1,207 research outputs found
On a class of time-Fractional continuous-State branching processes
We propose a class of non-Markov population models with continuous or discrete state space via a limiting procedure involving sequences of rescaled and randomly time-changed Galton – Watson processes. The class includes as specific cases the classical continuous-state branching processes and Markov branching processes. Several results such as the expressions of moments and the branching inequality governing the evolution of the process are presented and commented. The generalized Feller branching diffusion and the fractional Yule process are analyzed in detail as special cases of the general model
False-negative real-time polymerase chain reaction tests in COVID-19 patients: an epidemiological analysis of 302 patients
The broad spectrum of COVID-like patients initially negative at RT-PCR testing: a cohort study
GH replacement therapy and second neoplasms in adult survivors of childhood cancer: a retrospective study from a single institution.
An application of the Toronto Childhood Cancer Stage Guidelines in three population-based cancer registries: The case of central nervous tumors
Epigenome-wide association study in the European Prospective Investigation into Cancer and Nutrition (EPIC-Turin) identifies novel genetic loci associated with smoking
Are antigenic tests useful for detecting SARS-CoV-2 infections in patients accessing to emergency departments? Results from a North-West Italy hospital
Prokineticin 2 upregulation in the peripheral nervous system has a major role in triggering and maintaining neuropathic pain in the chronic constriction injury model
The new chemokine Prokineticin 2 (PROK2) and its receptors (PKR1 and PKR2) have a role in inflammatory pain and
immunomodulation. Here we identified PROK2 as a critical mediator of neuropathic pain in the chronic constriction injury (CCI)
of the sciatic nerve in mice and demonstrated that blocking the prokineticin receptors with two PKR1-preferring antagonists (PC1
and PC7) reduces pain and nerve damage. PROK2 mRNA expression was upregulated in the injured nerve since day 3 post injury
(dpi) and in the ipsilateral DRG since 6 dpi. PROK2 protein overexpression was evident in Schwann Cells, infiltrating macrophages
and axons in the peripheral nerve and in the neuronal bodies and some satellite cells in the DRG. Therapeutic treatment of
neuropathic mice with the PKR-antagonist, PC1, impaired the PROK2 upregulation and signalling. This fact, besides alleviating
pain, brought down the burden of proinflammatory cytokines in the damaged nerve and prompted an anti-inflammatory repair
program. Such a treatment also reduced intraneural oedema and axon degeneration as demonstrated by the physiological skin
innervation and thickness conserved in CCI-PC1 mice. These findings suggest that PROK2 plays a crucial role in neuropathic pain
and might represent a novel target of treatment for this disease
- …