73 research outputs found
The influence of long-range correlated defects on critical ultrasound propagation in solids
The effect of long-range correlated quenched structural defects on the
critical ultrasound attenuation and sound velocity dispersion is studied for
three-dimensional Ising-like systems. A field-theoretical description of the
dynamic critical effects of ultrasound propagation in solids is performed with
allowance for both fluctuation and relaxation attenuation mechanisms. The
temperature and frequency dependences of the dynamical scaling functions of the
ultrasound critical characteristics are calculated in a two-loop approximation
for different values of the correlation parameter of the Weinrib-Halperin
model with long-range correlated defects. The asymptotic behavior of the
dynamical scaling functions in hydrodynamic and critical regions is separated.
The influence of long-range correlated disorder on the asymptotic behavior of
the critical ultrasonic anomalies is discussed.Comment: 12 RevTeX pages, 3 figure
Quantization and Compressive Sensing
Quantization is an essential step in digitizing signals, and, therefore, an
indispensable component of any modern acquisition system. This book chapter
explores the interaction of quantization and compressive sensing and examines
practical quantization strategies for compressive acquisition systems.
Specifically, we first provide a brief overview of quantization and examine
fundamental performance bounds applicable to any quantization approach. Next,
we consider several forms of scalar quantizers, namely uniform, non-uniform,
and 1-bit. We provide performance bounds and fundamental analysis, as well as
practical quantizer designs and reconstruction algorithms that account for
quantization. Furthermore, we provide an overview of Sigma-Delta
() quantization in the compressed sensing context, and also
discuss implementation issues, recovery algorithms and performance bounds. As
we demonstrate, proper accounting for quantization and careful quantizer design
has significant impact in the performance of a compressive acquisition system.Comment: 35 pages, 20 figures, to appear in Springer book "Compressed Sensing
and Its Applications", 201
Pressure control of magnetic clusters in strongly inhomogeneous ferromagnetic chalcopyrites
Room-temperature ferromagnetism in Mn-doped chalcopyrites is a desire aspect when applying those materials to spin electronics. However, dominance of high Curie-temperatures due to cluster formation or inhomogeneities limited their consideration. Here we report how an external perturbation such as applied hydrostatic pressure in CdGeP2:Mn induces a two serial magnetic transitions from ferromagnet to non-magnet state at room temperature. This effect is related to the unconventional properties of created MnP magnetic clusters within the host material. Such behavior is also discussed in connection with ab initio density functional calculations, where the structural properties of MnP indicate magnetic transitions as function of pressure as observed experimentally. Our results point out new ways to obtain controlled response of embedded magnetic clusters
The influence of the mechanically activated amorphous form of calcium gluconate on the metabolism and mineral density of bone tissue in dental implantation in patients with chronic generalized periodontitis
The influence of mechanoactivated (nanodispersed) form of calcium gluconate (inside and locally) on the bone mineral density (BMD) and osteointegration processes in 89 patients aged 35-44 with chronic generalized periodontitis with reduced BMD within T-score from -1.1 to -2.5 SD was evaluated. The clinical condition, indicators of mineral metabolism (Ca, Mg, P) in blood plasma, markers of bone remodeling were studied. The inclusion of traditional training and accepted Protocol of dental implant receiving mechanically activated (nanosized) amorphous form of calcium gluconate in patients with chronic generalized periodontitis with reduced mineral density of bone tissue contributes to the correction of calcium-phosphorus metabolism and bone metabolism with the improvement of osseointegration of dental implants.ΠΡΠΎΠ²Π΅Π΄Π΅Π½Π° ΠΎΡΠ΅Π½ΠΊΠ° Π²Π»ΠΈΡΠ½ΠΈΡ ΠΌΠ΅Ρ
Π°Π½ΠΎΠ°ΠΊΡΠΈΠ²ΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠΉ (Π½Π°Π½ΠΎΠ΄ΠΈΡΠΏΠ΅ΡΡΠ½ΠΎΠΉ) ΡΠΎΡΠΌΡ ΠΊΠ°Π»ΡΡΠΈΡ Π³Π»ΡΠΊΠΎΠ½Π°ΡΠ° (Π²Π½ΡΡΡΡ ΠΈ ΠΌΠ΅ΡΡΠ½ΠΎ) Π½Π° ΠΌΠΈΠ½Π΅ΡΠ°Π»ΡΠ½ΡΡ ΠΏΠ»ΠΎΡΠ½ΠΎΡΡΡ ΠΊΠΎΡΡΠ½ΠΎΠΉ ΡΠΊΠ°Π½ΠΈ (ΠΠΠΊΡ) ΠΈ ΠΏΡΠΎΡΠ΅ΡΡΡ ΠΎΡΡΠ΅ΠΎΠΈΠ½ΡΠ΅Π³ΡΠ°ΡΠΈΠΈ Ρ 89 ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Π² Π²ΠΎΠ·ΡΠ°ΡΡΠ΅ 35-44 Π³ΠΎΠ΄Π° Ρ Ρ
ΡΠΎΠ½ΠΈΡΠ΅ΡΠΊΠΈΠΌ Π³Π΅Π½Π΅ΡΠ°Π»ΠΈΠ·ΠΎΠ²Π°Π½Π½ΡΠΌ ΠΏΠ°ΡΠΎΠ΄ΠΎΠ½ΡΠΈΡΠΎΠΌ ΡΠΎ ΡΠ½ΠΈΠΆΠ΅Π½Π½ΠΎΠΉ ΠΠΠΊΡ Π² ΠΏΡΠ΅Π΄Π΅Π»Π°Ρ
Ρ-score ΠΎΡ -1,1 Π΄ΠΎ -2,5 SD. ΠΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΎ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΎΠ΅ ΡΠΎΡΡΠΎΡΠ½ΠΈΠ΅, ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»ΠΈ ΠΌΠΈΠ½Π΅ΡΠ°Π»ΡΠ½ΠΎΠ³ΠΎ ΠΎΠ±ΠΌΠ΅Π½Π° (Ca, Mg, P) Π² ΠΏΠ»Π°Π·ΠΌΠ΅ ΠΊΡΠΎΠ²ΠΈ, ΠΌΠ°ΡΠΊΡΡΡ ΠΊΠΎΡΡΠ½ΠΎΠ³ΠΎ ΡΠ΅ΠΌΠΎΠ΄Π΅Π»ΠΈΡΠΎΠ²Π°Π½ΠΈΡ. ΠΠΊΠ»ΡΡΠ΅Π½ΠΈΠ΅ Π² ΡΡΠ°Π΄ΠΈΡΠΈΠΎΠ½Π½ΡΡ ΠΏΠΎΠ΄Π³ΠΎΡΠΎΠ²ΠΊΡ ΠΈ ΠΏΡΠΈΠ½ΡΡΡΠΉ ΠΏΡΠΎΡΠΎΠΊΠΎΠ» Π΄Π΅Π½ΡΠ°Π»ΡΠ½ΠΎΠΉ ΠΈΠΌΠΏΠ»Π°Π½ΡΠ°ΡΠΈΠΈ ΠΏΡΠΈΡΠΌΠ° ΠΌΠ΅Ρ
Π°Π½ΠΎΠ°ΠΊΡΠΈΠ²ΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠΉ (Π½Π°Π½ΠΎΠ΄ΠΈΡΠΏΠ΅ΡΡΠ½ΠΎΠΉ) Π°ΠΌΠΎΡΡΠ½ΠΎΠΉ ΡΠΎΡΠΌΡ ΠΊΠ°Π»ΡΡΠΈΡ Π³Π»ΡΠΊΠΎΠ½Π°ΡΠ° Ρ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Ρ Ρ
ΡΠΎΠ½ΠΈΡΠ΅ΡΠΊΠΈΠΌ Π³Π΅Π½Π΅ΡΠ°Π»ΠΈΠ·ΠΎΠ²Π°Π½Π½ΡΠΌ ΠΏΠ°ΡΠΎΠ΄ΠΎΠ½ΡΠΈΡΠΎΠΌ ΡΠΎ ΡΠ½ΠΈΠΆΠ΅Π½Π½ΠΎΠΉ ΠΌΠΈΠ½Π΅ΡΠ°Π»ΡΠ½ΠΎΠΉ ΠΏΠ»ΠΎΡΠ½ΠΎΡΡΡΡ ΠΊΠΎΡΡΠ½ΠΎΠΉ ΡΠΊΠ°Π½ΠΈ ΡΠΏΠΎΡΠΎΠ±ΡΡΠ²ΡΠ΅Ρ ΠΊΠΎΡΡΠ΅ΠΊΡΠΈΠΈ ΡΠΎΡΡΠΎΡΠ½ΠΎ-ΠΊΠ°Π»ΡΡΠΈΠ΅Π²ΠΎΠ³ΠΎ ΠΎΠ±ΠΌΠ΅Π½Π° ΠΈ ΠΌΠ΅ΡΠ°Π±ΠΎΠ»ΠΈΠ·ΠΌΠ° ΠΊΠΎΡΡΠ½ΠΎΠΉ ΡΠΊΠ°Π½ΠΈ Ρ ΡΠ»ΡΡΡΠ΅Π½ΠΈΠ΅ΠΌ ΠΎΡΡΠ΅ΠΎΠΈΠ½ΡΠ΅Π³ΡΠ°ΡΠΈΠΈ ΠΈ ΠΈΠΌΠΏΠ»Π°Π½ΡΠ°ΡΠΈΠΈ Π·ΡΠ±ΠΎΠ²
Angiotensin-converting enzyme activity and polymorphism of the angiotensin II type 1 receptor gene at hemorrhagic fever with renal syndrome
The research aimed to explore the changes of angiotensin-converting enzyme (ACE) blood activity and polymorphism of the angiotensin II type 1 receptor gene as disease predictor at hemorrhagic fever with renal syndrome (HFRS). In examination 409 patients at the age of 15 - 65 years were involved. ACE blood activity with the help of Buhlmann (Switzerland) ACE kinetic test was determined. Blood genomic DNA by phenol- chloroformic extraction was isolated, genetic locuses by polymerase chain reaction of DNA synthesis were researched. It was shown that the ACE blood activity at HFRS is risen and these changes the significanter the severer form of disease. Nonsignificant rising of enzyme activity only in feveric period of both ungravic and gravic forms was observed. In gravic form significant changes of ACE activity are observed, in complicated form - stable high enzyme activity during all disease took place. Analysis of angiotensin II type 1 receptor gene polymorphism shown that alleles * A1166 and *C1166, genotypes *A1166/* A1166 and * C1166/*C1166 are not associated with HFRS severity. Made conclusion that high ACE activity is not adaptive reaction due to defect in angiotensin II binding and it is an adequate metabolic response of an organism to endotheliotropic virus action.Π¦Π΅Π»Ρ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ - ΠΈΠ·ΡΡΠ΅Π½ΠΈΠ΅ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ Π°Π½Π³ΠΈΠΎΡΠ΅Π½Π·ΠΈΠ½ΠΏΡΠ΅Π²ΡΠ°ΡΠ°ΡΡΠ΅Π³ΠΎ ΡΠ΅ΡΠΌΠ΅Π½ΡΠ° (ΠΠΠ€) Π² ΡΡΠ²ΠΎΡΠΎΡΠΊΠ΅ ΠΊΡΠΎΠ²ΠΈ ΠΈ ΠΏΠΎΠ»ΠΈΠΌΠΎΡΡΠΈΠ·ΠΌΠ° Π³Π΅Π½Π° ΡΠ΅ΡΠ΅ΠΏΡΠΎΡΠ° Π°Π½Π³ΠΈΠΎΡΠ΅Π½Π·ΠΈΠ½Π° II (AT II) 1 ΡΠΈΠΏΠ° ΠΏΡΠΈ Π³Π΅ΠΌΠΎΡΡΠ°Π³ΠΈΡΠ΅ΡΠΊΠΎΠΉ Π»ΠΈΡ
ΠΎΡΠ°Π΄ΠΊΠ΅ Ρ ΠΏΠΎΡΠ΅ΡΠ½ΡΠΌ ΡΠΈΠ½Π΄ΡΠΎΠΌΠΎΠΌ (ΠΠΠΠ‘) ΠΊΠ°ΠΊ Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎΠ³ΠΎ ΠΏΡΠ΅Π΄ΠΈΠΊΡΠΎΡΠ° Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΡ. ΠΠ±ΡΠ»Π΅Π΄ΠΎΠ²Π°Π½Ρ 409 Π±ΠΎΠ»ΡΠ½ΡΡ
Ρ ΡΠ΅ΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈ ΠΏΠΎΠ΄ΡΠ²Π΅ΡΠΆΠ΄Π΅Π½Π½ΡΠΌ ΠΌΠ΅ΡΠΎΠ΄ΠΎΠΌ Π ΠΠΠ€ Π΄ΠΈΠ°Π³Π½ΠΎΠ·ΠΎΠΌ ΠΠΠΠ‘ Π² Π²ΠΎΠ·ΡΠ°ΡΡΠ΅ ΠΎΡ 15 Π΄Ρ 65 Π»Π΅Ρ. ΠΠΊΡΠΈΠ²Π½ΠΎΡΡΡ ΠΠΠ€ ΠΎΠΏΡΠ΅Π΄Π΅Π»ΡΠ»Π°ΡΡ ΠΊΠΈΠ½Π΅ΡΠΈΡΠ΅ΡΠΊΠΈ Ρ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΠ΅ΠΌ Π½Π°Π±ΠΎΡΠ° ΡΠΈΡΠΌΡ Buhlmann (Π¨Π²Π΅ΠΉΡΠ°ΡΠΈΡ). ΠΠ΅Π½ΠΎΠΌΠ½Π°Ρ ΠΠΠ ΠΈΠ· ΠΏΠ΅ΡΠΈΡΠ΅ΡΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΊΡΠΎΠ²ΠΈ Π²ΡΠ΄Π΅Π»ΡΠ»Π°ΡΡ ΠΌΠ΅ΡΠΎΠ΄ΠΎΠΌ ΡΠ΅Π½ΠΎΠ»-Ρ
Π»ΠΎΡΠΎΡΠΎΡΠΌΠ½ΠΎΠΉ ΡΠΊΡΡΡΠ°ΠΊΡΠΈΠΈ, Π³Π΅Π½ΠΎΡΠΈΠΏΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ Π»ΠΎΠΊΡΡΠΎΠ² ΠΈΠ·ΡΡΠ°Π΅ΠΌΠΎΠΉ ΠΠΠ ΠΏΡΠΎΠ²ΠΎΠ΄ΠΈΠ»Π°ΡΡ ΠΌΠ΅ΡΠΎΠ΄ΠΎΠΌ ΠΠ¦Π ΡΠΈΠ½ΡΠ΅Π·Π° ΠΠΠ. ΠΠΊΡΠΈΠ²Π½ΠΎΡΡΡ ΠΠΠ€ Π·Π°Π²ΠΈΡΠΈΡ ΠΈ ΠΎΡ ΡΠΎΡΠΌΡ, ΠΈ ΠΎΡ ΠΏΠ΅ΡΠΈΠΎΠ΄Π° ΠΠΠΠ‘: ΡΡΠ°ΡΠΈΡΡΠΈΡΠ΅ΡΠΊΠΈ Π½Π΅Π·Π½Π°ΡΠΈΠΌΠΎΠ΅ ΡΠ½ΠΈΠΆΠ΅Π½ΠΈΠ΅ Π½Π°Π±Π»ΡΠ΄Π°Π΅ΡΡΡ ΡΠΎΠ»ΡΠΊΠΎ Π² Π»ΠΈΡ
ΠΎΡΠ°Π΄ΠΎΡΠ½ΡΠΉ ΠΏΠ΅ΡΠΈΠΎΠ΄ ΡΡΠ΅Π΄Π½Π΅ΡΡΠΆΠ΅Π»ΠΎΠΉ ΠΈ ΡΡΠΆΠ΅Π»ΠΎΠΉ ΡΠΎΡΠΌΡ Π±Π΅Π· ΠΎΡΠ»ΠΎΠΆΠ½Π΅Π½ΠΈΠΉ; Π²ΠΎ Π²ΡΠ΅ ΠΎΡΡΠ°Π»ΡΠ½ΡΠ΅ ΠΏΠ΅ΡΠΈΠΎΠ΄Ρ ΠΈ ΠΏΡΠΈ Π²ΡΠ΅Ρ
ΡΠΎΡΠΌΠ°Ρ
Π½Π°Π±Π»ΡΠ΄Π°Π΅ΡΡΡ ΡΡΠ°ΡΠΈΡΡΠΈΡΠ΅ΡΠΊΠΈ Π·Π½Π°ΡΠΈΠΌΠ°Ρ Π³ΠΈΠΏΠ΅ΡΠ°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ ΠΠΠ€. ΠΡΠΈ ΡΡΠΆΠ΅Π»ΠΎΠΉ ΡΠΎΡΠΌΠ΅ Π±Π΅Π· ΠΎΡΠ»ΠΎΠΆΠ½Π΅Π½ΠΈΠΉ Π½Π°Π±Π»ΡΠ΄Π°ΡΡΡΡ ΡΠ΅Π·ΠΊΠΈΠ΅ ΠΊΠΎΠ»Π΅Π±Π°Π½ΠΈΡ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ ΠΠΠ€ Π² Π΄ΠΈΠ½Π°ΠΌΠΈΠΊΠ΅ Π±ΠΎΠ»Π΅Π·Π½ΠΈ. ΠΡΠΈ ΠΎΡΠ»ΠΎΠΆΠ½Π΅Π½Π½ΠΎΠΉ ΡΠΎΡΠΌΠ΅ ΠΈΠΌΠ΅Π΅Ρ ΠΌΠ΅ΡΡΠΎ ΡΡΠ°ΡΠΈΡΡΠΈΡΠ΅ΡΠΊΠΈ Π·Π½Π°ΡΠΈΠΌΠ°Ρ ΡΡΠ°Π±ΠΈΠ»ΡΠ½ΠΎ Π²ΡΡΠΎΠΊΠ°Ρ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ ΡΠ΅ΡΠΌΠ΅Π½ΡΠ° Π½Π° Π²ΡΠ΅ΠΌ ΠΏΡΠΎΡΡΠΆΠ΅Π½ΠΈΠΈ Π±ΠΎΠ»Π΅Π·Π½ΠΈ. ΠΠ½Π°Π»ΠΈΠ· ΠΏΠΎΠ»ΠΈΠΌΠΎΡΡΠΈΠ·ΠΌΠ° Π³Π΅Π½Π° ΡΠ΅ΡΠ΅ΠΏΡΠΎΡΠ° ΠΠ’ I11 ΡΠΈΠΏΠ° ΡΠ²ΠΈΠ΄Π΅ΡΠ΅Π»ΡΡΡΠ²ΡΡΡ ΠΎ ΡΠΎΠΌ, ΡΡΠΎ Π°Π»Π»Π΅Π»ΠΈ *Π1166 ΠΈ *Π‘1166, Π° ΡΠ°ΠΊΠΆΠ΅, Π³Π΅Π½ΠΎΡΠΈΠΏΡ *Π1166/*Π1166ΠΈ *Π‘1166/*Π‘1166 Π½Π΅ Π°ΡΡΠΎΡΠΈΠΈΡΠΎΠ²Π°Π½Ρ ΡΠΎ ΡΡΠ΅ΠΏΠ΅Π½ΡΡ ΡΡΠΆΠ΅ΡΡΠΈ ΡΠ΅ΡΠ΅Π½ΠΈΡ ΠΠΠΠ‘. ΠΠΎΠ²ΡΡΠ΅Π½ΠΈΠ΅ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ ΠΠΠ€ ΠΏΡΠΈ ΠΠΠΠ‘ Π½Π΅ Π½ΠΎΡΠΈΡ Π°Π΄Π°ΠΏΡΠΈΠ²Π½ΡΠΉ Ρ
Π°ΡΠ°ΠΊΡΠ΅Ρ ΠΈΠ·-Π·Π° Π΄Π΅ΡΠ΅ΠΊΡΠΎΠ² Π² ΡΠ΅ΡΠ΅ΠΏΡΠΈΠΈ AT II ΠΈ ΡΠ²Π»ΡΠ΅ΡΡΡ Π°Π΄Π΅ΠΊΠ²Π°ΡΠ½ΡΠΌ ΠΌΠ΅ΡΠ°Π±ΠΎΠ»ΠΈΡΠ΅ΡΠΊΠΈΠΌ ΠΎΡΠ²Π΅ΡΠΎΠΌ ΠΎΡΠ³Π°Π½ΠΈΠ·ΠΌΠ° Π² ΠΎΡΠ²Π΅Ρ Π½Π° Π²Π½Π΅Π΄ΡΠ΅Π½ΠΈΠ΅ ΡΠ½Π΄ΠΎΡΠ΅Π»ΠΈΠΎΡΡΠΎΠΏΠ½ΠΎΠ³ΠΎ Π²ΠΈΡΡΡΠ°
Results of integrated treatment of herpetic stomatitis with the inclusion of lipid concentrate of ERYX biomass
Aim. The study of the effectiveness of the use of the biologically active additive Reptin-plant in the complex treatment of patients with herpetic stomatitis.Materials and methods. We examined 189 patients with a diagnosis of herpetic stomatitis, which were divided into 2 groups depending on the receipt of complex antiviral therapy with the inclusion of ERYX biomass lipid concentrate in the treatment regimen and without it. The following were assessed: clinical status, index assessment of the state of the oral cavity, state of local immunity, frequency of relapses and duration of the latency period.Results. 57 (30.2%) patients were identified with a mild form of herpetic stomatitis (HS), the average severity of HS was determined in 93 (49.2%) and a severe course of the disease was diagnosed in 39 (20.6%) patients. Analysis of the index assessment of the state of the oral cavity (OHIS, PMA), molecular genetic parameters, immunological studies (lysozyme titer, phagocytosis, concentration of sIg A in saliva) showed a statistically significant difference when included in the complex treatment of Reptin-plant, demonstrating the benefits of using it.Conclusions. The use of ERYX biomass lipid concentrate in the complex treatment of herpetic stomatitis effectively affects the dynamics of the course of the disease, improves the quality of life of patients
MARKERY KOSTNOGO I OSTEOKLASTIChESKOGO DIFFERONOV PRI DEYSTVII POLIELEMENTOV MEDNO-TsINKOVOY KOLChEDANNOY RUDY
ΠΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ ΡΠΎΠ΄Π΅ΡΠΆΠ°Π½ΠΈΡ ΡΡΠ΄Π° ΡΠ»Π΅ΠΌΠ΅Π½ΡΠΎΠ² Π² Π²ΠΎΠ»ΠΎΡΠ°Ρ
Π³ΠΎΡΠ½ΡΠΊΠΎΠ² ΠΠΠ Β«Π£ΡΠ°Π»ΠΈΠ½ΡΠΊΠΈΠΉ ΠΠΠΒ», Π΄ΠΎΠ±ΡΠ²Π°ΡΡΠΈΡ
ΠΌΠ΅Π΄Π½ΠΎ-ΡΠΈΠ½ΠΊΠΎΠ²ΡΡ ΡΡΠ΄Ρ ΠΏΠΎΠ΄Π·Π΅ΠΌΠ½ΡΠΌ ΡΠΏΠΎΡΠΎΠ±ΠΎΠΌ, Π²ΡΡΠ²ΠΈΠ»ΠΎ ΡΡΠ°ΡΠΈΡΡΠΈΡΠ΅ΡΠΊΠΈ Π·Π½Π°ΡΠΈΠΌΠΎΠ΅ ΡΠ²Π΅Π»ΠΈΡΠ΅Π½ΠΈΠ΅ ΡΠΎΠ΄Π΅ΡΠΆΠ°Π½ΠΈΡ ΡΡΠ΄Π° ΡΡΠΆΠ΅Π»ΡΡ
ΠΌΠ΅ΡΠ°Π»Π»ΠΎΠ² [ΠΡΠ΄Π°ΡΠ΅Π²Π°, 2005; ΠΠ³Π»Π΅ΡΠ΄ΠΈΠ½ΠΎΠ² ΠΈ Π΄Ρ., 2011] Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΠ·ΡΡ ΠΈΡ
ΠΏΠΎΡΡΡΠΏΠ»Π΅Π½ΠΈΠ΅ ΠΈ Π½Π°ΠΊΠΎΠΏΠ»Π΅Π½ΠΈΠ΅ Π² ΡΠΊΠ°Π½ΡΡ
. ΠΡΠΈ Π΄Π»ΠΈΡΠ΅Π»ΡΠ½ΠΎΠΌ Π²Π²Π΅Π΄Π΅Π½ΠΈΠΈ ΠΏΠΎΡΠΎΡΠΊΠ° ΡΡΠ΄Ρ ΡΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ°Π»ΡΠ½ΡΠΌ ΠΆΠΈΠ²ΠΎΡΠ½ΡΠΌ ΡΠ°ΠΊΠΆΠ΅ ΡΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½ΠΎ Π·Π½Π°ΡΠΈΡΠ΅Π»ΡΠ½ΠΎΠ΅ ΡΠ²Π΅Π»ΠΈΡΠ΅Π½ΠΈΠ΅ ΡΠΎΠ΄Π΅ΡΠΆΠ°Π½ΠΈΡ ΡΡΠΎΠΉ Π³ΡΡΠΏΠΏΡ ΡΠ»Π΅ΠΌΠ΅Π½ΡΠΎΠ² Π² ΠΊΠΎΡΡΡΡ
[ΠΡΡΠ³Π°Π»Π΅Π΅Π² ΠΈ Π΄Ρ., 2013], ΡΡΠΎ ΡΠΎΠΏΡΠΎΠ²ΠΎΠΆΠ΄Π°Π»ΠΎΡΡ ΡΡΠΈΠ»Π΅Π½ΠΈΠ΅ΠΌ ΠΎΠΊΡΠΈΠ΄Π°ΡΠΈΠ²Π½ΡΡ
ΠΏΡΠΎΡΠ΅ΡΡΠΎΠ². ΠΠ»Π΅ΡΠΊΠΈ Π΄ΠΈΡΡΠ΅ΡΠΎΠ½Π° ΠΌΠΎΠ½ΠΎΠ½ΡΠΊΠ»Π΅Π°ΡΠ½ΡΡ
ΡΠ°Π³ΠΎΡΠΈΡΠΎΠ² ΠΊΠΎΡΡΠ½ΠΎΠΉ ΡΠΊΠ°Π½ΠΈ -ΠΎΡΡΠ΅ΠΎΠΊΠ»Π°ΡΡΡ ΡΡΠ²ΡΡΠ²ΠΈΡΠ΅Π»ΡΠ½ΠΎ ΡΠ΅Π°Π³ΠΈΡΡΡΡ Π½Π° Π²ΠΎΠ·Π΄Π΅ΠΉΡΡΠ²ΠΈΠ΅ Ρ
ΠΈΠΌΠΈΡΠ΅ΡΠΊΠΈΡ
ΡΠΎΠ΅Π΄ΠΈΠ½Π΅Π½ΠΈΠΉ ΠΈ Π² ΠΏΡΠΎΡΠ΅ΡΡΠ΅ Π°ΠΊΡΠΈΠ²Π½ΠΎΠ³ΠΎ ΡΡΠ½ΠΊΡΠΈΠΎΠ½ΠΈΡΠΎΠ²Π°Π½ΠΈΡ Π²ΡΡΠ²ΠΎΠ±ΠΎΠΆΠ΄Π°ΡΡ ΡΡΠ΄ ΡΠ΅ΡΠΌΠ΅Π½ΡΠΎΠ², ΠΊΠΎΡΠΎΡΡΠ΅ Π³Π΅Π½Π΅ΡΠΈΡΡΡΡ Π² Π·ΠΎΠ½Π΅ ΡΠ΅Π·ΠΎΡΠ±ΡΠΈΠΈ ΡΡΠΏΠ΅ΡΠΎΠΊΡΠΈΠ΄Π½ΡΠΉ Π°Π½ΠΈΠΎΠ½-ΡΠ°Π΄ΠΈΠΊΠ°Π» [VÀÀrΓ€niemi et al., 2004], ΠΈ ΡΡΠΈΠ»Π΅Π½ΠΈΠ΅ ΡΠ²ΠΎΠ±ΠΎΠ΄Π½ΠΎ-ΡΠ°Π΄ΠΈΠΊΠ°Π»ΡΠ½ΠΎΠ³ΠΎ ΠΎΠΊΠΈΡΠ»Π΅Π½ΠΈΡ Π² ΠΊΠΎΡΡΠ½ΠΎΠΉ ΡΠΊΠ°Π½ΠΈ ΠΌΠΎΠΆΠ΅Ρ Π±ΡΡΡ ΠΎΡΡΠ°ΠΆΠ΅Π½ΠΈΠ΅ΠΌ ΠΈΠ½ΡΠ΅Π½ΡΠΈΡΠΈΠΊΠ°ΡΠΈΠΈ ΡΠ΅Π·ΠΎΡΠ±ΡΠΈΠ²Π½ΡΡ
ΠΏΡΠΎΡΠ΅ΡΡΠΎΠ² ΠΏΡΠΈ Π΄Π΅ΠΉΡΡΠ²ΠΈΠΈ ΠΏΠΎΠ»ΠΈΡΠ»Π΅ΠΌΠ΅Π½ΡΠΎΠ² ΡΡΠ΄Ρ ΡΠ²Π΅ΡΠ½ΡΡ
ΠΌΠ΅ΡΠ°Π»Π»ΠΎΠ². Π¦Π΅Π»Ρ. ΠΠ·ΡΡΠ΅Π½ΠΈΠ΅ ΡΡΠΎΠ²Π½Ρ ΠΌΠ°ΡΠΊΠ΅ΡΠΎΠ² ΠΎΡΡΠ΅ΠΎΠ±Π»Π°ΡΡΠΎΠ³Π΅Π½Π΅Π·Π° ΠΈ ΠΎΡΡΠ΅ΠΎΠΊΠ»Π°ΡΡΠΎΠ³Π΅Π½Π΅Π·Π° ΠΏΡΠΈ Π΄Π΅ΠΉΡΡΠ²ΠΈΠΈ ΠΏΠΎΠ»ΠΈΡΠ»Π΅ΠΌΠ΅Π½ΡΠΎΠ² ΠΌΠ΅Π΄Π½ΠΎ-ΡΠΈΠ½ΠΊΠΎΠ²ΠΎΠΉ ΠΊΠΎΠ»ΡΠ΅Π΄Π°Π½Π½ΠΎΠΉ ΡΡΠ΄Ρ. ΠΠ°ΡΠ΅ΡΠΈΠ°Π» ΠΈ ΠΌΠ΅ΡΠΎΠ΄Ρ. 20 Π±Π΅Π»ΡΠΌ ΠΏΠΎΠ»ΠΎΠ²ΠΎΠ·ΡΠ΅Π»ΡΠΌ ΡΠ°ΠΌΡΠ°ΠΌ ΠΊΡΡΡ ΠΎΠΏΡΡΠ½ΠΎΠΉ Π³ΡΡΠΏΠΏΡ Π² ΡΠ΅ΡΠ΅Π½ΠΈΠ΅ ΡΡΠ΅Ρ
ΠΌΠ΅ΡΡΡΠ΅Π² Π΅ΠΆΠ΅Π΄Π½Π΅Π²Π½ΠΎ Π²Π½ΡΡΡΠΈΠΆΠ΅Π»ΡΠ΄ΠΎΡΠ½ΠΎ Π²Π²ΠΎΠ΄ΠΈΠ»ΠΈ ΡΡΡΠΏΠ΅Π½Π·ΠΈΡ ΠΏΠΎΡΠΎΡΠΊΠ° ΡΡΠ΄Ρ Π² 2% ΡΠ°ΡΡΠ²ΠΎΡΠ΅ ΠΊΡΠ°Ρ
ΠΌΠ°Π»Π° ΠΈΠ· ΡΠ°ΡΡΠ΅ΡΠ° 60 ΠΌΠ³/100Π³ ΠΌΠ°ΡΡΡ, 12 ΠΊΡΡΡ ΠΈΠ΄Π΅Π½ΡΠΈΡΠ½ΠΎΠΉ ΠΌΠ°ΡΡΡ (220-240Π³) ΠΏΠΎΠ»ΡΡΠ°Π»ΠΈ Π΅ΠΆΠ΅Π΄Π½Π΅Π²Π½ΠΎ ΡΠ°ΡΡΠ²ΠΎΡ ΠΊΡΠ°Ρ
ΠΌΠ°Π»Π°. Π ΡΡΡΠ±ΡΠ°ΡΡΡ
ΠΊΠΎΡΡΡΡ
(Π±Π΅Π΄ΡΠ΅Π½Π½Π°Ρ, Π±ΠΎΠ»ΡΡΠ΅Π±Π΅ΡΡΠΎΠ²Π°Ρ ΠΈ ΠΏΠ»Π΅ΡΠ΅Π²Π°Ρ) ΡΠ΅ΡΠ΅Π· 1,2 ΠΈ 3 ΠΌΠ΅ΡΡΡΠ° ΠΈΠ½ΡΠΎΠΊΡΠΈΠΊΠ°ΡΠΈΠΈ ΡΡΠ΄ΠΎΠΉ ΠΎΠΏΡΠ΅Π΄Π΅Π»ΡΠ»ΠΈ ΡΠΎΠ΄Π΅ΡΠΆΠ°Π½ΠΈΠ΅ Fe, Mg, Mn, Hg, Sr, Cr ΠΌΠ΅ΡΠΎΠ΄ΠΎΠΌ Π°ΡΠΎΠΌΠ½ΠΎ-Π°Π±ΡΠΎΡΠ±ΡΠΈΠΎΠ½Π½ΠΎΠΉ ΡΠΏΠ΅ΠΊΡΡΠΎΠΌΠ΅ΡΡΠΈΠΈ ΠΈ Cu, Zn, Cd b Pb Π²ΠΎΠ»ΡΡΠ°ΠΌΠΏΠ΅ΡΠΎΠΌΠ΅ΡΡΠΈΡΠ΅ΡΠΊΠΈΠΌ ΠΌΠ΅ΡΠΎΠ΄ΠΎΠΌ. Π ΠΏΠ»Π°Π·ΠΌΠ΅ ΠΊΡΠΎΠ²ΠΈ Π½Π° 3-ΠΉ ΠΌΠ΅ΡΡΡ ΡΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ° ΠΈΠ·ΡΡΠΈΠ»ΠΈ ΡΠΎΠ΄Π΅ΡΠΆΠ°Π½ΠΈΠ΅ ΡΠ°ΡΡΠ²ΠΎΡΠΈΠΌΠΎΠ³ΠΎ Π»ΠΈΠ³Π°Π½Π΄Π° ΡΠ΄Π΅ΡΠ½ΠΎΠ³ΠΎ ΡΠ°ΠΊΡΠΎΡΠ° ΡΡΠ°Π½ΡΠΊΡΠΈΠΏΡΠΈΠΈ ΠΊΠ°ΠΏΠΏΠ° Π (s RANKL), ΠΎΡΡΠ΅ΠΎΠΏΡΠΎΡΠ΅Π³Π΅ΡΠΈΠ½Π° (OPG) - Π»ΠΎΠΆΠ½ΠΎΠ³ΠΎ ΡΠ΅ΡΠ΅ΠΏΡΠΎΡΠ° RANKL ΠΈ ΡΠΊΠ»Π΅ΡΠΎΡΡΠΈΠ½Π°, ΠΈΡΠΏΠΎΠ»ΡΠ·ΡΡ ΡΠΎΠΎΡΠ²Π΅ΡΡΡΠ²ΡΡΡΠΈΠ΅ Π½Π°Π±ΠΎΡΡ ΡΠ΅Π°Π³Π΅Π½ΡΠΎΠ² (Biomedica, Medizinproducte Gmb), ΠΊΠΎΡΡΠ½ΠΎΠΉ ΡΠ΅Π»ΠΎΡΠ½ΠΎΠΉ ΡΠΎΡΡΠ°ΡΠ°Π·Ρ (ΠΠ©Π€, Β«Quidel CorporationΒ»)). Π Π³ΡΡΠΏΠΏΠ°Ρ
ΡΠ°ΡΡΡΠΈΡΡΠ²Π°Π»ΠΈ ΠΌΠ΅Π΄ΠΈΠ°Π½Ρ, ΠΌΠ΅ΠΆΠΊΠ²Π°ΡΡΠ°Π»ΡΠ½ΡΠ΅ ΠΈΠ½ΡΠ΅ΡΠ²Π°Π»Ρ, Π΄ΠΎΡΡΠΎΠ²Π΅ΡΠ½ΠΎΡΡΡ ΠΌΠ΅ΠΆΠ³ΡΡΠΏΠΏΠΎΠ²ΡΡ
ΡΠ°Π·Π»ΠΈΡΠΈΠΉ ΠΎΡΠ΅Π½ΠΈΠ²Π°Π»ΠΈ ΠΏΠΎ U-ΠΊΡΠΈΡΠ΅ΡΠΈΡ ΠΠ°Π½Π½Π°-Π£ΠΈΡΠ½ΠΈ. Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ. ΠΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΠ΅ ΡΡΠ΄Π° ΡΠ»Π΅ΠΌΠ΅Π½ΡΠΎΠ² Π² ΠΊΠΎΡΡΠΈ Π²ΡΡΠ²ΠΈΠ»ΠΎ, ΡΡΠΎ ΡΠΎΠ΄Π΅ΡΠΆΠ°Π½ΠΈΠ΅ Mn, Sr, Fe, Cu, Zn, Cd, Pb ΠΈ Hg ΠΏΠΎΠ²ΡΡΠ°Π΅ΡΡΡ ΠΊ ΠΊΠΎΠ½ΡΡ 3-Π³ΠΎ ΠΌΠ΅ΡΡΡΠ° ΡΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ° Ρ ΠΎΠΏΡΡΠ½ΠΎΠΉ Π³ΡΡΠΏΠΏΡ ΠΊΡΡΡ Π·Π½Π°ΡΠΈΡΠ΅Π»ΡΠ½ΠΎ (ΠΎΡ 1,5 Π΄ΠΎ 5 ΡΠ°Π·), Cr ΡΠ²Π΅Π»ΠΈΡΠΈΠ²Π°Π΅ΡΡΡ Π½Π΅Π·Π½Π°ΡΠΈΡΠ΅Π»ΡΠ½ΠΎ, Π° Mg ΡΠ½ΠΈΠΆΠ°Π΅ΡΡΡ. ΠΡΠΈ ΡΡΠΎΠΌ ΡΡΠΎΠ²Π΅Π½Ρ Fe ΠΈ Mn ΡΠ²Π΅Π»ΠΈΡΠΈΠ²Π°Π΅ΡΡΡ ΡΠΆΠ΅ ΡΠ΅ΡΠ΅Π· 1 ΠΌΠ΅ΡΡΡ ΠΈΠ½ΡΠΎΠΊΡΠΈΠΊΠ°ΡΠΈΠΈ, Π° Π·Π°ΡΠ΅ΠΌ Π½Π΅ ΠΏΠΎΠ΄Π²Π΅ΡΠ³Π°Π΅ΡΡΡ ΡΡΠ°ΡΠΈΡΡΠΈΡΠ΅ΡΠΊΠΈ Π·Π½Π°ΡΠΈΠΌΡΠΌ ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΡΠΌ. ΠΡΡΠ³ΠΈΠ΅ ΡΠ»Π΅ΠΌΠ΅Π½ΡΡ Π½Π°ΠΊΠ°ΠΏΠ»ΠΈΠ²Π°ΡΡΡΡ, Π΄ΠΎΡΡΠΈΠ³Π°Ρ ΠΌΠ°ΠΊΡΠΈΠΌΠ°Π»ΡΠ½ΠΎΠ³ΠΎ ΡΡΠΎΠ²Π½Ρ Π»ΠΈΡΡ ΠΊ ΠΊΠΎΠ½ΡΡ ΡΡΠ΅ΡΡΠ΅Π³ΠΎ ΠΌΠ΅ΡΡΡΠ°. Π‘ΠΎΠ΄Π΅ΡΠΆΠ°Π½ΠΈΠ΅ s RANKL Π² ΠΏΠ»Π°Π·ΠΌΠ΅ ΠΊΡΠΎΠ²ΠΈ ΠΆΠΈΠ²ΠΎΡΠ½ΡΡ
ΠΏΡΠΈ Π΄Π΅ΠΉΡΡΠ²ΠΈΠΈ ΠΏΠΎΠ»ΠΈΡΠ»Π΅ΠΌΠ΅Π½ΡΠΎΠ² ΡΡΠ΄Ρ ΠΏΡΠ°ΠΊΡΠΈΡΠ΅ΡΠΊΠΈ Π½Π΅ ΠΈΠ·ΠΌΠ΅Π½ΡΠ»ΠΎΡΡ, ΡΠΎΡΡΠ°Π²Π»ΡΡ 0,6 [0,12;1,29] ΠΏΠΌΠΎΠ»Ρ/Π» Π² ΠΊΠΎΠ½ΡΡΠΎΠ»Π΅ ΠΈ 0,63 [0,45; 0,75] ΠΏΠΌΠΎΠ»Ρ/Π» Π² ΠΎΠΏΡΡΠ½ΠΎΠΉ Π³ΡΡΠΏΠΏΠ΅. ΠΠ½Π°Π»ΠΎΠ³ΠΈΡΠ½Π°Ρ Π΄ΠΈΠ½Π°ΠΌΠΈΠΊΠ° Π²ΡΡΠ²ΠΈΠ»Π°ΡΡ ΠΈ ΠΏΡΠΈ ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΠΈ ΠΠ©Π€: 4,5 [1,6;6,9] Π/Π» ΠΈ 5,0 [3,8;6,3] Π/Π» ΡΠΎΠΎΡΠ²Π΅ΡΡΡΠ²Π΅Π½Π½ΠΎ, Ρ=0,42, Π° ΡΠΎΠ΄Π΅ΡΠΆΠ°Π½ΠΈΠ΅ OPG ΡΠ½ΠΈΠΆΠ°Π»ΠΎΡΡ Ρ 0,41 [0,4;0,44] ΠΏΠΌΠΎΠ»Ρ/Π» Π΄ΠΎ 0,3 [0,26;0,38] ΠΏΠΌΠΎΠ»Ρ/Π», Ρ=0,043. ΠΠΎΡΡΡΠΈΡΠΈΠ΅Π½Ρ sRANKL/OPG, Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΠ·ΡΡΡΠΈΠΉ ΠΎΠ±ΡΠ΅Π΅ Β«ΠΊΠΎΠ½Π²Π΅ΡΠ³Π΅Π½ΡΠ½ΠΎΠ΅Β» ΡΠΎΠΎΡΠ½ΠΎΡΠ΅Π½ΠΈΠ΅ ΠΏΡΠΎ- ΠΈ Π°Π½ΡΠΈΡΠ΅Π·ΠΎΡΠ±ΡΠΈΠ²Π½ΡΡ
ΡΠ΅Π³ΡΠ»ΡΡΠΎΡΠΎΠ² ΠΎΡΡΠ΅ΠΎΠΊΠ»Π°ΡΡΠ½ΠΎΠΉ Π΄ΠΈΡΡΠ΅ΡΠ΅Π½ΡΠΈΡΠΎΠ²ΠΊΠΈ ΠΈ Π°ΠΊΡΠΈΠ²Π°ΡΠΈΠΈ ΠΎΡΡΠ΅ΠΎΠΊΠ»Π°ΡΡΠΎΠ² [Hobauer, 2009], ΠΏΠΎΠ²ΡΡΠ°Π΅ΡΡΡ. Π£ ΠΆΠΈΠ²ΠΎΡΠ½ΡΡ
ΠΊΠΎΠ½ΡΡΠΎΠ»ΡΠ½ΠΎΠΉ Π³ΡΡΠΏΠΏΡ ΠΎΠ½ ΡΠΎΡΡΠ°Π²Π»ΡΠ΅Ρ 1,46 [1,2;1,51], Ρ ΠΎΠΏΡΡΠ½ΠΎΠΉ Π³ΡΡΠΏΠΏΡ - 2,1 [1,84;2,33], Ρ=0,041, ΡΡΠΎ ΠΎΡΡΠ°ΠΆΠ°Π΅Ρ ΠΈΠ½ΡΠ΅Π½ΡΠΈΡΠΈΠΊΠ°ΡΠΈΡ ΠΏΡΠΎΡΠ΅ΡΡΠΎΠ² ΠΎΡΡΠ΅ΠΎΠΊΠ»Π°ΡΡΠΎΠ³Π΅Π½Π΅Π·Π° ΠΈ ΡΠ΅Π·ΠΎΡΠ±ΡΠΈΠΈ. Π£ΡΠΎΠ²Π΅Π½Ρ ΡΠΊΠ»Π΅ΡΠΎΡΡΠΈΠ½Π° Ρ ΠΎΠΏΡΡΠ½ΠΎΠΉ Π³ΡΡΠΏΠΏΡ ΠΆΠΈΠ²ΠΎΡΠ½ΡΡ
ΠΏΠΎΠ²ΡΡΠ°Π»ΡΡ Ρ 12,3 [12,0;12,6] ΠΏΠΌΠΎΠ»Ρ/Π» Π΄ΠΎ 14,2 [12,5;14,7], Ρ=0,046. Π‘ΠΊΠ»Π΅ΡΠΎΡΡΠΈΠ½, Π²ΡΡΠ°Π±Π°ΡΡΠ²Π°Π΅ΠΌΡΠΉ ΠΎΡΡΠ΅ΠΎΡΠΈΡΠ°ΠΌΠΈ ΠΈ Π³ΠΈΠΏΠ΅ΡΡΡΠΎΡΠΈΡΠΎΠ²Π°Π½Π½ΡΠΌΠΈ Ρ
ΠΎΠ½Π΄ΡΠΎΡΠΈΡΠ°ΠΌΠΈ, ΡΠ²Π»ΡΠ΅ΡΡΡ Π½Π΅Π³Π°ΡΠΈΠ²Π½ΡΠΌ ΡΠ΅Π³ΡΠ»ΡΡΠΎΡΠΎΠΌ ΠΎΡΡΠ΅ΠΎΠ±Π»Π°ΡΡΠΎΠ³Π΅Π½Π΅Π·Π° [Bernardes et al., 2013], ΠΈ Π΅Π³ΠΎ ΠΏΠΎΠ²ΡΡΠ΅Π½ΠΈΠ΅ ΡΠ²ΠΈΠ΄Π΅ΡΠ΅Π»ΡΡΡΠ²ΡΠ΅Ρ ΠΎΠ± ΠΈΠ½Π³ΠΈΠ±ΠΈΡΠΎΠ²Π°Π½ΠΈΠΈ ΠΊΠΎΡΡΠ½ΠΎΠ³ΠΎ Π΄ΠΈΡΡΠ΅ΡΠΎΠ½Π°. ΠΡΠ²ΠΎΠ΄Ρ. ΠΠΎΠ»ΠΈΡΠ»Π΅ΠΌΠ΅Π½ΡΡ ΠΌΠ΅Π΄Π½ΠΎ-ΡΠΈΠ½ΠΊΠΎΠ²ΠΎΠΉ ΠΊΠΎΠ»ΡΠ΅Π΄Π°Π½Π½ΠΎΠΉ ΡΡΠ΄Ρ, Π½Π°ΠΊΠ°ΠΏΠ»ΠΈΠ²Π°ΡΡΡ Π² ΠΊΠΎΡΡΠ½ΠΎΠΉ ΡΠΊΠ°Π½ΠΈ, ΠΏΡΠΈΠ²ΠΎΠ΄ΡΡ ΠΊ Π°ΠΊΡΠΈΠ²Π°ΡΠΈΠΈ ΠΎΡΡΠ΅ΠΎΠΊΠ»Π°ΡΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ Π΄ΠΈΡΡΠ΅ΡΠΎΠ½Π° Π½Π° ΡΠΎΠ½Π΅ Π½Π΅ΠΊΠΎΡΠΎΡΠΎΠ³ΠΎ ΠΏΠΎΠ΄Π°Π²Π»Π΅Π½ΠΈΡ ΠΊΠΎΡΡΠ½ΠΎΠ³ΠΎ Π΄ΠΈΡΡΠ΅ΡΠΎΠ½Π° (ΠΎΡΡΠ΅ΠΎΠ±Π»Π°ΡΡΠΎΠ³Π΅Π½Π΅Π·Π°)
- β¦