CT-based tumour response criteria compared after combined treatment for liver metastases of colorectal cancer

open6noPurpose: The aim of this analysis is to compare different tumour response criteria (TRC) after chemotherapy combined with bevacizumab in liver metastases from colorectal cancer (mCRC) to ascertain the best early prognostic indicator of response. Methods and Materials: 103 target liver metastases from 65 mCRC patients treated with chemoterapy plus bevacizumab were examined at the Istituto Oncologico Veneto IOV-IRCSS (March 2008-January 2013). All patients had baseline CT and at least one follow-up scan. Tumour response was retrospectively analyzed by two radiologists using RECIST1.1, modified Choi, and Chun morphologic criteria. Tumour response, classified as good (complete or partial response) or poor (stable or progressive disease), was compared with progression-free survival (PFS) at first follow-up (t1) and time of best response. Interobserver agreement and concordance between TRC were measured. Results: At t1, 32.31% showed a good response according to RECIST1.1 (median PFS 11.1), 84.62% according to Choi (median PFS 10.8). These percentages rose to 49.23% (median PFS 12.1) and 87.69% (median PFS 10.8), respectively, at the time of best response. According to Chun, 67.69% showed a good response at the time of best response (median PFS 10.8). The Choi criteria detected a higher proportion of good responders at t1, showing a better correlation with PFS; all methods correlated with PFS at the time of best response. Conclusion: The Choi criteria proved more consistent in the early detection of response in mCRC treated with chemotherapy plus bevacizumab, underscoring the importance of using these criteria in the early assessment of response to combined treatment.openopenVarotto, A.; Di Grazia, L.; Aliberti, C.; Bergamo, F.; Nardin, M.; Pomerri, F.Varotto, A.; Di Grazia, L.; Aliberti, C.; Bergamo, F.; Nardin, M.; Pomerri, Fabi

Direct radiative effects by anthropogenic particles at a polluted site: Rome (Italy)

The direct radiative effect (DRE) by all (anthropogenic plus natural) and anthropogenic aerosols is calculated at the solar (0.3–4 μm) and infrared (4–200 μm) spectral range to better address the annual cycle of the anthropogenic aerosol impact at a site (Rome, Italy) significantly affected by pollution. Aerosol optical and microphysical properties from 2003 AERONET Sun/sky-photometer measurements and solar surface albedos based on MODIS satellite sensor data constitute the necessary input to radiative transfer simulations. Clear- and all-sky conditions are investigated by adopting ISCCP monthly products for high-, mid-, and low-cloud cover. It is shown that monthly mean values of aerosol optical depths by anthropogenic particles (AODa) are on average more than 50% of the corresponding all-aerosol-optical-depth (AOD) monthly means. In particular, the AODa/AOD ratio that varies within the (0.51–0.83) on autumn-winter (AW, October-March), varies within the (0.50–0.71) range on spring-summer (SS, April-September) as a consequence of the larger contribution of natural particles on SS. The surface (sfc), all-sky DRE by anthropogenic particles that is negative all year round at solar wavelengths, represents on average 60% and 51% of the all-sky sfc-DRE by all aerosols on AW and SS, respectively. The all-sky atmospheric forcing by anthropogenic particles (AFa) that is positive all year round, is little dependent on seasons: it varies within the (1.0–4.1)W/m2 and (2.0–4.2)W/m2 range on AW and SS, respectively. Conversely, the all-sky AF by all aerosols is characterized by a marked seasonality. As a consequence, the atmospheric forcing by anthropogenic particles that on average is 50% of the AF value on AW, decreases down to 36% of the AF value on SS. Infrared aerosol DREs that are positive all year round are significantly smaller than the corresponding absolute values of solar DREs. Clouds decrease on average ToA- and sfc-DRE absolute values by anthropogenic particles of 36% and 23%, respectively and are quite responsible of the seasonal dependence of aerosol forcing efficiencies by all and anthropogenic aerosols

monthly averaged anthropogenic aerosol direct radiative forcing over the mediterranean based on aeronet aerosol properties

Abstract. The all-sky direct radiative effect by anthropogenic aerosol (DREa) is calculated in the solar (0.3–4 μm) and infrared (4–200 μm) spectral ranges for six Mediterranean sites. The sites are differently affected by pollution and together reflect typical aerosol impacts that are expected over land and coastal sites of the central Mediterranean basin. Central to the simulations are aerosol optical properties from AERONET sun-/sky-photometer statistics for the year 2003. A discussion on the variability of the overall (natural + anthropogenic) aerosol properties with site location is provided. Supplementary data include MODIS satellite sensor based solar surface albedos, ISCCP products for high- mid- and low cloud cover and estimates for the anthropogenic aerosol fraction from global aerosol models. Since anthropogenic aerosol particles are considered to be smaller than 1 μm in size, mainly the solar radiation transfer is affected with impacts only during sun-light hours. At all sites the (daily average) solar DREa is negative all year round at the top of the atmosphere (ToA). Hence, anthropogenic particles produce over coastal and land sites of the central Mediterranean a significant cooling effect. Monthly DREa values vary from site to site and are seasonally dependent as a consequence of the seasonal dependence of available sun-light and microphysical aerosol properties. At the ToA the monthly average DREa is −(4±1) W m−2 during spring-summer (SS, April–September) and −(2±1) W m−2 during autumn-winter (AW, October–March) at the polluted sites. In contrast, it varies between −(3±1) W m−2 and −(1±1) W m−2 on SS and AW, respectively at the less polluted site. Due to atmospheric absorption the DREa at the surface is larger than at the ToA. At the surface the monthly average DREa varies between the most and the least polluted site between −(7±1) W m−2 and −(4±1) W m−2 during SS, and between −(4±3) W m−2 and −(1±1) W m−2 during AW. The DREa at infrared wavelengths is positive but negligible, especially at the ToA (<0.3 W m−2). The average of DREa monthly-means referring to all sites has allowed getting a ToA- and sfc-DREa yearly-mean value of −(3±2) and −(5±3) W m−2, respectively at solar wavelengths. Last data, even if refer to a particular year, indicate that the radiative energy-balance of Central Mediterranean land and coastal sites is quite affected by anthropogenic particles

Primary tumor sidedness and benefit from FOLFOXIRI plus bevacizumab as initial therapy for metastatic colorectal cancer. Retrospective analysis of the TRIBE trial by GONO

Right-sided metastatic colorectal cancer (mCRC) patients have poor prognosis and achieve limited benefit from first-line doublets plus a targeted agent. In this unplanned analysis of the TRIBE study, we investigated the prognostic and predictive impact of primary tumor sidedness in mCRC patients and the differential impact of the intensification of the chemotherapy in subgroups defined according to both primary tumor sidedness and RAS and BRAF mutational status

On distributed strains in a CFA pile via DFOSs measurements and numerical analysis

Fibre Optic Sensors (FOSs) offer unprecedented possibilities for the monitoring of engineering structures, such as foundation systems. Notably, the type of FOSs known as Distributed Fibre Optic Sensors (DFOSs) has the capability of monitoring variations in the observed physical field, such as strain and temperature, with spatial continuity along the fibre. This paper presents and discusses the distributed strain measurements collected along a continuous flight auger (CFA) pile, belonging to the foundation raft of a new bridge subjected to an acceptance static load test. The monitoring was performed using a DFOS system, which works according to the optical frequency domain reflectometry (OFDR) method and provides a spatial resolution of 10 mm and a strain resolution of 1 \u3bc\u3b5. The in-situ monitoring results were used to calibrate a 3D Finite Element Model of the foundation system. The soil properties for the numerical model were also selected on the basis of a load test previously carried out on a similar pile at the same sit

Разработка технологии автоматической сварки под слоем флюса тавровых балок на установке Corimpex

Объектом исследования является обзор существующих способов сварки тавровых балок и разработка новой технологии сварки тавровых балок под слоем флюса на автоматической сварочной линии. В результате проведенного исследования была разработана технология автоматической сварки тавровых балок под слоем флюса и технология правки остаточных деформаций балок непосредственно в процессе сварки, составлена циклограмма и маршрутно-операционная карта процесса сварки.The object of research is a review of existing methods of T-beam welding and the development of a new technology for T-beam welding on an automatic welding line. As a result of the research, the technology of automatic submerged arc T-beam welding and the technology of correcting residual beam deformations directly in the welding process was developed, a cyclogram and operating map of the welding process was compiled