'Het kriebelt om weer met de bijen te beginnen’

Dit jaar verzorgt Frans van Bussel een rubriek voor imkers die net met bijenhouden begonnen zijn. Hij maakt daarbij veel gebruik van het historische werk van Schotman, aangevuld met info van het internet. De centrale vraag is voor hem hoe de bijen onze manier van imkeren ervaren. In deze aflevering bericht Frans over de eerste stappen in de imkerij

Effects of yawed inflow on the aerodynamic and aeroacoustic performance of ducted wind turbines

Ducted Wind Turbines (DWTs) can be used for energy harvesting in urban areas where non-uniform inflows might be the cause of aerodynamic and acoustic performance degradation. For this reason, an aerodynamic and aero-acoustic analysis of DWTs in yawed inflow condition is performed for two duct geometries: a baseline commercial DWT model, DonQi®, and one with a duct having a higher cross-section camber with respect to the baseline, named DonQi D5. The latter has been obtained from a previous optimization study. A numerical investigation using Lattice-Boltzmann Very-Large-Eddy Simulations is presented. Data confirm that the aerodynamic performance improvement, i.e. increase of the power coefficient, is proportional to the increase of the duct thrust force coefficient. It is found that, placing the DWT at a yaw angle of 7.5 , the aerodynamic performances of the DonQi D5 DWT model are less affected by the yaw angle. On the other hand, this configuration shows an increase of broadband noise with respect to the baseline DonQi® one, both in non-yawed and yawed inflow conditions. This is associated to turbulent boundary layer trailing edge noise due to the turbulent flow structures developing along the surface of the duct

Rapid Mixing for Lattice Colorings with Fewer Colors

We provide an optimally mixing Markov chain for 6-colorings of the square lattice on rectangular regions with free, fixed, or toroidal boundary conditions. This implies that the uniform distribution on the set of such colorings has strong spatial mixing, so that the 6-state Potts antiferromagnet has a finite correlation length and a unique Gibbs measure at zero temperature. Four and five are now the only remaining values of q for which it is not known whether there exists a rapidly mixing Markov chain for q-colorings of the square lattice.Comment: Appeared in Proc. LATIN 2004, to appear in JSTA

Chloroquine dosing recommendations for pediatric COVID-19 supported by modeling and simulation

As chloroquine (CHQ) is part of the Dutch Centre for Infectious Disease Control COVID-19 experimental treatment guideline, pediatric dosing guidelines are needed. Recent pediatric data suggest that existing WHO dosing guidelines for children with malaria are suboptimal. The aim of our study was to establish best-evidence to inform pediatric CHQ doses for children infected with COVID-19. A previously developed physiologically-based pharmacokinetic (PBPK) model for CHQ was used to simulate exposure in adults and children and verified against published pharmacokinetic data. The COVID-19 recommended adult dosage regimen of 44mg/kg total was tested in adults and children to evaluate the extent of variation in exposure. Based on differences in AUC0-70h the optimal CHQ dose was determined in children of different ages compared to adults. Revised doses were re-introduced into the model to verify that overall CHQ exposure in each age band was within 5% of the predicted adult value. Simulations showed differences in drug exposure in children of different ages and adults when the same body-weight based dose is given. As such, we propose the following total cumulative doses: 35 mg/kg (CHQ base) for children 0-1 month, 47 mg/kg for 1-6 months, 55 mg/kg for 6 months-12 years and 44 mg/kg for adolescents and adults, not to exceed 3300 mg in any patient. Our study supports age-adjusted CHQ dosing in children with COVID-19 in order to avoid suboptimal or toxic doses. The knowledge-driven, model-informed dose selection paradigm can serve as a science-

Participatory research in times of COVID-19 and beyond: Adjusting your methodological toolkits

Solving grand environmental societal challenges calls for transdisciplinary and participatory methods in social-ecological research. These methods enable co-designing the research, co-producing the results, and co-creating the impacts together with concerned stakeholders. COVID-19 has had serious impacts on the choice of research methods, but reflections on recent experiences of "moving online"are still rare. In this perspective, we focus on the challenge of adjusting different participatory methods to online formats used in five transdisciplinary social-ecological research projects. The key added value of our research is the lessons learned from a comparison of the pros and cons of adjusting a broader set of methods to online formats. We conclude that combining the adjusted online approaches with well-established face-to-face formats into more inclusive hybrid approaches can enrich and diversify the pool of available methods for postpandemic research. Furthermore, a more diverse group of participants can be engaged in the research process

Participatory research in times of COVID-19 and beyond: Adjusting your methodological toolkits

Solving grand environmental societal challenges calls for transdisciplinary and participatory methods in social-ecological research. These methods enable co-designing the research, co-producing the results, and co-creating the impacts together with concerned stakeholders. COVID-19 has had serious impacts on the choice of research methods, but reflections on recent experiences of "moving online"are still rare. In this perspective, we focus on the challenge of adjusting different participatory methods to online formats used in five transdisciplinary social-ecological research projects. The key added value of our research is the lessons learned from a comparison of the pros and cons of adjusting a broader set of methods to online formats. We conclude that combining the adjusted online approaches with well-established face-to-face formats into more inclusive hybrid approaches can enrich and diversify the pool of available methods for postpandemic research. Furthermore, a more diverse group of participants can be engaged in the research process

The Structure of Chromatic Polynomials of Planar Triangulation Graphs and Implications for Chromatic Zeros and Asymptotic Limiting Quantities

We present an analysis of the structure and properties of chromatic polynomials $P(G_{pt,\vec m},q)$ of one-parameter and multi-parameter families of planar triangulation graphs $G_{pt,\vec m}$, where ${\vec m} = (m_1,...,m_p)$ is a vector of integer parameters. We use these to study the ratio of $|P(G_{pt,\vec m},\tau+1)|$ to the Tutte upper bound $(\tau-1)^{n-5}$, where $\tau=(1+\sqrt{5} \ )/2$ and $n$ is the number of vertices in $G_{pt,\vec m}$. In particular, we calculate limiting values of this ratio as $n \to \infty$ for various families of planar triangulations. We also use our calculations to study zeros of these chromatic polynomials. We study a large class of families $G_{pt,\vec m}$ with $p=1$ and $p=2$ and show that these have a structure of the form $P(G_{pt,m},q) = c_{_{G_{pt}},1}\lambda_1^m + c_{_{G_{pt}},2}\lambda_2^m + c_{_{G_{pt}},3}\lambda_3^m$ for $p=1$, where $\lambda_1=q-2$, $\lambda_2=q-3$, and $\lambda_3=-1$, and $P(G_{pt,\vec m},q) = \sum_{i_1=1}^3 \sum_{i_2=1}^3 c_{_{G_{pt}},i_1 i_2} \lambda_{i_1}^{m_1}\lambda_{i_2}^{m_2}$ for $p=2$. We derive properties of the coefficients $c_{_{G_{pt}},\vec i}$ and show that $P(G_{pt,\vec m},q)$ has a real chromatic zero that approaches $(1/2)(3+\sqrt{5} \ )$ as one or more of the $m_i \to \infty$. The generalization to $p \ge 3$ is given. Further, we present a one-parameter family of planar triangulations with real zeros that approach 3 from below as $m \to \infty$. Implications for the ground-state entropy of the Potts antiferromagnet are discussed.Comment: 57 pages, latex, 15 figure

Endothelial dysfunction and low-grade inflammation are associated with greater arterial stiffness over a 6-year period

Endothelial dysfunction and low-grade inflammation are associated with cardiovascular disease. Arterial stiffening plays an important role in cardiovascular disease and, thus, may be a mechanism through which endothelial dysfunction and/or low-grade inflammation lead to cardiovascular disease. We investigated the associations between, on the one hand, biomarkers of endothelial dysfunction (soluble endothelial selectin, thrombomodulin, and both vascular and intercellular adhesion molecules 1 and von Willebrand factor) and of low-grade inflammation (C-reactive protein, serum amyloid A, interleukin 6, interleukin 8, tumor necrosis factor-α and, soluble intercellular adhesion molecule 1) and, on the other hand, arterial stiffness over a 6-year period, in 293 healthy adults (155 women). Biomarkers were combined into mean z scores. Carotid, femoral, and brachial arterial stiffness and carotid-femoral pulse wave velocity were determined by ultrasonography. Measurements were obtained when individuals were 36 and 42 years of age. Associations were analyzed with generalized estimating equation and adjusted for sex, height, and mean arterial pressure. The endothelial dysfunction z score was inversely associated with femoral distensibility (β:-0.51 [95% CI:-0.95 to-0.06]) and compliance coefficients (β:-0.041 [95% CI:-0.076 to-0.006]) but not with carotid or brachial stiffness or carotid-femoral pulse wave velocity. The low-grade inflammation z score was inversely associated with femoral distensibility (β:-0.51 [95% CI:-0.95 to-0.07]) and compliance coefficients (β:-0.050 [95% CI:-0.084 to-0.016]) and with carotid distensibility coefficient (β:-0.910 [95% CI:-1.810 to-0.008]) but not with brachial stiffness or carotid-femoral pulse wave velocity. Biomarkers of endothelial dysfunction and low-grade inflammation are associated with greater arterial stiffness. This provides evidence that arterial stiffening may be a mechanism through which endothelial dysfunction and low-grade inflammation lead to cardiovascular disease