimicrobiana, anti-inflamatória e imunomodulatória por estudos in vitro e in vivo, entretanto, na cicatrização de feridas, os resultados foram conflitantes. No tratamento de dermatite por radiação e em queimaduras solares sua eficácia não foi comprovada e foram relatados casos de hepatite aguda devido ao consumo de preparações orais. Tendo em vista as várias atividades comprovadas e poucos relatos acerca de sua contra indicação, conclui-se que o uso desta espécie corrobora o vasto uso popular

Pharmacological Activities Of Aloe Vera (l.) Burm. F [propriedades Farmacológicas Da Aloe Vera (l.) Burm. F]

The Aloe vera (L.) Burm.f. has been used for thousands of years in traditional medicine to treat various ailments. The aim of this study was to carry out a bibliographical review on the pharmacological activity of Aloe vera. This review included books and national and international journals indexed to MEDLINE, LILACS and SciELO, in Portuguese, English and Spanish, using the key words mentioned. After the literature review, we found that several biological activities have been attributed to Aloe vera. Evidence suggests efficacy in the treatment of psoriasis, genital herpes, burns and hyperglycemia. Moreover, antineoplastic, antimicrobial, anti-inflammatory and immunomodulatory activities have also been demonstrated by in vitro and in vivo studies; however, in wound healing, the results were conflicting. In the treatment of radiation dermatitis and sunburn, its efficacy has not been proven, and cases of acute hepatitis from the consumption of oral preparations have been reported. Considering the various proven activities and the few reports about the contraindications of Aloe vera, we conclude that the use of this species confirms its wide popular usage.162299307Alonso, J., (2007) Tratados de fitofarmacos y nutraceuticos, p. 1150. , 2. ed. Argentina: Corpus EditorialInforme Técnico n. 47, , http://www.anvisa.gov.br, ANVISA., de 16 de novembro de 2011. Esclarecimentos sobre comercialização de Aloe vera (babosa) e suas avaliações de segurança realizadas na área de alimentos da Anvisa. Disponível em:, Acesso em: 21 de nov. de 2011Atherton, P., Aloe vera revisited (1997) The British Journal of Phytotherapy, 4 (4), pp. 176-183Baretta, Z., Aloe-induced hypokalemia in a patient with breast cancer during chemotherapy (2009) Annals of Oncology, 20 (8), pp. 1445-1446Bottenberg, M.M., Oral aloe vera induced hepatitis (2007) The Annals of Pharmacotherapy, 41 (10), pp. 1740-1743Carvalho, J.C.T., (2005) Formulário Médico Farmacêutico de Fitoterapia, p. 404. , 2. ed. Editora PharmabooksChandan, B.K., Hepatoprotective potential of Aloe barbadensis Mill. Against carbon tetrachloride induced hepatotoxicity (2007) Journal of Ethnopharmacology, 111 (3), pp. 560-566Cho, S., Dietary Aloe vera supplementation improves facial wrinkles and elasticity and it increases the type 1 procollagen gene expression in human skin in vivo (2009) Annals of Dermatology, 21 (1), pp. 6-11Choi, C.W., The wound-healing effect of a glycoprotein fraction isolated from aloe vera (2001) British Journal of Dermatology, 145 (4), pp. 535-545Choonhakarn, C., A prospective, randomized clinical trial comparing topical aloe vera with 0, 1% triamcinolone acetonide in mild to moderate plaque psoriais (2010) Journal of the European Academy of Dermatology and Venereology, 24 (2), pp. 168-172Choonhakarn, C., The efficacy of aloe vera gel in the treatment of oral lichen planus: A randomized controlled trial (2008) The British Journal of Dermatology, 158 (3), pp. 573-577Collins, C.E., Collins, C., Roentgen dermatitis treated with fresh whole leaf of aloe vera (1935) American Journal of Roentgenology, 33, pp. 396-397Cunha, A.P., (2005) Farmacognosia e Fotoquímica, p. 670. , 1. ed. Lisboa: Fundação Calouste GulbenkianDal'Belo, S.E., Moisturizing effect of cosmetic formulations containing Aloe vera extract in different concentrations assessed by sking bioengineering techniques (2006) Skin Research and Technology, 12 (4), pp. 241-246Das, S., Isolation and characterization of novel protein with anti-fungal and anti-inflammatory properties from Aloe vera leaf gel (2011) International Journal of Biological Macromolecules, 48 (1), pp. 38-43Davis, R.H., Anti-inflammatory and wound healing activity of a growth substance in Aloe vera (1994) Journal of the American Podiatric Medical Association, 84 (2), pp. 77-81Eshghi, F., Effects of Aloe vera cream on posthemorrhoidectomy pain and wound healing: Results of a randomized, blind, placebo-control study (2010) The Journal of Alternative and Complementary Medicine, 16 (6), pp. 647-650Eshun, K., He, Q., Aloe vera: A valuable ingredient for the food, pharmaceutical and cosmetic industries-a review (2004) Critical Reviews in Food Science and Nutrition, 44 (2), pp. 91-96Esmat, A.Y., Cytotoxicity of a natural anthraquinone (aloin) agains human breast cancer cell lines with and without Erb-2-Topoisomerase IIα coamplification (2006) Cancer Biology & Therapy, 5 (1), pp. 97-103Femenia, A., Compositional features of polysaccharides from Aloe vera (Aloe barbadensis Miller) plant tissues (1999) Carbohydrate Polymers, 39 (2), pp. 109-117Femenia, A., Effects of heat treatment and dehydration on bioactive polysaccharide acemannan and cell wall polymers from Aloe Barbadensis Miller (2003) Carbohydrate Polymers, 51 (4), pp. 397-405Ferro, V.A., In vitro susceptibilities of Shigella flexneri and streptococcus pyogenes to inner gel of Aloe barbadensis Miller (2003) Antimicrobial Agents and Chemothererapy, 47 (3), pp. 1137-1139Guerra, M.F.L., Uso empírico in natura de Aloe sp em portadores de conjuntivite (2008) Revista de Enfermagem da UFPE, 2 (1), pp. 36-46Gupta, R., Anti-tuberculosis activity of selected medicinal plants agains multi-drug resistant Mycobacterium tuberculosis isolates (2010) Indian Journal of Medical Research, 131, pp. 809-813. , junHaller, J.S., A drug for all seasons Medical and Pharmacological history of Aloe (1990) Bulletin of the New York Academy of Medicine, 66 (6), pp. 647-659Holanda, C.M.C.X., Effect of an extract of Aloe vera on the biodistribution of sodium pertechnetate (Na99mTcO4) in rats (2009) Acta. Cirúrgica Brasileira, 24 (5), pp. 383-386Horgan, D.J., Widespread dermatitis after topical treatment of chronic leg ulcers and stasis dermatitis (1988) Canadian Medical Association Journal, 138 (4), pp. 336-338Jettanacheawchankit, S., Acemannan stimulates gingival fibroblast proliferationexpressions of keratinocyte growth factor-1, vascular endothelial growth factor, and type 1 collagenand wound healing (2009) Journal of Pharmacological Sciences, 109, pp. 525-531Khorasani, G., Aloe versus silver sulfadiazine creams for second-degree burns: A randomized controlled study (2009) Surgery Today, 39 (7), pp. 587-591Langmead, L., Randomized, double-blind, placebo-controlled trial of oral aloe vera gel for active ulcerative colitis (2004) Alimentary Pharmacology & Therapeutics, 19 (7), pp. 739-747Lawrence, R., Isolation, purification and evaluation of antibacterial agents from Aloe vera (2009) Brazilian Journal of Microbiology, 40 (4), pp. 906-915Lee, S.S., The antimicrobial potential of 14 natural herbal dentifrices: Results of an in vitro diffusion method study (2004) Journal of the American Dental Association, 135 (5), pp. 1133-1141Lissoni, P., Biotherapy with the pineal immunomodulating hormone melatonin versus melatonin plus Aloe vera in untreatable advanced solid neoplasms (1998) Natural Immunity, 16 (1), pp. 27-33Lissoni, P., A Randomized study of chemotherapy versus biochemotherapy with chemotherapy plus Aloe arborescens in patients with metastatic cancer (2009) In vivo, 23 (1), pp. 171-175Lorenzi, H., Matos, F.J.A., (2008) Plantas medicinais no Brasil-Nativas e exóticas, p. 244. , 2. ed. São Paulo: Instituto PlantarumLoveman, A.B., Leaf of aloe vera in treatment of roentgen ray ulcers (1937) Archives of Dermatology and Syphilology, 36, pp. 838-843Maia-Filho, A.L.M., Efeito do gel da babosa (Aloe barbadensis Mill.) associado ao ultrassom em processo inflamatório agudo (2011) Revista Brasileira de Plantas Medicinais, 13 (2), pp. 146-150Mendonça, F.A.S., Effects of the application of Aloe vera (L.) and microcurrent on the healing of wounds surgically induced in wistar rats (2009) Acta Cirúrgica Brasileira, 24 (2), pp. 150-155Merchant, T.E., A phase III trial comparing an anionic phospholipid-based cream and aloe vera-based gel in the prevention of radiation dermatitis in pediatric patients (2007) Radiation Oncology, 2 (44). , http://www.ro-journal.com/content/2/1/45, Disponível em:, Acesso em: 25 abr. 2011Ngo, M.G., Oral Aloe vera for treatment of diabetes mellitus and dyslipidemia (2010) American Journal of Health-System Pharmacy, 67 (21), pp. 1804-1811Niciforovic, A., Antitumor effects of a natural anthracycline analog (aloin) involve altered activity of antioxidant enzymes in HeLaS3 cells (2007) Cancer Biology & Therapy, 6 (8), pp. 1211-1216Noor, A., Antidiabetic activity of Aloe vera and histology of organs in streptozotocin-induced diabetic rats (2008) Current Science, 94 (8), pp. 1070-1076Oliveira, S.M.A., Effect of a dentifrice containing Aloe vera on plaque and gengivitis control. A double-blind clinical study in humans (2008) Journal of Oral Applied Science, 16 (4), pp. 293-296Ozsoy, N., Implications for degenerative disorders-Antioxidative activity, total phenols, flavonoids, ascorbic acid, β-carotene and α-tocopherol in Aloe vera (2009) Oxidative Medicine and Cellular Longevity, 2 (2), pp. 99-106Park, M.Y., Evaluation of aloin and aloe-emodin as anti-inflammatory agents in aloe by using murine macrophages (2009) Bioscience, Biotechnology and Biochemistry, 73 (4), pp. 828-832Puataweepong, P., The efficacy of oral Aloe vera juice for radiation induced mucositis in head and neck cancer patients: A double-blind placebo-controlled study (2009) Asian Biomedicine, 3 (4), pp. 375-382Puerto, E.C., Efecto antiviral del extracto acuoso de Aloe barbadensis contra el vírus de la hepatitis B (2001) Revista Cubana de Plantas Medicinales, 6 (1), pp. 7-11Puvabanditsin, P., Vongtongsri, R., Efficacy of Aloe vera cream in prevention and treatment of sunburn and suntan (2005) Journal of Medical Association of Thailand, 88 (4), pp. 173-176Rabe, C., Acute hepatitis induced by an Aloe vera preparation: A case report (2005) World Journal of Gastroenterology, 11 (2), pp. 303-304Rajar, U.D.M., Efficacy of Aloe vera gel in the treatment of vulval lichen planus (2008) Journal of the College of Physicians and Surgeons Pakistan, 18 (10), pp. 612-614Rajasekaran, S., Antioxidant effect of Aloe vera gel extract in streptozotocin-induced diabetes in rats (2005) Pharmacological Reports, 57 (1), pp. 90-96Rivas, M.R., Acción antiasmática del Aloe vera em pacientes (2004) Revista Cubana de Plantas Medicinales, 9 (1)Rodríguez-Gonzales, V.M., Effects of pasteurization on bioactive polysaccharide acemannan and cell wall polymers from Aloe barbadensis Miller (2011) Carbohydrate Polymers, 86 (4), pp. 1675-1683Saini, M., Anti-tumor activity of Aloe vera against DMBA/croton oil-induced skin papillomagenesis in Swiss albino mice (2010) Journal of Environmental Pathology, Toxicology and Oncology, 29 (2), pp. 127-135Salazar-Sánchez, N., Efficacy of topical Aloe vera in patients with oral lichen planus: A randomized double-blind study (2010) Journal of Oral Pathology and Medicine, 39 (10), pp. 735-740Schmidt, J.M., Greenspoon, J.S., Aloe vera dermal wound gel is associated with a delay in wound healing (1991) Obstetrics & Gynecology, 78 (1), pp. 115-117Su, C.K., Phase II double-blind randomized study comparing oral aloe vera versus placebo to prevent radiation-related mucositis in patients with head-and-neck neoplasms (2004) International Journal of Radiation Oncology, Biology, Physics, 60 (1), pp. 171-177Surjushe, A., Aloe vera: A short review (2008) Indian Journal of Dermatology, 53 (4), pp. 163-166Syed, T.A., Management of psoriais with Aloe vera extract in a hydrophilic cream: A placebo-controlled, double-blind study (1996) Tropical Medicine and International Health, 1 (4), pp. 505-509Syed, T.A., Aloe vera extract 0, 5% in a hydrophilic cream versus Aloe vera gel for the management of genital herpes in males. A placebo-controlled, double-blind, comparative study (1996) Journal of the European Academy of Dermatology and Venereology, 7 (3), pp. 294-295Syed, T.A., Management of genital herpes in men with 0, 5% Aloe vera extract in a hydrophilic cream: A placebo-controlled double-blind study (1997) Journal of Dermatological Treatment, 8 (2), pp. 99-102Takahashi, M., Liposomes encapsulating Aloe vera leaf gel extract significantly enhance proliferation and collagen synthesis in human skin cell lines (2009) Journal of Oleo Science, 58 (12), pp. 643-650Takzare, N., Influence of Aloe vera gel on dermal wound healing process in rat (2009) Toxicology Mechanisms and Methods, 19 (1), pp. 73-77Tamura, N., Inhibition of infectious diseases by components from Aloe vera (2009) Bioscience Biotechnology and Biochemistry, 73 (4), pp. 950-953Tanaka, M., Identification of five phytosterols from aloe vera gel as anti-diabetic compounds (2006) Biological & Pharmaceutical Bulletin, 29 (7), pp. 1418-1422Teske, M., Trentini, A.M.M., (1997) Herbarium-Compêndio de Fitoterapia, p. 317. , 3. ed. Curitiba: Herbarium Laboratório BotânicoTomasin, R., Gomes-Marcondes, M.C.C., Oral administration of Aloe vera and honey reduces walker tumour growth by decreasing cell proliferation and increasing apoptosis in tumor tissue (2011) Phytotherapy Research, 25 (4), pp. 619-623Villalobos, O.J., Efecto de un enjuague bucal compuesto de Aloe vera en la placa bacteriana e inflamación gingival (2001) Acta. Odontológica Venezolana, 39 (2), pp. 16-24Vinson, J., Effect of Aloe vera preparations on the human bioavailability of vitamins C and E (2005) Phytomedicine, 12 (10), pp. 760-765Wagner, H., Wiesenauer, M., Fitoterapia: Fitofármacos, Farmacologia e Aplicações clínicas (2006) Pharmabooks, p. 424. , 2. ed(1999) WHO Monographs on selected medicinal plants, 1. , WHO, World Health Organization., Geneva: WHO PublicationsWilliams, M.S., Phase III double-blind evaluation of an Aloe vera gel as a prophylatic agent for radiation-induced skin toxicity (1996) International Journal Radiation Oncology Biology Physics, 36 (2), pp. 345-349Yang, H.N., Aloe-induced toxic hepatitis (2010) Journal of Korean Medical Science, 25 (3), pp. 492-495Yaron, A., Characterization of Aloe vera gel before and after autodegradation and stabilization of the natural fresh gel (1993) Phytotherapy Research, 7 (7), pp. 11-13Zhang, L., Tizard, I.R., Activation of a mouse macrophage cell line by acemannan: The major carbohydrate fraction from Aloe vera gel (1996) Immunopharmacology, 35, pp. 119-12

Pharmacological Activities Investigation Of Crude Extracts And Fractions From Qualea Grandiflora Mart.

This study investigates pharmacological activities of crude hydroalcoholic extract and fractions of Qualea grandiflora Mart. leaves employing different experimental models using mice. The treatment with crude hydroalcoholic extract (EH) in a dose of 500 mg/kg, i.p. caused: signs of central nervous system depressant action in the Hippocratic screening test, confirmed by the potentiation of sodium pentobarbital sleeping time. Increasing in the latency time of hot plate assay that indicate an analgesic effect; significantly delaying of the onset of clonic PTZ convulsions, increasing in the time for death, suppressing of the tonic PTZ convulsion, and decreasing of severity and number of convulsions. The median lethal dose of EH was 1.321 mg/kg. The convulsions induced by PTZ, ethyl ether fraction (300 mg/kg, i.p.) was more active in increasing the latency time for first convulsion, moreover, the hexane fraction, at the same dose, was more active in increasing the time for death and/or avoiding the death. Both did not cause disturbance in motor coordination at the dose of 500 mg/kg, assessed by rotarod test. These results suggest that the crude extract of leaves of Qualea grandiflora Mart. has a central nervous system depressant action, an analgesic effect and behave as a potential anticonvulsant. © 2006 Elsevier Ireland Ltd. All rights reserved.10711924Alves, T.M.A., Silva, A.F., Brandão, M., Grandi, T.S.M., Smânia, E.F.A., Smânia Jr., A., Zani, C.L., Biological screening of Brazilian medicinal plants (2000) Memórias do Instituto Oswaldo Cruz, 95, pp. 367-373Berkson, J., Why I prefer logists to probits (1951) Biometrics, 7, pp. 327-339Carlini, E.A., Burgos, V., Screening farmacológico de ansiolíticos: metodologia laboratorial e comparação entre o diazepam e clorobenzapam (1979) Revista da Associação Brasileira de Psiquiatria de São Paulo, 1, pp. 25-31Duham, N.W., Myia, T.S., A note on a simple apparatus for detecting neurological deficit in rats and mice (1957) Journal of the American Pharmacists Association, 46, pp. 208-209Goloubkova, T.D., Heckler, E., Rates, S.M.K., Henriques, J.A.P., Henriques, A.T., Inhibition of cytochrome P450-dependent monooxygenases by an alkaloid fraction from Helietta apiculata markedly potentiate the hypnotic action of pentobarbital (1998) Journal of Ethnopharmacology, 60, pp. 141-148Joly, A.B., (1993) Botânica-Introdução à Taxonomia Vegetal. 11 a ed., , Companhia Editora Nacional, São PauloKalbfleisch, J.D., Prentice, R.L., (1980) The Statistical Analysis of Failure Time Data, , John Wiley and Sons, New YorkKanjanapothi, D., Panthong, A., Letiprasertsuke, N., Taesotikul, T., Rujjanawate, C., Kaewpinit, D., Sudthayakorn, R., Pitasawat, B., Toxicity of crude extract of Kaempferia galanga L. (Proh Hom) (2004) Journal of Ethnopharmacology, 90, pp. 359-365Krall, R.L., Penry, J.K., White, B.G., Kupferberg, H.J., Swinyard, E.A., Antiepileptic drug development: anticonvulsants drug screening (1978) Epilepsia, 19, pp. 409-428Lichfield Jr., J.T., Wilcoxon, F., A simplied method of evaluating dose effect experiments (1949) Journal of Pharmacology and Experimental Therapeutics, 96, pp. 99-113Löscher, W., Schmidt, D., Which animal models should be used in the search for new antiepileptic drugs? A proposal based on experimental and clinical considerations (1988) Epilepsy Research, 2, pp. 145-181Löscher, W., Review: new visions in the pharmacology of anticonvulsant (1998) European Journal Pharmacology, 342, pp. 1-13Löscher, W., Fiedler, M., The role of technical, biological, and pharmacological factors in the laboratory evaluation of anticonvulsant drugs VII. Seasonal influences on anticonvulsant drug actions in mouse models of generalized seizures (2000) Epilepsy Research, 38, pp. 231-248Malmberg, A.B., Bannon, A.W., Models of nociception: hot-plate, tail-flick, and formalin tests inrodents (1999) Current Protocols in Neuroscience, pp. 8.9.1-8.9.15Malone, M.H., (1977) Pharmacological approaches to natural product, screening and evaluation. New natural products and plant drugs with pharmacological biological or therapeutical activity, , Springer-Verlag, Berlin pp. 24-53Miller, L.C., Tainter, M.L., Estimation of ED50 and its error by means of log probit graph paper (1944) Proceedings of the Society For Experimental Biology and Medicine, 57, pp. 261-264Rodrigues, V.E.G., Carvalho, D.A., Levantamento Etnobotânico de Plantas Medicinais no Domínio do Cerrado na Região do Alto Rio Grande-MG (2001) Ciências Agrotecnológicas, 25, pp. 102-123Silva, L.O., Costa, D.A., Santo Filho, K.E., Ferreira, H.D., Brandão, D., Levantamento florístico efitossociológico em duas áreas de cerrado (2002) Acta Botânica Brasílica, 16, pp. 43-53Swinyard, E.A., Kupferberg, H.J., Antiepileptic drugs: detection, quantification and evaluation (1988) Federation Proceedings, 44, pp. 2629-2633Swinyard, E.A., Woodhad, J.H., White, H.S., Franklin, M.R., Experimental selection, quantification and evaluation of anticonvulsants (1989) Antiepileptic Drugs. 3rd ed., 5, pp. 85-102. , levy R., Mattson R., Meldrum B., and Dreifuss J.K. (Eds), Raven Press Ltda, New York, capWang, H.H., Liao, J.F., Chen, C.F., Anticonvulsant effect of water extract of Scutellariae radix in mice (2000) Journal of Ethnopharmacology, 73, pp. 185-190Willianson, E., Okpako, D., Evans, F.J., (1996) Selection Preparation and Pharmacological Evaluation of Plant Material, , John Wiley and Sons, Chicheste

Testes fitoquímicos em extratos foliares de Oeceoclades maculata Lindl. (Orchidaceae)

O presente trabalho teve por objetivo determinar a capacidade antioxidante de Oeceoclades maculata. A atividade foi determinada de acordo com a capacidade do extrato hidroalcoólico das folhas reduzir o radical DPPH. Os resultados obtidos permitem concluir que os conteúdos de polifenóis e flavonas/flavonóis são maiores no extrato preparado a frio (EBHF) do que no extrato preparado a quente (EBHQ), sugerindo que o aquecimento usado na preparação do extrato altera esses componentes ativos. Portanto, para esta espécie deve ser realizado o método de extração a frio para conservar as substâncias que possuem atividade antioxidante

Caracterização anatômica, histoquímica e de classes de metabólitos secundários de folhas de Guzmania lingulata (L.) Mez.

Na medicina natural pouco se sabe sobre a importância curativa da maior parte das espécies pertencentes à Bromeliaceae. Tal fato evidencia a necessidade da realização de investigações para a comprovação de possíveis potenciais fitoterápicos em espécies dessa família. Guzmania lingulata é caracterizada como sendo uma das espécies de bromélia mais comercializada e conhecida popularmente, a qual é amplamente propagada no Brasil. O presente trabalho objetivou a caracterização anatômica e a identificação de classes de metabólitos secundários presentes em G. lingulata, por meio de análises anatômicas, histoquímicas e químicas. As folhas foram fixadas em FAA 50 e transferidas para etanol 50%. Para o estudo anatômico, secções transversais da porção mediana das lâminas foliares foram obtidas à mão livre e submetidas ao processo de dupla coloração com safranina e azul de astra, sendo, logo após, montadas em gelatina glicerinada. Para a triagem das classes de metabólitos secundários foram coletadas 10 folhas frescas que passaram pelo processo de maceração em solução hidroalcoólica 70% por sete dias, à temperatura ambiente. O filtrado resultante da filtração a vácuo foi evaporado sob vácuo a temperatura de 50ºC até a remoção total do etanol, sendo obtido desta forma o extrato bruto hidroalcoólico a frio (EBHF). Os resultados das secções histológicas permitiram a caracterização anatômico-foliar baseada na qualidade das secções manuais obtidas. Os testes em relação às classes de metabólitos secundários revelaram a presença de antocianinas e taninos e ausência de flavonóides e saponinas. Esses resultados estimulam a realização de estudos mais aprofundados para identificar e quantificar os compostos dessas e de outras classes de metabólitos

Physical, Chemical And Technological Characteristics Of Solanum Lycocarpum A. St. - Hill (solanaceae) Fruit Flour And Starch

Fruit of wolf (Solanum lycocarpum A. St. - HILL), found in Brazilian cerrado, has been used in the initial ripening stage as flour and/or starch in popular medicine due to its hypoglycemiant action. The aim of this work was to study the occurrence of phytochemical compounds, physical, chemical and technological characteristics of fruit of wolf flour and starch in the initial ripening stage. Flour and starch were extracted using known popularly and experimental methods (with sodium bisulfite) and chemical composition and technological characteristics were analyzed. The results were comparatively assessed by Tukey's test (p < 0.05). The recommendation for use was the extraction of flour and starch products by previously removing peels and seeds of fruit of wolf. The most relevant finding in this study is the high content of fibers in flour (23. g/100. g) and high content of resistant starch (32. g/100. g) in the fraction of starch extracted from fruit of wolf, which can explain their use as hypoglycemic agent. © 2011 Elsevier Ltd.44721432150(1995) Approved methods of the American Association of Cereal Chemists, , American Association of Cereal Chemist, St. Paul. (9a ed.). 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