Effects of the repeated distribution of sainfoin hay on the resistance and the resilience of goats naturally infected with gastrointestinal nematodes

Due to the high prevalence of anthelmintic resistance in goats, the need to explore novel approaches to control nematodes and to reduce the exclusive reliance on chemotherapy is strongly demanded in this host species. In sheep, several studies have shown that the consumption of tannin-rich legume forages was associated with positive effects on host resilience and resistance to parasite infection. In goats, studies on such interactions between tanniferous plants and nematode infections remain few. The objectives of the current study were to examine under natural conditions the effects of consumption of sainfoin hay by goats on the parasite populations and on host resilience. Eighteen adult cull goats naturally infected with Haemonchus contortus, Teladorsagia circumcincta and Trichostrongylus colubriformis were used in the study. At the start of the assay, the goats were allocated into two groups, balanced according to weight and the levels of egg excretion. The two groups grazed separate pastures for 3 months with similar stocking rates. Goats from group S received each month indoors, for 7 days, sainfoin hay and control goats (group C) received hay of ryegrass. The diets in both groups were made isoenergetic and isoproteic and the refusals measured. Individual parasitological and pathophysiological measurements were performed fortnightly in order to compare host resistance and resilience. At the end of the study, five goats per group were necropsied. The distribution of sainfoin was associated with: (1) a higher consumption of hay; (2) significant, lower levels of nematode egg excretion which was associated with a decrease in worm fertility but no change in worm population; however, the number of intestinal worms was reduced by 50% in group S; (3) a better host resilience. In particular, after 2 months of grazing, two control goats died and half of the remaining animals needed to be treated whereas this was not the case in group S. These differences were related to significant changes in pepsinogen and phosphate values (PCV) but not in pepsinogen and phosphate concentrations. These results demonstrate that a repeated distribution of sainfoin hay to grazing goats might be beneficial in regard of pasture contamination and host resilience. They suggest that administration of sainfoin hay might represent a valuable alternative and adjunct to reduce nematode infections in dairy goat flock. # 2004 Elsevier B.V. All rights reserved

Effects of condensed tannins on goats experimentally infected with Haemonchus contortus.

Although the use of tanniferous plants or condensed tannins as an alternative to anthelmintics to control gastrointestinal nematodes has been largely documented in sheep, studies remain scarce in goats. The objective of this study was therefore to assess the possible impact of condensed tannins in goats infected with adult Haemonchus contortus. Two groups of cull goats were experimentally infected with 10.000 L3 of H. contortus. After 4 weeks, quebracho extracts, representing 5% of the diet DM, were administered for 8 days to one of the two groups. Goats of the second group remained as controls. One week after the end of quebracho administration, the goats were euthanised. Individual egg excretion and pathophysiological parameters were measured weekly during the study. At the end of the study, worm counts were assessed and histological samples from the abomasa were taken to count the numbers of mucosal mast cells, globule leukocytes and eosinophils. The administration of tannins was associated with a significant decrease in egg excretion, which persisted until the end of experiment. This reduction was not associated with any difference in worm number but with a significant decrease in female fecundity. No significant changes in the mucosal density of the three inflammatory cell types were detected between the two groups. These results indicate that the major consequence of tannin consumption in goats is a reduction in worm fecundity and egg output, which does not seem related to significant changes in the local mucosal response

Log-Harnack Inequality for Stochastic Differential Equations in Hilbert Spaces and its Consequences

A logarithmic type Harnack inequality is established for the semigroup of solutions to a stochastic differential equation in Hilbert spaces with non-additive noise. As applications, the strong Feller property as well as the entropy-cost inequality for the semigroup are derived with respect to the corresponding distance (cost function)

Differences in receptivity to gastrointestinal infections with nematodes in dairy ewes: Influence of age and of the level of milk production

Resistance to anthelmintics in populations of gastrointestinal nematodes is a major concern in small ruminants. One solution to limit the spread of anthelmintic resistance is to apply treatments selectively by targeting the most susceptible animals within a flock. In dairy goats, previous studies have shown that, within a flock, goats in first lactation and those with high level of milk production were highly receptive to nematode infections. These results provided the rationale for targeted treatments. In dairy ewes, such epidemiological information on possible factors modulating the susceptibility to parasitism were still lacking. The objective of the current study was therefore to examine differences in the level of parasite infection and in the pathophysiological consequences in dairy ewes, depending on the age or on the level of milk production. In three farms, parasite egg excretion, and the serum concentrations of pepsinogen and inorganic phosphate were compared on one hand between primiparous and multiparous ewes; on the other hand, between ewes with the highest and the lowest level of milk production, within a cohort of 3–5-year old animals. Overall, the results did not indicate significant differences for both either the parasitological or pathophysiological measurements depending on the level of milk production. In contrast, significant differences were found according to age, indicating higher levels of infections in the primiparous ewes than in the multiparous ones and suggesting that this category of animals represents a particular parasitic risk within a flock

Effects of distribution of quebracho extracts on experimental Haemonchus contortus infections in goats

The effects of tannins on adult populations of Haemonchus contortus, Trichostrongylus colubriformis and Teladorsagia circumcincta in goats are characterised mainly by a decrease in egg excretion without any significant changes in worm number. In contrast, the impact of tannins on T. colubriformis or T. circumcincta third-stage larvae (L3) is associated with a significant reduction in worm establishment. The objective of the present study was to examine the effects of quebracho extract tannins on H. contortus L3. The consequences of consumption of sainfoin hay were also examined. Twenty-one naı¨ve kids were divided into three experimental groups. Group Q received quebracho extract and group S received sainfoin hay from days D3 to D5. Group C remained as an infected control group. All kids received 1500 L3 H. contortus on D0, D1 and D2. On D18, post-infection, the kids were slaughtered and the worm populations compared in the different groups. Compared to the control values, the worm counts decreased, respectively, by 33% and 38% in groups Q and S but the differences were not significant. No differences were found in pathophysiological measurements between the three groups. The results confirm differences in tannin effect according to nematode species but not parasitic stage

Environmental assessment of humic acid coated magnetic materials used as catalyst in photo-fenton processes

Persistent organic pollutants have been increasingly detected in natural waters, and this represents a real challenge to the quality of this resource. To remove these species, advanced treatment technologies are required. Among these technologies, Fenton-like and photo-Fenton-like processes have been investigated for the removal of pollutants from water. Delicate aspects of photo-Fenton processes are that light-driven processes are energy intensive and require a fair amount of chemical inputs, which strongly affects their overall environmental burdens. At present, aside from determining the efficiency of the processes to remove pollutants of a particular technology, it becomes fundamental to assess also the environmental sustainability of the overall process. In this work, the methodology of the life cycle assessment (LCA) was applied to identify the hotspots of using magnetite particles covered with humic acid (Fe3O4/HA) as a heterogeneous photo-Fenton catalyst for water remediation. The sustainability of the overall process was considered, and a comparative LCA study was performed between H2O2 and persulfate activation at different pH. The addition of humic substances to the particles allows the effectiveness of the catalyst to improve without increasing the environmental impacts; these processes are strongly correlated with energy consumption and therefore with the efficiency of the process. For this reason, working at acidic pH allows us to contain the impacts

Spitzer Observations of the z=2.73 Lensed Lyman Break Galaxy, MS1512-cB58

We present Spitzer infrared (IR) photometry and spectroscopy of the lensed Lyman break galaxy (LBG), MS1512-cB58 at z=2.73. The large (factor ~30) magnification allows for the most detailed infrared study of an L*_UV(z=3) LBG to date. Broadband photometry with IRAC (3-10 micron), IRS (16 micron), and MIPS (24, 70 & 160 micron) was obtained as well as IRS spectroscopy spanning 5.5-35 microns. A fit of stellar population models to the optical/near-IR/IRAC photometry gives a young age (~9 Myr), forming stars at ~98 M_sun/yr, with a total stellar mass of ~10^9 M_sun formed thus far. The existence of an old stellar population with twice the stellar mass can not be ruled out. IR spectral energy distribution fits to the 24 and 70 micron photometry, as well as previously obtained submm/mm, data give an intrinsic IR luminosity L_IR = 1-2 x10^11 L_sun and a star formation rate, SFR ~20-40 M_sun/yr. The UV derived star formation rate (SFR) is ~3-5 times higher than the SFR determined using L_IR or L_Halpha because the red UV spectral slope is significantly over predicting the level of dust extinction. This suggests that the assumed Calzetti starburst obscuration law may not be valid for young LBGs. We detect strong line emission from Polycyclic Aromatic Hydrocarbons (PAHs) at 6.2, 7.7, and 8.6 microns. The line ratios are consistent with ratios observed in both local and high redshift starbursts. Both the PAH and rest-frame 8 micron luminosities predict the total L_IR based on previously measured relations in starbursts. Finally, we do not detect the 3.3 micron PAH feature. This is marginally inconsistent with some PAH emission models, but still consistent with PAH ratios measured in many local star-forming galaxies.Comment: Accepted for publication in ApJ. aastex format, 18 pages, 7 figure

Far Ultraviolet Spectroscopic Explorer Survey of Magellanic Cloud Supernova Remnants

We report the progress to date from an ongoing unbiased ultraviolet survey of supernova remnants in the Magellanic Clouds using the Far Ultraviolet Spectroscopic Explorer (FUSE) satellite. This survey is obtaining spectra of a random large sample of Magellanic Cloud supernova remnants with a broad range of radio, optical, and X-ray properties. To date, 39 objects have been observed in the survey (38 in the LMC and one in the SMC) and 15 have been detected, a detection rate of nearly 40%. Our survey has nearly tripled the number of UV-detected SNRs in the Magellanic Clouds (from 8 to 22). Because of the diffuse source sensitivity of FUSE, upper limits on non-detected objects are quite sensitive in many cases. Estimated total luminosities in O~VI span a broad range from considerably brighter to many times fainter than the inferred soft X-ray luminosities, indicating that O~VI can be an important and largely unrecognized coolant in certain objects. We compare the optical and X-ray properties of the detected and non-detected objects but do not find a simple indicator for ultraviolet detectability. Non-detections may be due to clumpiness of the emission, high foreground extinction, slow shocks whose emission gets attenuated by the Magellanic interstellar medium, or a combination of these effects.Comment: 34 pages, 26 figures in 8 separate JPG figure files; the characteristics of individual detected supernova remnants are summarized in an Appendi

Urban biowaste-derived sensitizing materials for caffeine photodegradation

[EN] Caffeine-photosensitized degradation has been studied in the presence of bio-based materials derived from urban biowaste after aerobic aging. A peculiar fraction (namely bio-based substances (BBSs)), soluble in all the pH range, has been used as photosensitizing agent. Several caffeine photodegradation tests have been performed, and positive results have been obtained in the presence of BBSs and H2O2, without and with additional Fe(II) (photo-Fenton-like process). Moreover, hybrid magnetite-BBS nanoparticles have been synthesized and characterized, in order to improve the sensitizer recovery and reuse after the caffeine degradation. In the presence of such nanoparticles and H2O2 and Fe(II), the complete caffeine degradation has been attained in very short time. Both homogeneous and heterogeneous processes were run at pH = 5, milder condition compared to the classic photo-Fenton process.This work was performed with the financial support for academic interchange by the Marie Sklodowska-Curie Research and Innovation Staff Exchange project funded by the European Commission H2020-MSCA-RISE-2014 within the framework of the research project MAT4TREAT (project number 645551). Compagnia di San Paolo and University of Torino are gratefully acknowledged for funding Project Torino_call2014_L2_126 through BBando per il finanziamento di progetti di ricerca di Ateneo – anno 2014 (Project acronym: Microbusters). Additionally, authors would like to acknowledge Dr. Flavio R. Sives (La Plata, Argentina) for magnetization measurements.Prevot, AB.; Baino, F.; Fabbri, D.; Franzoso, F.; Magnacca, G.; Nistico, R.; Arques Sanz, A. (2017). Urban biowaste-derived sensitizing materials for caffeine photodegradation. Environmental Science and Pollution Research. 24(14):12599-12607. https://doi.org/10.1007/s11356-016-7763S1259912607241