Anterior cruciate ligament reconstruction with bone-patellar tendon-bone autograft versus allograft in young patients

Objectives: Traditionally, bone-patella tendon-bone (BTB) autograft has been the gold standard graft choice for younger, athletic patients requiring ACL reconstruction. However, donor site morbidity, post-operative patella fracture, and increased operative time have led many surgeons to choose BTB allograft for their reconstructions. Opponents of allografts feel that slower healing time, higher rate of graft failure, and potential for disease transmission makes them undesirable graft choices in athletic patients. The purpose of this study is to evaluate the clinical outcomes, both subjective and objective, of young patients that who have undergone either BTB autograft or allograft reconstructions with a minimum of 2-year follow-up. Methods: One hundred and twenty patients (60 autograft, 60 allograft), age 25 and below at time of surgery, were contacted after being retrospectively identified as patients having an ACL reconstruction with either a BTB allograft or autograft by one senior surgeon. Patients were administered the Lysholm Knee Scoring Scale and IKDC Subjective Knee Evaluation questionnaires. Fifty (25 BTB autograft and 25 BTB allograft) of the 120 returned for physical examination as well as completion of a single leg hop test and laxity evaluation using a KT-1000 arthrometer evaluation. Of the 120 patients contacted, there were a total of 7 failures (5.8%) requiring revision, 6 in the allograft group (86%) and 1 in the autograft group (14%). Results: The average Lysholm scores were 89.0 and 89.56 and the average IKDC scores were 90.8 and 92.1 in the autograft and allograft groups respectively. The differences in the Lysholm scores and the IKDC scores were not significant. The single leg hop and KT-1000 scores were also not significantly different. One autograft patient had a minor motion deficit. Three allograft patients had a grade 1 Lachman and pivot glide. One autograft patient and two allograft patients had mild patellafemoral crepitus. There was no significant difference in anterior knee pain between the two groups Conclusion: There is no significant difference in patient-rated outcome between ACL reconstructions using BTB autografts versus allografts. However, the overall study group did reveal an increased failure rate requiring revision in the allograft group. © The Author(s) 2015

British ‘Colonial governmentality’: slave, forced and waged worker policies in colonial Nigeria, 1896–1930

“This is an Accepted Manuscript of an article published by Taylor & Francis in Management & Organizational History on 22 Apr 2019, available online: https://doi.org/10.1080/17449359.2019.1578669

Response of lowland rice-ratooned rice-fluted pumpkin sequence to fertilizer in rainfed inland valley in derived savannah of Nigeria

Trial was carried out at Federal University of Agriculture, Abeokuta, Nigeria between 2010 and 2012 to determine response of lowland rice-ratooned rice-fluted pumpkin sequence to fertilizer. Experiment was laid out in Randomized Complete Block Design arranged in split-split plot in three replicates. Three rice genotypes constituted the main treatments sown in May and harvested in August. Split fertilizers application constituted sub-plot treatments were 90:45:45 (single dose), 45:22.5:22.5 &amp; 45:22.5:22.5 (1:1), 30:15:15 &amp; 60:30:30 (1:2) and 60:30:30 &amp; 30:15:15 (2:1) NPK ha-1 at tillering and heading. N-fertilizer rates were  sub-sub plot treatment and applied to ratooned ‘NERICA L-42’ had the tallest plants compare to others. ‘Ofada’ had the lowest number of days to 50 % flowering for main and ratooned rice, while ‘NERICA L-42’ had the highest number of days to 50 % heading. ‘NERICA L-41’ variety had the highest grain yield in main and ratooned rice. Based on this study, ‘NERICA L-41’ plus its ratooned rice obtained from single dose NPK and zero N-fertilizer plots produced grain yield of 4.69 t ha-1.</p

Avaliação e seleção de híbridos de cacaueiro em Rondônia Evaluation and selection of cacao hybrids in Rondônia

Este trabalho teve como objetivo avaliar e selecionar híbridos de cacaueiro, quanto a rendimento e qualidade de sementes, nas condições ecológicas do Município de Ouro Preto do Oeste, Rondônia. A seleção foi feita comparando-se, pelo teste de Duncan, as médias das medidas dos componentes de rendimento avaliados em um ensaio conduzido entre 1986 e 1991. O delineamento experimental usado foi o de blocos completos casualizados. Os melhores desempenhos, quanto aos caracteres avaliados, foram obtidos em cruzamentos que incluíram os clones POUND 7 e BE 10 (número total de frutos coletados), SCA 6 e PA 150 (número total de frutos sadios), PA 150 (peso total de sementes úmidas), IMC 67 e POUND 7 (peso médio de sementes úmidas por fruto). Na análise simultânea dos caracteres, os híbridos SCA 6 x ICS 1, PA 150 x SIC 328 e IMC 67 x BE 8 sobressaíram-se, em relação aos demais.<br>The goal of the present work was to evaluate and to select cacao hybrids with respect to seed yield and quality for ecological conditions of municipality of Ouro Preto do Oeste, Rondônia, Brazil. The selection was done comparing, by means of Duncan test, the yield measurement average in trial conducted from 1986 to 1991. A randomized complete block design was used. The best performance, considering total number of collected fruits, total number of healthy fruits, total weight of humid seeds and mean weight of humid seeds per fruit, were obtained from crosses involving POUND 7 and BE 10, SCA 6 and PA 150, PA 150, IMC 67 and POUND 7 clones, respectively. The hybrids SCA 6 x ICS 1, PA 150 x SIC 328 and IMC 67 x BE 8 were outstanding when compared to the others

In vitro efficacy of Coriandrum sativum, Lippia sidoides and Copaifera reticulata against Leishmania chagasi Eficácia in vitro de Coriandrum sativum, Lippia sidoides e Copaifera reticulata sobre Leishmania chagasi

The increased incidence of visceral leishmaniasis (VL) in Brazil is due to a lack of effective disease control measures. In addition to that, no effective treatment exists for canine VL in response to synthetic drugs. Thus, the objective of this study was to evaluate the effect of the essential oils of Coriandrum sativum and Lippia sidoides, and oleoresin from Copaifera reticulata, on Leishmania chagasi promastigotes and amastigotes. We also examined the toxicity of these treatments on the murine monocyte cell line RAW 264.7. To determine the IC50 a MTT test (3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) was performed on promastigotes, and an in situ ELISA assay was conducted on amastigotes. Here, we demonstrate that oleoresin from C. reticulata was effective against both promastigotes (IC50 of 7.88 µg.mL-1) and amastigotes (IC50 of 0.52 µg.mL-1), and neither of the two treatments differed significantly (p > 0.05) from pentamidine (IC50 of 2.149 µg.mL-1) and amphotericin B (IC50 of 9.754 µg.mL-1). Of the three plant oils tested, only oleoresin showed no toxicity toward monocyte, with 78.45% viability after treatment. Inhibition of promastigote and amastigote growth and the lack of cytotoxicity by C. reticulata demonstrate that oleoresin may be a viable option for analyzing the in vivo therapeutic effects of leishmanicidal plants<br>O aumento na incidência da Leishmaníase Visceral (LV) no Brasil deve-se à ineficácia das medidas de controle da doença. Além disso, não há tratamento efetivo para LV canina com drogas sintéticas. Assim, o objetivo deste trabalho foi avaliar o efeito dos óleos essenciais de Coriandrum sativum e de Lippia sidoides e do óleo-resina de Copaiferareticulata sobre promastigotas e amastigotas de Leishmania chagasi e analisar o grau de toxicidade sobre células monocíticas murinas RAW 264.7. Para determinar a CI50 sobre promastigotas foi usado teste MTT (brometo de 3-[4,5-dimetil-tiazol-2-il]-2,5-difeniltetrazólio) e sobre amastigotas foi realizado imunoensaio in situ pela técnica de ELISA. Os resultados obtidos comprovaram que o óleo-resina de C. reticulata foi o mais eficaz contra as formas promastigotas (CI50 de 7,88 µg.mL-1) e amastigotas (CI50 de 0,52 µg.mL-1) e em nenhum dos dois testes diferiu do controle pentamidina que obteve CI50 de 2,149 µg.mL-1, no teste sobre promastigotas, e anfotericina B que obteve CI50 de 9,754 µg.mL-1, nos testes com amastigotas (p > 0.05). Quanto à citotoxicidade apenas o óleo-resina não apresentou toxicidade com 78,45% de monócitos viáveis. Os resultados obtidos sobre promastigotas e amastigotas e a ausência de citotoxicidade do óleo-resina de C. reticulata evidenciam que este óleo-resina pode ser viável para a análise de seus efeitos terapêuticos em testes in vivo