SELECTIVE ORGANIC SYNTHESIS FOR SUSTAINABLE DEVELOPMENT

The data on the development of selective organic synthesis suitable for obtaining multifunctional organic compounds both linear and cyclic structures using environmentally benign, inexpensive and renewable resources summarized. This article is an extended abstract of a communication presented at the Conference Ecological Chemistry 201

Influence of external factors on the composition and therapeutic efficiency of propolis

Universitatea de Stat de Medicină și Farmacie „Nicolae Testemiţanu” din Republica Moldova, Institutul de Chimie afiliat Academiei de Știinţe al Republicii Moldova, Chișinău, Republica Moldova, Universitatea de Știinţe Agricole și Medicină Veterinară, Cluj-Napoca, România, Universitatea Agrară de Stat din Moldova, Chișinău, Republica MoldovaAbstract. From therapeutic point of view, propolis is one of the most valuable bee products, which proves its use in various pharmaceutical forms, and further research of this product worldwide. However the complex and diverse composition requires a complex study of both propolis and the factors that lead to the modification of the composition and respectively inevitably to the change of the therapeutic properties. This paper is a synthesis of the effects of the use of herbicides and insecticides on the composition and therapeutic properties of propolis. It was established that the presence of certain herbicides and insecticides propolis samples collected in different geographic areas, as is concluded to decrease the effect of the presence of the therapeutic properties of propolis in the presence of polluting factors mentioned above.Rezumat. Din punct de vedere terapeutic, propolisul reprezintă una dintre cele mai valoroase substanţe biologic active apicole, fapt dovedit de utilizarea lui tot mai largă în diverse prescripţii și forme farmaceutice, și studiul lui centrat, reluat în pandemie, la nivel mondial. Compoziţia complexă și diversă, necesită un studiu la fel de complex, atât al propolisului, cât și al factorilor ce pot duce la modificarea compoziţiei, și respectiv, la schimbarea potenţialului terapeutic. Lucrarea reprezintă o sinteză prioritar axată pe rezultatele studiilor efectelor utilizării erbicidelor și insecticidelor asupra compoziţiei și potenţialului terapeutic al propolisului. Astfel, prezenţa unor erbicide și insecticide în mostrele de propolis colectat în diferite zone geografice și climacterice, influenţează direct compoziţia propolisului, condiţionând diminuarea substanţială a potenţialului lui terapeutic

SYNTHESIS OF MONO-SUBSTITUTED AND SIMMETRICALLY 2, 5-DISUBSTITUTED 1, 3, 4-OXADIAZOLES

In recent years 1,3,4-oxadiazoles have received considerable attention due to their wide range of biological activities and practical importance. They form an important class of fi ve-member heterocyclic compounds with a variety of derivatives. This review will focus on several methods of synthesis for mono-substituted and symmetrically 2,5-disubstituted 1,3,4-oxadiazoles

THE REACTIONS OF (+)-2- AND (+)-3-CARENES WITH THE RETENTION OF THE BICYCLIC FRAMEWORK

Carane-type compounds have attracted attention in recent years due to their practical importance. This review is focused on describing the developments in the synthesis of trimethylbicyclo[4.1.0]heptanes and their unsaturated analogues from monoterpenes (+)-2- and (+)-3-carenes published mostly during the last decade

ADVANCES IN ORGANIC, BIOORGANIC AND NATURAL PRODUCTS CHEMISTRY IN THE INSTITUTE OF CHEMISTRY OF THE ACADEMY OF SCIENCES OF MOLDOVA

This overview deals with the advances in the investigation in the fi eld of organic, bioorganic and naturalproducts chemistry as well as the biologically active compounds in the Institute of Chemistry of the Academy of Sciences of Moldova

OCCURRENCE AND CHEMISTRY OF DIHYDROXYFUMARIC ACID

The paper summarizes literature data on occurrence of dihydroxyfumaric acid and its role in biological systems, as well as its chemical properties

OBSERVATIONS ON THE ANTIOXIDANT ACTIVITY OF NOVEL DIHYDROXYFUMARIC ACID DERIVATIVES

The paper describes the syntheses of new derivatives of dihydroxyfumaric acid and investigations of their antioxidant activities using the DPPH method

OPTICALLY ACTIVE CHRYSANTHEMIC ACID AND ITS ANALOGUES

Optically active chrysanthemic acid and its analogues have received considerable attention in recent years due to their practical importance. This review will focus on describing the developments in the synthesis of optically active chrysanthemic acid and its analogues. The transformation that will be covered includes the chemistry of enantiomerically pure 2,2-dimethyl 1,3-disubstituted cyclopropanes derived from monoterpene (+)-3-carene

NEW CATALYTIC SYSTEM FOR PREPARATION OF METHYL 2-(3-HYDROXY-2-OXO-2,3-DIHYDRO-1H-3- INDOLYL)ACRYLATES

A novel catalyst derived from the nitrile functionalized ionic liquids and DMAP promoted the MoritaBaylis-Hillman reaction of N-substituted isatines and the methyl acrylate with moderate up to high yields

Total Syntheses of Xiamycins A, C, F, H and Oridamycin A and Preliminary Evaluation of their Anti‐Fungal Properties

Divergent and enantiospecific total syntheses of the indolosesquiterpenoids xiamycins A, C, F, H and oridamycin A have been accomplished. The syntheses, which commence from (R)-carvone, employ a key photoinduced benzannulation sequence to forge the carbazole moiety characteristic of these natural products. Late-stage diversification from a common intermediate enabled the first syntheses of xiamycins C and F, and an unexpected one-pot oxidative decarboxylation, which may prove general, led to xiamycin H. All synthetic intermediates and the natural products were tested for anti-fungal activity. Xiamycin H emerged as an inhibitor of three agriculturally relevant fungal pathogens