SPoC: A novel framework for relating the amplitude of neuronal oscillations to behaviorally relevant parameters

Previously, modulations in power of neuronal oscillations have been functionally linked to sensory, motor and cognitive operations. Such links are commonly established by relating the power modulations to specific target variables such as reaction times or task ratings. Consequently, the resulting spatio-spectral representation is subjected to neurophysiological interpretation. As an alternative, independent component analysis (ICA) or alternative decomposition methods can be applied and the power of the components may be related to the target variable. In this paper we show that these standard approaches are suboptimal as the first does not take into account the superposition of many sources due to volume conduction, while the second is unable to exploit available information about the target variable. To improve upon these approaches we introduce a novel (supervised) source separation framework called Source Power Comodulation (SPoC). SPoC makes use of the target variable in the decomposition process in order to give preference to components whose power comodulates with the target variable. We present two algorithms that implement the SPoC approach. Using simulations with a realistic head model, we show that the SPoC algorithms are able extract neuronal components exhibiting high correlation of power with the target variable. In this task, the SPoC algorithms outperform other commonly used techniques that are based on the sensor data or ICA approaches. Furthermore, using real electroencephalography (EEG) recordings during an auditory steady state paradigm, we demonstrate the utility of the SPoC algorithms by extracting neuronal components exhibiting high correlation of power with the intensity of the auditory input. Taking into account the results of the simulations and real EEG recordings, we conclude that SPoC represents an adequate approach for the optimal extraction of neuronal components showing coupling of power with continuously changing behaviorally relevant parameters

Relationship between regional white matter hyperintensities and alpha oscillations in older adults

Aging is associated with increased white matter hyperintensities (WMHs) and with alterations of alpha oscillations (7–13 Hz). However, a crucial question remains, whether changes in alpha oscillations relate to aging per se or whether this relationship is mediated by age-related neuropathology like WMHs. Using a large cohort of cognitively healthy older adults (N=907, 60-80 years), we assessed relative alpha power, alpha peak frequency, and long-range temporal correlations (LRTC) from resting-state EEG. We further associated these parameters with voxel-wise WMHs from 3T MRI. We found that a higher prevalence of WMHs in the superior and posterior corona radiata as well as in the thalamic radiation was related to elevated alpha power, with the strongest association in the bilateral occipital cortex. In contrast, we observed no significant relation of the WMHs probability with alpha peak frequency and LRTC. Finally, higher age was associated with elevated alpha power via total WMH volume. We suggest that an elevated alpha power is a consequence of WMH affecting a spatial organization of alpha sources

Evaluation of the passive safety in cars adapted with steering control devices for disabled drivers

The purpose of this research is to analyse the influence of steering control devices for disabled people on passive safety. It is based on the advances made in the modelling and simulation of the driver position and in the suit verification test. The influence of these devices is studied through airbag deployment and/or its influence on driver safety. We characterise the different adaptations that are used in adapted cars that can be found mounted in vehicles in order to generate models that are verified by experimental test. A three-dimensional design software package was used to develop the model. The simulations were generated using a dynamic simulation program employing LS-DYNA finite elements. This program plots the geometry and assigns materials. The airbag is shaped, meshed and folded just as it is mounted in current vehicles. The thermodynamic model of expansion of gases is assigned, and the contact interfaces are defined. Static tests were carried out on the deployment of the airbag to contrast with and to validate the computational models and to measure the behaviour of the airbag when there are steering adaptations mounted in the vehicle. © 2011 Taylor & Francis.Masiá Vañó, J.; Eixerés Tomás, B.; Dols Ruiz, JF. (2011). Evaluation of the passive safety in cars adapted with steering control devices for disabled drivers. International Journal of Crashworthiness. 16(1):75-83. doi:10.1080/13588265.2010.514772S7583161Bedewi, N. E., Marzougui, D., & Motevalli, V. (1996). Evaluation of parameters affecting simulation of airbag deployment and interaction with occupants. International Journal of Crashworthiness, 1(4), 339-354. doi:10.1533/cras.1996.0025Chawla, A., Mukherjee, S., & Sharma, A. (2005). Development of FE meshes for folded airbags. International Journal of Crashworthiness, 10(3), 259-266. doi:10.1533/ijcr.2005.0343Cheng, Z., Rizer, A. L., & Pellettiere, J. A. (2003). Modeling and Simulation of OOP Occupant-Airbag Interaction. SAE Technical Paper Series. doi:10.4271/2003-01-0510Crandall, J. R., Bass, C. R., Pikey, W. D., Miller, H. J., Sikorski, J., & Wilkins, M. (1996). Thoracic response and injury with belt, driver side airbag, and force limited belt restraint systems. International Journal of Crashworthiness, 2(1), 119-132. doi:10.1533/cras.1997.0039Dalrymple, G. (1996). Effects of Assistive Steering Devices on Air Bag Deployment. SAE Technical Paper Series. doi:10.4271/960223Khan, M. U., & Moatamedi, M. (2008). A review of airbag test and analysis. International Journal of Crashworthiness, 13(1), 67-76. doi:10.1080/13588260701731674Khan, M. U., Moatamedi, M., Souli, M., & Zeguer, T. (2008). Multiphysics out of position airbag simulation. International Journal of Crashworthiness, 13(2), 159-166. doi:10.1080/13588260701788385Richert, J., Coutellier, D., Götz, C., & Eberle, W. (2007). Advanced smart airbags: The solution for real-life safety? International Journal of Crashworthiness, 12(2), 159-171. doi:10.1080/13588260701433461Ruff, C., Jost, T., & Eichberger, A. (2007). Simulation of an airbag deployment in out-of-position situations. Vehicle System Dynamics, 45(10), 953-967. doi:10.1080/0042311070153830

Developing cardiac and skeletal muscle share fast-skeletal myosin heavy chain and cardiac troponin-I expression

Skeletal muscle derived stem cells (MDSCs) transplanted into injured myocardium can differentiate into fast skeletal muscle specific myosin heavy chain (sk-fMHC) and cardiac specific troponin-I (cTn-I) positive cells sustaining recipient myocardial function. We have recently found that MDSCs differentiate into a cardiomyocyte phenotype within a three-dimensional gel bioreactor. It is generally accepted that terminally differentiated myocardium or skeletal muscle only express cTn-I or sk-fMHC, respectively. Studies have shown the presence of non-cardiac muscle proteins in the developing myocardium or cardiac proteins in pathological skeletal muscle. In the current study, we tested the hypothesis that normal developing myocardium and skeletal muscle transiently share both sk-fMHC and cTn-I proteins. Immunohistochemistry, western blot, and RT-PCR analyses were carried out in embryonic day 13 (ED13) and 20 (ED20), neonatal day 0 (ND0) and 4 (ND4), postnatal day 10 (PND10), and 8 week-old adult female Lewis rat ventricular myocardium and gastrocnemius muscle. Confocal laser microscopy revealed that sk-fMHC was expressed as a typical striated muscle pattern within ED13 ventricular myocardium, and the striated sk-fMHC expression was lost by ND4 and became negative in adult myocardium. cTn-I was not expressed as a typical striated muscle pattern throughout the myocardium until PND10. Western blot and RT-PCR analyses revealed that gene and protein expression patterns of cardiac and skeletal muscle transcription factors and sk-fMHC within ventricular myocardium and skeletal muscle were similar at ED20, and the expression patterns became cardiac or skeletal muscle specific during postnatal development. These findings provide new insight into cardiac muscle development and highlight previously unknown common developmental features of cardiac and skeletal muscle. © 2012 Clause et al

Open Database of Epileptic EEG with MRI and Postoperational Assessment of Foci—a Real World Verification for the EEG Inverse Solutions

This paper introduces a freely accessible database http://eeg.pl/epi, containing 23 datasets from patients diagnosed with and operated on for drug-resistant epilepsy. This was collected as part of the clinical routine at the Warsaw Memorial Child Hospital. Each record contains (1) pre-surgical electroencephalography (EEG) recording (10–20 system) with inter-ictal discharges marked separately by an expert, (2) a full set of magnetic resonance imaging (MRI) scans for calculations of the realistic forward models, (3) structural placement of the epileptogenic zone, recognized by electrocorticography (ECoG) and post-surgical results, plotted on pre-surgical MRI scans in transverse, sagittal and coronal projections, (4) brief clinical description of each case. The main goal of this project is evaluation of possible improvements of localization of epileptic foci from the surface EEG recordings. These datasets offer a unique possibility for evaluating different EEG inverse solutions. We present preliminary results from a subset of these cases, including comparison of different schemes for the EEG inverse solution and preprocessing. We report also a finding which relates to the selective parametrization of single waveforms by multivariate matching pursuit, which is used in the preprocessing for the inverse solutions. It seems to offer a possibility of tracing the spatial evolution of seizures in time

Electrospinning polypropylene with an amino acid as a strategy to bind the antimicrobial peptide Cys-LC-LL-37

Hospital isolation gowns are increasingly competitive, with brands and manufacturers contesting consumer preferences. The textile materials in contact with the skin can acquire secretions and multiresistant microorganisms, causing discomfort and health risks, respectively. A new nanofibrous substrate---polypropylene grafted with l-Cys---was developed with an increased crystallinity, providing its surface with --SH hooks necessary to efficiently cross-link the antimicrobial peptide Cys-LC-LL-37 in order to protect against nosocomial pathogens and their spread to community. Furthermore, this application does not require environmental control of humidity, and it is not susceptible to enzyme and microorganism degradation.The authors acknowledge the Fundação para a Ciência e Tecnologia (FCT) for the PhD Grant SFRH/ BD/91444/2012 and Programa Operacional Capital Humano (POCH) and European Union for co-funding the work.info:eu-repo/semantics/publishedVersio

Contamination Control and Assay Results for the Majorana Demonstrator Ultra Clean Components

The MAJORANA DEMONSTRATOR is a neutrinoless double beta decay experiment utilizing enriched Ge-76 detectors in 2 separate modules inside of a common solid shield at the Sanford Underground Research Facility. The DEMONSTRATOR has utilized world leading assay sensitivities to develop clean materials and processes for producing ultra-pure copper and plastic components. This experiment is now operating, and initial data provide new insights into the success of cleaning and processing. Post production copper assays after the completion of Module 1 showed an increase in U and Th contamination in finished parts compared to starting bulk material. A revised cleaning method and additional round of surface contamination studies prior to Module 2 construction have provided evidence that more rigorous process control can reduce surface contamination. This article describes the assay results and discuss further studies to take advantage of assay capabilities for the purpose of maintaining ultra clean fabrication and process design.Comment: Proceedings of Low Radioactivity Techniques (LRT May 2017, Seoul