73 research outputs found

    The influence of long-range correlated defects on critical ultrasound propagation in solids

    Full text link
    The effect of long-range correlated quenched structural defects on the critical ultrasound attenuation and sound velocity dispersion is studied for three-dimensional Ising-like systems. A field-theoretical description of the dynamic critical effects of ultrasound propagation in solids is performed with allowance for both fluctuation and relaxation attenuation mechanisms. The temperature and frequency dependences of the dynamical scaling functions of the ultrasound critical characteristics are calculated in a two-loop approximation for different values of the correlation parameter aa of the Weinrib-Halperin model with long-range correlated defects. The asymptotic behavior of the dynamical scaling functions in hydrodynamic and critical regions is separated. The influence of long-range correlated disorder on the asymptotic behavior of the critical ultrasonic anomalies is discussed.Comment: 12 RevTeX pages, 3 figure

    Quantization and Compressive Sensing

    Get PDF
    Quantization is an essential step in digitizing signals, and, therefore, an indispensable component of any modern acquisition system. This book chapter explores the interaction of quantization and compressive sensing and examines practical quantization strategies for compressive acquisition systems. Specifically, we first provide a brief overview of quantization and examine fundamental performance bounds applicable to any quantization approach. Next, we consider several forms of scalar quantizers, namely uniform, non-uniform, and 1-bit. We provide performance bounds and fundamental analysis, as well as practical quantizer designs and reconstruction algorithms that account for quantization. Furthermore, we provide an overview of Sigma-Delta (ΣΔ\Sigma\Delta) quantization in the compressed sensing context, and also discuss implementation issues, recovery algorithms and performance bounds. As we demonstrate, proper accounting for quantization and careful quantizer design has significant impact in the performance of a compressive acquisition system.Comment: 35 pages, 20 figures, to appear in Springer book "Compressed Sensing and Its Applications", 201

    Pressure control of magnetic clusters in strongly inhomogeneous ferromagnetic chalcopyrites

    Get PDF
    Room-temperature ferromagnetism in Mn-doped chalcopyrites is a desire aspect when applying those materials to spin electronics. However, dominance of high Curie-temperatures due to cluster formation or inhomogeneities limited their consideration. Here we report how an external perturbation such as applied hydrostatic pressure in CdGeP2:Mn induces a two serial magnetic transitions from ferromagnet to non-magnet state at room temperature. This effect is related to the unconventional properties of created MnP magnetic clusters within the host material. Such behavior is also discussed in connection with ab initio density functional calculations, where the structural properties of MnP indicate magnetic transitions as function of pressure as observed experimentally. Our results point out new ways to obtain controlled response of embedded magnetic clusters

    The influence of the mechanically activated amorphous form of calcium gluconate on the metabolism and mineral density of bone tissue in dental implantation in patients with chronic generalized periodontitis

    Get PDF
    The influence of mechanoactivated (nanodispersed) form of calcium gluconate (inside and locally) on the bone mineral density (BMD) and osteointegration processes in 89 patients aged 35-44 with chronic generalized periodontitis with reduced BMD within T-score from -1.1 to -2.5 SD was evaluated. The clinical condition, indicators of mineral metabolism (Ca, Mg, P) in blood plasma, markers of bone remodeling were studied. The inclusion of traditional training and accepted Protocol of dental implant receiving mechanically activated (nanosized) amorphous form of calcium gluconate in patients with chronic generalized periodontitis with reduced mineral density of bone tissue contributes to the correction of calcium-phosphorus metabolism and bone metabolism with the improvement of osseointegration of dental implants.ΠŸΡ€ΠΎΠ²Π΅Π΄Π΅Π½Π° ΠΎΡ†Π΅Π½ΠΊΠ° влияния ΠΌΠ΅Ρ…Π°Π½ΠΎΠ°ΠΊΡ‚ΠΈΠ²ΠΈΡ€ΠΎΠ²Π°Π½Π½ΠΎΠΉ (нанодиспСрсной) Ρ„ΠΎΡ€ΠΌΡ‹ ΠΊΠ°Π»ΡŒΡ†ΠΈΡ Π³Π»ΡŽΠΊΠΎΠ½Π°Ρ‚Π° (Π²Π½ΡƒΡ‚Ρ€ΡŒ ΠΈ мСстно) Π½Π° ΠΌΠΈΠ½Π΅Ρ€Π°Π»ΡŒΠ½ΡƒΡŽ ΠΏΠ»ΠΎΡ‚Π½ΠΎΡΡ‚ΡŒ костной Ρ‚ΠΊΠ°Π½ΠΈ (ΠœΠŸΠΊΡ‚) ΠΈ процСссы остСоинтСграции Ρƒ 89 ΠΏΠ°Ρ†ΠΈΠ΅Π½Ρ‚ΠΎΠ² Π² возрастС 35-44 Π³ΠΎΠ΄Π° с хроничСским Π³Π΅Π½Π΅Ρ€Π°Π»ΠΈΠ·ΠΎΠ²Π°Π½Π½Ρ‹ΠΌ ΠΏΠ°Ρ€ΠΎΠ΄ΠΎΠ½Ρ‚ΠΈΡ‚ΠΎΠΌ со сниТСнной ΠœΠŸΠΊΡ‚ Π² ΠΏΡ€Π΅Π΄Π΅Π»Π°Ρ… Ρ‚-score ΠΎΡ‚ -1,1 Π΄ΠΎ -2,5 SD. ИсслСдовано клиничСскоС состояниС, ΠΏΠΎΠΊΠ°Π·Π°Ρ‚Π΅Π»ΠΈ ΠΌΠΈΠ½Π΅Ρ€Π°Π»ΡŒΠ½ΠΎΠ³ΠΎ ΠΎΠ±ΠΌΠ΅Π½Π° (Ca, Mg, P) Π² ΠΏΠ»Π°Π·ΠΌΠ΅ ΠΊΡ€ΠΎΠ²ΠΈ, ΠΌΠ°Ρ€ΠΊΡ‘Ρ€Ρ‹ костного рСмодСлирования. Π’ΠΊΠ»ΡŽΡ‡Π΅Π½ΠΈΠ΅ Π² Ρ‚Ρ€Π°Π΄ΠΈΡ†ΠΈΠΎΠ½Π½ΡƒΡŽ ΠΏΠΎΠ΄Π³ΠΎΡ‚ΠΎΠ²ΠΊΡƒ ΠΈ принятый ΠΏΡ€ΠΎΡ‚ΠΎΠΊΠΎΠ» Π΄Π΅Π½Ρ‚Π°Π»ΡŒΠ½ΠΎΠΉ ΠΈΠΌΠΏΠ»Π°Π½Ρ‚Π°Ρ†ΠΈΠΈ ΠΏΡ€ΠΈΡ‘ΠΌΠ° ΠΌΠ΅Ρ…Π°Π½ΠΎΠ°ΠΊΡ‚ΠΈΠ²ΠΈΡ€ΠΎΠ²Π°Π½Π½ΠΎΠΉ (нанодиспСрсной) Π°ΠΌΠΎΡ€Ρ„Π½ΠΎΠΉ Ρ„ΠΎΡ€ΠΌΡ‹ ΠΊΠ°Π»ΡŒΡ†ΠΈΡ Π³Π»ΡŽΠΊΠΎΠ½Π°Ρ‚Π° Ρƒ ΠΏΠ°Ρ†ΠΈΠ΅Π½Ρ‚ΠΎΠ² с хроничСским Π³Π΅Π½Π΅Ρ€Π°Π»ΠΈΠ·ΠΎΠ²Π°Π½Π½Ρ‹ΠΌ ΠΏΠ°Ρ€ΠΎΠ΄ΠΎΠ½Ρ‚ΠΈΡ‚ΠΎΠΌ со сниТСнной ΠΌΠΈΠ½Π΅Ρ€Π°Π»ΡŒΠ½ΠΎΠΉ ΠΏΠ»ΠΎΡ‚Π½ΠΎΡΡ‚ΡŒΡŽ костной Ρ‚ΠΊΠ°Π½ΠΈ способствуСт ΠΊΠΎΡ€Ρ€Π΅ΠΊΡ†ΠΈΠΈ фосфорно-ΠΊΠ°Π»ΡŒΡ†ΠΈΠ΅Π²ΠΎΠ³ΠΎ ΠΎΠ±ΠΌΠ΅Π½Π° ΠΈ ΠΌΠ΅Ρ‚Π°Π±ΠΎΠ»ΠΈΠ·ΠΌΠ° костной Ρ‚ΠΊΠ°Π½ΠΈ с ΡƒΠ»ΡƒΡ‡ΡˆΠ΅Π½ΠΈΠ΅ΠΌ остСоинтСграции ΠΈ ΠΈΠΌΠΏΠ»Π°Π½Ρ‚Π°Ρ†ΠΈΠΈ Π·ΡƒΠ±ΠΎΠ²

    Angiotensin-converting enzyme activity and polymorphism of the angiotensin II type 1 receptor gene at hemorrhagic fever with renal syndrome

    Get PDF
    The research aimed to explore the changes of angiotensin-converting enzyme (ACE) blood activity and polymorphism of the angiotensin II type 1 receptor gene as disease predictor at hemorrhagic fever with renal syndrome (HFRS). In examination 409 patients at the age of 15 - 65 years were involved. ACE blood activity with the help of Buhlmann (Switzerland) ACE kinetic test was determined. Blood genomic DNA by phenol- chloroformic extraction was isolated, genetic locuses by polymerase chain reaction of DNA synthesis were researched. It was shown that the ACE blood activity at HFRS is risen and these changes the significanter the severer form of disease. Nonsignificant rising of enzyme activity only in feveric period of both ungravic and gravic forms was observed. In gravic form significant changes of ACE activity are observed, in complicated form - stable high enzyme activity during all disease took place. Analysis of angiotensin II type 1 receptor gene polymorphism shown that alleles * A1166 and *C1166, genotypes *A1166/* A1166 and * C1166/*C1166 are not associated with HFRS severity. Made conclusion that high ACE activity is not adaptive reaction due to defect in angiotensin II binding and it is an adequate metabolic response of an organism to endotheliotropic virus action.ЦСль исслСдования - ΠΈΠ·ΡƒΡ‡Π΅Π½ΠΈΠ΅ активности Π°Π½Π³ΠΈΠΎΡ‚Π΅Π½Π·ΠΈΠ½ΠΏΡ€Π΅Π²Ρ€Π°Ρ‰Π°ΡŽΡ‰Π΅Π³ΠΎ Ρ„Π΅Ρ€ΠΌΠ΅Π½Ρ‚Π° (АПЀ) Π² сывороткС ΠΊΡ€ΠΎΠ²ΠΈ ΠΈ ΠΏΠΎΠ»ΠΈΠΌΠΎΡ€Ρ„ΠΈΠ·ΠΌΠ° Π³Π΅Π½Π° Ρ€Π΅Ρ†Π΅ΠΏΡ‚ΠΎΡ€Π° Π°Π½Π³ΠΈΠΎΡ‚Π΅Π½Π·ΠΈΠ½Π° II (AT II) 1 Ρ‚ΠΈΠΏΠ° ΠΏΡ€ΠΈ гСморрагичСской Π»ΠΈΡ…ΠΎΡ€Π°Π΄ΠΊΠ΅ с ΠΏΠΎΡ‡Π΅Ρ‡Π½Ρ‹ΠΌ синдромом (Π“Π›ΠŸΠ‘) ΠΊΠ°ΠΊ Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎΠ³ΠΎ ΠΏΡ€Π΅Π΄ΠΈΠΊΡ‚ΠΎΡ€Π° заболСвания. ΠžΠ±ΡΠ»Π΅Π΄ΠΎΠ²Π°Π½Ρ‹ 409 Π±ΠΎΠ»ΡŒΠ½Ρ‹Ρ… с сСрологичСски ΠΏΠΎΠ΄Ρ‚Π²Π΅Ρ€ΠΆΠ΄Π΅Π½Π½Ρ‹ΠΌ ΠΌΠ΅Ρ‚ΠΎΠ΄ΠΎΠΌ РНИЀ Π΄ΠΈΠ°Π³Π½ΠΎΠ·ΠΎΠΌ Π“Π›ΠŸΠ‘ Π² возрастС ΠΎΡ‚ 15 дс 65 Π»Π΅Ρ‚. ΠΠΊΡ‚ΠΈΠ²Π½ΠΎΡΡ‚ΡŒ АПЀ ΠΎΠΏΡ€Π΅Π΄Π΅Π»ΡΠ»Π°ΡΡŒ кинСтичСски с использованиСм Π½Π°Π±ΠΎΡ€Π° Ρ„ΠΈΡ€ΠΌΡ‹ Buhlmann (ШвСйцария). ГСномная Π”ΠΠš ΠΈΠ· пСрифСричСской ΠΊΡ€ΠΎΠ²ΠΈ Π²Ρ‹Π΄Π΅Π»ΡΠ»Π°ΡΡŒ ΠΌΠ΅Ρ‚ΠΎΠ΄ΠΎΠΌ Ρ„Π΅Π½ΠΎΠ»-Ρ…Π»ΠΎΡ€ΠΎΡ„ΠΎΡ€ΠΌΠ½ΠΎΠΉ экстракции, Π³Π΅Π½ΠΎΡ‚ΠΈΠΏΠΈΡ€ΠΎΠ²Π°Π½ΠΈΠ΅ локусов ΠΈΠ·ΡƒΡ‡Π°Π΅ΠΌΠΎΠΉ Π”ΠΠš ΠΏΡ€ΠΎΠ²ΠΎΠ΄ΠΈΠ»Π°ΡΡŒ ΠΌΠ΅Ρ‚ΠΎΠ΄ΠΎΠΌ ПЦР синтСза Π”ΠΠš. ΠΠΊΡ‚ΠΈΠ²Π½ΠΎΡΡ‚ΡŒ АПЀ зависит ΠΈ ΠΎΡ‚ Ρ„ΠΎΡ€ΠΌΡ‹, ΠΈ ΠΎΡ‚ ΠΏΠ΅Ρ€ΠΈΠΎΠ΄Π° Π“Π›ΠŸΠ‘: статистичСски Π½Π΅Π·Π½Π°Ρ‡ΠΈΠΌΠΎΠ΅ сниТСниС Π½Π°Π±Π»ΡŽΠ΄Π°Π΅Ρ‚ΡΡ Ρ‚ΠΎΠ»ΡŒΠΊΠΎ Π² Π»ΠΈΡ…ΠΎΡ€Π°Π΄ΠΎΡ‡Π½Ρ‹ΠΉ ΠΏΠ΅Ρ€ΠΈΠΎΠ΄ срСднСтяТСлой ΠΈ тяТСлой Ρ„ΠΎΡ€ΠΌΡ‹ Π±Π΅Π· ослоТнСний; Π²ΠΎ всС ΠΎΡΡ‚Π°Π»ΡŒΠ½Ρ‹Π΅ ΠΏΠ΅Ρ€ΠΈΠΎΠ΄Ρ‹ ΠΈ ΠΏΡ€ΠΈ всСх Ρ„ΠΎΡ€ΠΌΠ°Ρ… Π½Π°Π±Π»ΡŽΠ΄Π°Π΅Ρ‚ΡΡ статистичСски значимая Π³ΠΈΠΏΠ΅Ρ€Π°ΠΊΡ‚ΠΈΠ²Π½ΠΎΡΡ‚ΡŒ АПЀ. ΠŸΡ€ΠΈ тяТСлой Ρ„ΠΎΡ€ΠΌΠ΅ Π±Π΅Π· ослоТнСний Π½Π°Π±Π»ΡŽΠ΄Π°ΡŽΡ‚ΡΡ Ρ€Π΅Π·ΠΊΠΈΠ΅ колСбания активности АПЀ Π² Π΄ΠΈΠ½Π°ΠΌΠΈΠΊΠ΅ Π±ΠΎΠ»Π΅Π·Π½ΠΈ. ΠŸΡ€ΠΈ ослоТнСнной Ρ„ΠΎΡ€ΠΌΠ΅ ΠΈΠΌΠ΅Π΅Ρ‚ мСсто статистичСски значимая ΡΡ‚Π°Π±ΠΈΠ»ΡŒΠ½ΠΎ высокая Π°ΠΊΡ‚ΠΈΠ²Π½ΠΎΡΡ‚ΡŒ Ρ„Π΅Ρ€ΠΌΠ΅Π½Ρ‚Π° Π½Π° всСм протяТСнии Π±ΠΎΠ»Π΅Π·Π½ΠΈ. Анализ ΠΏΠΎΠ»ΠΈΠΌΠΎΡ€Ρ„ΠΈΠ·ΠΌΠ° Π³Π΅Π½Π° Ρ€Π΅Ρ†Π΅ΠΏΡ‚ΠΎΡ€Π° АВ I11 Ρ‚ΠΈΠΏΠ° ΡΠ²ΠΈΠ΄Π΅Ρ‚Π΅Π»ΡŒΡΡ‚Π²ΡƒΡŽΡ‚ ΠΎ Ρ‚ΠΎΠΌ, Ρ‡Ρ‚ΠΎ Π°Π»Π»Π΅Π»ΠΈ *А1166 ΠΈ *Π‘1166, Π° Ρ‚Π°ΠΊΠΆΠ΅, Π³Π΅Π½ΠΎΡ‚ΠΈΠΏΡ‹ *А1166/*А1166ΠΈ *Π‘1166/*Π‘1166 Π½Π΅ ассоциированы со ΡΡ‚Π΅ΠΏΠ΅Π½ΡŒΡŽ тяТСсти тСчСния Π“Π›ΠŸΠ‘. ΠŸΠΎΠ²Ρ‹ΡˆΠ΅Π½ΠΈΠ΅ активности АПЀ ΠΏΡ€ΠΈ Π“Π›ΠŸΠ‘ Π½Π΅ носит Π°Π΄Π°ΠΏΡ‚ΠΈΠ²Π½Ρ‹ΠΉ Ρ…Π°Ρ€Π°ΠΊΡ‚Π΅Ρ€ ΠΈΠ·-Π·Π° Π΄Π΅Ρ„Π΅ΠΊΡ‚ΠΎΠ² Π² Ρ€Π΅Ρ†Π΅ΠΏΡ†ΠΈΠΈ AT II ΠΈ являСтся Π°Π΄Π΅ΠΊΠ²Π°Ρ‚Π½Ρ‹ΠΌ мСтаболичСским ΠΎΡ‚Π²Π΅Ρ‚ΠΎΠΌ ΠΎΡ€Π³Π°Π½ΠΈΠ·ΠΌΠ° Π² ΠΎΡ‚Π²Π΅Ρ‚ Π½Π° Π²Π½Π΅Π΄Ρ€Π΅Π½ΠΈΠ΅ эндотСлиотропного вируса

    Thermodynamic Properties of Methanol in the Critical and Supercritical Regions

    Full text link

    Results of integrated treatment of herpetic stomatitis with the inclusion of lipid concentrate of ERYX biomass

    Get PDF
    Aim. The study of the effectiveness of the use of the biologically active additive Reptin-plant in the complex treatment of patients with herpetic stomatitis.Materials and methods. We examined 189 patients with a diagnosis of herpetic stomatitis, which were divided into 2 groups depending on the receipt of complex antiviral therapy with the inclusion of ERYX biomass lipid concentrate in the treatment regimen and without it. The following were assessed: clinical status, index assessment of the state of the oral cavity, state of local immunity, frequency of relapses and duration of the latency period.Results. 57 (30.2%) patients were identified with a mild form of herpetic stomatitis (HS), the average severity of HS was determined in 93 (49.2%) and a severe course of the disease was diagnosed in 39 (20.6%) patients. Analysis of the index assessment of the state of the oral cavity (OHIS, PMA), molecular genetic parameters, immunological studies (lysozyme titer, phagocytosis, concentration of sIg A in saliva) showed a statistically significant difference when included in the complex treatment of Reptin-plant, demonstrating the benefits of using it.Conclusions. The use of ERYX biomass lipid concentrate in the complex treatment of herpetic stomatitis effectively affects the dynamics of the course of the disease, improves the quality of life of patients

    MARKERY KOSTNOGO I OSTEOKLASTIChESKOGO DIFFERONOV PRI DEYSTVII POLIELEMENTOV MEDNO-TsINKOVOY KOLChEDANNOY RUDY

    No full text
    ИсслСдованиС содСрТания ряда элСмСнтов Π² волосах горняков ОАО «Учалинский Π“ΠžΠšΒ», Π΄ΠΎΠ±Ρ‹Π²Π°ΡŽΡ‰ΠΈΡ… ΠΌΠ΅Π΄Π½ΠΎ-Ρ†ΠΈΠ½ΠΊΠΎΠ²ΡƒΡŽ Ρ€ΡƒΠ΄Ρƒ ΠΏΠΎΠ΄Π·Π΅ΠΌΠ½Ρ‹ΠΌ способом, выявило статистичСски Π·Π½Π°Ρ‡ΠΈΠΌΠΎΠ΅ ΡƒΠ²Π΅Π»ΠΈΡ‡Π΅Π½ΠΈΠ΅ содСрТания ряда тяТСлых ΠΌΠ΅Ρ‚Π°Π»Π»ΠΎΠ² [ΠšΡƒΠ΄Π°ΡˆΠ΅Π²Π°, 2005; АглСтдинов ΠΈ Π΄Ρ€., 2011] характСризуя ΠΈΡ… поступлСниС ΠΈ Π½Π°ΠΊΠΎΠΏΠ»Π΅Π½ΠΈΠ΅ Π² тканях. ΠŸΡ€ΠΈ Π΄Π»ΠΈΡ‚Π΅Π»ΡŒΠ½ΠΎΠΌ Π²Π²Π΅Π΄Π΅Π½ΠΈΠΈ ΠΏΠΎΡ€ΠΎΡˆΠΊΠ° Ρ€ΡƒΠ΄Ρ‹ ΡΠΊΡΠΏΠ΅Ρ€ΠΈΠΌΠ΅Π½Ρ‚Π°Π»ΡŒΠ½Ρ‹ΠΌ ΠΆΠΈΠ²ΠΎΡ‚Π½Ρ‹ΠΌ Ρ‚Π°ΠΊΠΆΠ΅ установлСно Π·Π½Π°Ρ‡ΠΈΡ‚Π΅Π»ΡŒΠ½ΠΎΠ΅ ΡƒΠ²Π΅Π»ΠΈΡ‡Π΅Π½ΠΈΠ΅ содСрТания этой Π³Ρ€ΡƒΠΏΠΏΡ‹ элСмСнтов Π² костях [НургалССв ΠΈ Π΄Ρ€., 2013], Ρ‡Ρ‚ΠΎ ΡΠΎΠΏΡ€ΠΎΠ²ΠΎΠΆΠ΄Π°Π»ΠΎΡΡŒ усилСниСм оксидативных процСссов. ΠšΠ»Π΅Ρ‚ΠΊΠΈ Π΄ΠΈΡ„Ρ„Π΅Ρ€ΠΎΠ½Π° ΠΌΠΎΠ½ΠΎΠ½ΡƒΠΊΠ»Π΅Π°Ρ€Π½Ρ‹Ρ… Ρ„Π°Π³ΠΎΡ†ΠΈΡ‚ΠΎΠ² костной Ρ‚ΠΊΠ°Π½ΠΈ -остСокласты Ρ‡ΡƒΠ²ΡΡ‚Π²ΠΈΡ‚Π΅Π»ΡŒΠ½ΠΎ Ρ€Π΅Π°Π³ΠΈΡ€ΡƒΡŽΡ‚ Π½Π° воздСйствиС химичСских соСдинСний ΠΈ Π² процСссС Π°ΠΊΡ‚ΠΈΠ²Π½ΠΎΠ³ΠΎ функционирования Π²Ρ‹ΡΠ²ΠΎΠ±ΠΎΠΆΠ΄Π°ΡŽΡ‚ ряд Ρ„Π΅Ρ€ΠΌΠ΅Π½Ρ‚ΠΎΠ², ΠΊΠΎΡ‚ΠΎΡ€Ρ‹Π΅ Π³Π΅Π½Π΅Ρ€ΠΈΡ€ΡƒΡŽΡ‚ Π² Π·ΠΎΠ½Π΅ Ρ€Π΅Π·ΠΎΡ€Π±Ρ†ΠΈΠΈ супСроксидный Π°Π½ΠΈΠΎΠ½-Ρ€Π°Π΄ΠΈΠΊΠ°Π» [VÀÀrΓ€niemi et al., 2004], ΠΈ усилСниС свободно-Ρ€Π°Π΄ΠΈΠΊΠ°Π»ΡŒΠ½ΠΎΠ³ΠΎ окислСния Π² костной Ρ‚ΠΊΠ°Π½ΠΈ ΠΌΠΎΠΆΠ΅Ρ‚ Π±Ρ‹Ρ‚ΡŒ ΠΎΡ‚Ρ€Π°ΠΆΠ΅Π½ΠΈΠ΅ΠΌ интСнсификации Ρ€Π΅Π·ΠΎΡ€Π±Ρ‚ΠΈΠ²Π½Ρ‹Ρ… процСссов ΠΏΡ€ΠΈ дСйствии полиэлСмСнтов Ρ€ΡƒΠ΄Ρ‹ Ρ†Π²Π΅Ρ‚Π½Ρ‹Ρ… ΠΌΠ΅Ρ‚Π°Π»Π»ΠΎΠ². ЦСль. Π˜Π·ΡƒΡ‡Π΅Π½ΠΈΠ΅ уровня ΠΌΠ°Ρ€ΠΊΠ΅Ρ€ΠΎΠ² остСобластогСнСза ΠΈ остСокластогСнСза ΠΏΡ€ΠΈ дСйствии полиэлСмСнтов ΠΌΠ΅Π΄Π½ΠΎ-Ρ†ΠΈΠ½ΠΊΠΎΠ²ΠΎΠΉ ΠΊΠΎΠ»Ρ‡Π΅Π΄Π°Π½Π½ΠΎΠΉ Ρ€ΡƒΠ΄Ρ‹. ΠœΠ°Ρ‚Π΅Ρ€ΠΈΠ°Π» ΠΈ ΠΌΠ΅Ρ‚ΠΎΠ΄Ρ‹. 20 Π±Π΅Π»Ρ‹ΠΌ ΠΏΠΎΠ»ΠΎΠ²ΠΎΠ·Ρ€Π΅Π»Ρ‹ΠΌ самцам крыс ΠΎΠΏΡ‹Ρ‚Π½ΠΎΠΉ Π³Ρ€ΡƒΠΏΠΏΡ‹ Π² Ρ‚Π΅Ρ‡Π΅Π½ΠΈΠ΅ Ρ‚Ρ€Π΅Ρ… мСсяцСв Π΅ΠΆΠ΅Π΄Π½Π΅Π²Π½ΠΎ Π²Π½ΡƒΡ‚Ρ€ΠΈΠΆΠ΅Π»ΡƒΠ΄ΠΎΡ‡Π½ΠΎ Π²Π²ΠΎΠ΄ΠΈΠ»ΠΈ ΡΡƒΡΠΏΠ΅Π½Π·ΠΈΡŽ ΠΏΠΎΡ€ΠΎΡˆΠΊΠ° Ρ€ΡƒΠ΄Ρ‹ Π² 2% растворС ΠΊΡ€Π°Ρ…ΠΌΠ°Π»Π° ΠΈΠ· расчСта 60 ΠΌΠ³/100Π³ массы, 12 крыс ΠΈΠ΄Π΅Π½Ρ‚ΠΈΡ‡Π½ΠΎΠΉ массы (220-240Π³) ΠΏΠΎΠ»ΡƒΡ‡Π°Π»ΠΈ Π΅ΠΆΠ΅Π΄Π½Π΅Π²Π½ΠΎ раствор ΠΊΡ€Π°Ρ…ΠΌΠ°Π»Π°. Π’ Ρ‚Ρ€ΡƒΠ±Ρ‡Π°Ρ‚Ρ‹Ρ… костях (бСдрСнная, Π±ΠΎΠ»ΡŒΡˆΠ΅Π±Π΅Ρ€Ρ†ΠΎΠ²Π°Ρ ΠΈ плСчСвая) Ρ‡Π΅Ρ€Π΅Π· 1,2 ΠΈ 3 мСсяца интоксикации Ρ€ΡƒΠ΄ΠΎΠΉ опрСдСляли содСрТаниС Fe, Mg, Mn, Hg, Sr, Cr ΠΌΠ΅Ρ‚ΠΎΠ΄ΠΎΠΌ Π°Ρ‚ΠΎΠΌΠ½ΠΎ-абсорбционной спСктромСтрии ΠΈ Cu, Zn, Cd b Pb Π²ΠΎΠ»ΡŒΡ‚Π°ΠΌΠΏΠ΅Ρ€ΠΎΠΌΠ΅Ρ‚Ρ€ΠΈΡ‡Π΅ΡΠΊΠΈΠΌ ΠΌΠ΅Ρ‚ΠΎΠ΄ΠΎΠΌ. Π’ ΠΏΠ»Π°Π·ΠΌΠ΅ ΠΊΡ€ΠΎΠ²ΠΈ Π½Π° 3-ΠΉ мСсяц экспСримСнта ΠΈΠ·ΡƒΡ‡ΠΈΠ»ΠΈ содСрТаниС растворимого Π»ΠΈΠ³Π°Π½Π΄Π° ядСрного Ρ„Π°ΠΊΡ‚ΠΎΡ€Π° транскрипции ΠΊΠ°ΠΏΠΏΠ° Π‘ (s RANKL), остСопротСгСрина (OPG) - Π»ΠΎΠΆΠ½ΠΎΠ³ΠΎ Ρ€Π΅Ρ†Π΅ΠΏΡ‚ΠΎΡ€Π° RANKL ΠΈ склСростина, ΠΈΡΠΏΠΎΠ»ΡŒΠ·ΡƒΡ ΡΠΎΠΎΡ‚Π²Π΅Ρ‚ΡΡ‚Π²ΡƒΡŽΡ‰ΠΈΠ΅ Π½Π°Π±ΠΎΡ€Ρ‹ Ρ€Π΅Π°Π³Π΅Π½Ρ‚ΠΎΠ² (Biomedica, Medizinproducte Gmb), костной Ρ‰Π΅Π»ΠΎΡ‡Π½ΠΎΠΉ фосфатазы (КЩЀ, Β«Quidel CorporationΒ»)). Π’ Π³Ρ€ΡƒΠΏΠΏΠ°Ρ… рассчитывали ΠΌΠ΅Π΄ΠΈΠ°Π½Ρƒ, ΠΌΠ΅ΠΆΠΊΠ²Π°Ρ€Ρ‚Π°Π»ΡŒΠ½Ρ‹Π΅ ΠΈΠ½Ρ‚Π΅Ρ€Π²Π°Π»Ρ‹, Π΄ΠΎΡΡ‚ΠΎΠ²Π΅Ρ€Π½ΠΎΡΡ‚ΡŒ ΠΌΠ΅ΠΆΠ³Ρ€ΡƒΠΏΠΏΠΎΠ²Ρ‹Ρ… Ρ€Π°Π·Π»ΠΈΡ‡ΠΈΠΉ ΠΎΡ†Π΅Π½ΠΈΠ²Π°Π»ΠΈ ΠΏΠΎ U-ΠΊΡ€ΠΈΡ‚Π΅Ρ€ΠΈΡŽ Манна-Π£ΠΈΡ‚Π½ΠΈ. Π Π΅Π·ΡƒΠ»ΡŒΡ‚Π°Ρ‚Ρ‹. ΠžΠΏΡ€Π΅Π΄Π΅Π»Π΅Π½ΠΈΠ΅ ряда элСмСнтов Π² кости выявило, Ρ‡Ρ‚ΠΎ содСрТаниС Mn, Sr, Fe, Cu, Zn, Cd, Pb ΠΈ Hg ΠΏΠΎΠ²Ρ‹ΡˆΠ°Π΅Ρ‚ΡΡ ΠΊ ΠΊΠΎΠ½Ρ†Ρƒ 3-Π³ΠΎ мСсяца экспСримСнта Ρƒ ΠΎΠΏΡ‹Ρ‚Π½ΠΎΠΉ Π³Ρ€ΡƒΠΏΠΏΡ‹ крыс Π·Π½Π°Ρ‡ΠΈΡ‚Π΅Π»ΡŒΠ½ΠΎ (ΠΎΡ‚ 1,5 Π΄ΠΎ 5 Ρ€Π°Π·), Cr увСличиваСтся Π½Π΅Π·Π½Π°Ρ‡ΠΈΡ‚Π΅Π»ΡŒΠ½ΠΎ, Π° Mg сниТаСтся. ΠŸΡ€ΠΈ этом ΡƒΡ€ΠΎΠ²Π΅Π½ΡŒ Fe ΠΈ Mn увСличиваСтся ΡƒΠΆΠ΅ Ρ‡Π΅Ρ€Π΅Π· 1 мСсяц интоксикации, Π° Π·Π°Ρ‚Π΅ΠΌ Π½Π΅ подвСргаСтся статистичСски Π·Π½Π°Ρ‡ΠΈΠΌΡ‹ΠΌ измСнСниям. Π”Ρ€ΡƒΠ³ΠΈΠ΅ элСмСнты Π½Π°ΠΊΠ°ΠΏΠ»ΠΈΠ²Π°ΡŽΡ‚ΡΡ, достигая максимального уровня лишь ΠΊ ΠΊΠΎΠ½Ρ†Ρƒ Ρ‚Ρ€Π΅Ρ‚ΡŒΠ΅Π³ΠΎ мСсяца. Π‘ΠΎΠ΄Π΅Ρ€ΠΆΠ°Π½ΠΈΠ΅ s RANKL Π² ΠΏΠ»Π°Π·ΠΌΠ΅ ΠΊΡ€ΠΎΠ²ΠΈ ΠΆΠΈΠ²ΠΎΡ‚Π½Ρ‹Ρ… ΠΏΡ€ΠΈ дСйствии полиэлСмСнтов Ρ€ΡƒΠ΄Ρ‹ практичСски Π½Π΅ измСнялось, составляя 0,6 [0,12;1,29] пмоль/Π» Π² ΠΊΠΎΠ½Ρ‚Ρ€ΠΎΠ»Π΅ ΠΈ 0,63 [0,45; 0,75] пмоль/Π» Π² ΠΎΠΏΡ‹Ρ‚Π½ΠΎΠΉ Π³Ρ€ΡƒΠΏΠΏΠ΅. Аналогичная Π΄ΠΈΠ½Π°ΠΌΠΈΠΊΠ° Π²Ρ‹ΡΠ²ΠΈΠ»Π°ΡΡŒ ΠΈ ΠΏΡ€ΠΈ ΠΎΠΏΡ€Π΅Π΄Π΅Π»Π΅Π½ΠΈΠΈ КЩЀ: 4,5 [1,6;6,9] Π•/Π» ΠΈ 5,0 [3,8;6,3] Π•/Π» соотвСтствСнно, Ρ€=0,42, Π° содСрТаниС OPG сниТалось с 0,41 [0,4;0,44] пмоль/Π» Π΄ΠΎ 0,3 [0,26;0,38] пмоль/Π», Ρ€=0,043. ΠšΠΎΡΡ„Ρ„ΠΈΡ†ΠΈΠ΅Π½Ρ‚ sRANKL/OPG, Ρ…Π°Ρ€Π°ΠΊΡ‚Π΅Ρ€ΠΈΠ·ΡƒΡŽΡ‰ΠΈΠΉ ΠΎΠ±Ρ‰Π΅Π΅ Β«ΠΊΠΎΠ½Π²Π΅Ρ€Π³Π΅Π½Ρ‚Π½ΠΎΠ΅Β» ΡΠΎΠΎΡ‚Π½ΠΎΡˆΠ΅Π½ΠΈΠ΅ ΠΏΡ€ΠΎ- ΠΈ Π°Π½Ρ‚ΠΈΡ€Π΅Π·ΠΎΡ€Π±Ρ‚ΠΈΠ²Π½Ρ‹Ρ… рСгуляторов остСокластной Π΄ΠΈΡ„Ρ„Π΅Ρ€Π΅Π½Ρ†ΠΈΡ€ΠΎΠ²ΠΊΠΈ ΠΈ Π°ΠΊΡ‚ΠΈΠ²Π°Ρ†ΠΈΠΈ остСокластов [Hobauer, 2009], ΠΏΠΎΠ²Ρ‹ΡˆΠ°Π΅Ρ‚ΡΡ. Π£ ΠΆΠΈΠ²ΠΎΡ‚Π½Ρ‹Ρ… ΠΊΠΎΠ½Ρ‚Ρ€ΠΎΠ»ΡŒΠ½ΠΎΠΉ Π³Ρ€ΡƒΠΏΠΏΡ‹ ΠΎΠ½ составляСт 1,46 [1,2;1,51], Ρƒ ΠΎΠΏΡ‹Ρ‚Π½ΠΎΠΉ Π³Ρ€ΡƒΠΏΠΏΡ‹ - 2,1 [1,84;2,33], Ρ€=0,041, Ρ‡Ρ‚ΠΎ ΠΎΡ‚Ρ€Π°ΠΆΠ°Π΅Ρ‚ ΠΈΠ½Ρ‚Π΅Π½ΡΠΈΡ„ΠΈΠΊΠ°Ρ†ΠΈΡŽ процСссов остСокластогСнСза ΠΈ Ρ€Π΅Π·ΠΎΡ€Π±Ρ†ΠΈΠΈ. Π£Ρ€ΠΎΠ²Π΅Π½ΡŒ склСростина Ρƒ ΠΎΠΏΡ‹Ρ‚Π½ΠΎΠΉ Π³Ρ€ΡƒΠΏΠΏΡ‹ ΠΆΠΈΠ²ΠΎΡ‚Π½Ρ‹Ρ… ΠΏΠΎΠ²Ρ‹ΡˆΠ°Π»ΡΡ с 12,3 [12,0;12,6] пмоль/Π» Π΄ΠΎ 14,2 [12,5;14,7], Ρ€=0,046. БклСростин, Π²Ρ‹Ρ€Π°Π±Π°Ρ‚Ρ‹Π²Π°Π΅ΠΌΡ‹ΠΉ остСоцитами ΠΈ Π³ΠΈΠΏΠ΅Ρ€Ρ‚Ρ€ΠΎΡ„ΠΈΡ€ΠΎΠ²Π°Π½Π½Ρ‹ΠΌΠΈ Ρ…ΠΎΠ½Π΄Ρ€ΠΎΡ†ΠΈΡ‚Π°ΠΌΠΈ, являСтся Π½Π΅Π³Π°Ρ‚ΠΈΠ²Π½Ρ‹ΠΌ рСгулятором остСобластогСнСза [Bernardes et al., 2013], ΠΈ Π΅Π³ΠΎ ΠΏΠΎΠ²Ρ‹ΡˆΠ΅Π½ΠΈΠ΅ ΡΠ²ΠΈΠ΄Π΅Ρ‚Π΅Π»ΡŒΡΡ‚Π²ΡƒΠ΅Ρ‚ ΠΎΠ± ΠΈΠ½Π³ΠΈΠ±ΠΈΡ€ΠΎΠ²Π°Π½ΠΈΠΈ костного Π΄ΠΈΡ„Ρ„Π΅Ρ€ΠΎΠ½Π°. Π’Ρ‹Π²ΠΎΠ΄Ρ‹. ΠŸΠΎΠ»ΠΈΡΠ»Π΅ΠΌΠ΅Π½Ρ‚Ρ‹ ΠΌΠ΅Π΄Π½ΠΎ-Ρ†ΠΈΠ½ΠΊΠΎΠ²ΠΎΠΉ ΠΊΠΎΠ»Ρ‡Π΅Π΄Π°Π½Π½ΠΎΠΉ Ρ€ΡƒΠ΄Ρ‹, накапливаясь Π² костной Ρ‚ΠΊΠ°Π½ΠΈ, приводят ΠΊ Π°ΠΊΡ‚ΠΈΠ²Π°Ρ†ΠΈΠΈ остСокластичСского Π΄ΠΈΡ„Ρ„Π΅Ρ€ΠΎΠ½Π° Π½Π° Ρ„ΠΎΠ½Π΅ Π½Π΅ΠΊΠΎΡ‚ΠΎΡ€ΠΎΠ³ΠΎ подавлСния костного Π΄ΠΈΡ„Ρ„Π΅Ρ€ΠΎΠ½Π° (остСобластогСнСза)
    • …
    corecore