Low flow venovenous bypasses in small dogs and pediatric patients undergoing replacement of the liver

A venovenous bypass for transplantation of the liver was developed and evaluated in dogs and applied clinically, with flows that averaged less than 500 milliliters per minute. Fatal pulmonary emboli were seen in two of 40 experiments. The venovenous flow in the four pediatric recipients was 200 to 1,200 milliliters per minute, and there were no complications

On p_T-broadening of high energy partons associated with the LPM effect in a finite-volume QCD medium

We study the contributions from radiation to $p_{\perp}$-broadening of a high energy parton traversing a QCD medium with a finite length $L$. The interaction between the parton and the medium is described by decorrelated static multiple scattering. Amplitudes of medium-induced gluon emission and parton self-energy diagrams are evaluated in the soft gluon limit in the BDMPS formalism. We find both the double-logarithmic correction from incoherent scattering, which is parametrically the same as that in single scattering, and the logarithmic correction from the LPM effect. Therefore, we expect a parametrically large correction from radiation to the medium-induced $p_\perp$-broadening in perturbative QCD.Comment: 19 pages, focusing only on calculations about the medium-induced diagrams, origin for double-log reinterpreted, final version to appear in JHE

Enablingmarkovian representations under imperfect information

Markovian systems are widely used in reinforcement learning (RL), when the successful completion of a task depends exclusively on the last interaction between an autonomous agent and its environment. Unfortunately, real-world instructions are typically complex and often better described as non-Markovian. In this paper we present an extension method that allows solving partially-observable non-Markovian reward decision processes (PONMRDPs) by solving equivalent Markovian models. This potentially facilitates Markovian-based state-of-the-art techniques, including RL, to find optimal behaviours for problems best described as PONMRDP. We provide formal optimality guarantees of our extension methods together with a counterexample illustrating that naive extensions from existing techniques in fully-observable environments cannot provide such guarantees

Spherical geometry and integrable systems

We prove that the cosine law for spherical triangles and spherical tetrahedra defines integrable systems, both in the sense of multidimensional consistency and in the sense of dynamical systems.Comment: 15 pages, 5 figure

Personalized object-based audio for hearing impaired TV viewers

Age demographics have led to an increase in the proportion of the population suffering from some form of hearing loss. The introduction of object-based audio to television broadcast has the potential to improve the viewing experience for millions of hearing impaired people. Personalization of object-based audio can assist in overcoming difficulties in understanding speech and understanding the narrative of broadcast media. The research presented here documents a Multi-Dimensional Audio (MDA) implementation of object-based clean audio to present independent object streams based on object category elicitation. Evaluations were carried out with hearing impaired people and participants were able to personalize audio levels independently for four object-categories using an on-screen menu: speech, music, background effects and foreground effects related to on-screen events. Results show considerable preference variation across subjects but indicate that expanding object-category personalization beyond a binary speech/non-speech categorization can substantially improve the viewing experience for some hearing impaired people

Birth, life and survival of Tidal Dwarf Galaxies

Advances on the formation and survival of the so-called Tidal Dwarf Galaxies (TDGs) are reviewed. The understanding on how objects of the mass of dwarf galaxies may form in debris of galactic collisions has recently benefited from the coupling of multi-wavelength observations with numerical simulations of galaxy mergers. Nonetheless, no consensual scenario has yet emerged and as a matter of fact the very definition of TDGs remains elusive. Their real cosmological importance is also a matter of debate, their presence in our Local Group of galaxies as well. Identifying old, evolved, TDGs among the population of regular dwarf galaxies and satellites may not be straightforward. However a number of specific properties (location, dark matter and metal content) that objects of tidal origin should have are reminded here. Examples of newly discovered genuine old TDGs around a nearby elliptical galaxy are finally presented.Comment: 9 pages, 5 figures, invited talk at JENAM 2010 symposium on "Dwarf Galaxies", v2:reference and acknowledgements update

2022 FDA TIDES (peptides and oligonucleotides) harvest

A total of 37 new drug entities were approved in 2022; although that year registered the lowest number of drug approvals since 2016, the TIDES class consolidated its presence with a total of five authorizations (four peptides and one oligonucleotide). Interestingly, 23 out of 37 drugs were first-in-class and thus received fast-track designation by the FDA in categories such as breakthrough therapy, priority review voucher, orphan drug, accelerated approval, and so on. Here, we analyze the TIDES approved in 2022 on the basis of their chemical structure, medical target, mode of action, administration route, and common adverse effects

2021 FDA TIDES (peptides and oligonucleotides) harvest

From the medical, pharmaceutical, and social perspectives, 2021 has been a year dominated by the COVID-19 pandemic. However, despite this global health crisis, the pharmaceutical industry has continued its endeavors, and 2021 could be considered an excellent year in terms of the drugs accepted by the US Food and Drug Administration (FDA). Thus, during this year, the FDA has approved 50 novel drugs, of which 36 are new chemical entities and 14 biologics. It has also authorized 10 TIDES (8 peptides, 2 oligonucleotides), in addition to 2 antibody-drug conjugates (ADCs) whose structures contain peptides. Thus, TIDES have accounted for about 24% of the approvals in the various drug categories. Importantly, this percentage has surpassed the figure in 2020 (10%), thus reflecting the remarkable success of TIDES. In this review, the approved TIDE-based drugs are analyzed on the basis of their chemical structure, medical target, mode of action, administration route, and adverse effects

A characterization of compact complex tori via automorphism groups

We show that a compact Kaehler manifold X is a complex torus if both the continuous part and discrete part of some automorphism group G of X are infinite groups, unless X is bimeromorphic to a non-trivial G-equivariant fibration. Some applications to dynamics are given.Comment: title changed, to appear in Math. An