The Role of Religion and Spirituality in the Care of Patients in Family Medicine

Aims: This thesis explored patients’ perspectives on discussing their religious and spiritual beliefs with their family physicians and family physicians’ behaviours in discussing patients’ religion and spirituality. Methods: This thesis examined the role of religion and spirituality in patient care in family medicine using qualitative and quantitative methodologies including in-depth interviews of patients and a survey of family physicians. Findings: The majority of participants believed that religion and spirituality was important in patient care in family medicine. Barriers and facilitators were identified to the integration of religion and spirituality into patient care. Both studies identified physician comfort level as a barrier and medical education as a potential solution. Conclusions: The majority of participants believed that patients’ religious and spiritual beliefs were important to know, but identified comfort level as a barrier to asking. Medical education on religion and spirituality in patient care is important to increasing physician comfort level

Discovery of a new radio galaxy within the error box of the unidentified gamma-ray source 3EG J1735-1500

We report the discovery of a new radio galaxy within the location error box of the gamma-ray source 3EG J1735-1500. The galaxy is a double-sided jet source forming a large angle with the line of sight. Optical observations reveal a V ~ 18 magnitude galaxy at the position of the radio core. Although the association with the EGRET source is not confirmed at the present stage, because there is a competing, alternative gamma-ray candidate within the location error contours which is also studied here, the case deserves further attention. The new radio galaxy can be used to test the recently proposed possibility of gamma-ray emitting radio galaxies beyond the already known case of Centaurus A

A Subset of Human Bromodomains Recognizes Butyryllysine and Crotonyllysine Histone Peptide Modifications

SummaryBromodomains are epigenetic readers that are recruited to acetyllysine residues in histone tails. Recent studies have identified non-acetyl acyllysine modifications, raising the possibility that these might be read by bromodomains. Profiling the nearly complete human bromodomain family revealed that while most human bromodomains bind only the shorter acetyl and propionyl marks, the bromodomains of BRD9, CECR2, and the second bromodomain of TAF1 also recognize the longer butyryl mark. In addition, the TAF1 second bromodomain is capable of binding crotonyl marks. None of the human bromodomains tested binds succinyl marks. We characterized structurally and biochemically the binding to different acyl groups, identifying bromodomain residues and structural attributes that contribute to specificity. These studies demonstrate a surprising degree of plasticity in some human bromodomains but no single factor controlling specificity across the family. The identification of candidate butyryl- and crotonyllysine readers supports the idea that these marks could have specific physiological functions

The detector control system of the ATLAS experiment

The ATLAS experiment is one of the experiments at the Large Hadron Collider, constructed to study elementary particle interactions in collisions of high-energy proton beams. The individual detector components as well as the common experimental infrastructure are supervised by the Detector Control System (DCS). The DCS enables equipment supervision using operator commands, reads, processes and archives the operational parameters of the detector, allows for error recognition and handling, manages the communication with external control systems, and provides a synchronization mechanism with the physics data acquisition system. Given the enormous size and complexity of ATLAS, special emphasis was put on the use of standardized hardware and software components enabling efficient development and long-term maintainability of the DCS over the lifetime of the experiment. Currently, the DCS is being used successfully during the experiment commissioning phase

De campañas de medidas a productos de salinidad: un tributo a las contribuciones de Jordi Font a la mision SMOS

Camps, Adriano ... et al.-- Special volume: Planet Ocean. Scientia Marina 80(Suppl.1) 2016.-- 14 pages, 20 figures[EN] This article summarizes some of the activities in which Jordi Font, research professor and head of the Department of Physical and Technological Oceanography, Institut de Ciències del Mar (CSIC, Spanish National Research Council) in Barcelona, has been involved as co-Principal Investigator for Ocean Salinity of the European Space Agency Soil Moisture and Ocean Salinity (SMOS) Earth Explorer Mission from the perspective of the Remote Sensing Lab at the Universitat Politècnica de Catalunya. We have probably left out some of his many contributions to salinity remote sensing, but we hope that this review will give an idea of the importance of his work. We focus on the following issues: 1) the new accurate measurements of the sea water dielectric constant, 2) the WISE and EuroSTARRS field experiments that helped to define the geophysical model function relating brightness temperature to sea state, 3) the FROG 2003 field experiment that helped to understand the emission of sea foam, 4) GNSS-R techniques for improving sea surface salinity retrieval, 5) instrument characterization campaigns, and 6) the operational implementation of the Processing Centre of Levels 3 and 4 at the SMOS Barcelona Expert Centre[ES] Este artículo resume algunas de las actividades en las que Jordi Font, profesor de investigación y jefe del Departamento de Física y Tecnología Oceanográfica, del Institut de Ciències del Mar (CSIC) en Barcelona, ha estado desarrollando como co-Investigador Principal de la parte de la misión SMOS de la ESA, una misión Earth Explorer, desde la perspectiva del Remote Sensing Lab, de la Universitat Politècnica de Catalunya. Seguramente, estamos olvidando algunas de sus muchas contribuciones a la teledetección de la salinidad, pero esperamos que esta revisión dé una idea de la importancia de su trabajo. Este artículo se focaliza en los siguientes puntos: 1) las medidas de alta calidad de la constante dieléctrica del agua marina, 2) las campañas de medidas WISE y EuroSTARRS que ayudaron a la definición del modelo geofísico relacionando la temperatura de brillo con el estado del mar, 3) la campaña de medidas FROG 2003 que ayudó a entender la emisión de la espuma marina 4) presentación de las técnicas de GNSS-R para la mejora de la recuperación de la salinidad superficial 5) campañas para la caracterización del instrumento y 6) la implantación del centro de procesado operacional de niveles 3 y 4 en el SMOS Barcelona Expert CentreThis work has been performed under research grants TEC2005-06863-C02-01/TCM, ESP2005-06823-C05 and ESP2007-65667-C04, AYA2008-05906-C02-01/ESP, AYA2010-22062-C05 and ESP2015-70014-C2-1-R, and EURYI 2004 awardPeer Reviewe

First NuSTAR Observations of Mrk 501 within a Radio to TeV Multi-Instrument Campaign

We report on simultaneous broadband observations of the TeV-emitting blazar Markarian 501 between 2013 April 1 and August 10, including the first detailed characterization of the synchrotron peak with Swift and NuSTAR. During the campaign, the nearby BL Lac object was observed in both a quiescent and an elevated state. The broadband campaign includes observations with NuSTAR, MAGIC, VERITAS, the Fermi Large Area Telescope, Swift X-ray Telescope and UV Optical Telescope, various ground-based optical instruments, including the GASP-WEBT program, as well as radio observations by OVRO, Metsähovi, and the F-Gamma consortium. Some of the MAGIC observations were affected by a sand layer from the Saharan desert, and had to be corrected using event-by-event corrections derived with a Light Detection and Ranging (LIDAR) facility. This is the first time that LIDAR information is used to produce a physics result with Cherenkov Telescope data taken during adverse atmospheric conditions, and hence sets a precedent for the current and future ground-based gamma-ray instruments. The NuSTAR instrument provides unprecedented sensitivity in hard X-rays, showing the source to display a spectral energy distribution (SED) between 3 and 79 keV consistent with a log-parabolic spectrum and hard X-ray variability on hour timescales. None (of the four extended NuSTAR observations) show evidence of the onset of inverse-Compton emission at hard X-ray energies. We apply a single-zone equilibrium synchrotron self-Compton (SSC) model to five simultaneous broadband SEDs. We find that the SSC model can reproduce the observed broadband states through a decrease in the magnetic field strength coinciding with an increase in the luminosity and hardness of the relativistic leptons responsible for the high-energy emission

Assessing the Effect of Four Types of Direct Mail Messages to Promote the Uptake of Residential Lead Remediation Funds

Objective To examine the efficacy of direct mailing using four types of messaging on promoting the uptake of residential lead remediation (RLR) funds in Lancaster, PA, USA. Study design We designed a quasi-experiment to assess the effect of 4 RLR messages sent to households in Lancaster, PA by direct mail between September and December 2020: a brief flyer (F); a detailed brochure + the flyer (BF); a health infographic + the flyer (IF); and an application form + the flyer (AFF). Methods Mailers were sent to addresses in four census tracts; each census tract received a different message. Both English and Spanish versions were sent. The outcomes were the event rate defined as the number of phone call inquiries received, and the number of applications received. The association between type of messaging and household type (owner-vs renter-occupied) was assessed using a chi square test. Results The event rates for the renter-occupied households were lower than for owner-occupied households, regardless of treatment. The event rates for renter-occupied households in the F, BF, IF and AFF groups were 0.00%, 0.35%, 0.12% and 0.18% respectively compared to 0.93%, 0.45%, 0.86% and 1.32% for homeowners. More applications were received from homeowners, and the event rate of the owner-occupied households was significantly different from that of renter-occupied homes (p-value = 0.001). Conclusions Event rates and applications received were higher for owner-occupied households than they were for renter-occupied households. Direct mailing of RLR information is feasible especially if households at high risk for lead poisoning are targeted

microRNA-184 induces a commitment switch to epidermal differentiation

miR-184 is a highly evolutionary conserved microRNA (miRNA) from fly to human. The importance of miR-184 was underscored by the discovery that point mutations in miR-184 gene led to corneal/lens blinding disease. However, miR-184-related function in vivo remained unclear. Here, we report that the miR-184 knockout mouse model displayed increased p63 expression in line with epidermal hyperplasia, while forced expression of miR-184 by stem/progenitor cells enhanced the Notch pathway and induced epidermal hypoplasia. In line, miR-184 reduced clonogenicity and accelerated differentiation of human epidermal cells. We showed that by directly repressing cytokeratin 15 (K15) and FIH1, miR-184 induces Notch activation and epidermal differentiation. The disease-causing miR-184C57U mutant failed to repress K15 and FIH1 and to induce Notch activation, suggesting a loss-of-function mechanism. Altogether, we propose that, by targeting K15 and FIH1, miR-184 regulates the transition from proliferation to early differentiation, while mis-expression or mutation in miR-184 results in impaired homeostasis

MicroRNAs in cardiac arrhythmia: DNA sequence variation of MiR-1 and MiR-133A in long QT syndrome.

Long QT syndrome (LQTS) is a genetic cardiac condition associated with prolonged ventricular repolarization, primarily a result of perturbations in cardiac ion channels, which predisposes individuals to life-threatening arrhythmias. Using DNA screening and sequencing methods, over 700 different LQTS-causing mutations have been identified in 13 genes worldwide. Despite this, the genetic cause of 30-50% of LQTS is presently unknown. MicroRNAs (miRNAs) are small (∼ 22 nucleotides) noncoding RNAs which post-transcriptionally regulate gene expression by binding complementary sequences within messenger RNAs (mRNAs). The human genome encodes over 1800 miRNAs, which target about 60% of human genes. Consequently, miRNAs are likely to regulate many complex processes in the body, indeed aberrant expression of various miRNA species has been implicated in numerous disease states, including cardiovascular diseases. MiR-1 and MiR-133A are the most abundant miRNAs in the heart and have both been reported to regulate cardiac ion channels. We hypothesized that, as a consequence of their role in regulating cardiac ion channels, genetic variation in the genes which encode MiR-1 and MiR-133A might explain some cases of LQTS. Four miRNA genes (miR-1-1, miR-1-2, miR-133a-1 and miR-133a-2), which encode MiR-1 and MiR-133A, were sequenced in 125 LQTS probands. No genetic variants were identified in miR-1-1 or miR-133a-1; but in miR-1-2 we identified a single substitution (n.100A> G) and in miR-133a-2 we identified two substitutions (n.-19G> A and n.98C> T). None of the variants affect the mature miRNA products. Our findings indicate that sequence variants of miR-1-1, miR-1-2, miR-133a-1 and miR-133a-2 are not a cause of LQTS in this cohort