Case report. A rare case of giant basal cell carcinoma and malignant melanoma

The presence of two several skin lesions in the same patient is a rare occurrence in dermatological findings. The associations of malignant melanoma (MM) and giant basal cell carcinoma (BCC) within the same patient have only been described in few cases in the literature.1,6 Is there a common genetic origin? However, until now the pathogenesis of collision tumors existing of MM and BCC remains unclear. We, therefore, report a case of association of MM and BCC in the same patient

A rare case of leiomyoma of the bladder

Bladder leiomyoma is a benign tumour of the bladder and constitute <0.5% of all bladder tumors. We report a clinical case of a 51‑year‑old female who presented with with symptomatic bladder leiomyoma. An ultrasound examination showed well-defined bladder leiomyoma in the right posterior bladder wall, which was excised through a transurethral resection. The pathologic diagnosis was bladder leiomyoma

A case of primary Hodgkin's lymphoma of the parotid gland. Case report and differentian diagnosis from Kuttner's Syndrom

Abstract We report a rare case of primary Hodgkin’s lymphoma (HL) of the submandibular gland, with initially diagnosis of Kuttner’s Syndrom. A 48 years old man was referred to our hospital foe evaluation of a submandibular mass. Although the initial Fine Needle Aspiration and subsequent cytology was highly suggestive for a cronic sialadenitis with lymphoid cells. After surgical gland removal we obtained a definitive diagnosis of Hodgkin’s lymphoma in submandibular gland a seat where the most common lymphoma tipe is B

Which is the most accurate diagnostic procedure in Tamoxifen treated breast cancer patients

Purpose: The aim of this study was to evaluate the diagnostic accuracy of bi-dimensional (2D) and three-dimensional (3D) transvaginal ultrasound (TVUS), hysterosonography (HSSG) and hysteroscopy in the detection of endometrial pathology in women treated with tamoxifen (TMX) for breast cancer. Methods: Forty-two patients, affected by breast cancer under treatment with TMX, underwent 2D-3D TVUS, HSSG and hysteroscopy completed by biopsy, after abnormal findings following a routine 2D TVUS examination. Results: 3D-TVUS was more accurate than 2D-TVUS in the detection of atrophic endometrium confirmed by biopsy and in the detection of endometrial polyps. HSSG and hysteroscopy detected atrophic endometrium and endometrial polyps significantly better than ultrasound scan. Endometrial carcinoma was detected in two cases, and in both HSSG and hysteroscopy were 100% diagnostic. Conclusion: In TMX treated breast cancer patients, HSSG and hysteroscopy provide more accurate diagnosis than 2D-3D ultrasound in the detection of treatment related endometrial lesions

Evaluating the expression of urokinase and tissue leukocyte being in benign and malignant breast disease

Introduction: Our objectives is to show that the expression of uPA leukocyte could be considered, in the future, as a marker of the expression of uPA in the malignant tissue and therefore a potential indicator of prognosis. Methods: We examined the expression of uPa in leukocytes and tissues of three groups of women: with breast cancer; with benign breast lesion and healthy women (control group). We used RT Real Time PCR assay. The expression of urokinase is significantly higher in malignant breast lumps compared to benign lesions. However, in women with carcinoma of the breast, malignant tissue expresses higher amounts of uPA than the healthy counterpart. There are no statistically significant differences in the expression of uPA, between tissues taken from women with benign lesions. The lymphocytes taken from healthy volunteers show a level of expression of uPA significantly lower than the other tested samples Lymphocytes extracted from cancer patients express higher amounts of uPA compared to lymphocytes belonging to women with benign breast lesions. The expression of uPA was compared with the clinical and biological parameters commonly used in clinical practice for the definition of the prognosis. The only exception found, concerns those tumors characterized by the simultaneous negativity for estrogen receptors, progesterone and HER2 (state of triple negative), in which the expression of uPA is very high. Results and conclusions: Our data show that uPA expressed by leukocytes of each individual patient is the mirror image of the one expressed by malignant nodular uPA.Introduction: Our objectives is to show that the expression of uPA leukocyte could be considered, in the future, as a marker of the expression of uPA in the malignant tissue and therefore a potential indicator of prognosis. Methods: We examined the expression of uPa in leukocytes and tissues of three groups of women: with breast cancer; with benign breast lesion and healthy women (control group). We used RT Real Time PCR assay. The expression of urokinase is significantly higher in malignant breast lumps compared to benign lesions. However, in women with carcinoma of the breast, malignant tissue expresses higher amounts of uPA than the healthy counterpart. There are no statistically significant differences in the expression of uPA, between tissues taken from women with benign lesions. The lymphocytes taken from healthy volunteers show a level of expression of uPA significantly lower than the other tested samples Lymphocytes extracted from cancer patients express higher amounts of uPA compared to lymphocytes belonging to women with benign breast lesions. The expression of uPA was compared with the clinical and biological parameters commonly used in clinical practice for the definition of the prognosis. The only exception found, concerns those tumors characterized by the simultaneous negativity for estrogen receptors, progesterone and HER2 (state of triple negative), in which the expression of uPA is very high. Results and conclusions: Our data show that uPA expressed by leukocytes of each individual patient is the mirror image of the one expressed by malignant nodular uPA

Open and / or laparoscopic surgical treatment of liver hydatic cysts

Hydatid disease is a severe parasitic disease with a widely ranging distribution. In the human being the liver is the most frequent organ affected. 1 The treatment should be individualized to the morphology, size, number and location of the cysts, that is why a variety of surgical operations have been advocated from complete resection like total pericystectomy or partial hepatectomy to laparoscopy to a minimally invasive procedures like percutaneous aspiration of cysts to conservative drug therapy. 3-4 This study compares laparoscopic versus open management of the hydatid cyst of liver the surgical approach to liver echinococcosis is still a controversial issue and shows our results of surgical treatment of liver hydatid cysts during a 3-years period

Weak Sequential Completeness of Uniform Algebras

We prove that a uniform algebra is weakly sequentially complete if and only if it is finite-dimensional

Pancreas divisum. Correlation between anatomical abnormalities and bile precipitation in the gallbladder in seven patients

Pancreas divisum is a genetic defect associated with recurrent acute pancreatitis due to insufficient drainage of the accessory pancreatic duct. Seven young patients diagnosed with pancreatic divisum and thickening of the gallbladder bile as shown on magnetic resonance cholangio-pancreatography without pancreatic ductal changes underwent laparoscopic cholecystectomy. During the mean follow-up of 32 months no episode of pancreatitis was reported. There is an association between PD and higher concentration of bile in the gallbladder. Cholecystectomy can be considered curative in patients with PD in the absence of indications for major surgery

Neurological modeling of what experts vs. non-experts find interesting

The P3 and related ERP's have a long history of use to identify stimulus events in subjects as part of oddball-style experiments. In this work we describe the ongoing development of oddball style experiments which attempt to capture what a subject finds of interest or curious, when presented with a set of visual stimuli i.e. images. This joint work between Dublin City University (DCU) and the European Space Agency's Advanced Concepts Team (ESA ACT) is motivated by the challenges of autonomous space exploration where the time lag for sending data back to earth for analysis and then communicating an action or decision back to the spacecraft means that decision-making is slow. Also, when extraterrestrial sensors capture data, the determination of what data to send back to earth is driven by an expertly devised rule set, that is scientists need to determine apriori what will be of interest. This cannot adapt to novel or unexpected data that a scientist may find curious. Our work is attempting to determine if it is possible to capture what a scientist (subject) finds of interest (curious) in a stream of image data through EEG measurement. One of the our challenges is to determine the difference between an expert and a lay subject response to stimulus. To investigate the theorized difference, we use a set of lifelog images as our dataset. Lifelog images are first person images taken by a small wearable camera which continuously records images whilst it is worn. We have devised two key experiments for use with this data and two classes of subjects. Our subjects are a person who has worn the personal camera, from which our collection of lifelog images is taken and who becomes our expert, and the remaining subjects are people who have no association with the captured images. Our first experiment is a traditional oddball experiment where the oddballs are people having coffee, and can be thought of as a directed information seeking task. The second experiment is to present a stream of lifelog images to the subjects and record which images cause a stimulus response. Once the data from these experiments has been captured our task is to compare the responses between the expert and lay subject groups, to determine if there are any commonalities between these groups or any distinct differences. If the latter outcome is the case the objective is then to investigate methods for capturing properties of images which cause an expert to be interested in a presented image. Further novelty is added to our work by the fact we are using entry-level off-the-shelf EEG devices, consisting of 4 nodes with a sampling rate of 255Hz