159 research outputs found
HER2 expression and efficacy of dose-dense anthracycline-containing adjuvant chemotherapy in breast cancer patients
No data are available on the role of HER2 overexpression in predicting the efficacy of dose-dense anthracycline-containing adjuvant chemotherapy in breast cancer patients. We retrospectively evaluated this role in patients enrolled in a phase III study comparing standard FEC21 (5-fluorouracil, epirubicin, and cyclophosphamide, administered every 3 weeks) vs dose-dense FEC14 (the same regimen repeated every 2 weeks). HER2 status was determined for 731 of 1214 patients. Statistical analyses were performed to test for interaction between treatment and HER2 status with respect to event-free survival (EFS) and overall survival (OS); EFS and OS were compared within each HER2 subgroup and within each treatment arm. Median follow-up was 6.7 years. Among FEC21-treated patients, both EFS (HR=2.07; 95% CI 1.27–3.38) and OS (HR=2.47; 95% CI 1.34–4.57) were significantly worse in HER2 + patients than in HER2 − patients. Among FEC14-treated patients, differences in either EFS (HR=1.21; 95% CI 0.65–2.24) or OS (HR=1.85; 95% CI 0.88–3.89) between HER2 + and HER2 − patients were not statistically significant. Interaction analysis suggested that the use of dose-dense FEC14 might remove the negative prognostic effect of HER2 overexpression on EFS and OS. Our data suggest a potential role of HER-2 overexpression in predicting the efficacy of dose-dense epirubicin-containing chemotherapy and the need to confirm this hypothesis in future prospective studies
Integration of targeted metabolomics and transcriptomics identifies deregulation of phosphatidylcholine metabolism in Huntington’s disease peripheral blood samples
Epidemiologia dell\u2019inquinamento da traffico: relazione tra piombo ematico, intensita\u2019 del traffico e sintomatologie respiratorie
Amniotic fluid prolactin and fetal lung maturity
Prolactin concentration and palmitic acid/stearic acid ratio were measured in 92 samples of amniotic fluid at various gestational ages. There was no correlation between prolactin concentration and palmitic acid/stearic acid ratio, when this ratio was greater than 5, that is when there was an obvious indication that fetal pulmonary maturation was complete. On the contrary there was a statistically significant negative correlation between prolactin levels and palmitic acid/stearic acid ratio when this ratio was lower than 5 (incomplete fetal pulmonary maturation)
Indagine ambientale ed epidemiologica su un gruppo di popolazione balneare e su soggetti controllo
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