1,862 research outputs found
The C-peptide Signaling
For years an assumption was made that C-peptide, a
byproduct of insulin biosynthesis, possessed no appreciable
physiologic role. As other contributions in this volume
amply testify, the time has come to re-evaluate that notion.
C-peptide either directly through interaction with its specific
cell-surface receptor or indirectly through an interaction
with a related membrane entity, exerts a unique effect
on several intracellular processes.We review here results of
studies attempting to elucidate such molecular effects of
C-peptide in different cell systems and tissues. Lacking a
purified C-peptide receptor, we also demonstrate C-peptide
effects on distinct elements of the insulin signal transduction
pathways
Análise econômico-financeira da produção de carvão vegetal no Rio Grande do Sul.
bitstream/item/79849/1/comunicado-264.pd
Enhancement of ferromagnetism by nickel doping in the 112 cobaltite EuBaCo2O5.50
The study of the ordered oxygen deficient perovskite EuBaCo2-xNixO5.50 shows
that the doping of cobalt sites by nickel induces a strong ferromagnetic
component at low temperature in the antiferromagnetic matrix of EuBaCo2O5.50.
This system exhibits indeed phase separation, i.e. consists of ferromagnetic
domains embedded in the antiferromagnetic matrix of EuBaCo2O5.50. Besides, a
magnetic transition is observed for the first time at 40K in the undoped and
nickel doped phases, which can be attributed to the ferromagnetic ordering of
the Eu3+ moments below this temperature. Moreover sharp ultra magnetization
multisteps are observed below 5K, characteristic of motion of domain walls in a
strong pinning system and very different from any metamagnetic transition
The Insulin-Like Growth Factor System and Neurological Complications in Diabetes
The IGF system plays vital roles in neuronal development,
metabolism, regeneration and survival. It consists of
IGF-I, IGF-II, insulin, IGF-I-receptor, and those of IGF-II
and insulin as well as IGF-binding proteins. In the last
decades it has become clear that perturbations of the IGF
system play important roles in the pathogenesis of diabetic
neurological complications. In the peripheral nervous system
IGF-I, insulin, and C-peptide particularly in type 1 diabetes
participate in the development of axonal degenerative
changes and contributes to impaired regenerative capacities.
These abnormalities of the IGF system appear to be
less pronounced in type 2 diabetes, which may in part account
for the relatively milder neurological complications
in this type of diabetes. The members of the IGF system
also provide anti-apoptotic effects on both peripheral and
central nervous system neurons. Furthermore, both insulin
and C-peptide and probably IGF-I possess gene regulatory
capacities on myelin constituents and axonal cytoskeletal
proteins. Therefore, replenishment of various members of
the IGF system provides a reasonable rational for prevention
and treatment of diabetic neurological complications
C-Peptide Prevents Hippocampal Apoptosis in Type 1 Diabetes
To explore mechanisms underlying central nervous system
(CNS) complications in diabetes, we examined hippocampal neuronal
apoptosis and loss, and the effect of C-peptide replacement
in type 1 diabetic BB/W rats. Apoptosis was demonstrated after
8 months of diabetes, by DNA fragmentation, increased number of
apoptotic cells, and an elevated ratio of Bax/Bcl-xL, accompanied
by reduced neuronal density in the hippocampus. No apoptotic activity
was detected and neuronal density was unchanged in 2-month
diabetic hippocampus, whereas insulin-like growth factor (IGF) activities
were impaired. In type 1 diabetic BB/W rats replaced with
C-peptide, no TdT-mediated dUTP nick-end labeling (TUNEL)-
positive cells were shown and DNA laddering was not evident in
hippocampus at either 2 or 8 months. C-peptide administration prevented
the preceding perturbation of IGF expression and reduced
the elevated ratio of Bax/Bcl-xL. Our data suggest that type 1 diabetes
causes a duration-dependent programmed cell death of the
hippocampus, which is partially prevented by C-peptide
Analisis Kemampuan Berbicara melalui Metodebernyanyi di Paud Terpadu Pontianak Barat
This study aims to analyze the ability to speak through the method of singing in PAUD Integrated Pontianak West West Kalimantan Province. The method used is qualitative research method. Research subjects are children Play Groups (KB), amounting to 17 children and 2 teachers. Data collection tools are: interview, observation, and documentation. Data analysis in this study using qualitative data analysis which includes: data collection, data reduction, display data, and conclusion drawing / verification. The results showed that the speaking ability of children of PAUD Playing Group of West Pontianak can be developed through the method of singing. The use of this singing method can improve children's speaking skills in terms of repeating the lyrics of the song being heard, pronouncing the lyrics of an already heard song, and answering simple questions about the lyrics of the song being heard. At the end of the study 90% of children were able to repeat the song lyrics, 65% of children were able to pronounce the lyrics of the flag, and 71% of the children could answer simple questions about the lyrics of the flag
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