Rockfall hazard assessment of the Monte Gallo Oriented Nature Reserve area (Southern Italy)

The Monte Gallo area is a carbonate relief that develops a significant nature reserve and highly attracts tourism to the urbanized area of the City of Palermo (Southern Italy). The slopes are affected by several rockfall events, which have also caused death, injuries, material damage, and a strong social and economic impact. Here, a detailed geological and geotechnical study to assess the rockfall hazard relating to two sectors of the mount has been carried out. The hazard assessment at the slope scale was performed based on geological, geomorphological, geomechanical, and seismic analysis. Using both analytical and empirical methods and by means of different software, the reconstruction of the propagation areas for the eastern sector of the Mount was possible. Results were used to better understand the overall structure, characterize the rockfall source areas' kinematics, and recognize the basic failure mechanisms. The obtained runout areas were compared with each other and with those of previous studies conducted in a neighboring area, as well as with the corresponding hazard area maps of the official cartography, which is being updated. It is expected to be supplemented with maps derived from empirical models

Rockfall hazards of Mount Pellegrino area (Sicily, Southern Italy)

A map derived by rockfall analysis at Mount Pellegrino is presented herein. The study area is affected by several phenomena of rockfall which caused numerous damage and a strong social and economic impact. Official reports and maps that give a general assessment of rockfall hazard are available in this respect, however, it would be advisable to provide a more specific cartographic support useful for land management and planning. The drafting of new maps showing the rockfall runout areas is an additional tool that may be used in conjunction with the existing maps as a means of risk mitigation and reduction. On the basis of geological, geomorphological, and geomechanical analysis and exploiting the information relating to a landslides inventory obtained by using both analytical and empirical methods, two different rockfall propagation areas were reconstructed. The final thematic map permit to appreciate the differences and similarities between the obtained runout areas

Analysis of the Rockfall Phenomena Contributing to the Evolution of a Pocket Beach Area Using Traditional and Remotely Acquired Data (Lo Zingaro Nature Reserve, Southern Italy)

The coastal domain of central western Sicily is characterized by the presence of rocky coasts, which mainly consist of pocket beaches situated between bedrock headlands that constitute ecological niches of great touristic and economic value. In this peculiar morphodynamic system, the sedimentary contributions are mainly derived from the rockfall that affects the back of nearby cliffs or the sediment supply of small streams that flow into it. In this study, we investigated the geomorphological processes and related landforms that contribute to the evolution of a pocket beach area located in a coastal sector of NW Sicily Island. The cliffs in this are affected by several rockfalls, and deposits from these rockfalls also add to the rate of sedimentary contribution. The analysis was conducted through the application of traditional approaches and contemporary methods that have previously been used to forecast the collection of input data in the field, often under difficult conditions due to the accessibility of the sites, and which have been supported by UAV surveys. Through the analysis of the digital models of terrain and orthophotos, geometrical and multitemporal analyses of landforms were carried out. A dedicated software was utilized for the detection of rockfall runout zones and block trajectories and for defining the automatic extraction of rock mass discontinuities. The data were compared with those derived from traditional geomechanical surveys. The availability of the existing and acquired remote sensing data proved essential for this study for both defining the reference geological model and for performing the site-specific analysis of rockfall

Chronic neural interfacing with cerebral cortex using single-walled carbon nanotube-polymer grids

Objective. The development of electrode arrays able to reliably record brain electrical activity is a critical issue in brain machine interface (BMI) technology. In the present study we undertook a comprehensive physico-chemical, physiological, histological and immunohistochemical characterization of new single-walled carbon nanotubes (SWCNT)-based electrode arrays grafted onto medium-density polyethylene (MD-PE) films. Approach. The long-term electrical stability, flexibility, and biocompatibility of the SWCNT arrays were investigated in vivo in laboratory rats by two-months recording and analysis of subdural electrocorticogram (ECoG). Ex-vivo characterization of a thin flexible and single probe SWCNT/polymer electrode is also provided. Main results. The SWCNT arrays were able to capture high quality and very stable ECoG signals across 8 weeks. The histological and immunohistochemical analyses demonstrated that SWCNT arrays show promising biocompatibility properties and may be used in chronic conditions. The SWCNT-based arrays are flexible and stretchable, providing low electrode-tissue impedance, and, therefore, high compliance with the irregular topography of the cortical surface. Finally, reliable evoked synaptic local field potentials in rat brain slices were recorded using a special SWCNT-polymer-based flexible electrode. Significance. The results demonstrate that the SWCNT arrays grafted in MD-PE are suitable for manufacturing flexible devices for subdural ECoG recording and might represent promising candidates for long-term neural implants for epilepsy monitoring or neuroprosthetic BMI

Melatonin and/or erythropoietin combined with hypothermia in a piglet model of perinatal asphyxia

AAs therapeutic hypothermia is only partially protective for neonatal encephalopathy, safe and effective adjunct therapies are urgently needed. Melatonin and erythropoietin show promise as safe and effective neuroprotective therapies. We hypothesized that melatonin and erythropoietin individually augment 12-h hypothermia (double therapies) and hypothermia + melatonin + erythropoietin (triple therapy) leads to optimal brain protection. Following carotid artery occlusion and hypoxia, 49 male piglets (<48 h old) were randomized to: (i) hypothermia + vehicle (n = 12), (ii) hypothermia + melatonin (20 mg/kg over 2 h) (n = 12), (iii) hypothermia + erythropoietin (3000 U/kg bolus) (n = 13) or (iv) tripletherapy (n = 12). Melatonin, erythropoietin or vehicle were given at 1, 24 and 48 h after hypoxia–ischaemia. Hypoxia–ischaemia severity was similar across groups. Therapeutic levels were achieved 3 hours after hypoxia–ischaemia for melatonin (15–30 mg/l) and within 30 min of erythropoietin administration (maximum concentration 10 000 mU/ml). Compared to hypothermia + vehicle, we observed faster amplitude-integrated EEG recovery from 25 to 30 h with hypothermia + melatonin (P = 0.02) and hypothermia + erythropoietin (P = 0.033) and from 55 to 60 h with tripletherapy (P = 0.042). Magnetic resonance spectroscopy lactate/N-acetyl aspartate peak ratio was lower at 66 h in hypothermia + melatonin (P = 0.012) and tripletherapy (P = 0.032). With hypothermia + melatonin, terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick-end labelled-positive cells were reduced in sensorimotor cortex (P = 0.017) and oligodendrocyte transcription factor 2 labelled-positive counts increased in hippocampus (P = 0.014) and periventricular white matter (P = 0.039). There was no reduction in terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick-end labelled-positive cells with hypothermia + erythropoietin, but increased oligodendrocyte transcription factor 2 labelled-positive cells in 5 of 8 brain regions (P < 0.05). Overall, melatonin and erythropoietin were safe and effective adjunct therapies to hypothermia. Hypothermia + melatonin double therapy led to faster amplitude-integrated EEG recovery, amelioration of lactate/N-acetyl aspartate rise and reduction in terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick-end labelled-positive cells in the sensorimotor cortex. Hypothermia + erythropoietin doubletherapy was in association with EEG recovery and was most effective in promoting oligodendrocyte survival. Tripletherapy provided no added benefit over the double therapies in this 72-h study. Melatonin and erythropoietin influenced cell death and oligodendrocyte survival differently, reflecting distinct neuroprotective mechanisms which may become more visible with longer-term studies. Staggering the administration of therapies with early melatonin and later erythropoietin (after hypothermia) may provide better protection; each therapy has complementary actions which may be time critical during the neurotoxic cascade after hypoxia–ischaemia