Polarized Deeply Inelastic Scattering (DIS) Structure Functions for Nucleons and Nuclei

We extract parton distribution functions (PDFs) and structure functions from recent experimental data of polarized lepton-DIS on nucleons at next-to-leading order (NLO) Quantum Chromodynamics. We apply the Jacobi polynomial method to the DGLAP evolution as this is numerically efficient. Having determined the polarized proton and neutron spin structure, we extend this analysis to describe 3He and 3H polarized structure functions, as well as various sum rules. We compare our results with other analyses from the literature.Comment: LaTeX, 12 pages, 11 figures, 6 tables. Update to match published versio

Polarized Deeply Inelastic Scattering (DIS) Structure Functions for Nucleons and Nuclei

We extract parton distribution functions (PDFs) and structure functions from recent experimental data of polarized lepton-DIS on nucleons at next-to-leading order (NLO) Quantum Chromodynamics. We apply the Jacobi polynomial method to the DGLAP evolution as this is numerically efficient. Having determined the polarized proton and neutron spin structure, we extend this analysis to describe 3He and 3H polarized structure functions, as well as various sum rules. We compare our results with other analyses from the literature.Comment: LaTeX, 12 pages, 11 figures, 6 tables. Update to match published versio

Epitope Mapping of Tetanus Toxin by Monoclonal Antibodies: Implication for Immunotherapy and Vaccine Design

Tetanus as a life-threatening disease is characterized by muscle spasm. The disease is caused by the neurotoxin of Clostridium tetani. Active form of tetanus neurotoxin is composed of the light chain (fragment A) and the heavy chain. Fragment A is a zinc metalloprotease, which cleaves the neuronal soluble N-ethylmaleimide-sensitive attachment receptor (SNARE) protein, leading to the blockade of inhibitory neurotransmitter release and subsequent generalized muscular spasm. Two functional domains of the heavy chain are fragment C, which is required for neuronal cell binding of the toxin and subsequent endocytosis into the vesicles, and fragment B, which is important for fragment A translocation across the vesicular membrane into the neuronal cytosol. Currently, polyclonal immunoglobulins against tetanus neurotoxin obtained from human plasma of hyper-immunized donors are utilized for passive immunotherapy of tetanus; however, these preparations have many disadvantages including high lot-to-lot heterogeneity, possibility of transmitting microbial agents, and the adverse reactions to the other proteins in the plasma. Neutralizing anti-tetanus neurotoxin monoclonal antibodies (MAbs) lack these drawbacks and could be considered as a suitable alternative for passive immunotherapy of tetanus. In this review, we provide an overview of the literature discussing epitope mapping of the published neutralizing MAbs against tetanus toxin. © 2019, Springer Science+Business Media, LLC, part of Springer Nature

Symmetry breaking effect on determination of polarized and unpolarized parton distributions

We perform a new extraction for unpolarized and polarized parton distribution functions considering a flavor decompositions for sea quarks and applying very recent deep inelastic scattering (DIS) and semi inclusive deep inelastic scattering (SIDIS) data in the fixed flavor number scheme (FFNS) framework. In the new symmetry breaking scenario the light quark and antiquark densities are extracted separately and new parametrization forms are determined for them. The heavy flavors contribution, including charm and bottom quarks, are also taken to be account for unpolarized distributions.Comment: Talk presented at 16th International QCD Conference (QCD12), Montpellier, France, July 2- 7, 2012. Submitted to Nuc. Phys. (Proc. Suppl.), 4 pages, 4 figure

Next-to-Leading order approximation of polarized valon and parton distributions

Polarized parton distributions and structure functions of the nucleon are analyzed in the improved valon model. The valon representation provides a model to represent hadrons in terms of quarks, providing a unified description of bound state and scattering properties of hadrons. Polarized valon distributions are seen to play an important role in describing the spin dependence of parton distributions in the leading order (LO) and next-to-leading order (NLO) approximations. In the polarized case, a convolution integral is derived in the framework of the valon model. The Polarized valon distribution in a proton and the polarized parton distributions inside the valon are necessary to obtain the polarized parton distributions in a proton. Bernstein polynomial averages are used to extract the unknown parameters of the polarized valon distributions by fitting to the available experimental data. The predictions for the NLO calculations of the polarized parton distributions and proton structure functions are compared with the LO approximation. It is shown that the results of the calculations for the proton structure function, $xg_1^p$, and its first moment, $\Gamma_{1}^p$, are in good agreement with the experimental data for a range of values of $Q^{2}$. Finally the spin contribution of the valons to the proton is calculated.Comment: 22 pages, 7 figures. Published in Journal of High Energy Physics (JHEP