Mating system in Pterocarpus macrocarpus Kurz in Thailand

The mating system in 11 natural populations of Pterocarpus macrocarpus Kurz in Thailand was investigated based on the mixed mating model using 16 isozyme markers. Single-locus outcrossing rates (tm) ranged from 0.719 to 0.959. Both ts and tm revealed a geographic pattern with western populations exhibiting higher outcrossing than eastern populations. Low estimates of outcrossing rates in eastern populations could be attributed to habitat characteristic, degree of disturbance, density, and distribution of flowering mature trees. Individual tree outcrossing rates (tmi) indicated that reduced population density associated with disturbance could result in low tm in some eastern population

A simple fluorescence-based cell viability assay for use in rat blood vessels in vitro

No abstract available

A simple fluorescence-based cell viability assay for use in rat blood vessels in vitro

No abstract available

Fluorescent myography: the analysis of isolated vascular smooth muscle cells of the rat labelled with bisbenzamide during vasoconstriction

No abstract available

Fluorescent myography: the analysis of isolated vascular smooth muscle cells of the rat labelled with bisbenzamide during vasoconstriction

No abstract available

[Evaluation of the clinical benefit of Permixon and tamsulosin in severe BPH patients--PERMAL study subset analysis]

Item does not contain fulltextOBJECTIVE: To compare the efficacy of the lipido-sterolic extract of Serenoa repens, Permixon, to that of the a-blocker, tamsulosin, in the treatment of severe low urinary tract symptoms (LUTS) of benign prostatic hyperplasia (BPH). METHODS: In a 12-month, double-blind, randomized study that showed equivalent efficacy of Permixon 320 mg/day and tamsulosin 0.4 mg/day ("PERMAL study"), 685 BPH patients with IPSS > 10 had been analyzed for efficacy. Of these, the 124 patients with severe LUTS (IPSS > 19) at randomization were retained for this subset analysis. After a 4-week run-in period, 59 and 65 patients had been randomized to tamsulosin and Permixon groups, respectively. Both treatment groups were compared regarding the evolution from baseline of total IPSS and its irritative and obstructive subscores. LUTS-related QpL, prostate volume, Qmax and MSF-4 (sexual activity questionnaire) at different time points over 1 year An analysis of variance of changes from baseline to end point was performed for all the parameters. The over-time evolutions of total, irritative and obstructive IPSS were further compared using a variance analysis for repeated measurements. RESULTS: At 12 months, total IPSS decreased by 7.8 with Permixon and 5.8 with tamsulosin (p = 0.051); the irritative symptoms improved significantly more (p = 0.049) with Permixon (- 2.9 versus - 1.9 with tamsulosin). The superiority of Permixon in reducing irritative symptoms appeared as soon as month 3 and was maintained up to month 12 (p = 0.03). CONCLUSION: Permixon 320 mg/day was shown to be slightly superior to tamsulosin 0.4 mg/day in reducing LUTS in severe BPH patients after 3 months and up to 12 months of treatment