Nucleophilic radiofluorination at room temperature via aziridinium intermediates

LDM TEPInternational audienc

Functional characterization of a new class of odorant-binding proteins in the moth Mamestra brassicae

International audienc

Effect of Early Discharge on Postoperative Comorbidity and Complications for Patients Undergoing Revision Total Knee Arthroplasty

Background: Total knee arthroplasty (TKA) is becoming an increasingly common procedure to alleviate knee pain often associated with osteoarthritis (OA) of the knee. As the number of TKAs performed continue to increase, there remains a debate regarding efficacy of discharging patients earlier than the conventional 3-4 days in the postoperative period. A variety of studies have begun to shown that early discharge has an economical benefit, while causing either a reduction or no difference in patient outcomes. This study aims to determine effect of early discharge on postoperative complications in those that undergo revision TKA. Methods: A retrospective cohort study was conducted using data collected through the American College of Surgeons National Quality Improvement Program Database. All patients who underwent revision TKA between 2007 and 2014 were identified and stratified into groups based on discharge date. The incidence of adverse events following surgery was evaluated with univariate and multivariate analyses where appropriate. Results: Patients that were discharged earlier were found to be less likely to develop a deep wound infection, urinary tract infection, sepsis or require a reoperation in the OR within 30 days. Furthermore, earlier discharge was found to be an independent risk factor for these complications. Conclusions: Patients that are discharged earlier have a decreased risk for a variety of complications in the postoperative period, while reducing economic burden. If patients are appropriate candidates, surgeons should consider early discharge as a viable option even in the revision TKA population

Pheromone binding proteins of the moth Mamestra brassicae : specificity of ligand binding

International audienc

In vivo evaluation of radiofluorinated caspases-3/7 inhibitors as radiotracers for apoptosis imaging and comparison with [18F]-ML-10 in a stroke model in the rat

CERVOXY COLL/LDM TEPInternational audienc

A new class of fluorinated 5-pyrrolidinylsulfonyl isatin caspase inhibitors for PET imaging of apoptosis

Thirteen compounds in a new class of fluorinated 5-pyrrolidinylsulfonyl isatin derivatives were synthesised that have potent and selective inhibitory activity against effector caspases-3 and -7. With in vivo animal PET imaging studies of cerebral ischemia being planned, N-benzylation with selected para-substituted benzylic halides allowed systematic variation of lipophilicity (logP 1.94–3.31) without decreasing inhibition potency (IC50). From this series the p-methoxybenzyl analogue was selected for initial ‘proof-of-concept’ [18F]-fluoride radiolabelling which proceeded in good yield and purity with no need for a protection/deprotection strategy. © 2013 Royal Society of Chemistr