Highlights of the Science and Life of Peter Varga (1946—2018)

Peter Varga has passed on October 27, 2018. His pioneering discoveries of chemical resolution at the atomic scale on surface alloys, atomic resolution of ultrathin alkali halides, nucleation of bcc iron in ultrathin films, and the microscopic structure of ultrathin alumina films stimulated worldwide research. In recognition of his outstanding scientific contributions, in December 2017 the Japanese Society for the Promotion of Science (JSPS) awarded him a prize for his distinguished contribution on the clarification of surface phenomena by atomic level investigations and the development of novel functional materials. This contribution highlights the life of Peter Varga as a scientist and as a person. With his elegance, his energy, his wit, and his generosity he was a close friend and role model to many of us, and showed us how to combine scientific curiosity and creativity with the lightness of being

Chicken BAFF

Members of the tumor necrosis factor (TNF) family play key roles in the regulation of inflammation, immune responses and tissue homeostasis. Here we describe the identification of the chicken homologue of mammalian B cell activating factor of the TNF family (BAFF/BLyS). By searching a chicken EST database we identified two overlapping cDNA clones that code for the entire open reading frame of chicken BAFF (chBAFF), which contains a predicted transmembrane domain and a putative furin protease cleavage site like its mammalian counterparts. The amino acid identity between soluble chicken and human BAFF is 76%, considerably higher than for most other known cytokines. The chBAFF gene is most strongly expressed in the bursa of Fabricius. Soluble recombinant chBAFF produced by human 293T cells interacted with the mammalian cell-surface receptors TACI, BCMA and BAFF-R. It bound to chicken B cells, but not to other lymphocytes, and it promoted the survival of splenic chicken B cells in culture. Furthermore, bacterially expressed chBAFF induced the selective expansion of B cells in the spleen and cecal tonsils when administered to young chicks. Our results suggest that like its mammalian counterpart, chBAFF plays an important role in survival and/or proliferation of chicken B cells

Cytokines of Birds: Conserved Functions

Targeted disruptions of the mouse genes for cytokines, cytokine receptors, or components of cytokine signaling cascades convincingly revealed the important roles of these molecules in immunologic processes. Cytokines are used at present as drugs to fight chronic microbial infections and cancer in humans, and they are being evaluated as immune response modifiers to improve vaccines. Until recently, only a few avian cytokines have been characterized, and potential applications thus have remained limited to mammals. Classic approaches to identify cytokine genes in birds proved difficult because sequence conservation is generally low. As new technology and high throughput sequencing became available, this situation changed quickly. We review here recent work that led to the identification of genes for the avian homologs of interferon-a/b (IFNa/b) and IFN-g, various interleukins (IL), and several chemokines. From the initial data on the biochemical properties of these molecules, a picture is emerging that shows that avian and mammalian cytokines may perform similar tasks, although their primary structures in most cases are remarkably different

STUDIES ON PLANT BILE PIGMENTS.

The (4 Z, 10 2, 15Ej-2,3-dihydrobilindione 4, along with the fully unsaturated (E, 2, Z)-analogue 8, has been prepared from the corresponding (Z, Z, Z)-isomer by a variation of Falk's method (Falk et ul., 1980). The photochemical and acid-catalyzed back-reactions have been studied by UV-vis and 'H-NMR spectroscopy

Identification of the relationship between Chinese Adiantum reniforme var. sinense and Canary Adiantum reniforme

© 2014 Wang et al.; licensee BioMed Central. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated

Determination of protein in conidia

Determination of protein in conidi

Lensing effect on the relative orientation between the Cosmic Microwave Background ellipticities and the distant galaxies

The low redshift structures of the Universe act as lenses in a similar way on the Cosmic Microwave Background light and on the distant galaxies (say at redshift about unity). As a consequence, the CMB temperature distortions are expected to be statistically correlated with the galaxy shear, exhibiting a non-uniform distribution of the relative angle between the CMB and the galactic ellipticities. Investigating this effect we find that its amplitude is as high as a 10% excess of alignement between CMB and the galactic ellipticities relative to the uniform distribution. The relatively high signal-to-noise ratio we found should makes possible a detection with the planned CMB data sets, provided that a galaxy survey follow up can be done on a sufficiently large area. It would provide a complementary bias-independent constraint on the cosmological parameters.Comment: 7 pages, 3 figures; uses emulateapj.sty; submitted to Ap