TESTING FOR MULTIPLE UPPER OUTLIERS IN DISTRIBUTION SAMPLES: A STUDY OF FOREIGN EXCHANGE DATA

In this study, the existences of k-upper outliers are investigated in distribution samples of gamma, Normal and exponential by carrying out a simulation of ten thousand at different values of n using algorithm introduced by Tietjen-Moore, test statistics, and critical values were equally estimated from the algorithm. A Normal Q-Q plot was made which aims at distinguishing a data set that follows a normal distribution and one that deviates from normality. The algorithm was applied to Nigeria-US dollars foreign exchange rate, both on raw and logarithmic transformed data. The simulation study reveals the existence of upper outliers more in Gamma and exponential samples than the Normal sample. Empirical analysis shows that there are upper outliers in the raw data set but no upper outliers are found in the transformed data. The result in this paper would help the researcher in business and economics to take time to explore data before use and properly transform accordingly to avoid error in estimation

Design and Development of aWeb Application for Matching Drug Addiction Treatment Services with Substance Users

One of the current and biggest problems in the system of emergency care for the drug overdose epidemic is the failure of information delivery on nearby treatment facilities. Even though some initiatives have tried to solve this issue, they either failed in delivering the information or in providing good usability. This paper presents the design and development of a web application that we refer to as DrugHelp.Care. This application delivers highly accurate, easy-to-understand, and targeted information in a timely manner for substance users and their well-wishers. It also provides an ecosystem for the treatment facilities with an easy-to-use interface to constantly update their complex information along with automatic email reminders and data completion progress indicators. Based on the requirements we have collected from substance users and treatment facilities, the application is designed and developed using the LAMP stack. A search engine for the substance users and their well-wishers preserves complete anonymity, which is very important to ensure the confidentiality of substance users

Evaluation of Growth Performance of Tomato in Response to Biochar and Arbuscular Mycorrhizal Fungi (Amf) Inoculation

Field experiment was conducted in 2013 and 2014 to evaluate growth performance of two tomato genotypes in response to biochar application and arbuscular mycorrhizal fungal (AMF) inoculation at the Teaching and Research Farm, Federal University of Agriculture, Abeokuta. The experiment was laid out in a split-split plot design with two tomato genotypes in the main plots, five levels of biochar application in the sub plots and two levels of AMF inoculation in the sub-sub plots. Data on plant height number of leaves and dry matter yields were generated and subjected to analysis of variance and significant means separated using Duncan’s Multiple Range Test at 5 % level of significance. The result shows that mycorrhizal inoculation significantly increased (p< 0.05) the shoot dry matter yield (2935.8 kg ha-1) when compared with non-mycorrhizal plants, there is no significant difference in number of leaves, height and root dry matter yield. Application of 20 t ha-1 of biochar significantly increased (p< 0.05) the shoot dry matter yields and plant height while no significant differences were observed in number of leaves and root dry matter yield. From the results obtained it can be concluded that AMF can successfully be inoculated into biochar amended soil to improve the performance of tomato plant.Keywords: Biochar; AMF; inoculation; tomato; growth performance

Statistiques de pêche en lagune Ebrié (Côte d'Ivoire): 1976 et 1977

In the Ebrié lagoon fishes are mostly caught by means of 6 kinds of fishing gear: small and large mesh gillnets (respectively 1.5-2 and 6.5-8 inches stretched mesh), cast-nets and multi-hooked lines for individual fishermen, and beach seines and ring-nets for collective fishing. Statistical data gathered during 1977 allowed an estimation of total catches: about 6700 tons. The bulk of the catch, 4800 tons, came from beach nets and ring nets, the contribution of which is nearly the same. Individual fishing gear, small mesh gillnets repesenting the main part, account for 25 to 30% of total catch; about 1900 tons for year 1977. Six species, or species groups, comprise more than 85% of the catch. In the Abidjan area, where marine influence is the more noticeable, ring nets are more numerous and their catches increased since 1975. On the other hand, fish captures in unsalted and brackish waters seem to show a stagnancy and a decrease in fish lengths; this phenomenon is probably in connection with beach-seine excessive fishing effort and/or their small meshes (one inch stretched)

Development of oil-in-water (o/w) nanoemulsion formulations for spontaneous transdermal delivery of ciprofloxacin

Nanoemulsions have attracted attention in delivery of therapeutically active agents since most of the new chemical entities are hydrophobic in nature and the delivery of poor water soluble drugs is a challenge. This study was carried out to adopt nanoemulsion as a means of entrapping ciprofloxacin in the oil phase of the emulsion for transdermal drug delivery. Nanoemulsions were formulated as oil in water (O/W) type and prepared by self-mild mechanical nanoemulsification method. The formulation consisted of Sandbox (Huracrepitan) and Sesame seed (Sesamumindicum) as the organic phase of the emulsion, Polyethylene (20) sorbitanmonooleate (Tween 80) and Polyethylene (20) sorbitanmonolaurate (Tween 20) as the surfactants and Polyehtylene glycol (PEG 400) as co-surfactant. The formulations were tested and characterized. Ciprofloxacin (0.075 g) was incorporated into the oil phase of the most stable nanoemulsion formulation prior emulsification and tested on Escherichia coli. Transdermal application was done on male Wister rats (R) followed by biopsification. The result showed the zones of inhibition of HCa3+Ciprofloxacin (Ciprofloxacin-loaded, Huracrpitan oil based nanoemulsion) and SSA3+Ciprofloxacin (Ciprofloxacin-loaded, Sesame oil based nanoemulsion) to be 26.00 and 25.00 mm respectively. The HPLC results showed that, out of 75000 µg of ciprofloxacin loaded in the oil phases of HCa3 and SSA3 formulations, 6.0076 (R2), 0.4112 (R3) and 6.7241 µg (R6) were absorbed in HCa3 while 1.9519 (R1), 1.2631 (R4) and 2.1801 µg (R5) were absorbed in SSA3. The SEM images revealed an encapsulation with globule size diameter of 94 and 63 nm respectively. The findings of this work showed that sandbox and Sesame seedoil based nanoemulsions are effective for transdermal drug delivery

A Pseudo-tRNA Modulates Antibiotic Resistance in \u3cem\u3eBacillus cereus\u3c/em\u3e

Bacterial genomic islands are often flanked by tRNA genes, which act as sites for the integration of foreign DNA into the host chromosome. For example, Bacillus cereus ATCC14579 contains a pathogenicity island flanked by a predicted pseudo-tRNA, tRNAOther, which does not function in translation. Deletion of tRNAOther led to significant changes in cell wall morphology and antibiotic resistance and was accompanied by changes in the expression of numerous genes involved in oxidative stress responses, several of which contain significant complementarities to sequences surrounding tRNAOther. This suggested that tRNAOther might be expressed as part of a larger RNA, and RACE analysis subsequently confirmed the existence of several RNA species that significantly extend both the 3′ and 5′-ends of tRNAOther. tRNAOther expression levels were found to be responsive to changes in extracellular iron concentration, consistent with the presence of three putative ferric uptake regulator (Fur) binding sites in the 5′ leader region of one of these larger RNAs. Taken together with previous data, this study now suggests that tRNAOther may function by providing a tRNA-like structural element within a larger regulatory RNA. These findings illustrate that while integration of genomic islands often leaves tRNA genes intact and functional, in other instances inactivation may generate tRNA-like elements that are then recruited to other functions in the cell

A Pseudo-tRNA Modulates Antibiotic Resistance in Bacillus cereus

Bacterial genomic islands are often flanked by tRNA genes, which act as sites for the integration of foreign DNA into the host chromosome. For example, Bacillus cereus ATCC14579 contains a pathogenicity island flanked by a predicted pseudo-tRNA, tRNA(Other), which does not function in translation. Deletion of tRNA(Other) led to significant changes in cell wall morphology and antibiotic resistance and was accompanied by changes in the expression of numerous genes involved in oxidative stress responses, several of which contain significant complementarities to sequences surrounding tRNA(Other). This suggested that tRNA(Other) might be expressed as part of a larger RNA, and RACE analysis subsequently confirmed the existence of several RNA species that significantly extend both the 39 and 5\u27-ends of tRNA(Other). tRNA(Other) expression levels were found to be responsive to changes in extracellular iron concentration, consistent with the presence of three putative ferric uptake regulator (Fur) binding sites in the 59 leader region of one of these larger RNAs. Taken together with previous data, this study now suggests that tRNA(Other) may function by providing a tRNA-like structural element within a larger regulatory RNA. These findings illustrate that while integration of genomic islands often leaves tRNA genes intact and functional, in other instances inactivation may generate tRNA-like elements that are then recruited to other functions in the cell

Neonatal mortality rates, characteristics, and risk factors for neonatal deaths in Ghana:analyses of data from two health and demographic surveillance systems

BACKGROUND: Reducing neonatal mortality rates (NMR) in developing countries is a key global health goal, but weak registration systems in the region stifle public health efforts. OBJECTIVE: To calculate NMRs, investigate modifiable risk factors, and explore neonatal deaths by place of birth and death, and cause of death in two administrative areas in Ghana. METHODS: Data on livebirths were extracted from the health and demographic surveillance systems in Navrongo (2004-2012) and Kintampo (2005-2010). Cause of death was determined from neonatal verbal autopsy forms. Univariable and multivariable logistic regression were used to analyse factors associated with neonatal death. Multiple imputations were used to address missing data. RESULTS: The overall NMR was 18.8 in Navrongo (17,016 live births, 320 deaths) and 12.5 in Kintampo (11,207 live births, 140 deaths). The annual NMR declined in both areas. 54.7% of the births occurred in health facilities. 70.9% of deaths occurred in the first week. The main causes of death were infection (NMR 4.3), asphyxia (NMR 3.7) and prematurity (NMR 2.2). The risk of death was higher among hospital births than home births: Navrongo (adjusted OR 1.14, 95% CI: 1.03-1.25, p = 0.01); Kintampo (adjusted OR 1.76, 95% CI: 1.55-2.00, p < 0.01). However, a majority of deaths occurred at home (Navrongo 61.3%; Kintampo 50.7%). Among hospital births dying in hospital, the leading cause of death was asphyxia; among hospital and home births dying at home, it was infection. CONCLUSION: The NMR in these two areas of Ghana reduced over time. Preventing deaths by asphyxia and infection should be prioritised, centred respectively on improving post-delivery care in health facilities and subsequent post-natal care at home

Human Infection with Rickettsia felis, Kenya

This flea-borne pathogen was detected in febrile patients in North Eastern Province, Kenya

Understanding the determinants of postnatal care uptake for babies: A mixed effects multilevel modelling of 2016–18 Papua New Guinea Demographic and Health Survey

Abstract Background Papua New Guinea (PNG) recorded 22 neonatal deaths out of every 1,000 livebirths in 2019. Some of these deaths are related to complications that arise shortly after childbirth; hence, postnatal care (PNC) utilisation could serve as a surviving strategy for neonates as recommended by the World Health Organisation. National level study on determinants of PNC uptake in PNG is limited. Utilising the Bronfenbrenner’s Ecological Model of Human Development, the study aimed at assessing determinants of PNC utilisation for babies by their mothers aged 15–49 in PNG. Methods The study used data from the women’s file of the 2016–18 PNG Demographic and Health Survey (2016–18 PNGDHS) and a sample of 4,908 women aged 15–49 who had complete information on the variables of interest to the study. Nineteen (19) explanatory variables were selected for the study whereas PNC for babies within first two months after being discharged after birth was the main outcome variable. At 95% confidence interval (95% CI), six multilevel logistic models were built. The Akaike Information Criterion (AIC) was used to assess models’ fit. All analyses were carried out using STATA version 14.0. Results Generally, 31% of the women utilised PNC for their babies. Women with primary education [aOR = 1.42, CI = 1.13–1.78], those belonging to the middle wealth quintile [aOR = 1.42, CI = 1.08–1.87], working class [aOR = 1.28, CI = 1.10–1.49], women who had the four or more ANC visits [aOR = 1.23, CI = 1.05–1.43], those with twins [aOR = 1.83, CI = 1.01–3.29], women who belonged to community of medium literate class [aOR = 1.75, CI = 1.34–2.27] and those of moderate socioeconomic status [aOR = 1.60, CI = 1.16–2.21] had higher odds of seeking PNC for their babies. The odds to seek PNC services for babies reduced among the cohabiting women [aOR = 0.79, CI = 0.64–0.96], those at parity four or more [aOR = 0.77, CI = 0.63–0.93], women who gave birth to small babies [aOR = 0.80, CI = 0.67–0.98] and residents in the Highlands region [aOR = 0.47, CI = 0.36–0.62]. Conclusions Maternal education, wealth quintile, occupation, partner’s education, ANC visits, marital status, parity, child size at birth, twin status, community literacy and socioeconomic status as well as region of residence were associated with PNC uptake for babies in PNG. Variation in PNC uptake for babies existed from one community/cluster to the other. There is the need to strengthen public health education to increase awareness about the benefits of seeking PNC services for babies among women in PNG. Such programs should consider maternal and community/cluster characteristics in their design. </jats:sec