407 research outputs found
An exact analytical solution for generalized growth models driven by a Markovian dichotomic noise
Logistic growth models are recurrent in biology, epidemiology, market models,
and neural and social networks. They find important applications in many other
fields including laser modelling. In numerous realistic cases the growth rate
undergoes stochastic fluctuations and we consider a growth model with a
stochastic growth rate modelled via an asymmetric Markovian dichotomic noise.
We find an exact analytical solution for the probability distribution providing
a powerful tool with applications ranging from biology to astrophysics and
laser physics
Evidence for Strong Itinerant Spin Fluctuations in the Normal State of CeFeAsO(0.89)F(0.11) Iron-Oxypnictides
The electronic structure in the normal state of CeFeAsO0.89F0.11 oxypnictide
superconductors has been investigated with x-ray absorption and photoemission
spectroscopy. All the data exhibit signatures of Fe d-electron itinerancy.
Exchange multiplets appearing in the Fe 3s core level indicate the presence of
itinerant spin fluctuations. These findings suggest that the underlying physics
and the origin of superconductivity in these materials are likely to be quite
different from those of the cuprate high-temperature superconductors. These
materials provide opportunities for elucidating the role of magnetic
fluctuations in high-temperature superconductivity.Comment: Shorter version. Accepted in Phys. Rev. Let
Electron Tomographic Studies of Mitochondrial Crista Topology: “Swirl” Mitochondria of Drosophila Flight Muscle
Extended abstract of a paper presented at Microscopy and Microanalysis 2007 in Ft. Lauderdale, Florida, USA, August 5 – August 9, 2007
Electronic Structure of CeFeAsO1-xFx (x=0, 0.11/x=0.12) compounds
We report an extensive study on the intrinsic bulk electronic structure of
the high-temperature superconductor CeFeAsO0.89F0.11 and its parent compound
CeFeAsO by soft and hard x-ray photoemission, x-ray absorption and soft-x-ray
emission spectroscopies. The complementary surface/bulk probing depth, and the
elemental and chemical sensitivity of these techniques allows resolving the
intrinsic electronic structure of each element and correlating it with the
local structure, which has been probed by extended-x-ray absorption fine
structure spectroscopy. The measurements indicate a predominant 4f1 (i.e. Ce3+)
initial state configuration for Cerium and an effective valence-band-to-4f
charge-transfer screening of the core hole. The spectra also reveal the
presence of a small Ce f0 initial state configuration, which we assign to the
occurrence of an intermediate valence state. The data reveal a reasonably good
agreement with the partial density of states as obtained in standard density
functional calculations over a large energy range. Implications for the
electronic structure of these materials are discussed.Comment: Accepted for publication in Phys. Rev.
Preparation of polymeric foams with a pore size gradient via Thermally Induced Phase Separation (TIPS)
Delivery Mode Shapes the Composition of the Lower Airways Microbiota in Newborns
Radical alterations in the human microbiota composition are well-known to be associated with many pathological conditions. If these aberrations are established at the time of birth, the risk of developing correlated pathologies throughout life is significantly increased. For this reason, all newborns should begin their lives with a proper microbiota in each body district. The present study aimed at demonstrating a correlation between the mode of delivery and the development of a well-balanced microbiota in the lower airways of newborns. 44 pregnant women were enrolled in this study. Microbiological comparative analysis was carried out on tracheobronchial secretions of babies born through vaginal delivery (VD) or caesarean section (CS). All samples showed the presence of bacterial DNA, regardless of the mode of delivery. No viable cultivable bacteria were isolated from the CS samples. On the contrary, VD allowed colonization of the lower airways by alive cultivable bacteria. The identification of bacterial species revealed that Lactobacillus spp. and Bacteroides vulgatus were the most common microorganisms in the lower airways of vaginally-delivered newborns. Data obtained from quantitative PCRs showed a significantly higher total bacterial load, as well as Firmicutes and Lactobacillus spp. amount, in VD samples than CS ones, while no statistically significant difference was found in Torque Teno Virus (TTV) load between samples. Taken together, our findings confirm the hypothesis that passage through the maternal vaginal canal determines more beneficial colonization of the lower airways in newborns
Structural and functional features and significance of the physical linkage between ER and mitochondria
The role of mitochondria in cell metabolism and survival is controlled by calcium signals that are commonly transmitted at the close associations between mitochondria and endoplasmic reticulum (ER). However, the physical linkage of the ER–mitochondria interface and its relevance for cell function remains elusive. We show by electron tomography that ER and mitochondria are adjoined by tethers that are ∼10 nm at the smooth ER and ∼25 nm at the rough ER. Limited proteolysis separates ER from mitochondria, whereas expression of a short “synthetic linker” (<5 nm) leads to tightening of the associations. Although normal connections are necessary and sufficient for proper propagation of ER-derived calcium signals to the mitochondria, tightened connections, synthetic or naturally observed under apoptosis-inducing conditions, make mitochondria prone to Ca2+ overloading and ensuing permeability transition. These results reveal an unexpected dependence of cell function and survival on the maintenance of proper spacing between the ER and mitochondria
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