Оптимизация элементов стальной многоэтажной рамы с использованием генетического алгоритма

This study presents the development and implementation of the genetic algorithm model in optimization of members of steel multistory frame. The developed model shows superior results when compared to the classical model of genetic algorithm because of higher speed and stability of decision searching. The results of the frame members optimization are provided.Настоящее исследование направлено на разработку и применение модели генетического алгоритма для оптимизации стальной многоэтажной рамы. Разработанная модель показывает лучший результат по сравнению с классической моделью как по скорости, так и по устойчивости поиска решения. Приведен пример с результатами оптимизации элементов рамы

Thiacalix[4]monocrowns with terpyridine functional groups as new structural units for luminescent polynuclear lanthanide complexes

© 2016 © 2016 A.E. Arbuzov Institute of Organic and Physical Chemistry.The synthesis and structure of thiacalix[4]monocrowns in 1,3-alternate configuration substituted by terpyridyl fragments on the lower rim are being discussed. It has been shown that the number of oxyethylene units in oligoethylene glycol chain affects the distribution of the yields of the cross-linking products leading to either thiacalix[4]monocrowns or bisthiacalix[4]arenes. Their complexation ability towards alkali metal and lanthanide ions has been studied using liquid extraction and MALDI TOF MS, in addition to luminescent properties of ligands and their lanthanide complexes. The NMR titration data discovered the participation of both crown ether and terpyridyl fragment in the coordination of lanthanide cations. The fluorescent titration showed the nonlinear emission response to the amount of lanthanide ions

Azide–akyne click approach to the preparation of dendrimer–type multi(thia)calix[4]arenes with triazole linkers

© ISUCT Publishing. The design of polymacrocyclic structures is of high importance for the improvement of recognition ability to various guests. We present a convenient approach towards two types of dendrimer-shaped pentakis-thiacalix[4]arenes with triazolyl linkers using the click reaction of tetraazidoalkoxycalixarenes with monoalkynyloxy derivatives, as well as tetraalkynyloxycalixarenes with monoazidoalkoxy derivatives. Mitsunobu alkylation of hydroxyl groups has been employed to afford tetrasubstituted derivatives in 1,3-alternate configuration. A facile procedure for the synthesis of monosubstituted cone precursors in high yields by the hydrolysis of one ether fragment in disubstituted counterparts under basic conditions (n-BuNH 2 or NaN 3 in DMF) has been suggested and optimized. CuAAC reaction has been conducted in microwave reactor and on a hot plate. It has been found that microwave irradiation promotes the reaction and the yields of products are as high as 40–80 %

The Problem of the Formation of Creative Activity in Preschool Children

В статье рассматриваются результаты опытно-экспериментальная работа по формированию творческой активности детей дошкольного возраста на основе игровой деятельности. Авторы в исследовании использовали следующие методики: «Коробка форм» Баландина Н.А. «Разрезные картинки» Горбачева И.А. «Дорисовывание фигур» Гаврилова В.Г.The article deals with experimental work on the formation of creative activity of preschool children on the basis of play activities

Formation of Creative Activity of Preschool Children Based on Play Activities

В статье рассматривается теория формирования творческой активности детей дошкольного возраста на основе игровой деятельности. Анализируется понятие творческая активность дошкольника. Изучены подходы ученых к данной проблеме.The article discusses the theory of the formation of creative activity of preschool children on the basis of play activities. The concept of creative activity of a preschooler is analyzed. The approaches of scientists to this problem have been studied

Synthesis and structure of lower rim-substituted alkynyl derivatives of thiacalix[4]arene

© 2015 Pleiades Publishing, Ltd. Lower-rim substituted bis- and tetrakis(alkynyloxy)thiacalix[4]arenes in cone and 1,3-alternate configurations were synthesized by the Mitsunobu reaction, and their structure was determined using homoand heteronuclear one- and two-dimensional NMR techniques. Bis(prop-2-yn-1-yloxy)thiacalix[4]arene was found to exist in conformational equilibrium whose position depends on the temperature and reaction conditions

Computer analysis of co-localization of transcription factor binding sites in genome by ChIP-seq data

Statistical features of the distribution of transcription factor binding sites in the mouse genome that are obtained by ChIP-seq experiments in embryonic stem cells have been considered. Clusters of sites that contain four or more different transcription factor binding sites in the mouse genome have been defined, also their location relatively to the regulatory regions of genes has been described. The presence of two types of site co-localization has been shown: clusters containing binding sites for factors Oct4, Nanog, Sox2, located in the distal regions, and clusters containing binding sites n-Myc, c-Myc, mainly located in the promoter regions of mouse genes. Analysis of new ChIPseq data about binding of transcription factors Nr5a2, Tbx3 in the same cell type has confirmed the division of clusters of transcription factors binding sites into two types: those containing the binding sites of regulators of pluripotency (Oct4, Nanog, and others) and those not. The computer program of the statistical data processing of gene location and chromatin domains that analyzes experimental data of site localization obtained by ChIP-seq in the mouse genome and the human genome has been developed. The presence of preferences at position of transcription factor binding sites of various types has been revealed, the distances between the nearest groups of TF binding sites Oct4, Nanog, Sox2 and TF binding sites n-Myc and c-Myc have been calculated using this program. The presence of nucleotide motifs of transcription factor binding sites in the selected areas of ChIP-seq has been estimated, nucleotide motifs have been refined. A correlation between the presence of motifs and the intensity of ChIPseq binding has been shown. Computer methods for estimating the clustering of different transcription factors binding sites for new data ChIP-seq have been developed. Programs are available upon the request to the authors

Computational problems of analysis of short next generation sequencing reads

Short read next generation sequencing (NGS) has significant impacts on modern genomics, genetics, cell biology and medicine, especially on meta-genomics, comparative genomics, polymorphism detection, mutation screening, transcriptome profiling, methylation profiling, chromatin remodelling and many more applications. However, NGS are prone for errors which complicate scientific conclusions. NGS technologies consist of shearing DNA molecules into collection of numerous small fragments, called a ‘library’, and their further extensive parallel sequencing. These sequenced overlapping fragments are called ‘reads’, they are assembled into contiguous strings. The contiguous sequences are in turn assembled into genomes for further analysis. Computational sequencing problems are those arising from numerical processing of sequenced samples. The numerical processing involves procedures such as: quality-scoring, mapping/assembling, and surprisingly, error-correction of a data. This paper is reviewing post-processing errors and computational methods to discern them. It also includes sequencing dictionary. We present here quality control of raw data, errors arising at the steps of alignment of sequencing reads to a reference genome and assembly. Finally this work presents identification of mutations (“Variant calling”) in sequencing data and its quality control

The study of bread and the influence of its properties on digestion

The aim of the study – to assess the quality of wheat and rye bread for compliance with GOST in the laboratory, examining the organoleptic properties and physico-chemical parameters.Цель исследования – провести оценку качества пшеничного и ржаного хлеба на соответствие санитарному законодательству в лаборатории: органолептические свойства и физико-химические показател