Self-dual Ginzburg-Landau vortices in a disk

We study the properties of the Ginzburg-Laundau model in the self-dual point for a two-dimensional finite system . By a numerical calculation we analyze the solutions of the Euler-Lagrange equations for a cylindrically symmetric ansatz. We also study the self-dual equations for this case. We find that the minimal energy configurations are not given by the Bogomol'nyi equations but by solutions to the Euler Lagrange ones. With a simple approximation scheme we reproduce the result of the numerical calculation.Comment: 8 pages, 4 figures, RevTex macro

Parasites of the red fox (Vulpes vulpes Linnaeus, 1758) in Murcia, southeast Spain

© 2007This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/. This document is the Published version of a Published Work that appeared in final form in Revue Médicine Vétérinaire.Fifty five red foxes were captured in Murcia province (Southeast Spain) and necropsied to evaluate parasitic infections. Fifteen helminth species were found, including five cestodes (Mesocestoides lineatus, Mesocestoides litteratus, Joyeuxiella pasqualei, Taenia pisiformis and Dipylidium caninum), nine nematodes (Pterygodermatites affinis, Toxocara canis, Trichuris vulpis, Toxascaris leonina, Oxynema crassispiculum, Eucoleus (Capillaria) aerophilus, Toxocara cati, Uncinaria stenocephala and Angiostrongylus, vasorum), and one acanthocephalan (Macracanthorhynchus catulinus). Coprological method revealed the presence of, Isospora spp. oocysts. Also, fleas and ticks were recovered from the carcasses, corresponding to Pulex irritans, Spilopsyllus cuniculi, Ctenocephalides felis felis, Rhipicephalus sanguineus, Ixodes ventalloi, and Ixodes ricinus. Both S. cuniculi and C. felis felis are first records in foxes in the Iberian PeninsulaNous avons réalisé une étude parasitologique chez le renard roux (Vulpes vulpes) dans la province de Murcie (sud-est de l’Espagne). Au total, 55 renards ont été collectés et autopsiés. L’examen coprologique parasitaire a révélé la présence d’oocystes d’Isospora spp. Nous avons trouvé quinze espèces de helminthes, desquels cinq sont cestodes (Mesocestoides lineatus, Mesocestoides litteratus, Joyeuxiella pasqualei, Taenia pisiformis et Dipylidium caninum) et neuf nématodes (Pterygodermatites affinis, Toxocara canis, Trichuris vulpis, Toxascaris leonina, Oxynema crassispiculum, Eucoleus (Capillaria) aerophilus, Toxocara cati, Uncinaria stenocephala et Angiostrongylus vasorum), et une espèce d’acanthocephalan (Macracanthorhynchus catulinus). Par ailleurs, nous avons identifié des puces et des tiques appartenant aux espèces Pulex irritans, Spilopsyllus cuniculi, Ctenocephalides felis felis, Rhipicephalus sanguineus, Ixodes ventalloi et Ixodes ricinus. C’est la première fois que S. cuniculi et C. felis felis ont été décrits chez le renard dans la Péninsule Ibérique

Non BPS noncommutative vortices

We construct exact vortex solutions to the equations of motion of the Abelian Higgs model defined in non commutative space, analyzing in detail the properties of these solutions beyond the BPS point. We show that our solutions behave as smooth deformations of vortices in ordinary space time except for parity symmetry breaking effects induced by the non commutative parameter $\theta$.Comment: 17 pages, 5 figure

Evolución de la innovación educativa en la Universidad Complutense: proyecto UNICOMEX

La evolución de la educación universitaria en España ha experimentado una enorme evolución en los últimos veinte años. Desde la enseñanza centrada en la clase magistral, con el consiguiente protagonismo del profesor, a lo que sucede actualmente, con el estudiante como eje principal, media todo un cambio en el planteamiento de nuestro sistema educativo universitario. La implantación del Espacio Europeo de Educación Superior (EEES) ha sido uno de los objetivos perseguidos por la Universidad Complutense de Madrid (UCM) en la última década. Con este fin existieron, hasta hace poco, las conocidas como Asignaturas Piloto (AP) e igualmente se convocan periódicamente, desde hace años, los Proyectos de Innovación Educativa (P.I.E.). Ambas herramientas han procurado facilitar dicha adaptación, así como promover un concepto transversal en la transmisión del conocimiento. Nuestro grupo de trabajo puede ser un ejemplo de lo que la UCM ha querido conseguir con ambas cosas. La asignatura ha participado en todas las convocatorias de AP, pasando por una evolución clara desde la clase magistral a los pequeños grupos de trabajo. Ha sido, además, el instrumento útil para ir desarrollando distintos P.I.E., hasta un total de nueve, tras formar un equipo interdisciplinar constituido por profesores universitarios y profesionales de diversos ámbitos. El último de estos PIE, concedido en el curso académico 2011-2012, consiste en la creación de un espacio virtual de referencia para el estudio de los animales exóticos, partiendo de los resultados obtenidos en proyectos anteriores. UNICOMEX (Universidad-Complutense-Exóticos) nace con el objetivo de poner al alcance de cualquiera una serie de recursos virtuales ordenados que faciliten el conocimiento biológico, anatómico y clínico de los animales exóticos, entendiendo como tales aquellos que, siendo de interés veterinario, no se consideran domésticos. La totalidad de su contenido está en español e inglés, con el fin de hacer de ella una herramienta virtual útil y abierta a la comunidad científica y didáctica internacional

TRIB3 silencing promotes the downregulation of Akt pathway and PAX3-FOXO1 in high-risk rhabdomyosarcoma

Fusion protein; RhabdomyosarcomaProteïna de fusió; RabdomiosarcomaProteína de fusión; RabdomiosarcomaRhabdomyosarcoma (RMS), such as other childhood tumors, has witnessed treatment advancements in recent years. However, high-risk patients continue to face poor survival rates, often attributed to the presence of the PAX3/7-FOXO1 fusion proteins, which has been associated with metastasis and treatment resistance. Despite efforts to directly target these chimeric proteins, clinical success remains elusive. In this study, the main aim was to address this challenge by investigating regulators of FOXO1. Specifically, we focused on TRIB3, a potential regulator of the fusion protein in RMS. Our findings revealed a prominent TRIB3 expression in RMS tumors, highlighting its correlation with the presence of fusion protein. By conducting TRIB3 genetic inhibition experiments, we observed an impairment on cell proliferation. Notably, the knockdown of TRIB3 led to a decrease in PAX3-FOXO1 and its target genes at protein level, accompanied by a reduction in the activity of the Akt signaling pathway. Additionally, inducible silencing of TRIB3 significantly delayed tumor growth and improved overall survival in vivo. Based on our analysis, we propose that TRIB3 holds therapeutic potential for treating the most aggressive subtype of RMS. The findings herein reported contribute to our understanding of the underlying molecular mechanisms driving RMS progression and provide novel insights into the potential use of TRIB3 as a therapeutic intervention for high-risk RMS patients.This research was funded by grants from Institut Català d’Oncologia (ICO), Instituto de Salud Carlos III (PI21/00640), Fundació la Marató de TV3, Fundació BOSCH, Iniciativa Tot per tu, Fundació Amics Joan Petit, Fundación Inocente, and Mi compañero de viaje

The QUIJOTE experiment: project overview and first results

QUIJOTE (Q-U-I JOint TEnerife) is a new polarimeter aimed to characterize the polarization of the Cosmic Microwave Background and other Galactic and extragalactic signals at medium and large angular scales in the frequency range 10-40 GHz. The multi-frequency (10-20~GHz) instrument, mounted on the first QUIJOTE telescope, saw first light on November 2012 from the Teide Observatory (2400~m a.s.l). During 2014 the second telescope has been installed at this observatory. A second instrument at 30~GHz will be ready for commissioning at this telescope during summer 2015, and a third additional instrument at 40~GHz is now being developed. These instruments will have nominal sensitivities to detect the B-mode polarization due to the primordial gravitational-wave component if the tensor-to-scalar ratio is larger than r=0.05.Comment: To appear in "Highlights of Spanish Astrophysics VIII", Proceedings of the XI Scientific Meeting of the Spanish Astronomical Society, Teruel, Spain (2014

QUIJOTE Experiment: status of telescopes and instrumentation

The QUIJOTE Experiment (Q-U-I JOint TEnerife) is a combined operation of two telescopes and three instruments working in the microwave band to measure the polarization of the Cosmic Microwave Background (CMB) from the northern hemisphere, at medium and large angular scales. The experiment is located at the Teide Observatory in Tenerife, one of the seven Canary Islands (Spain). The project is a consortium maintained by several institutions: the Instituto de Astrofísica de Canarias (IAC), the Instituto de Física de Cantabria (IFCA), the Communications Engineering Department (DICOM) at Universidad de Cantabria, and the Universities of Manchester and Cambridge. The consortium is led by the IAC