A look into the future of blockchain technology

In this paper, we use a Delphi approach to investigate whether, and to what extent, blockchain- based applications might affect firms' organizations, innovations, and strategies by 2030, and, consequently, which societal areas may be mainly affected. We provide a deep understanding of how the adoption of this technology could lead to changes in Europe over multiple dimensions, ranging from business to culture and society, policy and regulation, economy, and technology. From the projections that reached a significant consensus and were given a high probability of occurrence by the experts, we derive four scenarios built around two main dimensions: The digitization of assets and the change in business models

Solving an open problem about the G-Drazin partial order

[EN] G-Drazin inverses and the G-Drazin partial order for square matrices have been both recently introduced by Wang and Liu. They proved the following implication: If A is below B under the G-Drazin partial order, then any G-Drazin inverse of B is also a G-Drazin inverse of A. However, this necessary condition could not be stated as a characterization and the validity (or not) of the converse implication was posed as an open problem. In this paper, this problem is completely solved. It is obtained that the converse, in general, is false, and a form to construct counterexamples is provided. It is also proved that the converse holds under an additional condition (which is also necessary) as well as for some special cases of matrices.Partially supported by Universidad Nacional de Río Cuarto (Grant PPI 18/C472), CONICET (Grant PIP 112-201501-00433CO), and by ANPCyT (Grant PICT 2018-03492) Partially supported by Universidad Nacional de La Pampa, Facultad de Ingeniería (Grant Resol. Nro. 155/14) Partially supported by Ministerio de Economía, Industria y Competitividad of Spain (Grant Red de Excelencia MTM2017-90682-REDT), and by Universidad Nacional del Sur of Argentina (Grant 24/L108)Ferreyra, DE.; Lattanzi, M.; Levis, FE.; Thome, N. (2020). Solving an open problem about the G-Drazin partial order. The Electronic Journal of Linear Algebra. 36:55-66. http://hdl.handle.net/10251/161871S55663

The weak core inverse

[EN] In this paper, we introduce a new generalized inverse, called weak core inverse (or, in short, WC inverse) of a complex square matrix. This new inverse extends the notion of the core inverse defined by Baksalary and Trenkler (Linear Multilinear Algebra 58(6):681-697, 2010). We investigate characterizations, representations, and properties for this generalized inverse. In addition, we introduce weak core matrices (or, in short, WC matrices) and we show that these matrices form a more general class than that given by the known weak group matrices, recently investigated by H. Wang and X. Liu.In what follows, we detail the acknowledgements. D.E. Ferreyra, F.E. Levis, A.N. Priori - Partially supported by Universidad Nacional de Rio Cuarto (Grant PPI 18/C559) and CONICET (Grant PIP 112-201501-00433CO). D.E. Ferreyra F.E. Levis - Partially supported by ANPCyT (Grant PICT 201803492). D.E. Ferreyra, N. Thome -Partially supported by Universidad Nacional de La Pampa, Facultad de Ingenieria (Grant Resol. Nro. 135/19). N. Thome -Partially supported by Ministerio de Economia, Industria y Competitividad of Spain (Grant Red de Excelencia MTM2017-90682-REDT) and by Universidad Nacional del Sur of Argentina (Grant 24/L108). We would like to thank the Referees for their valuable comments and suggestions which helped us to considerably improve the presentation of the paperFerreyra, DE.; Levis, FE.; Priori, AN.; Thome, N. (2021). The weak core inverse. Aequationes Mathematicae. 95(2):351-373. https://doi.org/10.1007/s00010-020-00752-zS351373952Ben-Israel, A., Greville, T.N.E.: Generalized Inverses: Theory and Applications, 2nd edn. Springer, New York (2003)Baksalary, O.M., Trenkler, G.: Core inverse of matrices. Linear Multilinear Algebra 58(6), 681–697 (2010)Baksalary, O.M., Trenkler, G.: On a generalized core inverse. Appl. Math. Comput. 236(1), 450–457 (2014)Campbell, S.L., Meyer Jr., C.D.: Generalized Inverses of Linear Transformations. SIAM, Philadelphia (2009)Ceryan, N.: Handbook of Research on Trends and Digital Advances in Engineering Geology, Advances in Civil and Industrial Engineering. IGI Global, Hershey (2018)Chen, J.L., Mosić, D., Xu, S.Z.: On a new generalized inverse for Hilbert sapce operators. Quaest. Math. (2019). https://doi.org/10.2989/16073606.2019.1619104Cvetković-Ilić, D.S., Mosić, D., Wei, Y.: Partial orders on $$B(H)$$. Linear Algebra Appl. 481, 115–130 (2015)Djikić, M.S.: Lattice properties of the core-partial order. Banach J. Math. Anal. 11(2), 398–415 (2017)Doty, K.L., Melchiorri, C., Bonivento, C.: A theory of generalized inverses applied to robotics. Int. J. Robot. Res. 12(1), 1–19 (1993)Drazin, M.P.: Pseudo inverses in associative rings and semigroups. Am. Math. Mon. 65(7), 506–514 (1958)Ferreyra, D.E., Levis, F.E., Thome, N.: Revisiting of the core EP inverse and its extension to rectangular matrices. Quaest. Math. 41(2), 265–281 (2018)Ferreyra, D.E., Levis, F.E., Thome, N.: Maximal classes of matrices determining generalized inverses. Appl. Math. Comput. 333, 42–52 (2018)Ferreyra, D.E., Levis, F.E., Thome, N.: Characterizations of $$k$$-commutative equalities for some outer generalized inverses. Linear Multilinear Algebra 68(1), 177–192 (2020)Hartwig, R.E., Spindelböck, K.: Matrices for which $$A^*$$ and $$A^\dagger$$ conmmute. Linear Multilinear Algebra 14(3), 241–256 (1984)Liu, X., Cai, N.: High-order iterative methods for the DMP inverse. J. Math. Article ID 8175935, 6 p (2018)Malik, S., Thome, N.: On a new generalized inverse for matrices of an arbitrary index. Appl. Math. Comput. 226(1), 575–580 (2014)Malik, S., Rueda, L., Thome, N.: The class of $$m$$-EP and $$m$$-normal matrices. Linear Multilinear Algebra 64(11), 2119–2132 (2016)Manjunatha Prasad, K., Mohana, K.S.: Core EP inverse. Linear Multilinear Algebra 62(6), 792–802 (2014)Mehdipour, M., Salemi, A.: On a new generalized inverse of matrices. Linear Multilinear Algebra 66(5), 1046–1053 (2018)Mitra, S.K., Bhimasankaram, P., Malik, S.: Matrix Partial Orders, Shorted Operators and Applications, Series in Algebra, vol. 10. World Scientific Publishing Co. Pte. Ltd., Singapore (2010)Mosić, D., Stanimirović, P.S.: Composite outer inverses for rectangular matrices. Quaest. Math. (2019). https://doi.org/10.2989/16073606.2019.1671526Penrose, R.: A generalized inverse for matrices. Math. Proc. Cambr. Philos. Soc. 51(3), 406–413 (1955)Rakić, D.S., Dincić, N.C., Djordjević, D.S.: Core inverse and core partial order of Hilbert space operators. Appl. Math. Comput. 244(1), 283–302 (2014)Soleimani, F., Stanimirović, P.S., Soleymani, F.: Some matrix iterations for computing generalized inverses and balancing chemical equations. Algorithms 8(4), 982–998 (2015)Tosić, M., Cvetković-Ilić, D.S.: Invertibility of a linear combination of two matrices and partial orderings. Appl. Math. Comput. 218(9), 4651–4657 (2012)Wang, X.: Core-EP decomposition and its applications. Linear Algebra Appl. 508(1), 289–300 (2016)Wang, H., Chen, J.: Weak group inverse. Open Math. 16(1), 1218–1232 (2018)Wang, H., Liu, X.: The weak group matrix. Aequ. Math. 93(6), 1261–1273 (2019)Xiao, G.Z., Shen, B.Z., Wu, C.K., Wong, C.S.: Some spectral techniques in coding theory. Discrete Math. 87(2), 181–186 (1991)Zhou, M., Chen, J., Stanimirović, P., Katsikis, V.N., Ma, H.: Complex varying-parameter Zhang neural networks for computing core and core-EP inverse. Neural Process. Lett. 51, 1299–1329 (2020)Zhu, H.: On DMP inverses and $$m$$-EP elements in rings. Linear Multilinear Algebra 67(4), 756–766 (2019)Zhu, H., Patrício, P.: Several types of one-sided partial orders in rings. Rev. R. Acad. Cienc. Exactas Fís. Nat. Ser. A Mat. RACSAM 113, 3177–3184 (2019

One sided Star and Core orthogonality of matrices

We investigate two one-sided orthogonalities of matrices, the first of which is left (right) $*$-orthogonality for rectangular matrices and the other is left (right) core-orthogonality of index $1$ matrices. We obtain some basic results for these matrices, their canonical forms, and characterizations. Also, relations between left (right) orthogonal matrices and parallel sums are investigated. Finally under these one-sided orthogonalities we explore the conditions of additivity of the Moore-Penrose inverse and the core inverse

Characterizations of k-commutative equalities for some outer generalized inverses

[EN] In this paper, we present necessary and sufficient conditions for the k-commutative equality , where X is an outer generalized inverse of the square matrix A. Also, we give new representations for core EP, DMP, and CMP inverses of square matrices as outer inverses with prescribed null space and range. In addition, we characterize the core EP inverse as the solution of a new system of matrix equations.D. E. Ferreyra F. E. Levis Partially supported by a Consejo Nacional de Investigaciones Científicas y Técnicas CONICET s Posdoctoral Research Fellowship, UNRC [grant number PPI 18/C472] and CONICET [grant number PIP 112-201501-00433CO], respectively. N. Thome Partially supported by Secretaría de Estado de Investigación, Desarrollo e Innovación Ministerio de Economía, Industria y Competitividad of Spain [grant number DGI MTM2013-43678-P and Grant Red de Excelen- cia PMTM2017-90682-REDT]. D. E. Ferreyra and N. Thome Partially supported Universidad Nacional de La Pampa (UNLPam), Facultad de Ingeniería [grant Resol. No 155/14].Ferreyra, DE.; Levis, F.; Thome, N. (2018). Characterizations of k-commutative equalities for some outer generalized inverses. Linear and Multilinear Algebra. 1-16. https://doi.org/10.1080/03081087.2018.1500994S116Baksalary, O. M., & Trenkler, G. (2010). Core inverse of matrices. Linear and Multilinear Algebra, 58(6), 681-697. doi:10.1080/03081080902778222Manjunatha Prasad, K., & Mohana, K. S. (2013). Core–EP inverse. Linear and Multilinear Algebra, 62(6), 792-802. doi:10.1080/03081087.2013.791690Malik, S. B., & Thome, N. (2014). On a new generalized inverse for matrices of an arbitrary index. Applied Mathematics and Computation, 226, 575-580. doi:10.1016/j.amc.2013.10.060Mehdipour, M., & Salemi, A. (2017). On a new generalized inverse of matrices. Linear and Multilinear Algebra, 66(5), 1046-1053. doi:10.1080/03081087.2017.1336200Malik, S. B., Rueda, L., & Thome, N. (2016). The class ofm-EPandm-normal matrices. Linear and Multilinear Algebra, 64(11), 2119-2132. doi:10.1080/03081087.2016.1139037Wang, H. (2016). Core-EP decomposition and its applications. Linear Algebra and its Applications, 508, 289-300. doi:10.1016/j.laa.2016.08.008Wang H, Chen J. Weak group inverse. Available from: http://arxiv.org/abs/1704.08403v1Wei, Y. (1998). A characterization and representation of the generalized inverse A(2)T,S and its applications. Linear Algebra and its Applications, 280(2-3), 87-96. doi:10.1016/s0024-3795(98)00008-1Rakić, D. S., Dinčić, N. Č., & Djordjević, D. S. (2014). Core inverse and core partial order of Hilbert space operators. Applied Mathematics and Computation, 244, 283-302. doi:10.1016/j.amc.2014.06.112Stanimirović, P. S., Katsikis, V. N., & Ma, H. (2016). Representations and properties of theW-Weighted Drazin inverse. Linear and Multilinear Algebra, 65(6), 1080-1096. doi:10.1080/03081087.2016.1228810Ferreyra, D. E., Levis, F. E., & Thome, N. (2017). Revisiting the core EP inverse and its extension to rectangular matrices. Quaestiones Mathematicae, 41(2), 265-281. doi:10.2989/16073606.2017.1377779Deng, C. Y., & Du, H. K. (2009). REPRESENTATIONS OF THE MOORE-PENROSE INVERSE OF 2×2 BLOCK OPERATOR VALUED MATRICES. Journal of the Korean Mathematical Society, 46(6), 1139-1150. doi:10.4134/jkms.2009.46.6.1139Wang, H., & Liu, X. (2014). Characterizations of the core inverse and the core partial ordering. Linear and Multilinear Algebra, 63(9), 1829-1836. doi:10.1080/03081087.2014.97570

Arsenic trioxide and ascorbic acid interfere with the BCL2 family genes in patients with myelodysplastic syndromes: an ex-vivo study.

BACKGROUND: Arsenic Trioxide (ATO) is effective in about 20% of patients with myelodysplasia (MDS); its mechanisms of action have already been evaluated in vitro, but the in vivo activity is still not fully understood. Since ATO induces apoptosis in in vitro models, we compared the expression of 93 apoptotic genes in patients’ bone marrow before and after ATO treatment. For this analysis, we selected 12 patients affected by MDS who received ATO in combination with Ascorbic Acid in the context of the Italian clinical trial NCT00803530, EudracT Number 2005-001321-28. METHODS: Real-time PCR quantitative assays for genes involved in apoptosis were performed using TaqMan® Assays in 384-Well Microfluidic Cards “TaqMan® Human Apoptosis Array”. Quantitative RT-PCR for expression of EVI1 and WT1 genes was also performed. Gene expression values (Ct) were normalized to the median expression of 3 housekeeping genes present in the card (18S, ACTB and GAPDH). RESULTS: ATO treatment induced up-regulation of some pro-apoptotic genes, such as HRK, BAK1, CASPASE-5, BAD, TNFRSF1A, and BCL2L14 and down-regulation of ICEBERG. In the majority of cases with stable disease, apoptotic gene expression profile did not change, whereas in cases with advanced MDS more frequently pro-apoptotic genes were up-regulated. Two patients achieved a major response: in the patient with refractory anemia the treatment down-regulated 69% of the pro-apoptotic genes, whereas 91% of the pro-apoptotic genes were up-regulated in the patient affected by refractory anemia with excess of blasts-1. Responsive patients showed a higher induction of BAD than those with stable disease. Finally, WT1 gene expression was down-regulated by the treatment in responsive cases. CONCLUSIONS: These results represent the basis for a possible association of ATO with other biological compounds able to modify the apoptotic pathways, such as inhibitors of the BCL2 family

High dose sequential chemotherapy with autologous transplantation versus dose-dense chemotherapy MegaCEOP as first line treatment in poor-prognosis diffuse large cell lymphoma: an Intergruppo Italiano Linfomi randomized trial

Background and Objectives. Poor prognosis diffuse large cell lymphoma (DLCL) responds poorly to standard chemotherapy. Randomized studies comparing high-dose chemotherapy with autologous stem-cell transplantation (ASCT) against standard chemotherapy have produced conflicting results. Dose-dense chemotherapy with granulocyte colony-stimulating factor (G-CSF) support seems to hold promise. The purpose of this multicenter, randomized trial was to compare failure-free and overall survival in patients with poor prognosis DLCL treated with high-dose sequential (HDS) chemotherapy followed by ASCT or an outpatient dose-dense chemotherapy regimen (MegaCEOP). Design and Methods. Between 1996 and 2001, 130 DLCL patients, aged <= 60 years, with intermediate-high or high-risk disease, according to the International Prognostic Index score, and/or bone marrow involvement were enrolled. Sixty were randomized to HDS chemotherapy plus high-dose mitoxantrone and melphalan with ASCT (arm A) and 66 to the MegaCEOP regimen (6-8 courses of an escalated dose of cyclophosphamide and epirubicin plus vincristine and prednisone with G-CSF every 2-weeks) (arm B); 4 patients were considered ineligible. Results. The complete remission rate was 59% in arm A and 70% in arm B (p=0.18). After a median follow-up of 78 months, the 6-year failure-free survival was 45% in arm A and 48% in arm B (hazard ratio=1.15, 95% confidence intervals =0.72-1.84, p=0.56). The 5-year overall survival was 49% in arm A and 63% in arm B (hazard ratio=1.67, 95% confidence interval=0.98-2.85, p=0.06). Two cases of secondary acute myeloid leukemia were observed after treatment in group A. Interpretations and Conclusions. HDS and ASCT as initial therapy for patients with poor-prognosis DLCL does not provide a benefit over that of outpatient dose-dense MegaCEOP chemotherapy