Review of Golem: Modern Wars and Their Monsters by Maya Barzilai

The golem crosses many borders. A popular culture icon and an enduring image of creative power, its hybridity contributes to its elusive nature. What it is and what it means shifts over time. Maya Barzilai\u27s Golem: Modern Wars and Their Monsters takes a unique approach. Deeply interdisciplinary, as one must be to explore such a complex and paradoxical figure, and drawing on religious, literary, cinematic, and historical contexts, Barzilai weaves a rich tapestry of golem narratives. All the while, Barzilai keeps a clear eye on the golem\u27s ongoing association with war, seeing its birth in the clay trenches of World War One and tracing its later evolution as emblematic of nuclear weapons, computer technology, and Israeli military policy

Temma Berg, Professor of English

In this first Next Page column of 2018, Temma Berg, Professor of English, shares which texts have had a lasting influence on her teaching career and scholarship, how a chance meeting created a connection between her and one of her favorite childhood literary characters – Anne of Green Gables, which book she likes to give as a gift to friends who are retiring, and why she might just prefer to open another book rather than host a literary dinner party

Computer aided manual tracking

A scheme was developed to assist the human operator by augmenting an optic sight manual tracking loop with target rate estimates from a computer control algorithm which can either be a Kalman Filter or an alpha, beta, gamma filter. The idea is for the computer to provide rate tracking while the human operator is responsible for nullifying the tracking error. A simple schematic is shown to illustrate the implementation of this concept. A hybrid real-time man-in-loop simulation was used to compare the tracking performance of the same flight trajectory with or without this form of computer-aided track. Preliminary results show the advantage of computer-aided track against high speed aircraft at close range. However, good tracking before target state estimator maturity becomes more critical for aided track than without. Results are presented for a constant velocity flight trajectory

In the eye of the storm: T cell behavior in the inflammatory microenvironment.

Coordinated unfolding of innate and adaptive immunity is key to the development of protective immune responses. This functional integration occurs within the inflamed tissue, a microenvironment enriched with factors released by innate and subsequently adaptive immune cells and the injured tissue itself. T lymphocytes are key players in the ensuing adaptive immunity and their proper function is instrumental to a successful outcome of immune protection. The site of inflammation is a "harsh" environment in which T cells are exposed to numerous factors that might influence their behavior. Low pH and oxygen concentration, high lactate and organic acid content as well as free fatty acids and reactive oxygen species are found in the inflammatory microenvironment. All these components affect T cells as well as other immune cells during the immune response and impact on the development of chronic inflammation. We here overview the effects of a number of factors present in the inflammatory microenvironment on T cell function and migration and discuss the potential relevance of these components as targets for therapeutic intervention in autoimmune and chronic inflammatory diseases

Torsional rigidity for cylinders with a Brownian fracture

We obtain bounds for the expected loss of torsional rigidity of a cylinder $\Omega_L=(-L/2,L/2) \times \Omega\subset \R^3$ of length $L$ due to a Brownian fracture that starts at a random point in $\Omega_L,$ and runs until the first time it exits $\Omega_L$. These bounds are expressed in terms of the geometry of the cross-section $\Omega \subset \R^2$. It is shown that if $\Omega$ is a disc with radius $R$, then in the limit as $L \rightarrow \infty$ the expected loss of torsional rigidity equals $cR^5$ for some $c\in (0,\infty)$. We derive bounds for $c$ in terms of the expected Newtonian capacity of the trace of a Brownian path that starts at the centre of a ball in $\R^3$ with radius $1,$ and runs until the first time it exits this ball.Comment: 18 page

Non-Perturbative U(1) Gauge Theory at Finite Temperature

For compact U(1) lattice gauge theory (LGT) we have performed a finite size scaling analysis on $N_{\tau} N_s^3$ lattices for $N_{\tau}$ fixed by extrapolating spatial volumes of size $N_s\le 18$ to $N_s\to\infty$. Within the numerical accuracy of the thus obtained fits we find for $N_{\tau}=4$, 5 and~6 second order critical exponents, which exhibit no obvious $N_{\tau}$ dependence. The exponents are consistent with 3d Gaussian values, but not with either first order transitions or the universality class of the 3d XY model. As the 3d Gaussian fixed point is known to be unstable, the scenario of a yet unidentified non-trivial fixed point close to the 3d Gaussian emerges as one of the possible explanations.Comment: Extended version after referee reports. 6 pages, 6 figure

NIST torsion oscillator viscometer response: Performance on the LeRC active vibration isolation platform

Critical point viscosity measurements are limited to their reduced temperature approach to T(sub c) in an Earth bound system, because of density gradients imposed by gravity. Therefore, these classes of experiments have been proposed as good candidates for 'microgravity' science experiments where this limitation is not present. The nature of these viscosity measurements dictate hardware that is sensitive to low frequency excitations. Because of the vibratory acceleration sensitivity of a torsion oscillator viscometer, used to acquire such measurements, a vibration isolation sensitivity test was performed on candidate 'microgravity' hardware to study the possibility of meeting the stringent oscillatory sensitivity requirements of a National Institute of Standards and Technology (NIST) torsion oscillator viscometer. A prototype six degree of freedom active magnetic isolation system, developed at NASA Lewis Research Center, was used as the isolation system. The ambient acceleration levels of the platform were reduced to the noise floor levels of its control sensors, about one microgravity in the 0.1 to 10 Hz bandwidth

Multi-Overlap Simulations for Transitions between Reference Configurations

We introduce a new procedure to construct weight factors, which flatten the probability density of the overlap with respect to some pre-defined reference configuration. This allows one to overcome free energy barriers in the overlap variable. Subsequently, we generalize the approach to deal with the overlaps with respect to two reference configurations so that transitions between them are induced. We illustrate our approach by simulations of the brainpeptide Met-enkephalin with the ECEPP/2 energy function using the global-energy-minimum and the second lowest-energy states as reference configurations. The free energy is obtained as functions of the dihedral and the root-mean-square distances from these two configurations. The latter allows one to identify the transition state and to estimate its associated free energy barrier.Comment: 12 pages, (RevTeX), 14 figures, Phys. Rev. E, submitte

Structure of the Energy Landscape of Short Peptides

We have simulated, as a showcase, the pentapeptide Met-enkephalin (Tyr-Gly-Gly-Phe-Met) to visualize the energy landscape and investigate the conformational coverage by the multicanonical method. We have obtained a three-dimensional topographic picture of the whole energy landscape by plotting the histogram with respect to energy(temperature) and the order parameter, which gives the degree of resemblance of any created conformation with the global energy minimum (GEM).Comment: 17 pages, 4 figure

Polyunsaturated fatty acid-derived lipid mediators and T cell function

Copyright © 2014 Nicolaou, Mauro, Urquhart and Marelli-Berg . This is an open- access article distributed under the terms of the Creative Commons Attribution License (CC BY) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms