SYNTHESIS OF MONO-SUBSTITUTED AND SIMMETRICALLY 2, 5-DISUBSTITUTED 1, 3, 4-OXADIAZOLES

In recent years 1,3,4-oxadiazoles have received considerable attention due to their wide range of biological activities and practical importance. They form an important class of fi ve-member heterocyclic compounds with a variety of derivatives. This review will focus on several methods of synthesis for mono-substituted and symmetrically 2,5-disubstituted 1,3,4-oxadiazoles

ADVANCES IN ORGANIC, BIOORGANIC AND NATURAL PRODUCTS CHEMISTRY IN THE INSTITUTE OF CHEMISTRY OF THE ACADEMY OF SCIENCES OF MOLDOVA

This overview deals with the advances in the investigation in the fi eld of organic, bioorganic and naturalproducts chemistry as well as the biologically active compounds in the Institute of Chemistry of the Academy of Sciences of Moldova

OPTICALLY ACTIVE CHRYSANTHEMIC ACID AND ITS ANALOGUES

Optically active chrysanthemic acid and its analogues have received considerable attention in recent years due to their practical importance. This review will focus on describing the developments in the synthesis of optically active chrysanthemic acid and its analogues. The transformation that will be covered includes the chemistry of enantiomerically pure 2,2-dimethyl 1,3-disubstituted cyclopropanes derived from monoterpene (+)-3-carene

Total Syntheses of Xiamycins A, C, F, H and Oridamycin A and Preliminary Evaluation of their Anti‐Fungal Properties

Divergent and enantiospecific total syntheses of the indolosesquiterpenoids xiamycins A, C, F, H and oridamycin A have been accomplished. The syntheses, which commence from (R)-carvone, employ a key photoinduced benzannulation sequence to forge the carbazole moiety characteristic of these natural products. Late-stage diversification from a common intermediate enabled the first syntheses of xiamycins C and F, and an unexpected one-pot oxidative decarboxylation, which may prove general, led to xiamycin H. All synthetic intermediates and the natural products were tested for anti-fungal activity. Xiamycin H emerged as an inhibitor of three agriculturally relevant fungal pathogens

New copper(II) complexes with isoconazole: Synthesis, structures and biological properties

There is an increasing demand for novel metal-based complexes with biologically relevant molecules in technology and medicine. Three new Cu(II) coordination compounds with antifungal agent isoconazole (L), namely mononuclear complexes CuCl2(L)(2) (1), and Cu(O2CMe)(2)(L)(2)center dot 2H(2)O (2) and coordination polymer Cu(pht)(L)(2)(n) (3) (where H(2)pht - o-phthalic acid) were synthesized and characterized by IR spectroscopy, thermogravimetric analysis and X-ray crystallography. X-ray analysis showed that in all complexes, the isoconazole is coordinated to Cu(II) centres by a N atom of the imidazole fragment. In complex I, the square-planar environment of Cu(II) atoms is completed by two N atoms of isoconazole and two chloride ligands, whereas the Cu(II) atoms are coordinated by two N atoms from two isoconazole ligands and two O atoms from the different carboxylate residues: acetate in 2 and phthalate in 3. The formation of an infinite chain through the bridging phthalate ligand is observed in 3. The biosynthetic ability of micromycetes Aspergillus niger CNMN FD 10 in the presence of the prepared complexes 1-3 as well as the antifungal drug isoconazole were studied. Complexes 2 and 3 accelerate the biosynthesis of enzymes (beta-glucosidase, xylanase and endoglucanase) by this fungus. Moreover, a simplified and improved method for the preparation of isoconazole nitrate was developed

Cyclodextrins, from molecules to applications

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