31 research outputs found
Anterior approaches in juvenile nasopharyngeal angiofibromas with intracranial extension
The incidence of thyroid cartilage invasion through the anterior commissure in clinically early-staged laryngeal cancer
Extensive screening for occult malignant disease in idiopathic venous thromboembolism: a prospective randomized clinical trial
Patients with symptomatic idiopathic venous
thromboembolism and apparently cancer-free have an approximate
10% incidence of subsequent cancer. Apparently cancerfree
patients with acute idiopathic venous thromboembolism
were randomized to either the strategy of extensive screening for
occult cancer or to no further testing. Patients had a 2-year
follow-up period. Of the 201 patients, 99 were allocated to the
extensive screening group and 102 to the control group. In
13 (13.1%) patients, the extensive screening identified occult
cancer. In the extensive screening group, a single (1.0%)
malignancy became apparent during follow-up, whereas in the
control group a total of 10 (9.8%) malignancies became
symptomatic [relative risk, 9.7 (95% CI, 1.3\u201336.8; P < 0.01].
Overall, malignancies identified in the extensive screening group
were at an earlier stage and the mean delay to diagnosis was
reduced from 11.6 to 1.0 months (P < 0.001). Cancer-related
mortality during the 2 years follow-up period occurred in two
(2.0%) of the 99 patients of the extensive screening group vs.four (3.9%) of the 102 control patients [absolute difference,
1.9% (95% CI, )5.5\u201310.9)]. Although early detection of occult
cancers may be associated with improved treatment possibilities,
it is uncertain whether this improves the prognosi