Improving musculoskeletal injury surveillance methods in Special Operation Forces: A Delphi consensus study

Musculoskeletal injury mitigation is a priority in military organisations to protect personnel health and sustain a capable workforce. Despite efforts to prevent injury, inconsistencies exist in the evidence used to support these activities. There are many known limitations in the injury surveillance data reported in previous Special Operation Forces (SOF) research. Such studies often lack accurate, reliable, and complete data to inform and evaluate injury prevention activities. This research aimed to achieve expert consensus on injury surveillance methods in SOF to enhance the quality of data that could be used to inform injury prevention in this population. A Delphi study was conducted with various military injury surveillance stakeholders to seek agreement on improving surveillance methods in SOF. Iterative questionnaires using close and open-ended questions were used to collect views about surveillance methods related to injury case definitions and identifying essential and optional data requirements. Consensus was predefined as 75 % group agreement on an item. Sixteen participants completed two rounds of questionnaires required. Consensus was achieved for 17.9 % (n = 7) of questions in the first-round and 77.5 % (n = 38) of round two questions. Several challenges for surveillance were identified, including recording injury causation, SOF personnel’s injury reporting behaviours influencing accurate data collection, and surveillance system infrastructure limitations. Key military injury surveillance stakeholders support the need for improved data collection to enhance the evidence that underpins injury prevention efforts. The consensus process has resulted in preliminary recommendations to support future SOF injury surveillance

4D microstructural and electrochemical characterization of dissimilar metal corrosion in naval structural Joints

Dissimilar metal corrosion in aircraft and naval structures has proven to be a persistent challenge. Decades of research in the area have shown that such complex contact surfaces are subject to a combination of corrosive environments and mechanical loads. Hence, this multi-faceted problem must be understood from electrochemical, microstructural and mechanical standpoints to comprehensively understand corrosion damage in these systems. Please click Additional Files below to see the full abstract

Nonequilibrium dynamics of fully frustrated Ising models at T=0

We consider two fully frustrated Ising models: the antiferromagnetic triangular model in a field of strength, $h=H T k_B$, as well as the Villain model on the square lattice. After a quench from a disordered initial state to T=0 we study the nonequilibrium dynamics of both models by Monte Carlo simulations. In a finite system of linear size, $L$, we define and measure sample dependent "first passage time", $t_r$, which is the number of Monte Carlo steps until the energy is relaxed to the ground-state value. The distribution of $t_r$, in particular its mean value, $$, is shown to obey the scaling relation, $\sim L^2 \ln(L/L_0)$, for both models. Scaling of the autocorrelation function of the antiferromagnetic triangular model is shown to involve logarithmic corrections, both at H=0 and at the field-induced Kosterlitz-Thouless transition, however the autocorrelation exponent is found to be $H$ dependent.Comment: 7 pages, 8 figure

In situ three-dimensional study of corrosion fatigue crack initiation and growth of corroded 7075 aluminum alloys

Corrosion fatigue crack initiation in aluminum alloys can have significant effects on part life. An improved understanding of the mechanisms governing corrosion and corrosion fatigue damage of Al alloys is necessary. Alloy design and environmental chemistry have significant effects on corrosion fatigue crack initiation and growth. Influential alloy design features include alloy chemistry, precipitate structure, and grain structure. Environmental factors such as environmental chemistry and preexisting corrosion damage can also effect the corrosion fatigue behavior of the alloys. To investigate the effects of environment and precipitate size on corrosion fatigue of aluminum alloys, the in situ corrosion fatigue testing of corroded peak-aged and overaged 7075 Al alloys in 3.5 wt% NaCl solution will be presented. For this study, rolled 7075 Al alloy was heat-treated to peak-aged, overaged, and highly overaged conditions. The samples were machined, mechanically polished, masked, and then soaked in 3.5 wt.% NaCl solution for fifteen days to yield significant corrosion damage in a region of interest. The corroded specimens were fatigue tested in situ in 3.5 wt.% NaCl using synchrotron X-ray tomography to gain three dimensional information regarding fatigue crack initiation and growth characteristics. Hydrogen bubbles were observed within the crack during propagation, indicating chemical changes in the sample during corrosion fatigue. The crack initiation, growth, and bubble evolution were quantified and discussed. A relationship was observed between the bubble volume and crack surface area as the test progressed, which suggested an effect from stress at the crack tip. Ultimately, this in situ study provided new insights regarding the localized processes occurring during the corrosion fatigue cracking of aluminum alloys which previous post-mortem and two dimensional studies were unable to discover

CIS is a potent checkpoint in NK cell-mediated tumor immunity

The detection of aberrant cells by natural killer (NK) cells is controlled by the integration of signals from activating and inhibitory ligands and from cytokines such as IL-15. We identified cytokine-inducible SH2-containing protein (CIS, encoded by Cish) as a critical negative regulator of IL-15 signaling in NK cells. Cish was rapidly induced in response to IL-15, and deletion of Cish rendered NK cells hypersensitive to IL-15, as evidenced by enhanced proliferation, survival, IFN-γ production and cytotoxicity toward tumors. This was associated with increased JAK-STAT signaling in NK cells in which Cish was deleted. Correspondingly, CIS interacted with the tyrosine kinase JAK1, inhibiting its enzymatic activity and targeting JAK for proteasomal degradation. Cish -/- mice were resistant to melanoma, prostate and breast cancer metastasis in vivo, and this was intrinsic to NK cell activity. Our data uncover a potent intracellular checkpoint in NK cell-mediated tumor immunity and suggest possibilities for new cancer immunotherapies directed at blocking CIS function

Broken symmetry and the variation of critical properties in the phase behaviour of supramolecular rhombus tilings

The degree of randomness, or partial order, present in two-dimensional supramolecular arrays of isophthalate tetracarboxylic acids is shown to vary due to subtle chemical changes such as the choice of solvent or small differences in molecular dimensions. This variation may be quantified using an order parameter and reveals a novel phase behaviour including random tiling with varying critical properties as well as ordered phases dominated by either parallel or non-parallel alignment of neighbouring molecules, consistent with long-standing theoretical studies. The balance between order and randomness is driven by small differences in the intermolecular interaction energies, which we show, using numerical simulations, can be related to the measured order parameter. Significant variations occur even when the energy difference is much less than the thermal energy highlighting the delicate balance between entropic and energetic effects in complex self-assembly processes

The politics of the teaching of reading

Historically, political debates have broken out over how to teach reading in primary schools and infant classrooms. These debates and “reading wars” have often resulted from public concerns and media reportage of a fall in reading standards. They also reflect the importance placed on learning to read by parents, teachers, employers, and politicians. Public and media-driven controversies over the teaching of reading have resulted in intense public and professional debates over which specific methods and materials to use with beginning readers and with children who have reading difficulties. Recently, such debates have led to a renewed emphasis on reading proficiency and “standardized” approaches to teaching reading and engaging with literacy. The universal acceptance of the importance of learning to read has also led to vested interests in specific methods, reading programmes, and early literacy assessments amongst professional, business, commercial, and parental lobbying groups. This article traces these debates and the resulting growing support for a quantitative reductionist approach to early-reading programmes

Gravity modelling along CROP04 seismic profile

The processing and interpretation of seismic lines, together with the analysis of surficial geological data and hydrocarbon wells data, are powerful tools for the investigation of crust structures. Nevertheless, for depths exceeding that portion of crust usually investigated for commercial purposes, only geophysical data are generally available (among the others: NVR seismic from CROP project, DSS data, magnetic data, gravity data). In this context, the possibility of comparing two independent geophysical data sets, such as data from seismic exploration (CROP Project) and gravimetric analysis (Bouguer anomalies), is of particular interest for investigations into the deeper crust portion. In the present work gravity data modelling was used to study deep crust, constraints being provided by WARR data and by reflection seismic data obtained along the CROP04 profile that crosses the Southern Apennines (Italy) from Agropoli (SW) to Barletta (NE). A preliminary interpretation has been made of the regional gravity anomaly trend in deep crust in Southern Italy; the role of this anomaly trend as an independent constraint for the geological interpretation of the CROP04 seismic line is discussed

Comparison of published orthopaedic trauma trials following registration in Clinicaltrials.gov

<p>Abstract</p> <p>Background</p> <p>After the Food and Drug Administration Modernization Act of 1997, the registration of all clinical trials became mandatory prior to publication. Our primary objective was to determine publication rates for orthopaedic trauma trials registered with ClinicalTrials.gov. We further evaluated methodological consistency between registration and publication.</p> <p>Methods</p> <p>We searched Clinical Trials.gov for all trials related to orthopaedic trauma. We excluded active trials and trials not completed by July 2009, and performed a systematic search for publications resulting from registered closed trials. Information regarding primary and secondary outcomes, intervention, study sponsors, and sample size were extracted from registrations and publications.</p> <p>Results</p> <p>Of 130 closed trials, 37 eligible trials resulted in 16 publications (43.2%). We found no significant differences in publication rates between funding sources for industry sponsored studies and nongovernment/nonindustry sponsored studies (<it>p </it>> 0.05). About half the trials (45%) did not include the NCT ID in the publication. Two (10%) publications had major changes to the primary outcome measure and ten (52.6%) to sample size.</p> <p>Conclusions</p> <p>Registration of orthopaedic trauma trials does not consistently result in publication. When trials are registered, many do not cite NCT ID in the publication. Furthermore, changes that are not reflected in the registry of the trial are frequently made to the final publication.</p