13,122 research outputs found

    Spin interference and Fano effect in electron transport through a mesoscopic ring side-coupled with a quantum dot

    Full text link
    We investigate the electron transport through a mesoscopic ring side-coupled with a quantum dot(QD) in the presence of Rashba spin-orbit(SO) interaction. It is shown that both the Fano resonance and the spin interference effects play important roles in the electron transport properties. As the QD level is around the Fermi energy, the total conductance shows typical Fano resonance line shape. By applying an electrical gate voltage to the QD, the total transmission through the system can be strongly modulated. By threading the mesoscopic ring with a magnetic flux, the time-reversal symmetry of the system is broken, and a spin polarized current can be obtained even though the incident current is unpolarized.Comment: 5 pages, 5 figure

    Bone loss and aggravated autoimmune arthritis in HLA-DRβ1-bearing humanized mice following oral challenge with Porphyromonas gingivalis

    Get PDF
    BACKGROUND: The linkage between periodontal disease and rheumatoid arthritis is well established. Commonalities among the two are that both are chronic inflammatory diseases characterized by bone loss, an association with the shared epitope susceptibility allele, and anti-citrullinated protein antibodies. METHODS: To explore immune mechanisms that may connect the two seemingly disparate disorders, we measured host immune responses including T-cell phenotype and anti-citrullinated protein antibody production in human leukocyte antigen (HLA)-DR1 humanized C57BL/6 mice following exposure to the Gram-negative anaerobic periodontal disease pathogen Porphyromonas gingivalis. We measured autoimmune arthritis disease expression in mice exposed to P. gingivalis, and also in arthritis-resistant mice by flow cytometry and multiplex cytokine-linked and enzyme-linked immunosorbent assays. We also measured femoral bone density by microcomputed tomography and systemic cytokine production. RESULTS: Exposure of the gingiva of DR1 mice to P. gingivalis results in a transient increase in the percentage of Th17 cells, both in peripheral blood and cervical lymph nodes, a burst of systemic cytokine activity, a loss in femoral bone density, and the generation of anti-citrullinated protein antibodies. Importantly, these antibodies are not produced in response to P. gingivalis treatment of wild-type C57BL/6 mice, and P. gingivalis exposure triggered expression of arthritis in arthritis-resistant mice. CONCLUSIONS: Exposure of gingival tissues to P. gingivalis has systemic effects that can result in disease pathology in tissues that are spatially removed from the initial site of infection, providing evidence for systemic effects of this periodontal pathogen. The elicitation of anti-citrullinated protein antibodies in an HLA-DR1-restricted fashion by mice exposed to P. gingivalis provides support for the role of the shared epitope in both periodontal disease and rheumatoid arthritis. The ability of P. gingivalis to induce disease expression in arthritis-resistant mice provides support for the idea that periodontal infection may be able to trigger autoimmunity if other disease-eliciting factors are already present

    Decays of Zb(+) and Zb'(+) as hadronic molecules

    Full text link
    The two newly observed hidden-bottom mesons Zb(10610) and Zb'(10650) with quantum numbers J(P) = 1(+) are considered as hadronic molecules composed of BB(*) and B(*)B(*), respectively. We give predictions for the widths of the strong two-body decays Zb(+) to Upsilon(nS) + pi(+) and Zb'(+) to Upsilon(nS) + pi(+) in a phenomenological Lagrangian approach.Comment: 9 page
    • …
    corecore