FATIGUE TEST OF MATERIALS AND THEIR WELDED JOINTS USED IN VEHICLE MANUFACTURING

The Department of Mechanics at the Faculty of Transport Engineering of the BME took a considerable part in the research connected with vehicle manufacturing, and especially with the manufacturing of motor buses. During the past years, research was carried out into such materials, among others in [1], [2], which resulted in providing basic design data for both factories: GANZ-MA VAG and Ikarusz

Magnetic Field-Induced Condensation of Triplons in Han Purple Pigment BaCuSi2_2O6_6

Besides being an ancient pigment, BaCuSi$_2$O$_6$ is a quasi-2D magnetic insulator with a gapped spin dimer ground state. The application of strong magnetic fields closes this gap creating a gas of bosonic spin triplet excitations called triplons. The topology of the spin lattice makes BaCuSi$_2$O$_6$ an ideal candidate for studying the Bose-Einstein condensation of triplons as a function of the external magnetic field, which acts as a chemical potential. In agreement with quantum Monte Carlo numerical simulations, we observe a distinct lambda-anomaly in the specific heat together with a maximum in the magnetic susceptibility upon cooling down to liquid Helium temperatures.Comment: published on August 20, 200

A Description of Laying Hen Husbandry and Management Practices in Canada

Canadian laying hen farms are transitioning from conventional cage housing to furnished cage and non-cage housing systems to improve laying hen welfare. However, little is known about the current housing and management systems in Canada. This study addresses this knowledge gap by describing different housing and management practices used on farms where laying hens were housed in furnished cages or non-cage housing systems. A questionnaire covering farm and housing conditions, litter management, nutrition and feeding, environmental control, flock characteristics, rearing and placement, health, egg production and performance were distributed through provincial egg boards to 122 producers across Canada. Data were collected from 65 laying hen flocks (52.5% response rate) in 26 furnished cage, 17 single-tier and 22 multi-tier systems. Flocks were on average 45.1 ± 14.59 weeks old (range: 19–69 weeks). Frequencies of different management practices were calculated according to housing system. Most flocks were reared in the same housing system as they were housed in during lay, with the exception of furnished cage layers which were reared in conventional cage systems. Results indicated that a large proportion of non-cage systems were either fully slatted or had manure as a litter substrate, which could have implications for consumer perspectives on these systems. Further research is needed to develop clear recommendations on proper litter management for farmers. In general, flock health was managed through daily inspections and vaccination schemes, whereas veterinarian involvement on-farm was less common. Vaccination, hygiene, and effective biosecurity should be maintained to ensure good health in laying hens in furnished cage and non-cage systems during the transition to these systems

Altered serological and cellular reactivity to H-2 antigens after target cell infection with vaccinia virus

MICE generate cytotoxic T lymphocytes (CTL) which are able to lyse virus infected target cells in vitro after infection with lymphocytic choriomeningitis virus (LCMV) and pox-viruses1−3. CTL kill syngeneic and semiallogenic infected cells but not allogenic infected targets. Target cell lysis in these systems seems to be restricted by H-2 antigens, especially by the K or D end of the major histocompatibility complex (MHC). In experiments where virus specific sensitised lymphocytes kill virus infected allogenic target cells4 the effector lymphocytes have not been characterised exactly. Recent investigations suggest that the active cell in this assay, at least in the measles infection, is a non-thymus derived cell (H. Kreth, personal communication). An H-2 restriction of cell mediated cytolysis (CMC) to trinitrophenol (TNP)-modified lymphocytes has also been described5. Zinkernagel and Doherty6 postulated that the CTL is directed against syngeneic H-2 antigens and viral antigens and they suggested an alteration of H-2 induced by the LCMV infection. Earlier7 we found a close topological relationship between H-2 antigens and the target antigen(s) responsible for CMC in the vaccinia system. Here we report experiments which were carried out to prove alteration of H-2 after infection of L-929 fibroblasts with vaccinia virus

Investigating the spatial risk distribution of West Nile virus disease in birds and humans in southern Ontario from 2002 to 2005

<p>Abstract</p> <p>Background</p> <p>The West Nile virus (WNv) became a veterinary public health concern in southern Ontario in 2001 and has continued to threaten public health. Wild bird mortality has been shown to be an indicator for tracking the geographic distribution of the WNv. The purpose of this study was to investigate the latent risk distribution of WNv disease among dead birds and humans in southern Ontario and to compare the spatial risk patterns for the period 2002–2005. The relationship between the mortality fraction in birds and incidence rate in humans was also investigated.</p> <p>Methods</p> <p>Choropleth maps were created to investigate the spatial variation in bird and human WNv risk for the public health units of southern Ontario. The data were smoothed by empirical Bayesian estimation before being mapped. Isopleth risk maps for both the bird and human data were created to identify high risk areas and to investigate the potential relationship between the WNv mortality fraction in birds and incidence rates in humans. This was carried out by the geostatistical prediction method of kriging. A Poisson regression analysis was used to model regional human WNv case counts as a function of the spatial coordinates in the east and north direction and the regional bird mortality fractions. The presence of disease clustering and the location of disease clusters were investigated by the spatial scan test.</p> <p>Results</p> <p>The isopleth risk maps exhibited high risk areas that were relatively constant from year to year. There was an overlap in the bird and human high risk areas, which occurred in the central-west and south-west areas of southern Ontario. The annual WNv cause-specific mortality fractions in birds for 2002 to 2005 were 31.9, 22.0, 19.2 and 25.2 positive birds per 100 birds tested, respectively. The annual human WNv incidence rates for 2002 to 2005 were 2.21, 0.76, 0.13 and 2.10 human cases per 100,000 population, respectively. The relative risk of human WNv disease was 0.72 times lower for a public health unit that was 100 km north of another public health unit. The relative risk of human WNv disease increased by the factor 1.44 with every 10 positive birds per 100 tested. The scan statistic detected disease cluster in the bird and human data. The human clusters were not significant, when the analysis was conditioned on the bird data.</p> <p>Conclusion</p> <p>The study indicates a significant relationship between the spatial pattern of WNv risk in humans and birds.</p

Sediment history mirrors Pleistocene aridification in the Gobi Desert (Ejina Basin, NW China)

Central Asia is a large-scale source of dust transport, but it also held a prominent changing hydrological system during the Quaternary. A 223 m long sediment core (GN200) was recovered from the Ejina Basin (synonymously Gaxun Nur Basin) in NW China to reconstruct the main modes of water availability in the area during the Quaternary. The core was drilled from the Heihe alluvial fan, one of the world's largest alluvial fans, which covers a part of the Gobi Desert. Grain-size distributions supported by endmember modelling analyses, geochemical-mineralogical compositions (based on XRF and XRD measurements), and bioindicator data (ostracods, gastropods, pollen and non-pollen palynomorphs, and n-alkanes with leaf-wax delta D) are used to infer the main transport processes and related environmental changes during the Pleistocene. Magnetostratigraphy supported by radionuclide dating provides the age model. Grain- size endmembers indicate that lake, playa (sheetflood), fluvial, and aeolian dynamics are the major factors influencing sedimentation in the Ejina Basin. Core GN200 reached the pre-Quatemary quartz- and plagioclase-rich "Red Clay" formation and reworked material derived from it in the core bottom. This part is overlain by silt-dominated sediments between 217 and 110 m core depth, which represent a period of lacustrine and playa-lacustrine sedimentation that presumably formed within an endorheic basin. The upper core half between 110 and 0 m is composed of mainly silty to sandy sediments derived from the Heihe that have accumulated in a giant sediment fan until modem time. Apart from the transition from a siltier to a sandier environment with frequent switches between sediment types upcore, the clay mineral fraction is indicative of different environments. Mixed-layer clay minerals (chlorite/smectite) are increased in the basal Red Clay and reworked sediments, smectite is indicative of lacustrine-playa deposits, and increased chlorite content is characteristic of the Heihe river deposits. The sediment succession in core GN200 based on the detrital proxy interpretation demonstrates that lake-playa sedimentation in the Ejina Basin has been disrupted likely due to tectonic events in the southern part of the catchment around 1 Ma. At this time Heihe broke through from the Hexi Corridor through the Heli Shan ridge into the northern Ejina Basin. This initiated the alluvial fan progradation into the Ejina Basin. Presently the sediment bulge repels the diminishing lacustrine environment further north. In this sense, the uplift of the hinterland served as a tipping element that triggered landscape transformation in the northern Tibetan foreland (i.e. the Hexi Corridor) and further on in the adjacent northern intracontinental Ejina Basin. The onset of alluvial fan formation coincides with increased sedimentation rates on the Chinese Loess Plateau, suggesting that the Heihe alluvial fan may have served as a prominent upwind sediment source for it

Synthesis of graphene and graphene nanostructures by ion implantation and pulsed laser annealing

In this paper, we report a systematic study that shows how the numerous processing parameters associated with ion implantation (II) and pulsed laser annealing (PLA) can be manipulated to control the quantity and quality of graphene (G), few-layer graphene (FLG), and other carbon nanostructures selectively synthesized in crystalline SiC (c-SiC). Controlled implantations of Si− plus C− and Au + ions in c-SiC showed that both the thickness of the amorphous layer formed by ion damage and the doping effect of the implanted Au enhance the formation of G and FLG during PLA. The relative contributions of the amorphous and doping effects were studied separately, and thermal simulation calculations were used to estimate surface temperatures and to help understand the phase changes occurring during PLA. In addition to the amorphous layer thickness and catalytic doping effects, other enhancement effects were found to depend on other ion species, the annealing environment, PLA fluence and number of pulses, and even laser frequency. Optimum II and PLA conditions are identified and possible mechanisms for selective synthesis of G, FLG, and carbon nanostructures are discussed

NF-κB-mediated effects on behavior and cartilage pathology in a non-invasive loading model of post-traumatic osteoarthritis

OBJECTIVE: This study aimed to examine the temporal activation of NF-κB and its relationship to the development of pain-related sensitivity and behavioral changes in a non-invasive murine knee loading model of PTOA. METHOD: Following knee injury NF-κB activity was assessed longitudinally via in vivo imaging in FVB. Cg-Tg (HIV-EGFP,luc)8Tsb/J mice. Measures of pain-related sensitivity and behavior were also assessed longitudinally for 16 weeks. Additionally, we antagonized NF-κB signaling via intra-articular delivery of an IκB kinase two antagonist to understand how local NF-κB inhibition might alter disease progression. RESULTS: Following joint injury NF-κB signaling within the knee joint was transiently increased and peaked on day 3 with an estimated 1.35 p/s/cm CONCLUSION: These findings underscore the development of behavioral changes in this non-invasive loading model of PTOA and their relationships to NF-κB activation and pathology. They also highlight the potential chondroprotective effects of NF-κB inhibition shortly following joint injury despite limitations in preventing the long-term development of joint degeneration in this model of PTOA