599 research outputs found
Searches for lepton flavour violation
The search for lepton flavour violation in the charged-lepton Sector is one of the main present challenges of particle physics, since an observation of such a process, strongly suppressed in the Standard Model, could represent the first unambiguous evidence of physics beyond it. I review the main experimental programs looking for LFV, in the present and in the near future
Negative ion Time Projection Chamber operation with SF at nearly atmospheric pressure
We present measurements of drift velocities and mobilities of some innovative
negative ion gas mixtures at nearly atmospheric pressure based on SF as
electronegative capture agent and of pure SF at various pressures,
performed with the NITEC detector. NITEC is a Time Projection Chamber with 5 cm
drift distance readout by a GEMPix, a triple thin GEMs coupled to a
Quad-Timepix chip, directly sensitive to the deposited charge on each of the 55
55 m pixel. Our results contribute to expanding the knowledge
on the innovative use of SF as negative ion gas and extend to triple thin
GEMs the possibility of negative ion operation for the first time. Above all,
our findings show the feasibility of negative ion operation with
He:CF:SF at 610 Torr, opening extremely interesting possibility for
next generation directional Dark Matter detectors at 1 bar
Integrating Aerial Base Stations for sustainable urban mobile networks
The extensive densification of mobile networks is increasing the network energy consumption and leading to remarkable economical and sustainability concerns. At the same time, regulatory and physical constraints, especially in urban environments, may limit the network expansion and the free installation of Base Stations (BSs). In this context, High Altitude Platform Stations (HAPSs) are emerging as a promising solution to host aerial BSs that can provide additional capacity over a wide geographical area, to offload the on-ground mobile network and support a sustainable transition towards the 6G era. This paper investigates the potential of HAPS offloading to reduce the energy demand from the grid and the operational cost of mobile networks. Our results highlight the effectiveness of HAPS offloading in reducing the size of the RE supply that is required to achieve grid energy reduction on the terrestrial network, thus enhancing the feasibility of a sustainable evolution towards 6G networks. Different allocation strategies are designed and analyzed under several configuration settings, to dynamically adapt the HAPS capacity to the traffic variability in space and over time. A fine tuning of the strategy settings is proved effective in trading off physical constraints, operational cost, sustainability goals, and Quality of Service
Investigating The Physics Case of Running a B-Factory at the Y(5S) Resonance
We discuss the physics case of a high luminosity B-Factory running at the
Y(5S) resonance. We show that the coherence of the B meson pairs is preserved
at this resonance, and that Bs can be well distinguished from Bd and charged B
mesons. These facts allow to cover the physics program of a traditional
B-Factory and, at the same time, to perform complementary measurements which
are not accessible at the Y(4S). In particular we show how, despite the
experimental limitations in performing time-dependent measurements of Bs
decays, the same experimental information can be extracted, in several cases,
from the determination of time-integrated observables. In addition, a few
examples of the potentiality in measuring rare Bs decays are given. Finally, we
discuss how the study of Bs meson will improve the constraints on New Physics
parameters in the Bs sector, in the context of the generalized Unitarity
Triangle analysis.Comment: 47 pages, 22 figure
Mobile customer relationship management : An explorative investigation of the italian consumer market
Mobile customer relationship management (CRM) services seem to have all the characteristics commonly associated with successful mobile services and have accordingly been predicted to be among the most promising. However, real development of this sector has not been well explored so far, especially in relation to the actual supply of mobile CRM services to the public. The purpose of this paper is to reduce this gap by giving a first snapshot of the current development of the supply of mobile CRM services to consumers taken in the context of the Italian market. In order to do so, it firstly proposes a conceptual framework indicating the relevant aspects to investigate for assessing this kind of environments: the market, value propositions, actors and issues. Then it applies this framework to get an overview of the supply of mobile CRM services in Italy and provides some empirical insight about its current development obtained through an exhaustive survey of the current supply of 750 services from 353 firms
ULTRALIGHT RADAR FOR SMALL AND MICRO-UAV NAVIGATION
This paper presents a radar approach to navigation of small and micro Unmanned Aerial Vehicles (UAV) in environments challenging
for common sensors. A technique based on radar odometry is briefly explained and schemes for complete integration with other sensors
are proposed. The focus of the paper is set on ultralight radars and interpretation of outputs of such sensor when dealing with
autonomous navigation in complex scenario. The experimental setup used to analyse the proposed approach comprises one multi-rotor
UAV and one ultralight commercial radar. Results from flight tests in which both forward-only motion and mixed motion are presented
and analysed, providing a reference for understanding outputs of radar in complex scenarios. The radar odometry solution is compared
with ground truth provided by GPS sensor
Targeting RAGE prevents muscle wasting and prolongs survival in cancer cachexia
Background: Cachexia, a multifactorial syndrome affecting more than 50% of patients with advanced cancer and responsible for ~20% of cancer-associated deaths, is still a poorly understood process without a standard cure available. Skeletal muscle atrophy caused by systemic inflammation is a major clinical feature of cachexia, leading to weight loss, dampening patients' quality of life, and reducing patients' response to anticancer therapy. RAGE (receptor for advanced glycation end-products) is a multiligand receptor of the immunoglobulin superfamily and a mediator of muscle regeneration, inflammation, and cancer. Methods: By using murine models consisting in the injection of colon 26 murine adenocarcinoma (C26-ADK) or Lewis lung carcinoma (LLC) cells in BALB/c and C57BL/6 or Ager−/− (RAGE-null) mice, respectively, we investigated the involvement of RAGE signalling in the main features of cancer cachexia, including the inflammatory state. In vitro experiments were performed using myotubes derived from C2C12 myoblasts or primary myoblasts isolated from C57BL/6 wild type and Ager−/− mice treated with the RAGE ligand, S100B (S100 calcium-binding protein B), TNF (tumor necrosis factor)α±IFN (interferon) γ, and tumour cell- or masses-conditioned media to analyse hallmarks of muscle atrophy. Finally, muscles of wild type and Ager−/− mice were injected with TNFα/IFNγ or S100B in a tumour-free environment. Results: We demonstrate that RAGE is determinant to activate signalling pathways leading to muscle protein degradation in the presence of proinflammatory cytokines and/or tumour-derived cachexia-inducing factors. We identify the RAGE ligand, S100B, as a novel factor able to induce muscle atrophy per se via a p38 MAPK (p38 mitogen-activated protein kinase)/myogenin axis and STAT3 (signal transducer and activator of transcription 3)-dependent MyoD (myoblast determination protein 1) degradation. Lastly, we found that in cancer conditions, an increase in serum levels of tumour-derived S100B and HMGB1 (high mobility group box 1) occurs leading to chronic activation/overexpression of RAGE, which induces hallmarks of cancer cachexia (i.e. muscle wasting, systemic inflammation, and release of tumour-derived pro-cachectic factors). Absence of RAGE in mice translates into reduced serum levels of cachexia-inducing factors, delayed loss of muscle mass and strength, reduced tumour progression, and increased survival. Conclusions: RAGE is a molecular determinant in inducing the hallmarks of cancer cachexia, and molecular targeting of RAGE might represent a therapeutic strategy to prevent or counteract the cachectic syndrome
ULTRALIGHT RADAR FOR SMALL AND MICRO-UAV NAVIGATION
This paper presents a radar approach to navigation of small and micro Unmanned Aerial Vehicles (UAV) in environments challenging for common sensors. A technique based on radar odometry is briefly explained and schemes for complete integration with other sensors are proposed. The focus of the paper is set on ultralight radars and interpretation of outputs of such sensor when dealing with autonomous navigation in complex scenario. The experimental setup used to analyse the proposed approach comprises one multi-rotor UAV and one ultralight commercial radar. Results from flight tests in which both forward-only motion and mixed motion are presented and analysed, providing a reference for understanding outputs of radar in complex scenarios. The radar odometry solution is compared with ground truth provided by GPS sensor
- …