Three-dimensional reconstruction of CME-driven shock-streamer interaction from radio and EUV observations: a different take on the diagnostics of coronal magnetic fields

On 2014 October 30, a band-splitted type II radio burst associated with a coronal mass ejection (CME) observed by the Atmospheric Imaging Assembly (AIA) on board the Solar Dynamic Observatory (SDO) occurred over the southeast limb of the Sun. The fast expansion in all directions of the plasma front acted as a piston and drove a spherical fast shock ahead of it, whose outward progression was traced by simultaneous images obtained with the Nan\c{c}ay Radioheliograph (NRH). The geometry of the CME/shock event was recovered through 3D modeling, given the absence of concomitant stereoscopic observations, and assuming that the band-splitted type II burst was emitted at the intersection of the shock surface with two adjacent low-Alfven speed coronal streamers. From the derived spatiotemporal evolution of the standoff distance between shock and CME leading edge, we were finally able to infer the magnetic field strength $B$ in the inner corona. A simple radial profile of the form $B(r) = (12.6 \pm 2.5) r^{-4}$ nicely fits our results, together with previous estimates, in the range $r = 1.1-2.0$ solar radii.Comment: Accepted for publication in Astronomy & Astrophysics Letter

Plasma kisspeptin levels are associated with insulin secretion in nondiabetic individuals

To evaluate if plasma kisspeptin concentrations are associated with insulin secretion, as suggested by recent in vitro studies, independently of confounders. 261 nondiabetic subjects were stratified into tertiles according to kisspeptin values. Insulin secretion was assessed using indexes derived from oral glucose tolerance test (OGTT). After adjusting for age, gender, and BMI, subjects in the highest (tertile 3) kisspeptin group exhibited significantly lower values of insulinogenic index, corrected insulin response (CIR30), and Stumvoll indexes for first-phase and second-phase insulin release as compared with low (tertile 1) or intermediate (tertile 2) kisspeptin groups. Univariate correlations between kisspeptin concentration and metabolic variables showed that kisspeptin concentration was significantly and positively correlated with age, blood pressure, and 2-h post-load glucose, and inversely correlated with BMI, and waist circumference. There was an inverse relationship between kisspeptin levels and OGTT-derived indexes of glucose-stimulated insulin secretion. A multivariable regression analysis in a model including all the variables significantly correlated with kisspeptin concentration showed thar age (β = -0.338, P<0.0001), BMI (β = 0.272, P<0.0001), 2-h post-load glucose (β = -0.229, P<0.0001), and kisspeptin (β = -0.105, P = 0.03) remained associated with insulinogenic index. These factors explained 34.6% of the variance of the insulinogenic index. In conclusion, kisspeptin concentrations are associated with insulin secretion independently of important determinants of glucose homeostasis such as gender, age, adiposity, 2-h post-load glucose, and insulin sensitivity

A genetic algorithm for combined topology and shape optimisations

A method to find optimal topology and shape of structures is presented. With the first the optimal distribution of an assigned mass is found using an approach based on homogenisation theory, that seeks in which elements of a meshed domain it is present mass; with the second the discontinuous boundaries are smoothed. The problem of the optimal topology search has an ON/OFF nature and has suggested the employment of genetic algorithms. Thus in this paper a genetic algorithm has been developed, which uses as design variables, in the topology optimisation, the relative densities (with respect to effective material density) 0 or 1 of each element of the structure and, in the shape one, the coordinates of the keypoints of changeable boundaries constituted by curves. In both the steps the aim is that to find the variable sets producing the maximum stiffness of the structure, respecting an upper limit on the employed mass. The structural evaluations are carried out with a FEM commercial code, linked to the algorithm. Some applications have been performed and results compared with solutions reported in literature. \uc2\ua9 2003 Elsevier Science Ltd. All rights reserved

Lay-up optimization for the hull of a racing sailing yacht

Deformability and buckling load of yacht hulls with fiber reinforced plastic sandwich structure depend on the stack sequence of the skins. In this work an optimization of fiber directions of the laminae for a racing yacht is proposed. This procedure has been divided into three parts (i.e. material characterization, surface model definition, lay-up optimization). First of all a set of unidirectional specimens has been realized, by using the same fibers and matrix (carbon/epoxy) used for the hull as well as the same procedure and workers, in order to characterize the material according to American Society for Testing and Materials (ASTM) Standard D3039, employing strain gage technique. In the second part, by means of an original software in Turbo-Pascal (which uses the half-width value matrix as an input) linked to Pro/ENGINEER, it has been possible to obtain the body plan and surface and finite element (FE) models of the sailing yacht for the subsequent analyses. In the third step, an optimization procedure that uses the results of FE structural analyses in three different sailing configurations is performed, with the aim of obtaining the fiber directions that are able to minimize the yacht deformability, also taking into account the buckling loads. An approximate analytical model has been used in conjunction with a sweep technique in order to evaluate the best of the solutions

STR-855: INSTANTANEOUS DEFLECTIONS OF CONCRETE SLABS COMPUTED USING DISCRETIZED ANALYSIS

Excessive deflection of concrete floor slabs is a recurring serviceability problem (Gilbert 2012, Stivaros 2012). Current practice is to compute deflections using either a single-element idealization, where an average effective moment of inertia is assigned to the entire member, or a discretized analysis, where the member is idealized as discrete elements with unique effective moments of inertia. There are two equations available for calculating the effective moment of inertia, developed by Branson (1965) and by Bischoff (2005). Branson originally proposed two equations for effective moment of inertia, a 3rd-power equation for use in a single-element idealization and a 4th-power equation for use in a discretized-element idealization. Bischoff has proposed a single equation, based on a correct mechanical model, for use in a single-element idealization only. The research summarized in this paper investigates suitable modifications to Bischoff’s Equation for use in a discretized analysis. Simply supported members with various reinforcement ratios and live- to dead-load ratios are explored. Comparisons to experimental data are made to determine which deflection calculation procedure provides results closest to those observed

Insulin-like growth factor-1 is a negative modulator of glucagon secretion

Glucagon secretion involves a combination of paracrine, autocrine, hormonal, and autonomic neural mechanisms. Type 2 diabetes often presents impaired glucagon suppression by insulin and glucose. Insulin-like growth factor-I (IGF-1) has elevated homology with insulin, and regulates pancreatic β-cells insulin secretion. Insulin and IGF-1 receptors share considerable structure homology and function. We hypothesized the existence of a mechanism linking the inhibition of α-cells glucagon secretion to IGF-1. Herein, we evaluated the association between plasma IGF-1 and glucagon levels in 116 nondiabetic adults. After adjusting for age gender and BMI, fasting glucagon levels were positively correlated with 2-h post-load glycaemia, HOMA index and fasting insulin, and were negatively correlated with IGF-1 levels. In a multivariable regression, the variables independently associated to fasting glucagon were circulating IGF-1 levels, HOMA index and BMI, explaining 20.7% variation. To unravel the molecular mechanisms beneath IGF-1 and glucagon association, we investigated whether IGF-1 directly modulates glucagon expression and secretion in an in vitro model of α-cells. Our data showed that IGF-1 inhibits the ability of low glucose concentration to stimulate glucagon expression and secretion via activation of the phosphatidylinositol-3-kinase/Akt/FoxO1 pathway. Collectively, our results suggest a new regulatory role of IGF-1 on α-cells biological function

Red Blood Cells from Individuals with Abdominal Obesity or Metabolic Abnormalities Exhibit Less Deformability upon Entering a Constriction.

Abdominal obesity and metabolic syndrome (MS) are multifactorial conditions associated with increased risk of cardiovascular disease and type II diabetes mellitus. Previous work has demonstrated that the hemorheological profile is altered in patients with abdominal obesity and MS, as evidenced for example by increased whole blood viscosity. To date, however, no studies have examined red blood cell (RBC) deformability of blood from individuals with obesity or metabolic abnormalities under typical physiological flow conditions. In this study, we pumped RBCs through a constriction in a microfluidic device and used high speed video to visualize and track the mechanical behavior of ~8,000 RBCs obtained from either healthy individuals (n = 5) or obese participants with metabolic abnormalities (OMA) (n = 4). We demonstrate that the OMA+ cells stretched on average about 25% less than the healthy controls. Furthermore, we examined the effects of ingesting a high-fat meal on RBC mechanical dynamics, and found that the postprandial period has only a weak effect on the stretching dynamics exhibited by OMA+ cells. The results suggest that chronic rigidification of RBCs plays a key role in the increased blood pressure and increased whole blood viscosity observed in OMA individuals and was independent of an acute response triggered by consumption of a high-fat meal