595 research outputs found
Contribution of the adrenal gland to the production of androstenedione and testosterone during the first two years of life
Androstenedione and testosterone were measured in whole adrenal glands of 56 previously healthy boys who died suddenly between birth and 2 yr of age. In each adrenal gland, the concentration of androstenedione considerably exceeded that of testosterone. The highest concentrations were found during the first week of life (median, 295 ng/g; range, 98- 320 ng/g). Thereafter, values decreased rapidly until the end of the first year of life (median, 10 ng/g; range, 4.4-22.7 ng/g). Adrenal testosterone concentrations averaged 15% of those of androstenedione in the same gland and similarly decreased until the end of the first year. The decrease of adrenal androgen concentrations paralleled the involution of the fetal adrenal zone. A close correlation existed between the concentration of androstenedione in adrenal tissue and plasma. However, no correlation existed between adrenal and plasma testosterone. When the adrenals and testes of the same infant were compared, there was 10 times more androstenedione in the adrenals than in the testes during the first 2 yr of life. The testes contained more testosterone than the adrenals only during the first 4 months. Thus, in infant boys the adrenals are the main source of androstenedione during the first 2 yr. After the sixth month of life, they also are the main source of testosterone
Testosterone and androstenedione concentrations in human testis and epididymis during the first two years of life
Testosterone and androstenedione were measured in testicular and epididymal tissue of 37 previously healthy infants between 1 and 24 months of age who died suddenly. In half of the patients elevated plasma levels of cortisol and androstenedione suggested preterminal stress. Plasma testosterone levels, however, did not differ from those in healthy infants. Testicular testosterone concentrations were maximal in boys from 1-3 months of age (median, 36.6 ng/g; range, 7-380 ng/g) with peak values similar to those found in pubertal or even adult testes. Thereafter testicular testosterone concentrations decreased and after the age of 6 months all values were below 12.5 ng/g, which corresponds to the low normal range of older prepubertal boys. Plasma testosterone and testicular testosterone correlated significantly (P less than 0.001). On average the testicular concentrations were 36.4 times higher than the corresponding plasma concentrations. Testicular androstenedione was low but correlated significantly with testicular testosterone (P less than 0.001). Epididymal testosterone concentrations were surprisingly high (1-3 months: median, 10.3 ng/g; range, 4-42.7 ng/g) and averaged 30% of the testicular testosterone concentration. Thus, epididymal testosterone concentrations were significantly higher than the circulating plasma testosterone levels, indicating the capacity of the infant epididymis to accumulate androgens. These findings suggest that high local testosterone concentrations during early infancy are important not only for the testis itself but particularly for the developing epididymi
Relations of low contrast visual acuity, quality of life and multiple sclerosis functional composite: a cross-sectional analysis
Background: Although common and often disabling in multiple sclerosis (MS), visual dysfunction is currently not adequately accounted for in both clinical routine and MS trials. Sloan low contrast letter acuity (SLCLA) is a standardised chart-based measure of visual function particular at low contrast and has been suggested as additional visual component to the Multiple Sclerosis Functional Composite (MSFC). Here, we evaluate the relations between SLCLA, retinal integrity, MSFC, and quality of life (QoL) in MS patients. Methods: Cross-sectional analysis of retinal nerve fibre layer (RNFL) thickness, MSFC, SLCLA (2.5% and 1.25% contrast levels), visual evoked potentials, and QoL (Short Form (SF) 36, National Eye Institute Visual Functioning Questionnaire (NEIVFQ)) using baseline data of 92 MS patients from an ongoing prospective longitudinal trial. Relations between RNFL thickness or P100 latency and SLCLA were analysed using generalised estimating equations (GEE) accounting for intra-individual inter-eye dependencies and corrected for age, gender, and history of optic neuritis. Pearson’s correlations were used to assess relations between SLCLA, MSFC, and QoL. Results: SLCLA reflected RNFL thickness (p = 0.021) and P100 latency (p = 0.004) and predicted vision-related QoL, reflected by the NEIVFQ39 subscores “general vision” and “near activities” (p < 0.008 for both). SLCLA did not predict general QoL reflected by SF36. Implementing SLCLA into MSFC, thus creating a four-dimensional MSFC4, captured aspects of disability reflected by the NEIVFQ39 subscores “general vision” (r = 0.42, p < 0.0001) and “near activity” (r = 0.3, p = 0.014) which were not captured by standard MSFC3. Conclusions: SLCLA at 2.5% and 1.25% contrast levels correlates with retinal morphology and P100 latency and predicts some aspects of vision-related QoL in MS. More importantly, using a prospective cross-sectional approach we provide evidence that extending the MSFC by SLCLA as an additional visual component increases the performance of MSFC to capture MS-related disability. Longitudinal data on the relation between SLCLA, MSFC, and QoL will be available in the near future
Temporal visual resolution and disease severity in MS
OBJECTIVE: To examine temporal visual resolution assessed as critical flicker frequency (CFF) in patients with MS and to investigate associations with visual system damage and general disability and cognitive function. METHODS: Thirty-nine patients with MS and 31 healthy controls (HCs) were enrolled in this cross-sectional study and underwent CFF testing, high- and low-contrast visual acuity, alertness and information processing speed using the paced auditory serial addition task (PASAT), and retinal optical coherence tomography (OCT). In patients with MS, visual evoked potentials (VEPs) and Expanded Disability Status Scale (EDSS) scores were assessed. RESULTS: CFF in patients with MS (mean ± SD: 40.9 ± 4.4 Hz) was lower than in HCs (44.8 ± 4.4 Hz, p < 0.001). There was no significant CFF difference between eyes with and without previous optic neuritis (ON). CFF was not associated with visual acuity, VEP latency, the peripapillary retinal nerve fiber layer thickness, and the combined ganglion cell and inner plexiform layer volume. Instead, reduced CFF was associated with worse EDSS scores (r(2) = 0.26, p < 0.001) and alertness (r(2) = 0.42, p = 0.00042) but not with PASAT (p = 0.33). CONCLUSION: CFF reduction in MS occurs independently of ON and structural visual system damage. Its association with the EDSS score and alertness suggests that CFF reflects global disease processes and higher cortical processing rather than focal optic nerve or retinal damage
Electron correlation vs. stabilization: A two-electron model atom in an intense laser pulse
We study numerically stabilization against ionization of a fully correlated
two-electron model atom in an intense laser pulse. We concentrate on two
frequency regimes: very high frequency, where the photon energy exceeds both,
the ionization potential of the outer {\em and} the inner electron, and an
intermediate frequency where, from a ``single active electron''-point of view
the outer electron is expected to stabilize but the inner one is not. Our
results reveal that correlation reduces stabilization when compared to results
from single active electron-calculations. However, despite this destabilizing
effect of electron correlation we still observe a decreasing ionization
probability within a certain intensity domain in the high-frequency case. We
compare our results from the fully correlated simulations with those from
simpler, approximate models. This is useful for future work on ``real''
more-than-one electron atoms, not yet accessible to numerical {\em ab initio}
methods.Comment: 8 pages, 8 figures in an extra ps-file, submitted to Phys. Rev. A,
updated references and shortened introductio
On the Influence of Pulse Shapes on Ionization Probability
We investigate analytical expressions for the upper and lower bounds for the
ionization probability through ultra-intense shortly pulsed laser radiation. We
take several different pulse shapes into account, including in particular those
with a smooth adiabatic turn-on and turn-off. For all situations for which our
bounds are applicable we do not find any evidence for bound-state
stabilization.Comment: 21 pages LateX, 10 figure
On the absence of bound-state stabilization through short ultra-intense fields
We address the question of whether atomic bound states begin to stabilize in
the short ultra-intense field limit. We provide a general theory of ionization
probability and investigate its gauge invariance. For a wide range of
potentials we find an upper and lower bound by non-perturbative methods, which
clearly exclude the possibility that the ultra intense field might have a
stabilizing effect on the atom. For short pulses we find almost complete
ionization as the field strength increases.Comment: 34 pages Late
Multiphoton detachment of electrons from negative ions
A simple analytical solution for the problem of multiphoton detachment from
negative ions by a linearly polarized laser field is found. It is valid in the
wide range of intensities and frequencies of the field, from the perturbation
theory to the tunneling regime, and is applicable to the excess-photon as well
as near-threshold detachment. Practically, the formulae are valid when the
number of photons is greater than two. They produce the total detachment rates,
relative intensities of the excess-photon peaks, and photoelectron angular
distributions for the hydrogen and halogen negative ions, in agreement with
those obtained in other, more numerically involved calculations in both
perturbative and non-perturbative regimes. Our approach explains the extreme
sensitivity of the multiphoton detachment probability to the asymptotic
behaviour of the bound-state wave function. Rapid oscillations in the angular
dependence of the -photon detachment probability are shown to arise due to
interference of the two classical trajectories which lead to the same final
state after the electron emerges at the opposite sides of the atom when the
field is close to maximal.Comment: 27 pages, Latex, and PostScript figures fig1.ps, fig2.ps, fig3.ps,
accepted for publication in Phys. Rev.
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