The role of drag and gravity on dust concentration in a gravitationally unstable disc

We carry out three-dimensional smoothed particle hydrodynamics simulations to study the role of gravitational and drag forces on the concentration of large dust grains (St > 1) in the spiral arms of gravitationally unstable protoplanetary discs, and the resulting implications for planet formation. We find that both drag and gravity play an important role in the evolution of large dust grains. If we include both, grains that would otherwise be partially decoupled will become well coupled and trace the spirals. For the dust grains most influenced by drag (with Stokes numbers near unity), the dust disc quickly becomes gravitationally unstable and rapidly forms clumps with masses between 0.15–6M⊕. A large fraction of clumps are below the threshold where runaway gas accretion can occur. However, if dust self-gravity is neglected, the dust is unable to form clumps, despite still becoming trapped in the gas spirals. When large dust grains are unable to feel either gas gravity or drag, the dust is unable to trace the gas spirals. Hence, full physics is needed to properly simulate dust in gravitationally unstable discs. Dust trapping of large grains in spiral arms of discs stable to gas fragmentation could explain planet formation in very young discs by a population of planetesimals formed due to the combined roles of drag and gravity in the earliest stages of a disc’s evolution. Furthermore, it highlights that gravitationally unstable discs are not just important for forming gas giants quickly, it can also rapidly form Earth mass bodies

A HARPS-N mass for the elusive Kepler-37d::a case study in disentangling stellar activity and planetary signals

To date, only 18 exoplanets with radial velocity (RV) semi-amplitude <2 m s−1 have had their masses directly constrained. The biggest obstacle to RV detection of such exoplanets is variability intrinsic to stars themselves, e.g. nuisance signals arising from surface magnetic activity such as rotating spots and plages, which can drown out or even mimic planetary RV signals. We use Kepler-37 – known to host three transiting planets, one of which, Kepler-37d, should be on the cusp of RV detectability with modern spectrographs – as a case study in disentangling planetary and stellar activity signals. We show how two different statistical techniques – one seeking to identify activity signals in stellar spectra, and another to model activity signals in extracted RVs and activity indicators – can each enable a detection of the hitherto elusive Kepler-37d. Moreover, we show that these two approaches can be complementary, and in combination, facilitate a definitive detection and precise characterization of Kepler-37d. Its RV semi-amplitude of 1.22 ± 0.31 m s−1 (mass 5.4 ± 1.4 M⊕) is formally consistent with TOI-178b’s $1.05^{+0.25}_{-0.30}$ m s−1, the latter being the smallest detected RV signal of any transiting planet to date, though dynamical simulations suggest Kepler-37d’s mass may be on the lower end of our 1σ credible interval. Its consequent density is consistent with either a water-world or that of a gaseous envelope ($\sim 0.4{{\ \rm per\ cent}}$ by mass) surrounding a rocky core. Based on RV modelling and a re-analysis of Kepler-37 TTVs, we also suggest that the putative (non-transiting) planet Kepler-37e should be stripped of its ‘confirmed’ status

Anti-cancer effects and mechanism of actions of aspirin analogues in the treatment of glioma cancer

INTRODUCTION: In the past 25 years only modest advancements in glioma treatment have been made, with patient prognosis and median survival time following diagnosis only increasing from 3 to 7 months. A substantial body of clinical and preclinical evidence has suggested a role for aspirin in the treatment of cancer with multiple mechanisms of action proposed including COX 2 inhibition, down regulation of EGFR expression, and NF-κB signaling affecting Bcl-2 expression. However, with serious side effects such as stroke and gastrointestinal bleeding, aspirin analogues with improved potency and side effect profiles are being developed. METHOD: Effects on cell viability following 24 hr incubation of four aspirin derivatives (PN508, 517, 526 and 529) were compared to cisplatin, aspirin and di-aspirin in four glioma cell lines (U87 MG, SVG P12, GOS – 3, and 1321N1), using the PrestoBlue assay, establishing IC50 and examining the time course of drug effects. RESULTS: All compounds were found to decrease cell viability in a concentration and time dependant manner. Significantly, the analogue PN517 (IC50 2mM) showed approximately a twofold increase in potency when compared to aspirin (3.7mM) and cisplatin (4.3mM) in U87 cells, with similar increased potency in SVG P12 cells. Other analogues demonstrated similar potency to aspirin and cisplatin. CONCLUSION: These results support the further development and characterization of novel NSAID derivatives for the treatment of glioma

TOUCH-UP Gradient Amplification Method

We report a unique amplification technique that works efficiently and specifically over a temperature range, rather than at one specific temperature, throughout the amplification process. As bisulfite-modified DNA is one of the difficult to amplify templates, we used this technique to amplify regions of promoter-associated CpG island for 11 genes using this template. This technique amplified specific products for every gene without requiring any optimization