2,872 research outputs found
Niche inheritance: a cooperative pathway to enhance cancer cell fitness though ecosystem engineering
Cancer cells can be described as an invasive species that is able to
establish itself in a new environment. The concept of niche construction can be
utilized to describe the process by which cancer cells terraform their
environment, thereby engineering an ecosystem that promotes the genetic fitness
of the species. Ecological dispersion theory can then be utilized to describe
and model the steps and barriers involved in a successful diaspora as the
cancer cells leave the original host organ and migrate to new host organs to
successfully establish a new metastatic community. These ecological concepts
can be further utilized to define new diagnostic and therapeutic areas for
lethal cancers.Comment: 8 pages, 1 Table, 4 Figure
Polarity control of carrier injection at ferroelectric/metal interfaces for electrically switchable diode and photovoltaic effects
We investigated a switchable ferroelectric diode effect and its physical
mechanism in Pt/BiFeO3/SrRuO3 thin-film capacitors. Our results of electrical
measurements support that, near the Pt/BiFeO3 interface of as-grown samples, a
defective layer (possibly, an oxygen-vacancy-rich layer) becomes formed and
disturbs carrier injection. We therefore used an electrical training process to
obtain ferroelectric control of the diode polarity where, by changing the
polarization direction using an external bias, we could switch the transport
characteristics between forward and reverse diodes. Our system is characterized
with a rectangular polarization hysteresis loop, with which we confirmed that
the diode polarity switching occurred at the ferroelectric coercive voltage.
Moreover, we observed a simultaneous switching of the diode polarity and the
associated photovoltaic response dependent on the ferroelectric domain
configurations. Our detailed study suggests that the polarization charge can
affect the Schottky barrier at the ferroelectric/metal interfaces, resulting in
a modulation of the interfacial carrier injection. The amount of
polarization-modulated carrier injection can affect the transition voltage
value at which a space-charge-limited bulk current-voltage (J-V) behavior is
changed from Ohmic (i.e., J ~ V) to nonlinear (i.e., J ~ V^n with n \geq 2).
This combination of bulk conduction and polarization-modulated carrier
injection explains the detailed physical mechanism underlying the switchable
diode effect in ferroelectric capacitors.Comment: Accepted for publication in Phys. Rev.
Modelling of Tirapazamine effects on solid tumour morphology
Bioreductive drugs are in clinical practice to exploit the resistance from tumour microenvironments especially in the hypoxic region of tumour. We pre-sented a tumour treatment model to capture the pharmacology of one of the most prominent bioreductive drugs, Tirapazamine (TPZ) which is in clinical trials I and II. We calculated solid tumour mass in our previous work and then integrated that model with TPZ infusion. We calculated TPZ cytotoxicity, concentration, penetra-tion with increasing distance from blood vessel and offered resistance from micro-environments for drug penetration inside the tumour while considering each cell as an individual entity. The impact of these factors on tumour morphology is also showed to see the drug behaviour inside animals/humans tumours. We maintained the heterogeneity factors in presented model as observed in real tumour mass es-pecially in terms of cells proliferation, cell movement, extracellular matrix (ECM) interaction, and the gradients of partial oxygen pressure (pO2) inside tumour cells during the whole growth and treatment activity. The results suggest that TPZ high concentration in combination with chemotherapy should be given to get maximum abnormal cell killing. This model can be a good choice for oncologists and re-searchers to explore more about TPZ action inside solid tumour
Judah Folkman, a pioneer in the study of angiogenesis
More than 30 years ago, Judah Folkman found a revolutionary new way to think about cancer. He postulated that in order to survive and grow, tumors require blood vessels, and that by cutting off that blood supply, a cancer could be starved into remission. What began as a revolutionary approach to cancer has evolved into one of the most exciting areas of scientific inquiry today. Over the years, Folkman and a growing team of researchers have isolated the proteins and unraveled the processes that regulate angiogenesis. Meanwhile, a new generation of angiogenesis research has emerged as well, widening the field into new areas of human disease and deepening it to examine the underlying biological processes responsible for those diseases
Rewritable nanoscale oxide photodetector
Nanophotonic devices seek to generate, guide, and/or detect light using
structures whose nanoscale dimensions are closely tied to their functionality.
Semiconducting nanowires, grown with tailored optoelectronic properties, have
been successfully placed into devices for a variety of applications. However,
the integration of photonic nanostructures with electronic circuitry has always
been one of the most challenging aspects of device development. Here we report
the development of rewritable nanoscale photodetectors created at the interface
between LaAlO3 and SrTiO3. Nanowire junctions with characteristic dimensions
2-3 nm are created using a reversible AFM writing technique. These nanoscale
devices exhibit a remarkably high gain for their size, in part because of the
large electric fields produced in the gap region. The photoconductive response
is gate-tunable and spans the visible-to-near-infrared regime. The ability to
integrate rewritable nanoscale photodetectors with nanowires and transistors in
a single materials platform foreshadows new families of integrated
optoelectronic devices and applications.Comment: 5 pages, 5 figures. Supplementary Information 7 pages, 9 figure
METH-2 silencing and promoter hypermethylation in NSCLC
The antiangiogenic factor METH-2 (ADAMTS-8) was identified in a previous dual-channel cDNA microarray analysis to be at least two-fold under-represented in 85% (28 out of 33) of primary non-small-cell lung carcinomas (NSCLCs). This observation has been validated in an independent series of NSCLCs and adjacent normal tissues by comparative multiplex RT—PCR, and METH-2 mRNA expression was dramatically reduced in all 23 tumour samples analysed. Immunohistochemical analysis of the same sample set demonstrated that METH-2 was strongly expressed in 14 out of 19 normal epithelial sites examined but only one out of 20 NSCLCs. DNA methylation analysis of the proximal promoter region of this gene revealed abnormal hypermethylation in 67% of the adenocarcinomas and 50% of squamous cell carcinomas, indicating that epigenetic mechanisms are involved in silencing this gene in NSCLC. No homozygous deletions of METH-2 were found in lung cancer cell lines. Allelic imbalance in METH-2 was assessed by an intronic single nucleotide polymorphism (SNP) assay and observed in 44% of informative primary samples. In conclusion, the downregulation of METH-2 expression in primary NSCLC, often associated with promoter hypermethylation, is a frequent event, which may be related to the development of the disease
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