Calderón-Zygmund operators and their commutators on generalized weighted Orlicz-Morrey spaces

In this paper, we obtain the necessary and sufficient conditions for the weak/strong boundedness of the Calderón-Zygmund operators in generalized weighted Orlicz-Morrey spaces. We also study the boundedness of the commutators of Calderón-Zygmund operators on these spaces. Moreover, the boundedness of Calderón-Zygmund operators in the vector-valued setting is given. © 202

Law Professor Comment Letter on Harmonization of Private Offering Rules

Comment letter filed on Sept. 24, 2019. File No. S7-08-19 We are fifteen law professors whose scholarship and teaching focuses on securities regulation. We appreciate the opportunity to comment on the U.S. Securities and Exchange Commission’s (“SEC” or the “Commission”) Concept Release on Harmonization of Securities Offering Exemptions (the “Concept Release”)

Minimal brain dysfunction in children of preschool age in the city of Makhachkala

To study the prevalence of minimal brain dysfunction (MBD) in children of preschool age in the city of Makhachkala 600 children were examined. In result of the conducted research it is established that MMD is observed in 72(12%) children. The symptoms of MMD were often found in children from 2.5 to 4.5 years – 48(8%).In mothers of children with MMD the complications were found during gestation in 61 (10,7%) cases. In the first year in children with MMD inflammatory diseases and 91.4%, complications inflammatory were observed: intracranial hypertension of 26.0%, complications after vaccination 83,0%, traumatic brain injury is 21.4%.С целью изучения распространенности минимальной мозговой дисфункции (ММД) у детей дошкольного возраста в г. Махачкала было обследовано 600 детей. В результате проведенного исследования установлено, что ММД наблюдается у 72(12%) детей. Чаще признаки ММД встречались у детей от 2,5 до 4,5 лет – 48(8%). У матерей детей с ММД в 61 (10,7%) случае отмечались осложнения во время гестации. В течение первого года у детей с ММД наблюдались заболевания воспалительного характера - 91,4%, осложнения не воспалительного характера: внутричерепная гипертензия 26,0%, осложнения после прививки 83,0%, черепно-мозговая травма 21,4%

Analysis of the etiological structure and antibiotic sensitivity of patents to infection of respiratory tract determined in Makhachkala

Infections of the pulmonary system, being the most common pathologies in humans, can cause serious complications. In this regard, it is essential to select etiopathogen and to provide adequate treatment of different clinical forms of respiratory infections, to solve the issue of necessary, the appointment of antibacterial therapy, to choose the drugs most active against the alleged causal germs. In recent years, there has been an increasing amount of evidence that has led to a review of traditional views on the etiology and regimens of antibacterial chemotherapy for respiratory infections.Инфекции органов легочной системы, являясь наиболее частыми патологиями у человека, могут стать причиной серьезных осложнений. В связи с этим крайне важно выделить этиопатоген и обеспечить адекватное лечение различных клинических форм респираторных инфекций, решить вопрос о необходимости назначения антибактериальной терапии, выбрать препараты, наиболее активные в отношении предполагаемых причинных микробов. В последние годы отмечается все больше данных, которые заставляют пересмотреть традиционные взгляды на этиологию и схемы антибактериальной химиотерапии респираторных инфекций

Случай из практики: капсуло‑ассоциированный плоскоклеточный рак молочнойжелезы

Breast augmentation with the use of silicone breast implants is a routine practice for breast surgeons. Breast implant capsule‑associated squamous cell carcinoma is a rare and aggressive malignant tumor accounting for less than 0,1 % of invasive breast cancer. Currently there is no single concept of a complex therapy for such tumors due to the low incidence rate. The article describes a case of a 49‑year‑old female patient after surgical treatment of left‑sided breast implant capsule‑associated squamous cell carcinoma diagnosed in 2019. After the disease progression the patient underwent removal of the chest wall tumor with resection of ribs 3–5, allo‑and autoplasty, and left axillary lymph node dissection (ALND). In most cases, breast implant capsule‑associated squamous cell carcinoma is treated surgically but the role of adjuvant chemotherapy, radiation therapy, and endocrine therapy is still ambiguous.Выполнение аугментационной маммопластики молочных желез с использованием силиконовых эндопротезов является рутинной практикой онкомаммологов. Капсуло-ассоциированный плоскоклеточный рак молочной железы является редким и агрессивным злокачественным новообразованием, составляющим менее 0,1 % от инвазивного рака молочного железы.До настоящего времени в связи с низкой заболеваемостью подобными опухолями не существует единой концепции в комплексном лечении данной патологии. В статье описывается случай лечения пациентки 49 лет после хирургического удаления капсуло-ассоциированного плоскоклеточного рака левой молочной железы в 2019 году. После прогрессирования заболевания спустя год пациентке выполнено удаление опухоли грудной стенки с резекцией 3–5 ребер, алло-и аутопластикой, подмышечной лимфаденэктомией (ЛАЭ) слева. В большинстве случаев, основным лечением капсуло-ассоциированного плоскоклеточного рака молочной железы является хирургическое вмешательство, однако роль адъювантной химиотерапии, лучевой терапии и эндокринотерапии все еще не однозначна

Clinical features of post-COVID-19 period. Results of the international register “Dynamic analysis of comorbidities in SARS-CoV-2 survivors (AKTIV SARS-CoV-2)”. Data from 6-month follow-up

Aim. To study the clinical course specifics of coronavirus disease 2019 (COVID-19) and comorbid conditions in COVID-19 survivors 3, 6, 12 months after recovery in the Eurasian region according to the AKTIV register. Material and methods.The AKTIV register was created at the initiative of the Eurasian Association of Therapists. The AKTIV register is divided into 2 parts: AKTIV 1 and AKTIV 2. The AKTIV 1 register currently includes 6300 patients, while in AKTIV 2 — 2770. Patients diagnosed with COVID-19 receiving in- and outpatient treatment have been anonymously included on the registry. The following 7 countries participated in the register: Russian Federation, Republic of Armenia, Republic of Belarus, Republic of Kazakhstan, Kyrgyz Republic, Republic of Moldova, Republic of Uzbekistan. This closed multicenter register with two nonoverlapping branches (in- and outpatient branch) provides 6 visits: 3 in-person visits during the acute period and 3 telephone calls after 3, 6, 12 months. Subject recruitment lasted from June 29, 2020 to October 29, 2020. Register will end on October 29, 2022. A total of 9 fragmentary analyzes of the registry data are planned. This fragment of the study presents the results of the post-hospitalization period in COVID-19 survivors after 3 and 6 months. Results. According to the AKTIV register, patients after COVID-19 are characterized by long-term persistent symptoms and frequent seeking for unscheduled medical care, including rehospitalizations. The most common causes of unplanned medical care are uncontrolled hypertension (HTN) and chronic coronary artery disease (CAD) and/or decompensated type 2 diabetes (T2D). During 3- and 6-month follow-up after hospitalization, 5,6% and 6,4% of patients were diagnosed with other diseases, which were more often presented by HTN, T2D, and CAD. The mortality rate of patients in the post-hospitalization period was 1,9% in the first 3 months and 0,2% for 4-6 months. The highest mortality rate was observed in the first 3 months in the group of patients with class II-IV heart failure, as well as in patients with cardiovascular diseases and cancer. In the pattern of death causes in the post-hospitalization period, following cardiovascular causes prevailed (31,8%): acute coronary syndrome, stroke, acute heart failure. Conclusion. According to the AKTIV register, the health status of patients after COVID-19 in a serious challenge for healthcare system, which requires planning adequate health system capacity to provide care to patients with COVID-19 in both acute and post-hospitalization period