Role of orientation reference selection in motion sickness

Previous experiments with moving platform posturography have shown that different people have varying abilities to resolve conflicts among vestibular, visual, and proprioceptive sensory signals used to control upright posture. In particular, there is one class of subjects with a vestibular disorder known as benign paroxysmal positional vertigo (BPPV) who often are particularly sensitive to inaccurate visual information. That is, they will use visual sensory information for the control of their posture even when that visual information is inaccurate and is in conflict with accurate proprioceptive and vestibular sensory signals. BPPV has been associated with disorders of both posterior semicircular canal function and possibly otolith function. The present proposal hopes to take advantage of the similarities between the space motion sickness problem and the sensory orientation reference selection problems associated with the BPPV syndrome. These similarities include both etiology related to abnormal vertical canal-otolith function, and motion sickness initiating events provoked by pitch and roll head movements. The objectives of this proposal are to explore and quantify the orientation reference selection abilities of subjects and the relation of this selection to motion sickness in humans

Normal and abnormal human vestibular ocular function

The major motivation of this research is to understand the role the vestibular system plays in sensorimotor interactions which result in spatial disorientation and motion sickness. A second goal was to explore the range of abnormality as it is reflected in quantitative measures of vestibular reflex responses. The results of a study of vestibular reflex measurements in normal subjects and preliminary results in abnormal subjects are presented in this report. Statistical methods were used to define the range of normal responses, and determine age related changes in function

Role of orientation reference selection in motion sickness

The overall objective of this proposal is to understand the relationship between human orientation control and motion sickness susceptibility. Three areas related to orientation control will be investigated. These three areas are (1) reflexes associated with the control of eye movements and posture, (2) the perception of body rotation and position with respect to gravity, and (3) the strategies used to resolve sensory conflict situations which arise when different sensory systems provide orientation cues which are not consistent with one another or with previous experience. Of particular interest is the possibility that a subject may be able to ignore an inaccurate sensory modality in favor of one or more other sensory modalities which do provide accurate orientation reference information. We refer to this process as sensory selection. This proposal will attempt to quantify subjects' sensory selection abilities and determine if this ability confers some immunity to the development of motion sickness symptoms. Measurements of reflexes, motion perception, sensory selection abilities, and motion sickness susceptibility will concentrate on pitch and roll motions since these seem most relevant to the space motion sickness problem. Vestibulo-ocular (VOR) and oculomotor reflexes will be measured using a unique two-axis rotation device developed in our laboratory over the last seven years. Posture control reflexes will be measured using a movable posture platform capable of independently altering proprioceptive and visual orientation cues. Motion perception will be quantified using closed loop feedback technique developed by Zacharias and Young (Exp Brain Res, 1981). This technique requires a subject to null out motions induced by the experimenter while being exposed to various confounding sensory orientation cues. A subject's sensory selection abilities will be measured by the magnitude and timing of his reactions to changes in sensory environments. Motion sickness susceptibility will be measured by the time required to induce characteristic changes in the pattern of electrogastrogram recordings while exposed to various sensory environments during posture and motion perception tests. The results of this work are relevant to NASA's interest in understanding the etiology of space motion sickness. If any of the reflex, perceptual, or sensory selection abilities of subjects are found to correlate with motion sickness susceptibility, this work may be an important step in suggesting a method of predicting motion sickness susceptibility. If sensory selection can provide a means to avoid sensory conflict, then further work may lead to training programs which could enhance a subject's sensory selection ability and therefore minimize motion sickness susceptibility

Age-related changes in human posture control: Motor coordination tests

Postural responses to support surface displacements were measured in 214 normal human subjects ranging in age from 7 to 81 years. Motor tests measured leg muscle Electromyography (EMG) latencies, body sway, and the amplitude and timing of changes in center of pressure displacements in response to sudden forward and backward horizontal translations of the support surface upon which the subjects stood. There were small increases in both EMG latencies and the time to reach the peak amplitude of center of pressure responses with increasing age. The amplitude of center of pressure responses showed little change with age if the amplitude measures were normalized by a factor related to subject height. In general, postural responses to sudden translations showed minimal changes with age, and all age related trends which were identified were small relative to the variability within the population

The Dynamics of Energy Systems and the Logistic Substitution Model. Vol. 2. Theoretical Part

The application of a certain rule, even if always successful in practice, confronts very strong psychological barriers if it lacks a certain logical frame linking it causally to the body of accepted knowledge. Phenomena rooted in social behavior are always very difficult to "explain" in such a way, because if we rely too much on the basic, irrational, and stochastic roots of our decisions, then the explanation is rejected as "too mechanistic". If on the other hand we rely on the perception people have of themselves, as rational and wise decision makers, then we fall into a maze of ad hoc explanations that strongly resembles local politics. Economists, who have faced a much similar problem, have made a great, partially successful, effort in describing and organizing the monetary measurables of human activity. Although they too miss primary causes they can introduce concepts of minimization and optimization which permit choices and structuring of the systems. Our attempt to "hook" the market penetration rules to the accepted scientific system have followed both routes. Fleck takes the stochastic "irrational" view. Social processes, and introduction of a new technology is a social process, are seen as the envelope of a maze of tiny decisions, causally unrelated, and, like nails in the path of a falling ball, slowing down its chute and "diffusing" its landing point. A good social example of this process is given by the diffusion of an infection e.g. the common flue. Although in a case-by-case analysis the biologist can give a fair causal description of the process, the contacts that lead to the diffusion are within another realm of causality and are better described stochastically. Learning processes are well described in such a way, and they yield logistic curves. Fleck then visualizes the diffusion of a technology as a social learning process under constraints. The stability of the curves is a mark of the stability of man and society as learning structures. The weak point of the theory is that the critical parameters have to be measured post hoc, and they are not reducible to other measurements that could be made before the penetration is initiated. Peterka on the other hand follows a more classical route, taking economics as a driving force. He assumes that an industry to expand has to generate profits. External capital can produce some time-shifts, providing actual money for expected gains, but the picture is not much blurred. Consequently, as substitution is driven by differential growth rates, these rates must be driven by differential profits. Perhaps a weak point of this theory is that differential profits must be constant (if smoothed) over long periods in order to produce well-behaved logistics. This feeds back to regular progress curves and automatic price leveling. We can invert the reasoning and look for the stable progress curves and price leveling whose existence can be postulated from the very regular evolution of market penetration curves. This would greatly add to our understanding of the system. The treatment by Peterka is quite general and produces curves which can specialize as logistic, but may also have more complex expressions. In general, the "graininess" of the data does not permit to distinguish between the various curves, and we usually stick to our logistic, which has the great advantage of straightforward simplicity. Altogether we think that the basic objective of the grant has been fulfilled. We explored the field experimentally showing the great efficiency of our model in organizing data, and we tried two ways to bring its working under logical scrutiny. The fact that during this operation we have presumably generated more problems than we solved is a good indication that we are plowing a fertile field

Age-related changes in human posture control: Sensory organization tests

Postural control was measured in 214 human subjects ranging in age from 7 to 81 years. Sensory organization tests measured the magnitude of anterior-posterior body sway during six 21 s trials in which visual and somatosensory orientation cues were altered (by rotating the visual surround and support surface in proportion to the subject's sway) or vision eliminated (eyes closed) in various combinations. No age-related increase in postural sway was found for subjects standing on a fixed support surface with eyes open or closed. However, age-related increases in sway were found for conditions involving altered visual or somatosensory cues. Subjects older than about 55 years showed the largest sway increases. Subjects younger than about 15 years were also sensitive to alteration of sensory cues. On average, the older subjects were more affected by altered visual cues whereas younger subjects had more difficulty with altered somatosensory cues

The Dynamics of Energy Systems and the Logistic Substitution Model. Executive Summary

This is a report on the work done at the International Institute for Applied Systems Analysis in 1976 to 1977 under a grant from Volkswagenwerk Foundation, whose objective was to explore the potential and the mechanisms of logistic analysis to describe the structure and the evolution of energy systems. Volume One contains the phenomenological part. About 300 cases were examined, some of which are reported in detail. The quality of the logistic description is generally excellent, even for cases extending 150 years into the past and with all the perturbations such a long time span entails, and consequently we thought it appropriate to extend the description into the future and use it for prediction. This was not really the objective of the grant but 'it naturally arises from the work and provides food for thought. Projections in the current literature appear to be in fact strongly inconsistent with the past, which casts doubts on their realizability, and are even internally inconsistent, which reinforces these doubts. The fact that numerous "free" choices at the social level lead to very regular overall patterns should perhaps temper the feeling of being caught in a deterministic clockwork. In Volume Two, devoted to the theoretical work, F. Fleck deals specifically with this problem showing the final regularity derived from a set of stochastic, i.e. "free", decisions. V. Peterka, on the other hand, operates at a more aggregated level, where one can start to speak of economic determinism. He describes a form of fate we are more ready to accept, if only grudgingly. Our exploration has generated more problems than we have solved; thus the field appears very fertile for future research

Role of orientation reference selection in motion sickness

Three areas related to human orientation control are investigated: (1) reflexes associated with the control of eye movements and posture; (2) the perception of body rotation and position with respect to gravity; and (3) the strategies used to resolve sensory conflict situations which arise when different sensory systems provide orientation cues which are not consistent with one another or with previous experience. Of particular interest is the possibility that a subject may be able to ignore an inaccurate sensory modality in favor of one or more other sensory modalities which do provide accurate orientation reference information. This process is referred as sensory selection. This proposal will attempt to quantify subject's sensory selection abilities and determine if this ability confers some immunity to the development of motion sickness symptoms

Age-related changes in human vestibulo-ocular reflexes: Sinusoidal rotation and caloric tests

The dynamic response properties of horizontal vestibulo-ocular reflex (VOR) were characterized in 216 human subjects ranging in age from 7 to 81 years. The object of this cross-sectional study was to determine the effects of aging on VOR dynamics, and to identify the distributions of parameters which describe VOR responses to caloric and to sinusoidal rotational stimuli in a putatively normal population. Caloric test parameters showed no consistent trend with age. Rotation test parameters showed declining response amplitude and slightly less compensatory response phase with increasing age. The magnitudes of these changes were not large relative to the variability within the population. The age-related trends in VOR were not consistent with the anatomic changes in the periphery reported by others which showed an increasing rate of peripheral hair cell and nerve fiber loss in subjects over 55 years. The poor correlation between physiological and anatomical data suggest that adaptive mechanisms in the central nervous system are important in maintaining the VOR

Age-related changes in human vestibulo-ocular and optokinetic reflexes: Pseudorandom rotation tests

The dynamic response properties of horizontal vestibulo-ocular reflex (VOR) and optokinetic reflex (OKR) were characterized in 216 human subjects ranging in age from 7 to 81 years. The object of this cross-sectional study was to determine the effects of aging on VOR and OKR reflex dynamics, and to identify the distributions of parameters which describe VOR and OKR responses to pseudorandom stimuli in a putatively normal population. In general, VOR and OKR response parameters changed in a manner consistent with declining function with increasing age. For the VOR this was reflected in declining response amplitudes, although the magnitude of the decline was small relative to the variability of the data. For the OKR the lag time of the response, probably associated with the time required for visual information processing, increased linearly with age at a rate of about 1 ms per year