Stability of additive-free water-in-oil emulsions

We calculate ion distributions near a planar oil-water interface within non-linear Poisson-Boltzmann theory, taking into account the Born self-energy of the ions in the two media. For unequal self-energies of cations and anions, a spontaneous charge separation is found such that the water and oil phase become oppositely charged, in slabs with a typical thickness of the Debye screening length in the two media. From the analytical solutions, the corresponding interfacial charge density and the contribution to the interfacial tension is derived, together with an estimate for the Yukawa-potential between two spherical water droplets in oil. The parameter regime is explored where the plasma coupling parameter exceeds the crystallization threshold, i.e. where the droplets are expected to form crystalline structures due to a strong Yukawa repulsion, as recently observed experimentally. Extensions of the theory that we discuss briefly include numerical calculations on spherical water droplets in oil, and analytical calculations of the linear PB-equation for a finite oil-water interfacial width.Comment: 9 pages, 4 figures, accepted by JPCM for proceedings of LMC

Single-chip CMOS optical microspectrometer

Numerous applications, e.g., systems for chemical analysis by optical absorption and emission line characterization, will benefit from the availability of low-cost single-chip spectrometers. A single-chip CMOS optical microspectrometer containing an array of 16 addressable Fabry–Perot etalons (each one with different resonance cavity length), photodetectors and circuits for read-out, multiplexing and driving a serial bus interface has been fabricated. The result is a chip that can operate using only four external connections (including Vdd and Vss). covering the visible spectral range of the spectrum with FWHM = 18 nm. Frequency output and serial bus interface allow easy multi-sensor, multi-chip interfacing using a microcontroller or a personal computer. Power consumption is 1250 µW for a clock frequency of 1 MHzFundação para a Ciência e a Tecnologia (FCT

Optical microspectrometer using a micro-instrumentation platform

MEMS are usually designed for measuring one parameter and on-chip co-integration of sensor (microstructure) and readout circuits is often pursued. In a multi-parameter measurement system, yield considerations and fabrication compatibility problems favor micro-instruments based on active Si-MCM techniques. The generic device is based on a stacked structure with a universally applicable active silicon MCM platform that contains all the infrastructural functions of a measurement system. Customizing the microsystem requires flip-chip attach of sensor dies and a commercially available microcontroller die, which is subsequently programmed for the intended application. The micro-instrument features a data pre processing capability to provide high-level data (e.g. spectral information rather than raw sensor data) and to communicate with a host processor intelligently.STW - project DEL 55.3733.TU Delft, Fundação para a Ciência e Tecnologia (FCT) - Program Praxis XXI-BD/5181/95

A single-chip CMOS optical microspectrometer with light-to-frequency converter and bus interface

A single-chip CMOS optical microspectrometer containing an array of 16 addressable Fabry–Perot etalons (each one with a different resonance cavity length), photodetectors, and circuits for readout, multiplexing, and driving a serial bus interface has been fabricated in a standard 1.6 um CMOS technology (chiparea 3.9x4.2 mm2). The result is a chip that can operate using only four external connections (including and ) covering the optical range of 380–500 nm with full-width half-maximum (FWHM) = 18 nm. Frequency output and serial bus interface allow easy multisensor and multichip interfacing using a microcontroller or a personal computer. Power consumption is 1250 W for a clock frequency of 1 MHz.Fundação para a Ciência e a Tecnologia (FCT

Targeting the Four Pillars of Enterohepatic Bile Salt Cycling; Lessons From Genetics and Pharmacology

Bile salts play a pivotal role in lipid homeostasis, are sensed by specialized receptors, and have been implicated in various disorders affecting the gut or liver. They may play a role either as culprit or as potential panacea. Four very efficient transporters mediate most of the hepatic and intestinal bile salt uptake and efflux, and are each essential for the efficient enterohepatic circulation of bile salts. Starting from the intestinal lumen, conjugated bile salts cross the otherwise impermeable lipid bilayer of (primarily terminal ileal) enterocytes through the apical sodium–dependent bile acid transporter (gene SLC10A2) and leave the enterocyte through the basolateral heteromeric organic solute transporter, which consists of an alpha and beta subunit (encoded by SLC51A and SLC51B). The Na+-taurocholate cotransporting polypeptide (gene SLC10A1) efficiently clears the portal circulation of bile salts, and the apical bile salt export pump (gene ABCB11) pumps the bile salts out of the hepatocyte into primary bile, against a very steep concentration gradient. Recently, individuals lacking either functional Na+-taurocholate cotransporting polypeptide or organic solute transporter have been described, completing the quartet of bile acid transport deficiencies, as apical sodium–dependent bile acid transporter and bile salt export pump deficiencies were already known for years. Novel pathophysiological insights have been obtained from knockout mice lacking functional expression of these genes and from pharmacological transporter inhibition in mice or humans. Conclusion: We provide a concise overview of the four main bile salt transport pathways and of their status as possible targets of interventions in cholestatic or metabolic disorders

Propagation of thermal excitations in a cluster of vortices in superfluid 3He-B

We describe the first measurement on Andreev scattering of thermal excitations from a vortex configuration with known density, spatial extent, and orientations in 3He-B superfluid. The heat flow from a blackbody radiator in equilibrium rotation at constant angular velocity is measured with two quartz tuning fork oscillators. One oscillator creates a controllable density of excitations at 0.2Tc base temperature and the other records the thermal response. The results are compared to numerical calculations of ballistic propagation of thermal quasiparticles through a cluster of rectilinear vortices.Comment: 6 pages, 4 figure

CMOS compatible optical sensors with thin film interference filters : fabrication and characterization

Optical microsystems with high spectral selectivity and fabrication compatible with a standard CMOS process have been realized. PN junction photodiodes are used for photodetection. A multi-layer optical filter fabricated on top of the active photodiode forms a Fabry-Perot optical resonance cavity. The resonance wavelength can be designed within the entire visible spectrum. The filters are fabricated by depositing thin layers (SiO2, Al, Ag) with thickness and composition optimized for the required spectral response. Operation is demonstrated on a device with a 20nm Al/250nm SiO2/45nm Ag filter resulting in a narrow transmission peak (FWHM=18nm) with maximum responsivity of 14.8 mA/W at 420nm. IC-fabrication compatibility of this device allows the on-chip integration of A-to-D conversion based on a frequency or bitstream signal.STW - Project DEL.3733

Reduction of radiation dose using 80 kV tube voltage: a feasible strategy?

Cardiolog

Nasal hyperreactivity and inflammation in allergic rhinitis

The history of allergic disease goes back to 1819, when Bostock described his own ‘periodical affection of the eyes and chest’, which he called ‘summer catarrh’. Since they thought it was produced by the effluvium of new hay, this condition was also called hay fever. Later, in 1873, Blackley established that pollen played an important role in the causation of hay fever. Nowadays, the definition of allergy is ‘An untoward physiologic event mediated by a variety of different immunologic reactions’. In this review, the term allergy will be restricted to the IgE-dependent reactions. The most important clinical manifestations of IgE-dependent reactions are allergic conjunctivitis, allergic rhinitis, allergic asthma and atopic dermatitis. However, this review will be restricted to allergic rhinitis. The histopathological features of allergic inflammation involve an increase in blood flow and vascular permeability, leading to plasma exudation and the formation of oedema. In addition, a cascade of events occurs which involves a variety of inflammatory cells. These inflammatory cells migrate under the influence of chemotactic agents to the site of injury and induce the process of repair. Several types of inflammatory cells have been implicated in the pathogenesis of allergic rhinitis. After specific or nonspecific stimuli, inflammatory mediators are generated from cells normally found in the nose, such as mast cells, antigen-presenting cells and epithelial cells (primary effector cells) and from cells recruited into the nose, such as basophils, eosinophils, lymphocytes, platelets and neutrophils (secondary effector cells). This review describes the identification of each of the inflammatory cells and their mediators which play a role in the perennial allergic processes in the nose of rhinitis patients

IVUS detects more coronary calcifications than MSCT; matter of both resolution and cross-sectional assessment?

Vascular Biology and Interventio